Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinolD W Sepkovic
Institute for Biomedical Research, Hackensack University Medical Center, Hackensack, NJ 07601, USA
Nutr Cancer 41:57-63. 2001
..The assay provides an objective marker of consumption using a noninvasive biological fluid and illustrates that diindolylmethane may be used as a marker of compliance in I3C dietary intervention studies...
- Steroids as procarcinogenic agents
H Leon Bradlow
The David and Alice Jurist Institute for Biomedical Research, HUMC, 30 Prospect Ave, Hackensack, NJ 07601, USA
Ann N Y Acad Sci 1028:216-32. 2004
..Of the various hormones produced in the body, only aldosterone does not cause any cancers, although excess aldosterone can cause Conn's syndrome, which may be detected by the resultant hypertension...
- Diindolylmethane (DIM) spontaneously forms from indole-3-carbinol (I3C) during cell culture experiments
H L Bradlow
David and Alice Jurist Institute for Medical Research, HUMC Hackensack, NJ 07601, USA
In Vivo 24:387-91. 2010
..This suggests that DIM is the predominant active agent and that I3C is a precursor, 'pro-drug' in vivo. However, in cell culture studies carried out in neutral solutions, I3C has been considered fully active...
- Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer
H Leon Bradlow
David and Alice Jurist Institute for Medical Research, Hackensack University Medical Center Hackensack, NJ 07601, USA
In Vivo 22:441-5. 2008
..Because DIM provides a predictable, safer response than the mélange of compounds derived from I3C DIM should be regarded as the chemoprotective compound of choice...
- The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer
Marilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
Breast Cancer Res Treat 74:235-54. 2002
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- Urinary estrogen metabolites and breast cancer: differential pattern of risk found with pre- versus post-treatment collection
Jay H Fowke
Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
Steroids 68:65-72. 2003
..We investigated the association between the relative concentrations of these metabolites in urine (2-OHE/16-OHE) and breast cancer in a case-control study of Chinese women living in Shanghai...
- Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer
Kathie M Dalessandri
Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3200, USA
Nutr Cancer 50:161-7. 2004
..020), DIM (P =0. 045), and cortisol (P = 0.039), and a nonsignificant increase of 47% in the 2-OHE1/16alpha-OHE1 ratio from 1.46 to 2.14 (P=0.059). In this pilot study, DIM increased the 2-hydroxylation of estrogen urinary metabolites...
- Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood
Marilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:686-97. 2002
..These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women...
- Urinary estrogen metabolites and their ratio among Asian American women
Roni T Falk
Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, MSC 7234, Suite 7070, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:221-6. 2005
..Our study suggests that the ratio of 2-OHE(1):16alpha-OHE(1) may be a marker for lifestyle influences on estrogen metabolism associated with westernization...
- Estrogen metabolism and breast cancer
Geoffrey C Kabat
Department of Preventive Medicine, School of Medicine, Stony Brook University, New York, USA
Epidemiology 17:80-8. 2006
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- Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer
Heather Greenlee
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, 7th Floor, New York, NY 10032, USA
Breast Cancer Res Treat 102:111-7. 2007
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- Diet and breast cancer
H Leon Bradlow
David and Alice Jurist Institute for Research, Hackensack University Medical Center, Hackensack, New Jersey 07601, USA
Ann N Y Acad Sci 963:247-67. 2002
..These effects are not merely theoretical actions in cell culture and tissue explants; they have been demonstrated in human patients as a range of studies have demonstrated...
