Reaction mechanism of melatonin oxidation by reactive oxygen species in vitroDominique Bonnefont-Rousselot
EA 4466, Département de Biologie Expérimentale, Métabolique et Clinique, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
J Pineal Res 50:328-35. 2011
..Finally, a reaction mechanism was proposed for the oxidation of melatonin in vitro...
- Melatonin: action as antioxidant and potential applications in human disease and aging
Dominique Bonnefont-Rousselot
EA 3617, Département de Biologie Expérimentale, Métabolique et Clinique, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, 4 avenue de l Observatoire, 75006 Paris, France
Toxicology 278:55-67. 2010
..Its global action on oxidative stress, together with its rhythmicity that plays a role in several metabolic functions, lead melatonin to be of great interest for future clinical research in order to improve public health...
- In vitro low-density lipoprotein oxidation by copper or *OH/O*(2)(-): new features on carbonylation and fragmentation of apolipoprotein B during the lag phase
Stéphanie Zarev
Laboratoire de Biochimie Métabolique et Clinique, Faculte de Pharmacie, Paris, France
Arch Biochem Biophys 404:10-7. 2002
..By contrast, apolipoprotein B carbonylated fragmentation was detected in the lag phase of *OH/O*(2)(-) oxidized LDL...
- Chain-breaking activity of resveratrol and piceatannol in a linoleate micellar model
Yara Rhayem
EA 3617, Departement de Biochimie, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, 75006 Paris, France
Chem Phys Lipids 155:48-56. 2008
..A lower limit for the LOO rate constant has been estimated for piceatannol (>/=1.4x10(5)M(-1)s(-1)) and for resveratrol (>/=0.3x10(5)M(-1)s(-1))...
- Impairment of thioredoxin reductase activity by oxidative stress in human rheumatoid synoviocytes
Herve Lemarechal
Biochemistry laboratory Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Free Radic Res 41:688-98. 2007
....
- Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress
Matthieu Frombaum
EA 4466 Stress Cellulaire, Physiopathologie, stratégies nutritionnelles et thérapeutiques innovantes, Universite Paris Descartes, UFR des Sciences Pharmaceutiques et Biologiques, 4, avenue de l Observatoire, 75006 Paris, France
Free Radic Res 45:293-302. 2011
..These results suggest potential therapeutic intervention targeting resveratrol or piceatannol administration to improve endothelial dysfunction...
- Melatonin related compounds inhibit lipid peroxidation during copper or free radical-induced LDL oxidation
Dominique Bonnefont-Rousselot
Laboratoire de Biochimie, Hôpital de la Salpêtrière AP HP, Paris, France
J Pineal Res 33:109-17. 2002
..It would be interesting to test in vivo if DTBHB and GWC20 which exhibit a strong capacity to inhibit in vitro LDL oxidation would reduce or not atherosclerosis in animals susceptible to this pathology...
- Protection of endogenous beta-carotene in LDL oxidized by oxygen free radicals in the presence of supraphysiological concentrations of melatonin
Dominique Bonnefont-Rousselot
Laboratoire de Biochimie B, Hopital de la Salpetriere, Assistance Publique Hopitaux de Paris AP HP, Paris, France
Redox Rep 8:95-104. 2003
..The effect of melatonin seemed to be the highest for a melatonin concentration of 250 x 10(-6) mol/l...
- Melatonin protects PLPC liposomes and LDL towards radical-induced oxidation
Catherine Marchetti
UMR S 775, Bases Moléculaires de la Réponse aux Xénobiotiques, UFR Biomédicale des Saints Pères, Universite Paris Descartes, Paris, France
J Pineal Res 51:286-96. 2011
..Moreover, melatonin clearly slowed radio-induced apolipoprotein B carbonylation and protected ?-tocopherol and ?-carotene in LDL...
- Interaction between non-anionic phospholipids and cytochrome c induced by reactive oxygen species
Nazha Sidahmed-Adrar
Equipe de Physico Chimie des Espèces Radicalaires, CNRS UMR 8601, Universite Paris Descartes, 45 Rue des Saints Peres, 75006 Paris, France
Chem Phys Lipids 163:538-44. 2010
..Even if it is known to preferentially interact with cardiolipin, this work shows that Cyt c is also able to interact with hydroperoxide species of non-anionic phospholipids...
- trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion
Valerie Nivet-Antoine
Equipe d accueil 4466 Faculté de Pharmacie, Universite Paris Descartes, Paris, France
Biochimie 92:1766-71. 2010
..This is the first report of a major implication of the Trx1/Txnip system in hepatic I/R injuries. It also affirms the importance of the antioxidant effect of T-res on the Trx1/Txnip system...
- Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of trans-resveratrol in aqueous solutions
Laurent Camont
Département de Biochimie EA 3617, Universite Paris Descartes, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75006 Paris, France
Rapid Commun Mass Spectrom 24:634-42. 2010
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- Does dietary ornithine alpha-ketoglutarate supplementation protect the liver against ischemia-reperfusion injury?
Heidi Schuster
Laboratoire de Biologie de la Nutrition, EA2498, Faculte de Pharmacie, Universite Paris 5, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
Clin Nutr 24:375-84. 2005
..This action can tentatively be attributed to the role of OKG as a glutamine precursor rather than to the synthesis of arginine and nitric oxide...
- Blood pressure-lowering response to amlodipine as a determinant of the antioxidative activity of small, dense HDL3
Boris Hansel
Service d Endocrinologie Métabolisme, Hopital de la Pitie, Paris, France
Am J Cardiovasc Drugs 11:317-25. 2011
..This study aimed to assess the effect of 1 month's treatment with amlodipine on HDL AOX in hypertensive subjects...
- Radiolytic yield of cardiolipin peroxidation by gamma rays in large unilamellar vesicles of phosphatidylcholine
Nazha Sid Ahmed-Adrar
Laboratoire de Chimie Physique, CNRS UMR 8601, UFR Biomedicale, Universite Paris Descartes, 75006 Paris, France
Radiat Res 171:622-30. 2009
..e. PLPC and CL, with a higher sensitivity to CL oxidation. It can be concluded that a little amount of CL (10-15% CL/ PLPC concentration ratio) may exert a strong protective effect against the HO(.)-induced peroxidation of PLPC...
- Metformin suppresses high glucose-induced poly(adenosine diphosphate-ribose) polymerase overactivation in aortic endothelial cells
Meriem Mahrouf-Yorgov
EA 3617 Biochimie Radicalaire et Atteintes Vasculaires, Universite Paris Descartes, UFR des Sciences Pharmaceutiques et Biologiques, 4, avenue de l Observatoire, F75006 Paris, France
Metabolism 58:525-33. 2009
..We propose that some of the beneficial effects of metformin on vascular endothelial cell functions in diabetes may be related to its inhibitory effect on PARP overactivation and its deleterious consequences...
- Radical-induced oxidation of trans-resveratrol
Laurent Camont
EA 4466, Département de Biologie Expérimentale, Métabolique et Clinique, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Sorbonne Paris Cité, 4 avenue de l Observatoire, 75006 Paris, France
Biochimie 94:741-7. 2012
..Two reaction pathways involving HO()-induced trans-RVT primary radicals have been proposed to explain the formation of the oxidation end-products of trans-RVT...
- Online H/D exchange liquid chromatography as a support for the mass spectrometric identification of the oxidation products of melatonin
Fabrice Collin
Laboratoire de Chimie Physique, CNRS UMR 8601, Universite Paris Descartes, 45 Rue des Saints Peres, 75006 Paris, France
J Mass Spectrom 44:318-29. 2009
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- Quantification of the water/lipid affinity of melatonin and a pinoline derivative in lipid models
Jamila Mekhloufi
Laboratoire de Chimie Physique, UFR Biomédicale des Saints Pères, Universite Paris 5, Paris, France
J Pineal Res 42:330-7. 2007
..e. k(LOO.+melatonin)) >or= 9.0 x 10(4)m(-1)s(-1) and k(LOO.+GWC22) >or= 3.5 x 10(5)m(-1)s(-1)...
- Resveratrol opposite effects on rat tissue lipoperoxidation: pro-oxidant during day-time and antioxidant at night
Wafa Gadacha
Laboratoire de Biochimie Médicale et Biologie Moléculaire, INSERM U 13, Faculte de Medecine Pierre et Marie Curie, Paris, France
Redox Rep 14:154-8. 2009
..Resveratrol behaved as an antioxidant during the dark span and as a pro-oxidant during the light span. These data suggested a day/night rhythm in basal lipoperoxidation and in resveratrol antioxidant effect...
- Atheroprotective reverse cholesterol transport pathway is defective in familial hypercholesterolemia
Natacha Bellanger
Institut National de la Sante et de la Recherche Medicale, UMRS 939, Hopital de la Pitie, Paris, France
Arterioscler Thromb Vasc Biol 31:1675-81. 2011
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- Expression and extracellular release of Trx80, the truncated form of thioredoxin, by TNF-alpha- and IL-1beta-stimulated human synoviocytes from patients with rheumatoid arthritis
Herve Lemarechal
Biochemistry Laboratory, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Clin Sci (Lond) 113:149-55. 2007
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- Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions
Laurent Camont
Département de Biochimie EA 3617, Universite Paris Descartes, Faculte de Pharmacie, 4 avenue de l Observatoire, 75006 Paris, France
Anal Chim Acta 634:121-8. 2009
..All these data are transferable to 150 mM NaCl and 10 mM phosphate buffer solutions, which could be particularly useful for cell culture, ex vivo and in vivo studies...
- Glucose and reactive oxygen species
Dominique Bonnefont-Rousselot
Laboratoire de Biochimie Métabolique et Clinique, Faculté de Pharmacie and Laboratoire de Biochimie B, Hopital de la Salpetriere, Paris, France
Curr Opin Clin Nutr Metab Care 5:561-8. 2002
..This review aims at presenting new concepts of glucose-induced damage in diabetes via an increased production of oxygen free radicals...
- Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia
Alexina Orsoni
INSERM UMRS939, Hopital de la Pitie, Paris, France
J Lipid Res 53:767-75. 2012
..However, LDL apheresis is without impact on the intrinsic ability of HDL particles to promote either cellular free cholesterol efflux from macrophages or to deliver CE to hepatic cells...
- Hypoxia induces nitric oxide synthase in rheumatoid synoviocytes: consequences on NADPH oxidase regulation
Camille Chenevier-Gobeaux
Laboratoire de Biochimie, Groupe Hospitalier Cochin Broca Hôtel Dieu, Assistance Publique Hopitaux de Paris AP HP, Universite Paris Descartes, Paris Cedex, France
Free Radic Res 46:628-36. 2012
..Synovial cell metabolism under hypoxia conditions might be different from that in normoxia...
- Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease)
Amandine Georges
INSERM U781, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, 75015, France
Orphanet J Rare Dis 6:1. 2011
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- One third of the variability in HDL-cholesterol level in a large dyslipidaemic population is predicted by age, sex and triglyceridaemia: The Paris La Pitié Study
Boris Hansel
Service d Endocrinologie Métabolisme AP HP, Hopital de la Pitie, Paris, France
Curr Med Res Opin 22:1149-60. 2006
....
- Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1
Nadjat Ouslimani
Departement de Biochimie, Faculte de Pharmacie, EA 3617, Biochimie radicalaire et atteintes vasculaires, F75006 Paris, France
Metabolism 56:308-13. 2007
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- Molecular spectrum of autosomal dominant hypercholesterolemia in France
Marie Marduel
Institut National de la Sante et de la Recherche Medicale, U781, 75015, Paris, France 2 Université Paris Descartes, 75006, Paris, France
Hum Mutat 31:E1811-24. 2010
..9%, APOB 6.6%, PCSK9 0.7%. Finally, in 19.0% of the probands,no mutation was found, thus underscoring the existence of ADH mutations located in still unknown genes...
- Impaired glucose tolerance in patients with amyotrophic lateral sclerosis
Pierre Francois Pradat
APHP, Hopital de la Pitie Salpetriere, Fédération des Maladies du Système Nerveux, Paris, France
Amyotroph Lateral Scler 11:166-71. 2010
..The origin of glucose homeostasis abnormalities in ALS may be multifactorial and deserves further investigation...
- Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: Potential benefits to cardiovascular diseases
Matthieu Frombaum
EA 4466 Stress Cellulaire, Physiopathologie, stratégies nutritionnelles et thérapeutiques innovantes, Universite Paris Descartes, Sorbonne Paris Cité, UFR des Sciences Pharmaceutiques et Biologiques, 4, avenue de l Observatoire, 75006 Paris, France
Biochimie 94:269-76. 2012
..This review presents the latest findings on the molecular effects of resveratrol and other stilbene derivatives on the various actors that modulate *NO bioavailability during oxidative stress...
- Blood oxidative stress status in patients with macrophagic myofasciitis
Dominique Bonnefont-Rousselot
Laboratoire des lipides Pavillon B Delessert, Hôpital de la Pitié AP HP 83, Boulevard de l Hopital, 75651, Paris, Cedex 13, France
Biomed Pharmacother 58:516-9. 2004
..Nevertheless, since no deficiency in these elements has been observed, no supplementation is to be considered...
- Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment
Audrey Arfi
CNRS UMR8151, Paris, F 75006, France
Mol Genet Metab 103:18-25. 2011
..These results suggest that anti-inflammatory intervention may be of potential benefit in MPS IIIA disease...
- Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred
Arnaud Galbois
Universite Pierre et Marie Curie, Service d Hepato Gastroenterologie, Hôpital de la Pitié Salpêtrière AP HP, Paris, France
J Hepatol 52:839-45. 2010
....
- Paradoxical protective effect of aminoguanidine toward low-density lipoprotein oxidation: inhibition of apolipoprotein B fragmentation without preventing its carbonylation. Mechanism of action of aminoguanidine
Iness Jedidi
CNRS UMR8601, Laboratoire de Chimie-Physique, Paris, France
Biochemistry 42:11356-65. 2003
..We hypothesize that, even in the presence of AMG, a nonnegligible proportion of (*)OH radicals remained able to initiate oxidation of the LDL protein moiety, leading to apoB carbonylation...
- What are the best reference values for a normal serum alanine transaminase activity (ALT)? Impact on the presumed prevalence of drug induced liver injury (DILI)
Helmi M'Kada
Assistance Publique Hôpitaux de Paris UPMC Liver Center, Paris, France
Regul Toxicol Pharmacol 60:290-5. 2011
..Regulatory agencies still use ULN-ALT for the definition of drug adverse events such as drug induced liver disease (DILI)...
- The role of antioxidant micronutrients in the prevention of diabetic complications
Dominique Bonnefont-Rousselot
Laboratoire de biochimie métabolique et clinique EA 3617, Faculte de Pharmacie, Paris, France
Treat Endocrinol 3:41-52. 2004
..Above all, individuals with diabetes should be educated about the importance of consuming adequate amounts of vitamins and minerals from natural food sources, within the constraints of recommended sugar and carbohydrate intake...
- Cryptogenic cirrhosis in a patient with familial hypocholesterolemia due to a new truncated form of apolipoprotein B
Dominique Bonnefont-Rousselot
Functional Unit of Biochemistry of Metabolic Diseases, Laboratory of Metabolic Biochemistry, La Pitié Salpêtrière Hospital AP HP, Paris, France
Eur J Gastroenterol Hepatol 21:104-8. 2009
..We described here an unusual clinical observation of a patient with FHBL and early development of liver cirrhosis due to a new truncated form of apoB...
- Protective effects of regulatory amino acids on ischemia-reperfusion injury in the isolated perfused rat liver
Heidi Schuster
Laboratoire de Biologie de la Nutrition, EA2498, , , Paris, France
Scand J Gastroenterol 41:1342-9. 2006
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- Acute pancreatitis in a cohort of 129 patients referred for severe hypertriglyceridemia
Celia Lloret Linares
Nutrition, Pitie Salpetriere Hospital, AP HP, Paris, France
Pancreas 37:13-2. 2008
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- A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
Vlad Ratziu
Universite Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Hopital Pitie Salpetriere, Inserm UMR_S 938, Paris, France
J Hepatol 54:1011-9. 2011
..To date, no studies have assessed the efficacy and safety of high-dose UDCA (HD-UDCA) in patients with NASH...
- Rosuvastatin versus pravastatin in dyslipidemic HIV-1-infected patients receiving protease inhibitors: a randomized trial
Elisabeth Aslangul
Universite Paris Descartes, France
AIDS 24:77-83. 2010
..Pravastatin is recommended for patients with protease inhibitor-associated dyslipidemia. Rosuvastatin is the statin most effective on low-density lipoprotein cholesterol (LDL-c) in non-HIV patients...
