Stéphanie Blanchard

Summary

Publications

  1. ncbi 2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1
    Stéphanie Blanchard
    S BIO Pte Ltd, The Capricorn, Singapore Science Park II, Singapore, Singapore
    Bioorg Med Chem Lett 22:2880-4. 2012
  2. ncbi Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors
    Stéphanie Blanchard
    S BIO Pte Ltd, The Capricorn, Singapore Science Park II, Singapore 117528, Singapore
    Bioorg Med Chem Lett 20:2443-7. 2010
  3. ncbi Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus k
    Anthony D William
    S BIO Pte Ltd, 1 Science Park Road, No 05 09, The Capricorn, Singapore Science Park II, 117528, Singapore
    J Med Chem 55:169-96. 2012
  4. ncbi Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)
    Anders Poulsen
    S BIO Pte Ltd, 1 Science Park Road, 05 09 The Capricorn, Singapore Science Park II, Singapore, 117 528, Singapore
    J Comput Aided Mol Des 26:437-50. 2012
  5. ncbi Structure-based design of Aurora A & B inhibitors
    Anders Poulsen
    S BIO Pte Ltd, 1 Science Park Road, 05 09 The Capricorn, Singapore Science Park II, 117 528, Singapore, Singapore
    J Comput Aided Mol Des 22:897-906. 2008
  6. ncbi Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor
    Anthony D William
    S BIO Pte Ltd, The Capricorn, Singapore Science Park II, Singapore
    J Med Chem 54:4638-58. 2011
  7. ncbi Structure-based design of PDK1 inhibitors
    Anders Poulsen
    S BIO Pte Ltd, 1 Science Park Road, 05 09 The Capricorn, Singapore Science Park II, Singapore 117528, Singapore
    Bioorg Med Chem Lett 22:305-7. 2012

Collaborators

  • Haishan Wang
  • Anders Poulsen
  • Anthony D William
  • Kee Chuan Goh
  • Harish Nagaraj
  • Meredith Williams
  • Evelyn Tan
  • Brian Dymock
  • Mohammed Khalid Pasha
  • Ee Ling Teo
  • Eric T Sun
  • Angeline C H Lee
  • Kantharaj Ethirajulu
  • Ramesh Jayaraman
  • Jeanette M Wood
  • Brian W Dymock
  • Anthony William
  • Angeline Lee
  • Eeling Teo
  • Wai Chung Ong
  • Chang Kai Soh
  • Changyong Hu
  • Chai Ping Lee
  • Chaiping Lee
  • Siok Kun Goh
  • Stefan Hart
  • Dizhong Chen
  • Zahid Bonday
  • Noah Tu
  • Chee Pang Ng
  • Weiping Deng
  • Kay Lin Goh
  • Eric Sun

Detail Information

Publications7

  1. ncbi 2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1
    Stéphanie Blanchard
    S BIO Pte Ltd, The Capricorn, Singapore Science Park II, Singapore, Singapore
    Bioorg Med Chem Lett 22:2880-4. 2012
    ..The synthesis, SAR and ADME properties of this series of compounds are discussed culminating in the discovery of compound 6 which possessed sub-micromolar cell proliferation activity and 65% oral bioavailability in mice...
  2. ncbi Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors
    Stéphanie Blanchard
    S BIO Pte Ltd, The Capricorn, Singapore Science Park II, Singapore 117528, Singapore
    Bioorg Med Chem Lett 20:2443-7. 2010
    ..Several promising leads were optimized for selectivity towards Aurora B. Excellent binding affinity and good selectivity were achieved with optimized compounds in isolated Aurora subfamily assays...
  3. ncbi Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus k
    Anthony D William
    S BIO Pte Ltd, 1 Science Park Road, No 05 09, The Capricorn, Singapore Science Park II, 117528, Singapore
    J Med Chem 55:169-96. 2012
    ..26h (SB1317/TG02) was progressed into development in 2010 and is currently undergoing phase 1 clinical trials in advanced leukemias and multiple myeloma...
  4. ncbi Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)
    Anders Poulsen
    S BIO Pte Ltd, 1 Science Park Road, 05 09 The Capricorn, Singapore Science Park II, Singapore, 117 528, Singapore
    J Comput Aided Mol Des 26:437-50. 2012
    ..Another selective JAK2/FLT3 inhibitor, 33 (SB1578), has entered phase 1 clinical development for the non-oncology indication rheumatoid arthritis...
  5. ncbi Structure-based design of Aurora A & B inhibitors
    Anders Poulsen
    S BIO Pte Ltd, 1 Science Park Road, 05 09 The Capricorn, Singapore Science Park II, 117 528, Singapore, Singapore
    J Comput Aided Mol Des 22:897-906. 2008
    ..Finally we calculate the conformational energy penalty of the putative bioactive conformation of our inhibitors and show that this property correlates well with the Aurora A binding affinity...
  6. ncbi Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor
    Anthony D William
    S BIO Pte Ltd, The Capricorn, Singapore Science Park II, Singapore
    J Med Chem 54:4638-58. 2011
    ..Compound 21c (SB1518) was selected as a development candidate and progressed into clinical trials where it is currently in phase 2 for MF and lymphoma...
  7. ncbi Structure-based design of PDK1 inhibitors
    Anders Poulsen
    S BIO Pte Ltd, 1 Science Park Road, 05 09 The Capricorn, Singapore Science Park II, Singapore 117528, Singapore
    Bioorg Med Chem Lett 22:305-7. 2012
    ..This improved both binding to the enzyme and physiochemical properties without compromising ligand efficiency...