H D Spapen

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. ncbi N-acetylcysteine in clinical sepsis: a difficult marriage
    Herbert Spapen
    Intensive Care Department, Academic Hospital, Vrije Universiteit Brussels, Belgium
    Crit Care 8:229-30. 2004
  2. ncbi Effects of N-acetylcysteine on microalbuminuria and organ failure in acute severe sepsis: results of a pilot study
    Herbert D Spapen
    Intensive Care Department, Academic Hospital, Vrije Universiteit Brussel, Laarbeeklaan, 101, B 1090 Brussels, Belgium
    Chest 127:1413-9. 2005
  3. ncbi Diagnostic markers of sepsis in the emergency department
    H D Spapen
    Intensive Care Department, Academic Hospital, Vrije Universiteit Brussels, Laarbeeklaan 101 B 1090 Brussels, Belgium
    Acta Clin Belg 61:138-42. 2006
  4. ncbi Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
    Jean Francois Dhainaut
    Service de Reanimation Medicale, Centre Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
    Thromb Haemost 90:642-53. 2003
  5. ncbi The glycemia threat in sepsis: too high, too low, or too... variable!
    Herbert D Spapen
    Crit Care Med 36:2459-60. 2008

Detail Information

Publications5

  1. ncbi N-acetylcysteine in clinical sepsis: a difficult marriage
    Herbert Spapen
    Intensive Care Department, Academic Hospital, Vrije Universiteit Brussels, Belgium
    Crit Care 8:229-30. 2004
    ..Studies that put these highly favourable properties to the clinical test remain scarce but are definitely needed to determine whether N-acetylcysteine has a place in our therapeutic armamentarium against sepsis...
  2. ncbi Effects of N-acetylcysteine on microalbuminuria and organ failure in acute severe sepsis: results of a pilot study
    Herbert D Spapen
    Intensive Care Department, Academic Hospital, Vrije Universiteit Brussel, Laarbeeklaan, 101, B 1090 Brussels, Belgium
    Chest 127:1413-9. 2005
    ..N-acetylcysteine (NAC) has been shown to decrease capillary leakage in experimental sepsis. The present study investigated the effect of early treatment with NAC on microalbuminuria and organ dysfunction in severe clinical sepsis...
  3. ncbi Diagnostic markers of sepsis in the emergency department
    H D Spapen
    Intensive Care Department, Academic Hospital, Vrije Universiteit Brussels, Laarbeeklaan 101 B 1090 Brussels, Belgium
    Acta Clin Belg 61:138-42. 2006
    ..However, PCT measurement is more costly, time-consuming, and not widespread available. New markers for rapid diagnosis of sepsis (e.g. TREM-1) are under investigation...
  4. ncbi Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
    Jean Francois Dhainaut
    Service de Reanimation Medicale, Centre Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
    Thromb Haemost 90:642-53. 2003
    ..These latter two effects may occur at the local or cellular level. The systemic biomarkers reported here might not be the most appropriate approach to demonstrate these potential effects of drotrecogin alfa (activated)...
  5. ncbi The glycemia threat in sepsis: too high, too low, or too... variable!
    Herbert D Spapen
    Crit Care Med 36:2459-60. 2008