Leon Plaghki

Summary

Country: Belgium

Publications

  1. ncbi EEG and laser stimulation as tools for pain research
    Leon Plaghki
    Unité de Réadaptation et Médecine Physique READ, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Curr Opin Investig Drugs 6:58-64. 2005
  2. ncbi How do we selectively activate skin nociceptors with a high power infrared laser? Physiology and biophysics of laser stimulation
    L Plaghki
    Unité de réadaptation READ, Universite Catholique de Louvain, 53 avenue Mounier, B 1200 Brussels, Belgium
    Neurophysiol Clin 33:269-77. 2003
  3. ncbi Systematic overview of the pharmacological management of postherpetic neuralgia. An evaluation of the clinical value of critically selected drug treatments based on efficacy and safety outcomes from randomized controlled studies
    L Plaghki
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Dermatology 208:206-16. 2004
  4. ncbi Electrophysiological correlates of attentional orientation in humans to strong intensity deviant nociceptive stimuli, inside and outside the focus of spatial attention
    Valery Legrain
    Unité de Neurosciences Cognitives NESC, Faculte de Psychologie et des Sciences de l Education, Universite Catholique de Louvain, Place du Cardinal Mercier 10, B 1348, Louvain la Neuve, Belgium
    Neurosci Lett 339:107-10. 2003
  5. ncbi Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potentials
    Michael Ragé
    Faculty of Medicine, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    J Neurol 258:1852-64. 2011
  6. ncbi Nociceptive steady-state evoked potentials elicited by rapid periodic thermal stimulation of cutaneous nociceptors
    Andre Mouraux
    Institute of Neuroscience, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Neurosci 31:6079-87. 2011
  7. ncbi Involuntary orientation of attention to unattended deviant nociceptive stimuli is modulated by concomitant visual task difficulty. Evidence from laser evoked potentials
    Valery Legrain
    Unité de Neurosciences Cognitives NESC, Faculte de Psychologie et des Sciences de l Education, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Clin Neurophysiol 116:2165-74. 2005
  8. ncbi Single-trial detection of human brain responses evoked by laser activation of Adelta-nociceptors using the wavelet transform of EEG epochs
    Andre Mouraux
    Laboratoire de neurophysiologie NEFY, Universite Catholique de Louvain, Louvain, Belgium
    Neurosci Lett 361:241-4. 2004
  9. ncbi Nociceptive processing in the human brain of infrequent task-relevant and task-irrelevant noxious stimuli. A study with event-related potentials evoked by CO2 laser radiant heat stimuli
    Valery Legrain
    Unité de Neurosciences Cognitives NESC, Faculte de Psychologie et des Sciences de l Education, Universite Catholique de Louvain, Place du Cardinal Mercier 10, B 1348 Louvain la Neuve, Belgium
    Pain 103:237-48. 2003
  10. ncbi Exogenous and endogenous components of ultralate (C-fibre) evoked potentials following CO2 laser stimuli to tiny skin surface areas in healthy subjects
    Emmanuelle Opsommer
    Faculty of Medicine, Universite Catholique de Louvain, Avenue Mounier 53 READ 5375, B 1200, Brussels, Belgium
    Neurophysiol Clin 33:78-85. 2003

Detail Information

Publications19

  1. ncbi EEG and laser stimulation as tools for pain research
    Leon Plaghki
    Unité de Réadaptation et Médecine Physique READ, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Curr Opin Investig Drugs 6:58-64. 2005
    ..These electrophysiological responses are modulated by stimulus-driven and, even more extensively, top-down processes. The specificity and validity of these components for pain research are currently under intense scrutiny...
  2. ncbi How do we selectively activate skin nociceptors with a high power infrared laser? Physiology and biophysics of laser stimulation
    L Plaghki
    Unité de réadaptation READ, Universite Catholique de Louvain, 53 avenue Mounier, B 1200 Brussels, Belgium
    Neurophysiol Clin 33:269-77. 2003
    ....
  3. ncbi Systematic overview of the pharmacological management of postherpetic neuralgia. An evaluation of the clinical value of critically selected drug treatments based on efficacy and safety outcomes from randomized controlled studies
    L Plaghki
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Dermatology 208:206-16. 2004
    ..This study systematically reviews current evidence on drug treatments commonly used in postherpetic neuralgia...
  4. ncbi Electrophysiological correlates of attentional orientation in humans to strong intensity deviant nociceptive stimuli, inside and outside the focus of spatial attention
    Valery Legrain
    Unité de Neurosciences Cognitives NESC, Faculte de Psychologie et des Sciences de l Education, Universite Catholique de Louvain, Place du Cardinal Mercier 10, B 1348, Louvain la Neuve, Belgium
    Neurosci Lett 339:107-10. 2003
    ..It is suggested that attentional switching could have been triggered by neural systems having detected sharp increase of intensity. Weak deviant stimuli were not salient enough to induce attentional switching...
  5. ncbi Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potentials
    Michael Ragé
    Faculty of Medicine, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    J Neurol 258:1852-64. 2011
    ..924). Although this performance was not statically different from that of warm and cold detection threshold, LEPs offer an advantage over QST given that they bypass the subjective report and are therefore unbiased by perceptual factors...
  6. ncbi Nociceptive steady-state evoked potentials elicited by rapid periodic thermal stimulation of cutaneous nociceptors
    Andre Mouraux
    Institute of Neuroscience, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Neurosci 31:6079-87. 2011
    ....
  7. ncbi Involuntary orientation of attention to unattended deviant nociceptive stimuli is modulated by concomitant visual task difficulty. Evidence from laser evoked potentials
    Valery Legrain
    Unité de Neurosciences Cognitives NESC, Faculte de Psychologie et des Sciences de l Education, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Clin Neurophysiol 116:2165-74. 2005
    ..If true the P400 effect (1) should be produced when attention is focused on a task in another sensory modality (primary task), and (2) should be modulated by the primary task difficulty...
  8. ncbi Single-trial detection of human brain responses evoked by laser activation of Adelta-nociceptors using the wavelet transform of EEG epochs
    Andre Mouraux
    Laboratoire de neurophysiologie NEFY, Universite Catholique de Louvain, Louvain, Belgium
    Neurosci Lett 361:241-4. 2004
    ..Results showed that this method accurately identified single-trial EEG responses to Adelta-nociceptor activation...
  9. ncbi Nociceptive processing in the human brain of infrequent task-relevant and task-irrelevant noxious stimuli. A study with event-related potentials evoked by CO2 laser radiant heat stimuli
    Valery Legrain
    Unité de Neurosciences Cognitives NESC, Faculte de Psychologie et des Sciences de l Education, Universite Catholique de Louvain, Place du Cardinal Mercier 10, B 1348 Louvain la Neuve, Belgium
    Pain 103:237-48. 2003
    ..It suggests that at least an early part of the LEP positivity (P360) is independent of P3-activities...
  10. ncbi Exogenous and endogenous components of ultralate (C-fibre) evoked potentials following CO2 laser stimuli to tiny skin surface areas in healthy subjects
    Emmanuelle Opsommer
    Faculty of Medicine, Universite Catholique de Louvain, Avenue Mounier 53 READ 5375, B 1200, Brussels, Belgium
    Neurophysiol Clin 33:78-85. 2003
    ..5 ms with maximum amplitude at Pz. This latest peak may represent an endogenous P3-like component as it is linked to the subject's detection of the target stimulus (rare events)...
  11. ncbi The time course of CO2 laser-evoked responses and of skin nerve fibre markers after topical capsaicin in human volunteers
    Michael Ragé
    Unité READ, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Clin Neurophysiol 121:1256-66. 2010
    ....
  12. ncbi An adaptive procedure for routine measurement of light-touch sensitivity threshold
    Anne D Berquin
    Physical Medicine and Rehabilitation, Cliniques Universitaires St Luc, Brussels, Belgium
    Muscle Nerve 42:328-38. 2010
    ..Accurate use of Semmes-Weinstein monofilaments requires prior calibration, correction for humidity, and use of a validated procedure. In this study we provide normative data that can be used with our algorithm...
  13. ncbi How many response levels do children distinguish on faces scales for pain assessment?
    Céline Decruynaere
    Unité de Réadaptation et Médecine Physique READ 5375, Faculte de Medecine, Universite Catholique de Louvain, Tour Pasteur, Brussels, Belgium
    Eur J Pain 13:641-8. 2009
    ..These results strongly recommend a reduction in the number of response levels of faces scales for pain assessment in children...
  14. ncbi Measure of experimental pain using Rasch analysis
    Céline Decruynaere
    Unité de Réadaptation et Médecine Physique READ 5375, Universite Catholique de Louvain, Tour Pasteur, Avenue Mounier 53, 1200 Bruxelles, Belgium
    Eur J Pain 11:469-74. 2007
    ..Advantages and disadvantages of this methodology will be discussed in terms of subsequent possible mathematical analyses, statistical tests and implications for experimental and clinical investigations...
  15. ncbi The fine tuning of pain thresholds: a sophisticated double alarm system
    Leon Plaghki
    Unité READ, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 5:e10269. 2010
    ..We propose an alternative solution to the conventional methods that only measure a single "threshold of pain", without knowing which of the two systems is involved...
  16. ncbi Tactile roughness discrimination of the finger pad relies primarily on vibration sensitive afferents not necessarily located in the hand
    Xavier Libouton
    Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    Behav Brain Res 229:273-9. 2012
    ....
  17. ncbi Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection effects on laser evoked potentials
    Valery Legrain
    Unite de Neurosciences Cognitives, Faculte de Psychologie et des Sciences de l Education, Universite Catholique de Louvain, Place Cardinal Mercier 10, B 1348 Louvain la Neuve, Belgium
    Pain 99:21-39. 2002
    ..This probability effect was not due to P3b-related processes that were observed at a later latency (600 ms). Indeed, P600 could be seen as a P3b evoked by conscious detection of rare targets...
  18. ncbi Tactile roughness discrimination threshold is unrelated to tactile spatial acuity
    Xavier Libouton
    Rehabilitation and Physical Medicine Unit, Universite Catholique de Louvain, Brussels, Belgium
    Behav Brain Res 208:473-8. 2010
    ....
  19. ncbi Laser-evoked potentials correlate with clinical evolution in a case of spontaneous and recurrent complex regional pain syndrome type I
    Valérie Moreau
    Cliniques Universitaires Saint Luc, Service de médecine physique et réadaptation, Brussels, Belgium
    Clin J Pain 23:375-9. 2007
    ..Further studies are needed to test this hypothesis...