F R Opperdoes

Summary

Country: Belgium

Publications

  1. ncbi Enzymes of carbohydrate metabolism as potential drug targets
    F R Opperdoes
    Christian de Duve Institute of Cellular Pathology, ICP TROP 74 39, Avenue Hippocrate 74, B 1200, Brussels, Belgium
    Int J Parasitol 31:482-90. 2001
  2. ncbi Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different Kinetoplastida
    V Hannaert
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology ICP, and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    J Mol Evol 47:728-38. 1998
  3. ncbi The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme
    P A Michels
    International Institute of Cellular and Molecular Pathology and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    Eur J Biochem 250:698-704. 1997
  4. ncbi Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase
    N Chevalier
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology and Laboratory of Biochemistry, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Biochem 267:1464-72. 2000
  5. ncbi Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase
    F Duffieux
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology and the Laboratory of Biochemistry, Universite Catholique de Louvain, Avenue Hippocrate 74, 1200 Brussels, Belgium
    J Biol Chem 275:27559-65. 2000
  6. ncbi Molecular cloning and analysis of two tandemly linked genes for pyruvate kinase of Trypanosoma brucei
    S Allert
    International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases, Brussels, Belgium
    Eur J Biochem 200:19-27. 1991
  7. ncbi Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme
    M Marchand
    International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases, Brussels, Belgium
    Eur J Biochem 184:455-64. 1989
  8. ncbi Demonstration of glycosomes (microbodies) in the Bodonid flagellate Trypanoplasma borelli (Protozoa, Kinetoplastida)
    F R Opperdoes
    International Institute of Cellular and Molecular Pathology, , Brussels, Belgium
    Mol Biochem Parasitol 30:155-63. 1988
  9. ncbi Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei
    M Marchand
    International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases, Brussels, Belgium
    Mol Biochem Parasitol 29:65-75. 1988
  10. ncbi Possible localisation of dolichol-dependent mannosyltransferase of Trypanosoma brucei to the rough endoplasmic reticulum
    M Prado-Figueroa
    Research Unit for Tropical Diseases, International Institute of Cellular and Molecular Pathology, Brussels, Belgium
    Mol Biochem Parasitol 63:255-64. 1994

Collaborators

Detail Information

Publications17

  1. ncbi Enzymes of carbohydrate metabolism as potential drug targets
    F R Opperdoes
    Christian de Duve Institute of Cellular Pathology, ICP TROP 74 39, Avenue Hippocrate 74, B 1200, Brussels, Belgium
    Int J Parasitol 31:482-90. 2001
    ....
  2. ncbi Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different Kinetoplastida
    V Hannaert
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology ICP, and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    J Mol Evol 47:728-38. 1998
    ..The division of the Kinetoplastida into two suborders, Bodonina and Trypanosomatina, was well supported. Within the letter group, the Trypanosoma species appeared to be monophyletic, whereas the other trypanosomatids form a second clade...
  3. ncbi The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme
    P A Michels
    International Institute of Cellular and Molecular Pathology and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    Eur J Biochem 250:698-704. 1997
    ..brucei PFK shows many structural differences, even at the active site, when compared with other ATP-dependent PFKs. These differences offer great potential for the structure-based design of trypanocidal drugs...
  4. ncbi Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase
    N Chevalier
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology and Laboratory of Biochemistry, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Biochem 267:1464-72. 2000
    ..The presence of distinct nonhomologous PGAMs in the parasite and its human host offers great potential for the design of selective inhibitors which could form leads for new trypanocidal drugs...
  5. ncbi Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase
    F Duffieux
    Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology and the Laboratory of Biochemistry, Universite Catholique de Louvain, Avenue Hippocrate 74, 1200 Brussels, Belgium
    J Biol Chem 275:27559-65. 2000
    ..The corresponding enzymes have been overexpressed in Escherichia coli and purified, and their biochemical characteristics have been determined...
  6. ncbi Molecular cloning and analysis of two tandemly linked genes for pyruvate kinase of Trypanosoma brucei
    S Allert
    International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases, Brussels, Belgium
    Eur J Biochem 200:19-27. 1991
    ..The polypeptide is shorter than that of most other pyruvate kinases and the calculated net charge is only +3...
  7. ncbi Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme
    M Marchand
    International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases, Brussels, Belgium
    Eur J Biochem 184:455-64. 1989
    ..Agaricic acid, a potent inhibitor of various glycosomal enzymes of T. brucei, has also a strong, irreversible effect on glucose-6-phosphate isomerase, while leaving the yeast and mammalian enzymes relatively unaffected...
  8. ncbi Demonstration of glycosomes (microbodies) in the Bodonid flagellate Trypanoplasma borelli (Protozoa, Kinetoplastida)
    F R Opperdoes
    International Institute of Cellular and Molecular Pathology, , Brussels, Belgium
    Mol Biochem Parasitol 30:155-63. 1988
    ..Apparently the presence of glycosomes is a characteristic of all Kinetoplastida...
  9. ncbi Characterization of the genes for fructose-bisphosphate aldolase in Trypanosoma brucei
    M Marchand
    International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases, Brussels, Belgium
    Mol Biochem Parasitol 29:65-75. 1988
    ..We have previously proposed that the positively charged residues may be involved in the import of the proteins into the organelles...
  10. ncbi Possible localisation of dolichol-dependent mannosyltransferase of Trypanosoma brucei to the rough endoplasmic reticulum
    M Prado-Figueroa
    Research Unit for Tropical Diseases, International Institute of Cellular and Molecular Pathology, Brussels, Belgium
    Mol Biochem Parasitol 63:255-64. 1994
    ..It is concluded that the formation of dolichol phosphoryl mannose from GDP-mannose and dolichyl phosphate in T. brucei occurs mainly in the rough endoplasmic reticulum...
  11. ncbi Localisation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the mitochondrial matrix of Trypanosoma brucei procyclics
    N Heise
    Christian de Duve Institute of Cellular Pathology ICP, and Laboratory of Biochemistry, Catholic University of Louvain, Brussels, Belgium
    Z Naturforsch C 55:473-7. 2000
    ..brucei procyclics is the explanation for a high 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in these protozoan organelles...
  12. ncbi The electrochemical proton gradient in the bloodstream form of Trypanosoma brucei is dependent on the temperature
    B H ter Kuile
    Research Unit for Tropical Diseases, International Institute of Cellular and Molecular Pathology, Brussels, Belgium
    Mol Biochem Parasitol 55:21-7. 1992
    ..brucei when it resides in the bloodstream of the mammalian host at 37 degrees C; and (iii) that below 26 degrees C an electrochemical proton gradient is maintained over the plasma membrane...
  13. ncbi Alkyl dihydroxyacetone phosphate synthase in glycosomes of Trypanosoma brucei
    A W Zomer
    Centre for Biomembranes and Lipid Enzymology, Utrecht, The Netherlands
    Biochim Biophys Acta 1257:167-73. 1995
    ..It is concluded that T. brucei glycosomes contain the enzymes responsible for glycero-ether bond formation analogous to mammalian peroxisomes...
  14. ncbi Glyceraldehyde-phosphate dehydrogenase from Trypanosoma brucei. Comparison of the glycosomal and cytosolic isoenzymes
    O Misset
    Eur J Biochem 162:501-7. 1987
    ..This observation explains in part the great difference in subunit size between the two T. brucei isoenzymes and suggests that at least one of these insertions is responsible for import of the glycosomal isoenzyme into the organelle...
  15. ncbi Glycolysis as a target for the design of new anti-trypanosome drugs
    C L Verlinde
    Department of Biological Structure, Biomolecular Structure Center, University of Washington, Seattle, USA
    Drug Resist Updat 4:50-65. 2001
    ..For some trypanosomatid enzymes, potent and selective inhibitors have already been developed that affect only the growth of cultured trypanosomatids, and not mammalian cells...
  16. ncbi The Trypanosoma cruzi proteome
    J A Atwood
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
    Science 309:473-6. 2005
    ..The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes...
  17. ncbi The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei
    J J Van Hellemond
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands
    Biochem Soc Trans 33:967-71. 2005
    ..Therefore the citric acid cycle in trypanosomes does not function as a cycle...