A-M Marini

Summary

Country: Belgium

Publications

  1. ncbi In vivo N-glycosylation of the mep2 high-affinity ammonium transporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus
    A M Marini
    Laboratoire de Physiologie Cellulaire, Universite Libre de Bruxelles, CP300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Mol Microbiol 38:552-64. 2000
  2. ncbi Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters
    Anna Maria Marini
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041, Gosselies, Belgium
    Curr Genet 49:364-74. 2006
  3. ncbi From yeast ammonium transporters to Rhesus proteins, isolation and functional characterization
    A M Marini
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Transfus Clin Biol 13:95-6. 2006
  4. ncbi Physiological role of the putative ammonium transporter RhCG in the mouse
    S Biver
    Laboratoire de Biologie du Developpement, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Transfus Clin Biol 13:167-8. 2006
  5. ncbi Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae
    André Feller
    Institut de Recherches Microbiologiques J M Wiame, Laboratoire de Microbiologie, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Biol Chem 281:28546-54. 2006
  6. ncbi The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium
    Mélanie Boeckstaens
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
    Mol Microbiol 64:534-46. 2007
  7. ncbi Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the Mep/Amt/Rh family and impact on filamentation
    Mélanie Boeckstaens
    Laboratoire de Physiologie Moléculaire de la Cellule, IBMM, the Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, Gosselies, Belgium
    J Biol Chem 283:21362-70. 2008
  8. ncbi Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model
    Concettina La Motta
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Pisa, Italy
    J Med Chem 51:3182-93. 2008
  9. ncbi Mitochondrial permeability transition induced by novel pyridothiopyranopyrimidine derivatives: potential new antimitochondrial antitumour agents
    Lisa Dalla Via
    Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5 I-35131 Padova, Italy
    Biochem Pharmacol 72:1657-67. 2006
  10. ncbi Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis
    Federico Da Settimo
    Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 51:5798-806. 2008

Collaborators

  • B Andre
  • B Costa
  • Mélanie Boeckstaens
  • Federico Da Settimo
  • Concettina La Motta
  • Silvia Salerno
  • Sabrina Taliani
  • Francesca Simorini
  • Ettore Novellino
  • André Feller
  • S Biver
  • Lisa Dalla Via
  • Barbara Cosimelli
  • Claudia Martini
  • Stefania Sartini
  • Nicola Simola
  • Micaela Morelli
  • Marusca Bellandi
  • Giovanni Greco
  • Vittorio Limongelli
  • Luciana Marinelli
  • Eleonora Da Pozzo
  • Antonio Toninello
  • S Scohy
  • C Szpirer
  • J Szpirer
  • Evelyne Dubois

Detail Information

Publications10

  1. ncbi In vivo N-glycosylation of the mep2 high-affinity ammonium transporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus
    A M Marini
    Laboratoire de Physiologie Cellulaire, Universite Libre de Bruxelles, CP300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Mol Microbiol 38:552-64. 2000
    ..Mep2 glycosylation is not required for pseudohyphal differentiation in response to ammonium starvation, and its absence causes only a slight reduction in the affinity of the transporter for its substrate...
  2. ncbi Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters
    Anna Maria Marini
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041, Gosselies, Belgium
    Curr Genet 49:364-74. 2006
    ..Hence, this aspartate residue might play a preserved functional role in Mep/Amt/Rh proteins...
  3. ncbi From yeast ammonium transporters to Rhesus proteins, isolation and functional characterization
    A M Marini
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Transfus Clin Biol 13:95-6. 2006
    ..Using yeast as an expression tool, we have started a structure-function analysis of distinct members from the Mep/Amt/Rh super-family...
  4. ncbi Physiological role of the putative ammonium transporter RhCG in the mouse
    S Biver
    Laboratoire de Biologie du Developpement, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, rue des Professeurs Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Transfus Clin Biol 13:167-8. 2006
    ..To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene...
  5. ncbi Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae
    André Feller
    Institut de Recherches Microbiologiques J M Wiame, Laboratoire de Microbiologie, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Biol Chem 281:28546-54. 2006
    ..The apparent Rsp5-, Bul1/2-dependent Gln3 activation keeps to the cellular status, as it is only observed in cells having left the balanced phase of exponential growth...
  6. ncbi The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium
    Mélanie Boeckstaens
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
    Mol Microbiol 64:534-46. 2007
    ..Finally, we show that Mep2 participates, through ammonium leakage compensation, in pseudohyphal growth induced by amino acid starvation. This argues further in favour of tight coupling of Mep2 transport and sensor functions...
  7. ncbi Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the Mep/Amt/Rh family and impact on filamentation
    Mélanie Boeckstaens
    Laboratoire de Physiologie Moléculaire de la Cellule, IBMM, the Université Libre de Bruxelles, Rue des Professeurs Jeener et Brachet 12, Gosselies, Belgium
    J Biol Chem 283:21362-70. 2008
    ..Our overall data suggest the existence of two functional groups of Mep/Amt-type proteins with different transport mechanisms and distinct impacts on cell physiology and signaling...
  8. ncbi Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model
    Concettina La Motta
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Pisa, Italy
    J Med Chem 51:3182-93. 2008
    ..Computational studies on the ALR2 inhibitors were performed to rationalize the structure-activity relationships observed and to provide the basis for further structure-guided design of novel ALR2 inhibitors...
  9. ncbi Mitochondrial permeability transition induced by novel pyridothiopyranopyrimidine derivatives: potential new antimitochondrial antitumour agents
    Lisa Dalla Via
    Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo, 5 I-35131 Padova, Italy
    Biochem Pharmacol 72:1657-67. 2006
    ..PTP1 also induces DNA fragmentation in intact cells. As regards PTP2, the presence of the p-toluensulphonamido group makes the lead chromophore unable to induce any effect on mitochondria...
  10. ncbi Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis
    Federico Da Settimo
    Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 51:5798-806. 2008
    ..The results of this study suggested that the novel N,N-disubstituted indol-3-ylglyoxylamides may represent a promising class of compounds potentially suited for the treatment of anxiety disorders...