Mario Ubaldo Manto

Summary

Country: Belgium

Publications

  1. ncbi A novel approach for treating cerebellar ataxias
    Mario Manto
    FNRS Neurologie, ULB Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Med Hypotheses 71:58-60. 2008
  2. ncbi Acute ataxia with axial myoclonus during pregnancy
    Mario-Ubaldo Manto
    Fonds National de la Recherche Scientifique, , Bruxelles, Belgique
    Eur Neurol 48:55-8. 2002
  3. ncbi The wide spectrum of spinocerebellar ataxias (SCAs)
    Mario Ubaldo Manto
    FNRS Neurologie, Hôpital Erasme ULB, Bruxelles, Belgium
    Cerebellum 4:2-6. 2005
  4. ncbi Diversity and complexity of roles of granule cells in the cerebellar cortex. Editorial
    Mario Manto
    FNRS Neurologie, Unité d Etude du Mouvement, 808 Route de Lennik, 1070, Bruxelles, Belgium
    Cerebellum 11:1-4. 2012
  5. ncbi A new myohaptic instrument to assess wrist motion dynamically
    Mario Manto
    FNRS, Neurologie ULB Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Sensors (Basel) 10:3180-94. 2010
  6. ncbi Evaluation of a wearable orthosis and an associated algorithm for tremor suppression
    Mario Manto
    Service de Neurologie, Hôpital Erasme ULB, Bruxelles, Belgium
    Physiol Meas 28:415-25. 2007
  7. ncbi A possible mechanism for the beneficial effect of ethanol in essential tremor
    M Manto
    Laboratoire de Neurologie Expérimentale, ULB Erasme, Bruxelles, Belgium
    Eur J Neurol 15:697-705. 2008
  8. ncbi The cerebellum, cerebellar disorders, and cerebellar research--two centuries of discoveries
    Mario Manto
    FNRS ULB Erasme, Brusells, Belgium
    Cerebellum 7:505-16. 2008
  9. ncbi Tremorgenesis: a new conceptual scheme using reciprocally innervated circuit of neurons
    Mario Manto
    FNRS ULB Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    J Transl Med 6:71. 2008
  10. ncbi Mechanisms of human cerebellar dysmetria: experimental evidence and current conceptual bases
    Mario Manto
    Laboratoire de Neurologie Expérimentale, FNRS ULB, Bruxelles, Belgium
    J Neuroeng Rehabil 6:10. 2009

Collaborators

Detail Information

Publications32

  1. ncbi A novel approach for treating cerebellar ataxias
    Mario Manto
    FNRS Neurologie, ULB Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Med Hypotheses 71:58-60. 2008
    ..A successful treatment of combined neurostimulation would lead to a new and readily available approach in the management of cerebellar ataxias. This new therapy is safe, feasible and may bring symptomatic improvement...
  2. ncbi Acute ataxia with axial myoclonus during pregnancy
    Mario-Ubaldo Manto
    Fonds National de la Recherche Scientifique, , Bruxelles, Belgique
    Eur Neurol 48:55-8. 2002
  3. ncbi The wide spectrum of spinocerebellar ataxias (SCAs)
    Mario Ubaldo Manto
    FNRS Neurologie, Hôpital Erasme ULB, Bruxelles, Belgium
    Cerebellum 4:2-6. 2005
    ..Our knowledge of the molecular mechanisms of SCAs is rapidly growing, and the development of relevant animal models of SCAs is bringing hope for effective therapies in human...
  4. ncbi Diversity and complexity of roles of granule cells in the cerebellar cortex. Editorial
    Mario Manto
    FNRS Neurologie, Unité d Etude du Mouvement, 808 Route de Lennik, 1070, Bruxelles, Belgium
    Cerebellum 11:1-4. 2012
    ..This special issue highlights novel avenues in our understanding of the roles of this key neuronal population of the cerebellar cortex, ranging from developmental up to physiological and pathological points of view...
  5. ncbi A new myohaptic instrument to assess wrist motion dynamically
    Mario Manto
    FNRS, Neurologie ULB Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Sensors (Basel) 10:3180-94. 2010
    ..The instrument allows the extraction of an electrophysiological signature of a cerebellar deficit...
  6. ncbi Evaluation of a wearable orthosis and an associated algorithm for tremor suppression
    Mario Manto
    Service de Neurologie, Hôpital Erasme ULB, Bruxelles, Belgium
    Physiol Meas 28:415-25. 2007
    ..This new approach will provide new insights into the understanding of motor control...
  7. ncbi A possible mechanism for the beneficial effect of ethanol in essential tremor
    M Manto
    Laboratoire de Neurologie Expérimentale, ULB Erasme, Bruxelles, Belgium
    Eur J Neurol 15:697-705. 2008
    ..The hypothesis of a disregulation of N-methyl-D-aspartate (NMDA) pathways has been suggested. It was shown experimentally that infusion of NMDA in cerebellar nuclei down-regulates glutamate release...
  8. ncbi The cerebellum, cerebellar disorders, and cerebellar research--two centuries of discoveries
    Mario Manto
    FNRS ULB Erasme, Brusells, Belgium
    Cerebellum 7:505-16. 2008
    ....
  9. ncbi Tremorgenesis: a new conceptual scheme using reciprocally innervated circuit of neurons
    Mario Manto
    FNRS ULB Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    J Transl Med 6:71. 2008
    ..It provides the rationale for decreasing membrane excitability by acting on a normal ion channel in a context of impaired external inhibition...
  10. ncbi Mechanisms of human cerebellar dysmetria: experimental evidence and current conceptual bases
    Mario Manto
    Laboratoire de Neurologie Expérimentale, FNRS ULB, Bruxelles, Belgium
    J Neuroeng Rehabil 6:10. 2009
    ....
  11. ncbi Cerebellar ataxias
    Mario Manto
    Fonds National de la Recherche Scientifique Neurologie, Laboratoire de Neurologie Expérimentale, ULB, Bruxelles, Belgium
    Curr Opin Neurol 22:419-29. 2009
    ..The identification of the causative mutations of many hereditary ataxias and the development of relevant animal models bring hope for effective therapies in neurodegenerative ataxias...
  12. ncbi Animal models of human cerebellar ataxias: a cornerstone for the therapies of the twenty-first century
    Mario Manto
    FNRS Laboratoire de Neurologie Expérimentale, Universite Libre de Bruxelles, ULB Erasme, 1070 Brussels, Belgium
    Cerebellum 8:137-54. 2009
    ..It is anticipated that the twenty-first century will be the century of effective therapies in the field of cerebellar ataxias. The animal models are a cornerstone to reach this goal...
  13. ncbi Afferent facilitation of corticomotor responses is increased by IgGs of patients with NMDA-receptor antibodies
    Mario Manto
    FNRS Neurologie ULB, Laboratoire de Neurologie Expérimentale, 808 Route de Lennik, 1070, Bruxelles, Belgium
    J Neurol 258:27-33. 2011
    ..Our results highlight that IgGs of patients with NMDA-R antibodies induce a state of corticomotor hyperexcitability following application of HFS over the prefrontal area...
  14. ncbi In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
    Mario Manto
    FNRS Laboratoire de Neurologie Expérimentale, ULB, Belgium
    Orphanet J Rare Dis 5:31. 2010
    ..Patients' antibodies cause a decrease of the density of NMDA-R and synaptic mediated currents, but the in vivo effects on the extracellular glutamate and glutamatergic transmission are unknown...
  15. ncbi Toxic agents causing cerebellar ataxias
    Mario Manto
    Unité d Etude du Mouvement, FNRS Neurologie, ULB Erasme, Brussels, Belgium
    Handb Clin Neurol 103:201-13. 2012
    ..Moreover, the patient's status may require immediate therapies when the intoxication is life-threatening...
  16. ncbi On the cerebello-cerebral interactions
    Mario Ubaldo Manto
    Department of Neurology and Laboratory of Experimental Neurology, Hôpital Erasme ULB, Brussels, Belgium
    Cerebellum 5:286-8. 2006
    ..Complexity of circuitries and non optimal theoretical frameworks continue to hamper our understanding of cerebellar operations...
  17. ncbi Modulation of excitability as an early change leading to structural adaptation in the motor cortex
    Mario Manto
    Department of Neurology, Hôpital Erasme ULB, Route de Lennik, Bruxelles, Belgium
    J Neurosci Res 83:177-80. 2006
    ....
  18. ncbi Depression of extra-cellular GABA and increase of NMDA-induced nitric oxide following acute intra-nuclear administration of alcohol in the cerebellar nuclei of the rat
    Mario Manto
    Laboratoire de Neurologie Expérimentale, Hôpital Erasme ULB, Brussels, Belgium
    Cerebellum 4:230-8. 2005
    ..The hypothesis of AMPA neurotoxicity, which has convincing arguments during chronic exposure, is challenged in this model of acute cerebellar nuclear toxicity of alcohol...
  19. ncbi Invariability of the privileged direction of the maximal EMG activity during speed-related activation for reaching in the vertical plane
    M U Manto
    Universite Libre de Bruxelles, Hôpital Erasme Neurologie, 808, Route de Lennik, 1070 Bruxelles, Belgium
    Neurol Res 24:801-8. 2002
    ..Therefore, we suggest that the selection of the privileged direction of the M Peak EMG represents a robust parameter to study the neuromuscular control strategy underlying the specification of movement direction...
  20. ncbi A second mechanism of increase of cerebellar hypermetria in humans
    Mario Ubaldo Manto
    Fonds National de la Recherche Scientifique, Bruxelles and Université du Travail, Charleroi, Belgium
    J Physiol 547:989-94. 2003
    ..Hyperventilation induced a marked decrease in cerebral blood flow velocities. The mechanism of this provocative test is original and is distinct from the mechanism of the load-induced increase of hypermetria...
  21. ncbi Bilateral high-frequency synchronous discharges: a new form of tremor in humans
    Mario Ubaldo Manto
    Fonds National de la Recherche Scientifique, Laboratoire du Mouvement, Service Neurologie ULB, 808, Route de Lennik 1070, Bruxelles, Belgium
    Arch Neurol 60:416-22. 2003
    ....
  22. ncbi Dynamically responsive intervention for tremor suppression
    Mario Manto
    Fonds National de la Recherche Scientifique, , 808, Route de Lennik, 1070 Bruxelles, Belgium
    IEEE Eng Med Biol Mag 22:120-32. 2003
  23. ncbi Directional tuning of speed-related activation for reaching in the vertical plane in cerebellar ataxia
    M U Manto
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Hôpital Erasme Neurologie, 808, Route de Lennik, 1070 Bruxelles, Belgium
    Neurol Res 25:434-44. 2003
    ..Privileged directions associated with M Peak EMG and Net Vectors are erroneous. We demonstrate that the cerebellum plays a determinant and unsuspected role in the spatial modulation of activation during speed-related action for reaching...
  24. ncbi Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases
    Mario Ubaldo Manto
    Laboratoire de Neurologie Expérimentale, Hopital Erasme, Universite Libre de Bruxelles, Bruxelles, Belgium
    Ann Neurol 61:544-51. 2007
    ..However, the pathogenic role of GAD-Ab in neurological diseases remains a matter of debate...
  25. ncbi Interaction between repetitive stimulation of the sciatic nerve and functional ablation of cerebellar nucleus interpositus in the rat
    Nordeyn Oulad Ben Taib
    Service de Neurochirurgie, Hospital Erasme, ULB, Bruxelles, Belgium
    Cerebellum 3:21-6. 2004
    ....
  26. ncbi Episodic see-saw nystagmus in spino-cerebellar ataxia type 2 (SCA-2)
    Mario-Ubaldo Manto
    Fonds National de la Recherche Scientifique, Neurologie, 808, Route de Lennik, 1070 Bruxelles, Belgium
    Cerebellum 1:91-2. 2002
  27. ncbi Modulation of motor cortex excitability by sustained peripheral stimulation: the interaction between the motor cortex and the cerebellum
    Andreas R Luft
    Abt für Allgemeine Neurologie, Hertie Center for Clinical Brain Research, Universitat Tubingen, Tubingen, Germany
    Cerebellum 4:90-6. 2005
    ..It appears that the interpositus nucleus is a main subcortical modulator of the excitability changes occurring in the motor cortex, which may be a substrate of early plasticity effective in motor learning and recovery from lesion...
  28. ncbi Sporadic late onset paroxysmal cerebellar ataxia
    Mario-Ubaldo Manto
    J Neurol 250:230-1. 2003
  29. ncbi Clinical symptoms of cerebellar disease and their interpretation
    Duane E Haines
    Cerebellum 6:360-74. 2007
  30. ncbi Composite cerebellar functional severity score: validation of a quantitative score of cerebellar impairment
    Sophie Tezenas du Montcel
    AP HP, Department of Biostatistics and Medical Informatics, Pitié Salpêtrière Charles Foix Clinical Research Unit, University Pierre et Marie Curie, Paris, France
    Brain 131:1352-61. 2008
    ....
  31. ncbi Nitric oxide in the cerebellum of mutant mice
    Mario-Ubaldo Manto
    Cerebellum 3:130-2. 2004
  32. ncbi Myorhythmia associated with Hodgkin's lymphoma
    Valerie Wiener
    J Neurol 250:1382-4. 2003