Research Topics
Species | Pierre van der BruggenSummaryAffiliation: Ludwig Institute for Cancer Research Country: Belgium Publications
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Publications
Tumor-specific shared antigenic peptides recognized by human T cellsPierre van der Bruggen
Ludwig Institute for Cancer Research and Cellular Genetics Unit, Universite de Louvain, 74 avenue Hippocrate UCL 74 59, B 1200 Brussels, Belgium
Immunol Rev 188:51-64. 2002..These approaches have led to the identification of many new antigenic peptides presented by class I or class II molecules. We also describe some aspects of the processing and presentation of these antigenic peptides...- A polyclonal anti-vaccine CD4 T cell response detected with HLA-DP4 multimers in a melanoma patient vaccinated with MAGE-3.DP4-peptide-pulsed dendritic cellsYi Zhang
Ludwig Institute for Cancer Research and Cellular Genetics Unit, , Brussels, Belgium
Eur J Immunol 35:1066-75. 2005..A detailed analysis of one patient showed an anti-MAGE-3.DP4 CD4 T cell amplification of at least 3000-fold upon immunization. TCR analysis of the clones from this patient demonstrated a polyclonal response against the MAGE-3 peptide... - A MAGE-3 peptide presented by HLA-DR1 to CD4+ T cells that were isolated from a melanoma patient vaccinated with a MAGE-3 proteinYi Zhang
Ludwig Institute for Cancer Research and Cellular Genetics Unit, , Brussels, Belgium
J Immunol 171:219-25. 2003..Another of these DR1-restricted CD4(+) clones recognized not only the MAGE-3/12 peptide but also homologous peptides encoded by genes MAGE-1, 2, 4, 6, 10, and 11... - Human T cell responses against melanomaThierry Boon
Ludwig Institute for Cancer Research, Brussels Branch, and Cellular Genetics Unit, Universite de Louvain, Brussels, Belgium
Annu Rev Immunol 24:175-208. 2006..In patients who do respond to the vaccine, the antivaccine T cells probably succeed in reversing focally this immunosuppression and trigger a broad activation of other antitumor T cells, which proceed to destroy the tumor... - A MAGE-1 antigenic peptide recognized by human cytolytic T lymphocytes on HLA-A2 tumor cellsSabrina Ottaviani
Ludwig Institute for Cancer Research and Cellular Genetics Unit, University of Louvain, 74 avenue Hippocrate, UCL 74.59, 1200 Brussels, Belgium
Cancer Immunol Immunother 54:1214-20. 2005..These results indicate that the MAGE-1.A2 peptide can be used for antitumoral vaccination... - An antigenic peptide produced by peptide splicing in the proteasomeNathalie Vigneron
Ludwig Institute for Cancer Research and Cellular Genetics Unit, Universite de Louvain, B 1200 Brussels, Belgium
Science 304:587-90. 2004..Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate. Our results reveal an unanticipated aspect of the proteasome function of producing antigenic peptides... - Correlation between tumor regression and T cell responses in melanoma patients vaccinated with a MAGE antigenChristophe Lonchay
Ludwig Institute for Cancer Research, Brussels Branch of Human Cell Genetics, , 74 avenue Hippocrate, UCL 7459, B-1200 Brussels, Belgium
Proc Natl Acad Sci U S A 101:14631-8. 2004..It is possible that even those CTL responses that are below our present detection level can trigger a sequence of events that leads to tumor regression... - Processing and presentation of tumor antigens and vaccination strategiesPierre van der Bruggen
Ludwig Institute for Cancer Research and Cellular Genetics Unit, Institute of Cellular Pathology, , 74 avenue Hippocrate, UCL 7459, B-1200 Brussels, Belgium
Curr Opin Immunol 18:98-104. 2006.... - Monitoring of anti-vaccine CD4 T cell frequencies in melanoma patients vaccinated with a MAGE-3 proteinYi Zhang
Ludwig Institute for Cancer Research, Brussels Branch and Cellular Genetics Unit, , Brussels, Belgium
J Immunol 174:2404-11. 2005..The 13 anti-MAGE-3 clones, which corresponded to five different TCR clonotypes, recognized the same peptide presented by HLA-DR1... - The production of a new MAGE-3 peptide presented to cytolytic T lymphocytes by HLA-B40 requires the immunoproteasomeErwin S Schultz
Cellular Genetics Unit, Ludwig Institute for Cancer Research, , 74 Ave, Hippocrate UCL 74.59, B-1200 Brussels, Belgium
J Exp Med 195:391-9. 2002..This is the first example of a tumor-specific antigen exclusively presented by tumor cells expressing the immunoproteasome... - Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cellsNicolas van Baren
Ludwig Institute for Cancer Research, 74 avenue Hippocrate, UCL7459, B 1200 Brussels, Belgium E mail
J Clin Oncol 23:9008-21. 2005.... - A new MAGE-4 antigenic peptide recognized by cytolytic T lymphocytes on HLA-A24 carcinoma cellsSabrina Ottaviani
Ludwig Institute for Cancer Research and Institute of Cellular Pathology, Cellular Genetics Unit, , 74 avenue Hippocrate, UCL 7459, B-1200 Brussels, Belgium
Cancer Immunol Immunother 55:867-72. 2006..This MAGE-4 peptide could represent an interesting target for immunotherapy because it is presented by HLA-A24 molecules, which are widely expressed in different ethnic groups... - A new LAGE-1 peptide recognized by cytolytic T lymphocytes on HLA-A68 tumorsZhaojun Sun
Ludwig Institute for Cancer Research Institute of Cellular Pathology, Cellular Genetics Unit, , 74 avenue Hippocrate, UCL 7459, 1200, Brussels, Belgium
Cancer Immunol Immunother 55:644-52. 2006..These results indicate that the LAGE-1.A68 peptide can be used for antitumoral vaccination. We observed also that specific T cells could be detected in a blood sample with a high sensitivity by using an A68/LAGE-1 fluorescent multimer... - T-cell responses of vaccinated cancer patientsPierre G Coulie
Cellular Genetics Unit, Christian de Duve Institute of Cellular Pathology, Universite de Louvain, Avenue Hippocrate 74, UCL 7459, B 1200 Brussels, Belgium
Curr Opin Immunol 15:131-7. 2003..However, a correlation between these T-cell responses and the tumor regressions has not yet been established. It appears that some patients display tumor regression with an unexpectedly low frequency of anti-vaccine T cells... - CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulationJavier Carrasco
Ludwig Institute for Cancer Research, 74 avenue Hippocrate, UCL 7459, B 1200 Brussels, Belgium
Blood 108:2897-905. 2006..This concept leads to a reinterpretation of the significance of the presence of CD45RA+ CD8+ memory cells in patients affected by viral infections or by cancer... - Selective identification of HLA-DP4 binding T cell epitopes encoded by the MAGE-A gene familyXiao Fei Wang
Protein Engineering and Research Department, CEA Saclay, 91191 Gif sur Yvette, France
Cancer Immunol Immunother 56:807-18. 2007..We also show that the immunoreactivity of CD4+ T cell epitopes restricted to the same HLA II molecule may vary from one individual to another, as a result of inter-individual variations in the CD4+ T cell repertoire... - A reversible functional defect of CD8+ T lymphocytes involving loss of tetramer labelingNathalie Demotte
Ludwig Institute for Cancer Research, Brussels, Belgium
Eur J Immunol 32:1688-97. 2002..They also indicate that tetramers may fail to reveal some CTL bearing the relevant TCR, even when such functionally arrested CTL retain the potential to participate in immune responses because their defect is reversible... - Tumor-reactive CD4+ T cell responses to the melanoma-associated chondroitin sulphate proteoglycan in melanoma patients and healthy individuals in the absence of autoimmunityCornelia Erfurt
Department of Dermatology, University Hospital of Erlangen, Hartmannstrasse 14, Erlangen, Germany
J Immunol 178:7703-9. 2007.... - Vaccination of a melanoma patient with mature dendritic cells pulsed with MAGE-3 peptides triggers the activity of nonvaccine anti-tumor cellsJavier Carrasco
Ludwig Institute for Cancer Research, Cellular Genetics Unit, Universite Catholique de Louvain, Brussels, Belgium
J Immunol 180:3585-93. 2008.... - Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytesNathalie Demotte
Ludwig Institute for Cancer Research, 1200 Brussels, Belgium Cellular Genetics Unit, Institute of Cellular Pathology, Universite Catholique de Louvain, 1200 Brussels, Belgium
Immunity 28:414-24. 2008..The separation of TCR and CD8 molecules could be one major mechanism of anergy in tumors and other chronic stimulation conditions... - CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia AMarc Jacquemin
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Blood 101:1351-8. 2003..A similar phenomenon may occur with other mutations associated to an increased incidence of inhibitor formation... - Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanomaWim H J Kruit
Erasmus Medical Center-Daniel den Hoed Cancer Center, Department of Internal Oncology, Rotterdam, The Netherlands
Int J Cancer 117:596-604. 2005.... - Functional analysis of tumor-specific Th cell responses detected in melanoma patients after dendritic cell-based immunotherapyErwin S Schultz
Department of Dermatology, University Hospital of Erlangen, Hartmannstrasse 14, D 91052 Erlangen, Germany
J Immunol 172:1304-10. 2004..Moreover, these T cells exhibited cytolytic activity involving Fas-Fas ligand interactions. These findings support that vaccination-induced CD4+ Th cells might play an important functional role in antitumor immunity... - Identification of new antigenic peptide presented by HLA-Cw7 and encoded by several MAGE genes using dendritic cells transduced with lentivirusesKarine Breckpot
Department of Physiology and Immunology, Medical School of the Vrije Universiteit Brussel, Brussels, Belgium
J Immunol 172:2232-7. 2004..The risk of tumor escape due to appearance of Ag-loss variants should be reduced by the fact that the peptide is encoded by several MAGE genes... - Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptideAude Bonehill
Laboratory of Molecular and Cellular Therapy, Department of Physiology-Immunology, Medical School of the Vrije Universiteit Brussel, 1090 Brussels, Belgium
Cancer Res 63:5587-94. 2003..Similar results were obtained with a recombinant Ii containing the MAGE-A3 epitope presented in the context of HLA-DR13... - Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II moleculesAude Bonehill
Laboratory of Molecular and Cellular Therapy, Department of Physiology-Immunology, Medical School of the Vrije Universiteit Brussel, Brussels, Belgium
J Immunol 172:6649-57. 2004..Furthermore, DCs electroporated after maturation are more efficient in Ag presentation than DCs electroporated before maturation... - Side-by-side comparison of lentivirally transduced and mRNA-electroporated dendritic cells: implications for cancer immunotherapy protocolsMelissa Dullaers
Laboratory of Molecular and Cellular Therapy, Department of Physiology-Immunology, Medical School of the Vrije Universiteit Brussel, Laarbeeklaan 103/E, 1090 Brussels, Belgium
Mol Ther 10:768-79. 2004..Both types of modified murine DC were able to induce OVA-specific cytotoxic T cells in vivo; however, the mRNA-electroporated DC were less potent. Our data indicate that this may be related to their impaired IL-12 production... - Lentivirally transduced dendritic cells as a tool for cancer immunotherapyKarine Breckpot
Department of Physiology and Immunology, Medical School of the Vrije Universiteit Brussel (VUB, Laarbeeklaan 103/E, 1090 Brussels, Belgium
J Gene Med 5:654-67. 2003..The composition of the transfer vector has a major impact on the transduction efficiency... - Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancerChristoph Grunau
Institut de Genetique Humaine, CNRS UPR 1142, Montpellier, France
Genes Chromosomes Cancer 43:11-24. 2005..Consequently, we propose BAGE hypomethylation as a new, highly informative epigenetic biomarker for the diagnosis of cancer, whose hypomethylation in cancer may be causally related to that of juxtacentromeric satellite DNA... - New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profileMyriam Ruault
Institut de Genetique Humaine, CNRS UPR 1142, 141, rue de la Cardonille, 34396 Montpellier, France
Eur J Hum Genet 10:833-40. 2002..We suggest that the pattern of expression restricted to cancer/testis is a feature of the few genes mapping to juxtacentromeric regions... - [General principles and first clinical trials of therapeutic vaccines against cancer]Jean Francois Baurain
Centre du Cancer, Cliniques Universitaires Saint Luc, Oncology Department, 54 Avenue Hippocrate, B 1200 Bruxelles, Belgique
Bull Cancer 95:327-35. 2008..Current research projects aim at elucidating the mechanisms of this resistance and to develop new vaccination strategies that circumvent this roadblock... - Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytesSimon P Graham
International Livestock Research Institute, Nairobi, Kenya
Proc Natl Acad Sci U S A 103:3286-91. 2006..These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites... - YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathwayNathalie Sauvonnet
Microbial Pathogenesis Unit, Christian de Duve, , Brussels, Belgium
Mol Microbiol 45:805-15. 2002..Consistent with the observation that YopH inactivated the Akt pathway, YopH inhibited PI 3-kinase-dependent secretion of interleukin 2 and proliferation. These data reveal a new effect of YopH in Yersinia pathogenesis... - Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parvaSimon P Graham
International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
Infect Immun 76:685-94. 2008..These data demonstrate that the identified antigens are inherently dominant in animals with the corresponding MHC genotypes...