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Genomes and Genes | Isabelle A LeclercqSummaryCountry: Belgium Publications
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Publications
Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibitionNicolas Charette
Laboratory of Gastroenterology, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, 1200 Brussels, Belgium
Mol Cancer 9:256. 2010..We investigated in vitro the effect of salirasib on cell growth as well as its mechanism of action in human hepatoma cell lines (HepG2, Huh7, and Hep3B) and its in vivo effect in a subcutaneous xenograft model with HepG2 cells...- Nonalcoholic fatty liver disease: the potential role of nutritional managementIsabelle A Leclercq
Laboratory of Gastroenterology, Universite Catholique de Louvain UCL, Brussels, Belgium
Curr Opin Clin Nutr Metab Care 11:766-73. 2008..To review available data pertaining to dietary imbalances and metabolic alterations leading to the development of fatty liver disease and nutritional managements... - Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequencesIsabelle A Leclercq
Laboratory of Gastroenterology, Faculty of Medicine, Universite Catholique de Louvain, GAEN 53 79, Avenue Mounier, 53, B 1200 Brussels, Belgium
J Hepatol 47:142-56. 2007..Finally, activation of stellate cells will set in motion a fibrogenic response that paves the way to cirrhosis... - Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat dietNicolas Lanthier
Laboratoire d Hépato Gastro Entérologie, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, UCL GAEN 5379, Ave E Mounier 53, 1200 Brussels, Belgium
FASEB J 25:4301-11. 2011..Preventive and prolonged KC depletion ameliorates insulin sensitivity and prevents adipose tissue inflammation, suggesting a communication between the liver and the adipose tissue in the development of HFD-induced metabolic alterations... - Efficacy of lanreotide in preventing the occurrence of chemically induced hepatocellular carcinoma in ratsIvan Borbath
Gastroenterology Laboratory, Faculte de Medecine, Universite Catholique de Louvain, Bruxelles, Belgium
Chem Biol Interact 183:238-48. 2010..Further work on the anti-tumoral effect of lanreotide is called for to assess the mechanistic relationships of its anti-proliferative and anti-angiogenic actions on liver neoplastic cells... - Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injuryNoémi K M Van Hul
Laboratory of Gastroenterology, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
Hepatology 49:1625-35. 2009..Those observations may reveal a fundamental role for the established hepatic microenvironment or niche during the process of activation and differentiation of liver progenitor cells... - Kupffer cell activation is a causal factor for hepatic insulin resistanceNicolas Lanthier
Laboratoire de gastro entérologie, Universite Catholique de Louvain, GAEN 53 79, Ave Mounier 53, B 1200 Brussels, Belgium
Am J Physiol Gastrointest Liver Physiol 298:G107-16. 2010.... - Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in miceAlain Da Silva Morais
Laboratoire de Gastroenterologie, Universite Catholique de Louvain UCL, Brussels, Belgium
Int J Mol Med 19:105-12. 2007..Our data demonstrate that, although having anti-fibrotic properties in rats, PPARgamma agonists do not prevent activation of HSCs in vitro, nor hepatic fibrogenesis in vivo in mice... - Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammationAlain Da Silva Morais
Laboratoire de gastro entérologie, Universite Catholique de Louvain, GAEN 53 79, Brussels, Belgium
J Hepatol 50:489-500. 2009..Peroxisome proliferator-activated receptor gamma (PPARgamma) agonist drugs, like pioglitazone (PGZ), are proposed as treatments for steatohepatitis. Their mechanisms of action remain ill-clarified... - Development of hepatic fibrosis occurs normally in AMPK-deficient miceAlain Da Silva Morais
Gastroenterology Laboratory, Universite Catholique de Louvain UCL, B 1200 Brussels, Belgium
Clin Sci (Lond) 118:411-20. 2010..Activation of AMPK in HSCs inhibits in vitro fibrogenesis. By contrast, low AMPK activity does not prevent HSC activation in vitro nor in in vivo fibrosis... - Participation of liver progenitor cells in liver regeneration: lack of evidence in the AAF/PH rat modelAnge Clarisse Dusabineza
Laboratory of Hepato Gastroenterology, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Brussels, Belgium
Lab Invest 92:72-81. 2012..These observations suggest that, in this model, the efficient recovery of the liver function was ensured rather by the proliferation of mature hepatocytes than by the LPC expansion and differentiation into hepatocytes... - Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targetsBarbara D Pachikian
Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
PLoS ONE 6:e23365. 2011..In conclusion, n-3 PUFA depletion in liver phospholipids leads to activation of SREBP-1c and lipogenesis, which contributes to hepatic steatosis... - Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cellsRodolphe Carpentier
de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
Gastroenterology 141:1432-8, 1438.e1-4. 2011..We investigated the role of the ductal plate in hepatic morphogenesis... - Defective hepatic regeneration after partial hepatectomy in leptin-deficient mice is not rescued by exogenous leptinIsabelle A Leclercq
Laboratory of Gastroenterology, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
Lab Invest 86:1161-71. 2006..Thus, leptin does not directly signal to liver cells to promote hepatocyte proliferation, and the obese phenotype is not solely responsible for impaired regeneration... - Pathogenesis of steatohepatitis: insights from the study of animal modelsIsabelle A Leclercq
Laboratoire de Gastroenterologie, Universite Catholique de Louvain UCL, Brussels, Belgium
Acta Gastroenterol Belg 70:25-31. 2007..In conclusion, our work demonstrates the importance of oxidative stress in the pathogenesis of NASH, the role of intrahepatic lipid overload and underlies the links between adipose tissue and the liver... - The metabolic syndrome: how it may influence hepatic stellate cell activation and hepatic fibrosisNicolas Lanthier
Laboratory of Gastroenterology, Universite Catholique de Louvain, Brussels, Belgium
Curr Opin Clin Nutr Metab Care 12:404-11. 2009..To highlight the metabolic or inflammatory components, deregulated in or pathogenic for the metabolic syndrome, that may, directly or indirectly, modulate hepatic fibrogenesis... - Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotideIvan Borbath
Gastroenterology Laboratory, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate, 10, Brussels 1200, Belgium
Cancer Sci 98:1831-9. 2007..In conclusion, lanreotide significantly decreases early carcinogenic transformation in a two-step rat model. As lanreotide has a low toxicity profile, we believe it would be interesting to evaluate its effect in chemoprevention of HCC... - Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazoneIsabelle A Leclercq
Laboratory of Gastroenterology, Faculty of Medicine, Universite Catholique de Louvain UCL, Brussels, Belgium
Lab Invest 87:56-65. 2007..In conclusion, PGZ alleviates steatosis and steatohepatitis induced by the MCD diet, an effect associated with correction of intrahepatic insulin resistance... - Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in miceIsabelle A Leclercq
Gastroenterology Unit, Universite Catholique de Louvain UCL, GAEN UCL 53 79, avenue E Mounier, 53, B 1200 Brussels, Belgium
J Hepatol 41:926-34. 2004..We analysed the role of NF-kappaB redox-sensitive signalling pathway of inflammatory recruitment in experimental steatohepatitis... - Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidationIsabelle Gerin
Laboratory for Physiological Chemistry, de Duve Institute, Universite Catholique de Louvain, 1200 Bruxelles, Belgium
J Biol Chem 285:33652-61. 2010..These results add an additional layer of complexity to our understanding of lipid homeostasis and might open possibilities for future therapeutic intervention... - Why and How Meet n-3 PUFA Dietary Recommendations?Olivier Molendi-Coste
Laboratory of Hepato Gastroenterology, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain UCL, GAEN 53 79 Avenue Mounier, 53, 1200 Brussels, Belgium
Gastroenterol Res Pract 2011:364040. 2011.... - Hepatic endoplasmic reticulum stress in obesity: Deeper insights into processes, but are they relevant to nonalcoholic steatohepatitis?Isabelle A Leclercq
Laboratory of Hepato Gastroenterology, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Brussels, Belgium
Hepatology 54:2261-6. 2011..Hence, we established that abnormal lipid and calcium metabolism are important contributors to hepatic ER stress in obesity. (HEPATOLOGY 2011... - Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis?Isabelle A Leclercq
Gastroenterology Unit, Belgian National Fonds for Scientific Research, Universite Catholique de Louvain, Brussels, Belgium
Clin Sci (Lond) 106:235-7. 2004..Thus efficiency of antioxidant defence mechanisms, by setting the threshold at which pro-oxidants would become injurious, might represent a determining factor for disease progression from stable steatosis to steatohepatitis... - NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitisAileen Dela Pena
Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW, Australia
J Hepatol 46:304-13. 2007..g., gp91phox) renders NADPH oxidase inactive. We tested whether activated inflammatory cells contribute to oxidant stress in steatohepatitis... - Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injuryIsabelle A Leclercq
Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, NSW, Australia
Gastroenterology 124:1451-64. 2003..Our aim was to establish whether defective liver regeneration in ob/ob mice is a direct consequence of leptin-dependent, intracellular signaling mechanisms controlling cell-cycle regulation in hepatocytes...