Research Topics
| P HolvoetSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Publications
The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic miceP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
Arterioscler Thromb Vasc Biol 20:459-66. 2000..It is, however, critical for LCAT-induced hyperalphalipoproteinemia and HDL remodeling independent of the lipid-binding properties of apoAI...- Arg123-Tyr166 domain of human ApoA-I is critical for HDL-mediated inhibition of macrophage homing and early atherosclerosis in miceP Holvoet
Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
Arterioscler Thromb Vasc Biol 21:1977-83. 2001..Thus, the Arg123-Tyr166 central domain of apoA-I is critical for reducing oxidative stress, macrophage homing, and early atherosclerosis in apoE knockout mice independent of its role in HDL production and cholesterol efflux... - Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition studyPaul Holvoet
Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium
Arterioscler Thromb Vasc Biol 23:1444-8. 2003..Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort... - Circulating oxidized LDL is a useful marker for identifying patients with coronary artery diseaseP Holvoet
Center for Molecular and Vascular Biology, Catholic University of Leuven, Leuven, Belgium
Arterioscler Thromb Vasc Biol 21:844-8. 2001..Thus, circulating oxidized LDL is a sensitive marker of CAD. Addition of oxidized LDL to the established risk factors may improve cardiovascular risk prediction... - Oxidized low density lipoprotein is a prognostic marker of transplant-associated coronary artery diseaseP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
Arterioscler Thromb Vasc Biol 20:698-702. 2000..The development of transplant CAD was associated with a further increase of plasma levels of oxidized LDL (chi(2)=14, P=0.0002). Oxidized LDL is a prognostic marker of transplant CAD... - The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohortPaul Holvoet
Center for Experimental Surgery and Anesthesiology, Catholic University, Leuven, Belgium
Diabetes 53:1068-73. 2004..22-4.15). We concluded that the metabolic syndrome, a risk factor for CHD, is associated with higher levels of circulating oxLDL that are associated with a greater disposition to atherothrombotic coronary disease... - Oxidized LDL and coronary heart diseasePaul Holvoet
Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
Acta Cardiol 59:479-84. 2004..Finally, elevated oxidized LDL predicted myocardial infarction in the Health ABC cohort consisting of well-functioning elderly people, even after adjusting for age, gender, race, smoking, and the metabolic syndrome... - Malondialdehyde-modified LDL as a marker of acute coronary syndromesP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
JAMA 281:1718-21. 1999..Release of circulating malondialdehyde (MDA)-modified low-density lipoprotein (LDL) may reflect endothelial injury or plaque instability... - Oxidative modification of low-density lipoproteins in atherothrombosisP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Acta Cardiol 53:253-60. 1998..At present, in the absence of prospective studies, the causative role of oxidatively modified LDL in atherothrombosis is, however, not established... - Oxidation of low density lipoproteins in the pathogenesis of atherosclerosisP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Atherosclerosis 137:S33-8. 1998..g. vitamin E), estrogen supplementation and increased levels of high density lipoproteins (HDL) may, at least partially, be due to the inhibition of oxidation of LDL or to the reversal of the atherothrombotic effects of oxidized LDL... - Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout miceP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
J Clin Invest 102:379-85. 1998..Amino acid sequences of apo AII, which is considered to be less antiatherogenic, can be used to restore the structure of apo AI and thereby its antiatherogenicity... - LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigsP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Arterioscler Thromb Vasc Biol 18:415-22. 1998.... - Oxidized low density lipoproteins in patients with transplant-associated coronary artery diseaseP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Arterioscler Thromb Vasc Biol 18:100-7. 1998..047). Thus, the present study demonstrates that plasma levels of oxidized LDL correlate with the extent of CAD in heart transplant patients and suggests that elevated levels of oxidized LDL may be a marker for CAD... - Thrombosis and atherosclerosisP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Curr Opin Lipidol 8:320-8. 1997..Plasminogen activator inhibitor-1 inhibits smooth muscle cell migration and, in the presence of vitronectin, promotes the clearance of thrombin by LDL receptor-related protein at sites of endothelial injury... - beta-VLDL hypercholesterolemia relative to LDL hypercholesterolemia is associated with higher levels of oxidized lipoproteins and a more rapid progression of coronary atherosclerosis in rabbitsP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Arterioscler Thromb Vasc Biol 17:2376-82. 1997.... - Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient miceR Quarck
Center for Molecular and Vascular Biology, Department of Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
Circulation 103:2495-500. 2001..The effect of adenovirus-mediated expression of PAF-AH on injury-induced neointima formation and spontaneous atherosclerosis was studied in apolipoprotein E-deficient mice... - Oxidized low-density lipoprotein-induced expression of ABCA1 in blood monocytes precedes coronary atherosclerosis and is associated with plaque complexity in hypercholesterolemic pigsB Geeraert
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
J Thromb Haemost 5:2529-36. 2007..Previously, we identified 18 genes in coronary plaque macrophages of hypercholesterolemic pigs that correlated with plaque oxLDL... - Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery diseaseP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Circulation 98:1487-94. 1998..Therefore, the association between plasma levels of oxidized LDL and malondialdehyde (MDA)-modified LDL and acute coronary syndromes and stable CAD was investigated. METHODS and.. - HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- miceG Theilmeier
Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
FASEB J 14:2032-9. 2000..This protective mechanism is independent of the function of HDL as cholesterol acceptor. Modulation of lipoprotein oxidation by PAF-AH may prevent leukocyte recruitment to the vessel wall, a key feature in atherogenesis... - Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant miceB Geeraert
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases and Leuven Food Science and Nutrition Research Centre, Katholieke Universiteit Leuven, Leuven, Belgium
Int J Obes (Lond) 34:569-77. 2010..Therefore, we investigated its effects on insulin resistance, inflammation and oxidative stress related to atherosclerosis in obese insulin-resistant mice... - Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient miceB De Geest
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Circulation 96:4349-56. 1997.... - Rosuvastatin restores superoxide dismutase expression and inhibits accumulation of oxidized LDL in the aortic arch of obese dyslipidemic miceW Verreth
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit, Leuven, Belgium
Br J Pharmacol 151:347-55. 2007.... - Oxidized LDL and HDL: antagonists in atherothrombosisA Mertens
Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
FASEB J 15:2073-84. 2001..Both enzymes actively protect hypercholesterolemic mice against atherosclerosis. Oxidized LDL inhibits these enzymes. Thus, oxidized LDL and HDL are indeed antagonists in the development of cardiovascular disease... - Characterization of a chimeric plasminogen activator consisting of a single-chain Fv fragment derived from a fibrin fragment D-dimer-specific antibody and a truncated single-chain urokinaseP Holvoet
Center for Thrombosis and Vascular Research, University of Leuven, Belgium
J Biol Chem 266:19717-24. 1991..5-fold increase of the potency of the two-chain form... - Restenosis and gene therapyR Quarck
Department of Experimental Surgery and Anaesthesiology, University of Leuven, Campus Gasthuisberg O and N, Herestraat 49, B-3000 Leuven, Belgium
Expert Opin Biol Ther 1:79-91. 2001..The potential of different vector systems and devices for local gene transfer in the arterial wall is discussed... - Endothelial dysfunction, oxidation of low-density lipoprotein, and cardiovascular diseaseP Holvoet
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Ther Apher 3:287-93. 1999..Oxidized LDL may contribute to the progression of atherosclerosis by enhancing endothelial injury by inducing foam cell generation and smooth muscle proliferation... - Adipose tissue expression of gelatinases in mouse models of obesityH R Lijnen
Center for Molecular and Vascular Biology, University of Leuven, Belgium
Thromb Haemost 85:1111-6. 2001..The presence of MMP-2 in the adipose tissue was confirmed immunologically and its localization in adipocytes revealed by immunogold electron microscopy. The potential functional role of MMP-2 in adipose tissue remains to be determined... - Molecular and functional characterization of ovine cardiac valve-derived interstitial cells in primary isolates and culturesJ Yperman
Centrum voor Experimentele Heelkunde en Anaesthesiologie, Katholieke Universiteit Leuven, Leuven, Belgium
Tissue Eng 10:1368-75. 2004..We conclude that ovine valve interstitial cells undergo phenotypic modulation to activated myofibroblasts under culture conditions but retain stable matrix production... - Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndromePaul Holvoet
Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Belgium
JAMA 299:2287-93. 2008..Experimental data support the hypothesis that oxidized low-density lipoprotein (LDL) is associated with the metabolic syndrome. However, this hypothesis has not been tested in humans... - Oxidized LDL and the metabolic syndromePaul Holvoet
Arterioscler Thromb Vasc Biol 26:e31; author reply e31-2. 2006 - Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndromeBharti Mackness
University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
Arterioscler Thromb Vasc Biol 26:1545-50. 2006..Paraoxonase1 (PON1), a high-density lipoprotein (HDL)-associated antioxidant enzyme that prevents the oxidation of low-density lipoprotein (LDL), is low in the metabolic syndrome... - Metabolic syndrome and the risk of cardiovascular disease in older adultsJaved Butler
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Am Coll Cardiol 47:1595-602. 2006..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults... - Obesity, the metabolic syndrome, and oxidized LDLPaul Holvoet
Am J Clin Nutr 83:1438; author reply 1438-9. 2006 - The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA)Paul Holvoet
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
Atherosclerosis 194:245-52. 2007..95 mg/dl; P=0.0002). Adjustment for risk factor correlates attenuated associations with subclinical CVD (P=0.026). In conclusion, oxLDL is associated with subclinical CVD by its relationship with many cardiovascular risk factors... - Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosisSoraya Taleb
Institut National de la Sante et de la Recherche Medicale, U689, 41 Bd de la Chapelle, Paris, France
Arterioscler Thromb Vasc Biol 27:2691-8. 2007..Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality. However, the precise molecular pathways responsible for this close association remain poorly understood... - Analytical performance and diagnostic accuracy of immunometric assays for the measurement of circulating oxidized LDLPaul Holvoet
Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
Clin Chem 52:760-4. 2006.... - Lipoprotein peroxidation and mobility limitation: results from the Health, Aging, and Body Composition StudyMatteo Cesari
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville 32608, USA
Arch Intern Med 165:2148-54. 2005..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)... - Obesity, regional body fat distribution, and the metabolic syndrome in older men and womenBret H Goodpaster
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Arch Intern Med 165:777-83. 2005..We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults... - Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosisAnn Mertens
Cardiovascular Research Unit at the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N, Herestraat 49, B-3000 Leuven, Belgium
Circulation 107:1640-6. 2003..Transient LCAT overexpression was associated with a reduction of oxidative stress and atherosclerosis... - The complex link between oxidised low-density lipoprotein and unstable anginaGiampaolo Niccoli
Institute of Cardiology, Catholic University, Rome, Italy
J Cardiovasc Med (Hagerstown) 8:387-91. 2007..We also assessed the correlation between plaque or plasma ox-LDL and angiographic complex stenosis morphology... - Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AIHerta M Crauwels
Division of Pharmacology T2, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
Cardiovasc Res 59:189-99. 2003..We investigated whether vasomotor dysfunction develops in aged apoE(-/-), whether the defect was systemic (hypercholesterolemia-dependent) or focal (plaque-related), and the effect of human apolipoprotein AI transgenesis (apoAI/E(-/-))... - Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant miceWim Verreth
Cardiovascular Research Unit of the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
Circulation 110:3259-69. 2004..Improved lipid metabolism and insulin signaling is associated with decreased tissue deposition of oxidized LDL that increases cardiovascular risk in persons with the metabolic syndrome... - Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigsPeter Verhamme
Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, KU Leuven, Campus Gasthuisberg, O and N, Herestraat 49, Leuven, Belgium
Cardiovasc Res 56:135-44. 2002..Increased migration and decreased apoptosis of SMC may contribute to the disappearance of the a-cellular core after lipid lowering... - Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffnessAn Van den Bergh
Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Disease, Katholieke Universiteit Leuven, Provisorium I, Minderbroedersstraat 19, K U Leuven postbus 01033 FEHA, 3000 Leuven, Belgium
Cardiovasc Res 77:371-9. 2008..The differential impact of type II diabetes and the metabolic syndrome on left ventricular function, however, remains incompletely defined... - Angio-associated migratory cell protein and smooth muscle cell migration in development of restenosis and atherosclerosisPaul Holvoet
J Am Coll Cardiol 52:312-4. 2008 - Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplastyGregor Theilmeier
Center for Molecular and Vascular Biology, Campus Gasthuisberg, O and N, Herestraat 49, B-3000, Leuven, Belgium
Cardiovasc Res 55:385-95. 2002..Our in vitro data suggest that this decrease can be due to macrophage-induced matrix degradation and reduced VSMC adhesion and to impaired VSMC migration. Oxidised LDL mimics the inhibitory effect of hypercholesterolemic serum... - Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary flow reserve and reduced capillary densityGregor Theilmeier
Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
Circulation 106:1140-6. 2002..CONCLUSION: LDL hypercholesterolemia in minipigs impaired LV response to dobutamine stress in the absence of coronary stenosis... - Domain structure and lipid interaction in human apolipoproteins A-I and E, a general modelHiroyuki Saito
National Institute of Health Sciences, Osaka Branch, Osaka 540 0006, Japan
J Biol Chem 278:23227-32. 2003..Because apoE behaves similarly, this mechanism is probably a general feature for lipid interaction of other exchangeable apolipoproteins, such as apoA-IV... - The importance of catch-up growth after early malnutrition for the programming of obesity in male ratFlorence Bieswal
Laboratory of Cell Biology, University of Louvain, Louvain-la-Neuve, Belgium
Obesity (Silver Spring) 14:1330-43. 2006..DISCUSSION: Catch-up growth immediately after early malnutrition should be a key point for the programming of obesity... - Increased levels of low-density lipoprotein oxidation in patients with familial hypercholesterolemia and in end-stage renal disease patients on hemodialysisLambertus Van Tits
Department of Medicine, Division of General Internal Medicine, UMC Nijmegen, Nijmegen, The Netherlands
Lab Invest 83:13-21. 2003..We conclude that cholesterol-lowering therapy does not normalize elevated LDL oxidation levels in FH patients and elevated LDL oxidation level in FH and in ESRD might mirror atherosclerosis... - Application of NIRS in mice: a study comparing the oxygenation of cerebral blood and main tissue oxygenation of mice and ratGeofrey De Visscher
Laboratory of Cardiovascular Research, CEHA, Catholic University of Leuven, Leuven, Belgium
Adv Exp Med Biol 578:197-202. 2006 - Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipidsHiroyuki Saito
Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Abramson Research Center, 3625 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
J Biol Chem 279:20974-81. 2004..1 and -0.04 kcal/mol per residue, respectively. These results indicate that alpha-helix formation, especially in the C-terminal regions, provides the energetic source for high affinity binding of apoA-I to lipids... - Effects of enrichment of fibroblasts with unesterified cholesterol on the efflux of cellular lipids to apolipoprotein A-IKristin Gillotte-Taylor
Department of Biochemistry, MCP Hahnemann University, Philadelphia, Pennsylvania 19129, USA
J Biol Chem 277:11811-20. 2002.... - Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cellsPaul Holvoet
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, PB 705, B 3000 Leuven, Belgium
Arterioscler Thromb Vasc Biol 26:1558-65. 2006..We searched for the strongest gene correlates of oxLDL in macrophages in coronary plaques and studied the effect of oxLDL on their expression in THP-1 cells...