Willem Flameng

..We studied the incidence of PPM and its potential effects on clinical outcome in patients undergoing aortic valve replacement using the Carpentier-Edwards Perimount bioprosthesis...

..We compared this new valve with the Perimount valve (Edwards Lifesciences, Irvine, CA) in a randomized prospective study in adolescent sheep...

..We determined the possible effects of age, antimineralization treatments, circulatory implant conditions, prosthesis design, and valve-related structural aspects on valve calcification in adolescent sheep...

..Furthermore, clinically available stentless porcine and bovine xenografts were studied as an alternative to homografts...

..However, it is unknown whether this can be related to future structural valve deterioration (SVD) of the bioprosthesis...

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..Its durability should, however, be investigated in comparison with alternative tissues in a randomized trial...

..However, their effect on contractile dysfunction and impaired cardiac functional reserve is unknown...

..GA fixation after acellularization causes important inhomogeneous tissue mineralization. Photo-oxidation combines optimal tissue fixation with superior anticalcification characteristics...

..In sheep, blood contact increased tissue calcification significantly, mainly in aortic wall samples. Arterial pressure did not enhance mineralization of aortic wall tissue...

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..The study aim was to evaluate the very long-term patient survival, clinical and hemodynamic status after aortic valve replacement (AVR) with the Edwards PRIMA model 2500 stentless porcine aortic valve...

..CONCLUSIONS: IP reduces unloaded MVO(2), and preserves contractility, diastolic function, and ventriculo-arterial coupling after 30 min global myocardial ischemia in an in-vivo sheep model...

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..In conclusion, thrombolysis is an attractive first-line therapy for patients with PVT, with clinical outcomes comparing favorably with the standard surgical approach...

..Prolonged aortic crossclamping can increase mortality and morbidity after aortic valve replacement in elderly and high-risk patients. Sutureless implantation of the prosthesis has the potential to shorten aortic crossclamp time...

..The differential impact of type II diabetes and the metabolic syndrome on left ventricular function, however, remains incompletely defined...

..The thrombosis caused severe mechanical dysfunction only in the bileaflet valves, probably due to their delicate hinge mechanism. These findings may be used in the further development of an animal model of mechanical valve thrombosis...

..We sought to investigate the effect of a catheter-mounted microaxial blood pump (Impella, Aachen, Germany) on myocardial infarct size...

..71 +/- 1.27 in the Photofix valves versus 10.78 +/- 77.22 in the Freestyle valves (P < 0.05). CONCLUSION: Photo-oxidation of a porcine stentless valve prevents calcification not only in the cusps but also in the aortic wall portion...

..To use in vivo instead of in vitro cell seeding in heart valve tissue engineering...

..We assessed serial echocardiographic follow-up of valve function as an indicator of the durability of mitral valve repair...

..A high ratio indicates that the change in parameter reflects inotropic rather than load change. This ratio was highest for PRSW, which seems to be the best parameter for judging contractility differences in mice...

..CONCLUSIONS: The Contegra conduit's performance was clearly superior to that of the control MH100 conduit when implanted in the pulmonary artery position in juvenile sheep for 5 months...

..In conclusion, glucose tolerance and load-dependent left ventricular performance parameters were different between 4 mice background strains, but PRSW was comparable...

..This study showed that macrophages are the clear driving force of FBR, dependent on milieu, and myofibroblast deposition and differentiation...

..However, surgical valve replacement is a therapeutic option that, although it has a significant mortality, needs to be considered in selected patients and leads to improvement in functional capacity and survival...

..Different serum conditions did not lead to different beta-actin levels. CONCLUSION: Due to the variation in expression, beta-actin cannot be used as a reference for gene expression of ovine-derived heart valve IC in culture...

..From this result, we can conclude that the immunohistochemical panel for sheep has been extensively expanded with respect to cardiovascular research...

..CONCLUSION: Our case demonstrates that simultaneous valve surgery and repair of a superior mesenteric artery mycotic aneurysm by sewing a vein patch in the neck of the artery is a viable treatment option...

..In addition, NIRS is found to be a robust technique: even when path lengths are altered after probe insertion, physiological alterations can still be examined...

..The identification of specific primitive cells during FBR may have important implications for the inflammatory responses to inert materials and their use in tissue prostheses...

..Differences in pain scores could still be demonstrated one month after discharge. CONCLUSIONS: This study suggests that partial upper sternotomy improves pulmonary function and reduces pain in comparison with standard full sternotomy...

..We assessed serial echocardiographic follow-up of valve function as an indicator of the durability of mitral valve repair...

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..Further research with more in vitro and animal testing is required to statistically validate these findings...

..Ischemic preconditioning would thus be clinically significant when the ischemic damage is severe...

..CONCLUSION: LDL hypercholesterolemia in minipigs impaired LV response to dobutamine stress in the absence of coronary stenosis...

..We conclude that myocardial stunning is not caused by altered myofibrillar function and protein degradation but may be partly due to the oxidative modification of as yet undefined proteins...

..The patient survives now for more than 14 years, the longest reported survival of a primary synovial sarcoma of the pericardium...

..CONCLUSIONS: Loss of T-tubules reduces the synchrony of SR Ca2+ release. This could contribute to reduced efficiency of excitation-contraction coupling in heart failure, though dyssynchrony in human failing cells appears to be modest...

..We therefore studied the effect of serotonin and acetylcholine on tension generated by isolated coronary artery segments from control and brain dead dogs...

..Atomic absorption spectrometry showed low tissue calcium content. A clinical safety and feasibility trial with an allograft valve prepared the same way showed excellent short-term results in 6 patients...

..This study confirms the need to include blood contact as a factor in in vivo pre-clinical valve testing...

..This study resulted in a prototype of a compact pulsatile flow system for the creation of TE aortic valves. In addition a biocompatibility study of the used materials is performed...

..However, the pattern of calcification is somewhat different between the two groups...

..It accentuated that the correct implantation technique for stentless procedures is extremely important in order to prevent early degeneration...

..The aim of this study was to evaluate morphological and histological changes in a TE heart valve consisting of decellularized porcine matrices seeded with viable autologous vascular endothelial cells (AVEC)...

..Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, however, is unknown...

..We therefore conclude that, in rats subjected to CHI, pentobarbital is unable to perform its beneficial effects on the cerebral metabolism...

..01). CONCLUSIONS: RPC by transient occlusion of the iliac artery improves lung gas exchange after repeated coronary artery occlusion and reperfusion mimicking OPCAB surgery, and preserves low PVR in sheep...

..They could be increased by BAY K-8644 or by isoproterenol. We conclude that the I(to)-like currents are due to monovalent cation flow through L-type Ca(2+) channels, which in pig myocytes show low sensitivity to nifedipine...