Research Topics
Species | W JennesSummaryAffiliation: Institute of Tropical Medicine Country: Belgium Publications
| Collaborators
|
Detail Information
Publications
Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligandsWim Jennes
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
J Immunol 177:6588-92. 2006..In addition, exposed seronegatives more frequently possessed AB KIR genotypes, which contain more activating KIR. The data support an important role for NK cells and KIR/HLA interactions in antiviral immunity...- The predominance of Human Immunodeficiency Virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitnessHarr F Njai
HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, 155 Nationalestraat, B 2000 Antwerp, Belgium
Retrovirology 3:40. 2006..Growth competition experiments were carried out at equal multiplicity of infection in activated T cells and monocyte-derived dendritic cells (MO-DC) in parallel... - Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Côte d'IvoireWim Jennes
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
AIDS Res Hum Retroviruses 18:171-7. 2002..05) in peripheral blood. These data indicate that increased percentages of beta-chemokine-producing T cells in HIV-1-infected subjects correlate with disease progression and are a sign of viremia-driven chronic T cell activation... - Higher homologous and lower cross-reactive Gag-specific T-cell responses in human immunodeficiency virus type 2 (HIV-2) than in HIV-1 infectionWim Jennes
Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Antwerp, Belgium
J Virol 82:8619-28. 2008..Understanding the nature of immune control of HIV-2 infection could be crucial for HIV vaccine design... - Suppressed cellular alloimmune responses in HIV-exposed seronegative female sex workersW Jennes
Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
Clin Exp Immunol 143:435-44. 2006..Our data support the hypothesis that suppressed cellular alloimmune responses may play a role in protection against HIV infection... - Disturbed secretory capacity for macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta in progressive HIV infectionWim Jennes
Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium
AIDS Res Hum Retroviruses 20:1087-91. 2004..Furthermore, we demonstrated that the detection of beta-chemokines in HIV patients by different methods may indeed result in contradictory findings... - HIV-specific T helper responses and frequency of exposure among HIV-exposed seronegative female sex workers in Abidjan, Cote d'IvoireWim Jennes
Department of Microbiology, Laboratory of Immunology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
J Infect Dis 189:602-10. 2004..The characteristics of human immunodeficiency virus (HIV) exposure that determine the induction of HIV-specific T cells and, in particular, T helper cells are not well understood... - Cellular human immunodeficiency virus (HIV)-protective factors: a comparison of HIV-exposed seronegative female sex workers and female blood donors in Abidjan, Côte d'IvoireWim Jennes
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
J Infect Dis 187:206-14. 2003..These data indicate that ESN FSWs differ from HIV-seronegative female blood donors with respect to immunological factors that have no clear protective potential against HIV transmission... - Enhanced ELISPOT detection of antigen-specific T cell responses from cryopreserved specimens with addition of both IL-7 and IL-15--the Amplispot assayWim Jennes
Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, CA, USA
J Immunol Methods 270:99-108. 2002..This method will be particularly useful for the assessment of antigen-stimulated cytokine production by T cells in cryopreserved biological specimens... - Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligandsWim Jennes
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
PLoS ONE 6:e17043. 2011..Our data suggest that group B KIR haplotypes and lack of specific inhibitory KIR ligand genes, genotypes considered to favor NK cell activation, are predictive of HIV-1 disease progression... - Poorly soluble peptides can mimic authentic ELISPOT responsesR Karl Karlsson
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
J Immunol Methods 285:89-92. 2004..Filtering the peptide prevented non-specific spot formation. These findings underscore the need for appropriate controls and proper peptide preparation in order to reduce the risk of false-positive ELISPOT responses... - Dominant ex vivo cross-stimulation of CD8+ T-cells with whole soluble gag protein in HIV-infected subjectsAn Tavernier
Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium
J Acquir Immune Defic Syndr 41:548-56. 2006..Soluble HIV proteins are often used to detect HIV-specific CD4+ T-helper cell responses in vitro. However, exogenous antigens can also indirectly stimulate CD8+ T-cells and thus complicate assessment of CD4+ T-cell responses... - Unprotected sex and alloimmune activationWim Jennes
Lancet 363:1474; author reply 1474-5. 2004