Gust Verbruggen

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage
    Jun Wang
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 48:1281-91. 2003
  2. ncbi Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification
    Gust Verbruggen
    Correspondence to Gust Verbruggen, Ghent University Hospital, Rheumatology Department, De Pintelaan 185, BE 9000 Ghent, Belgium
    Ann Rheum Dis 71:891-8. 2012
  3. ncbi Osteochondral repair in synovial joints
    Gust Verbruggen
    Ghent University Hospital, Department of Rheumatology, Ghent, Belgium
    Curr Opin Rheumatol 19:265-71. 2007
  4. ncbi Characterisation of human knee meniscus cell phenotype
    P C M Verdonk
    Department of Rheumatology, Ghent University, Belgium
    Osteoarthritis Cartilage 13:548-60. 2005
  5. ncbi Chondroprotective drugs in degenerative joint diseases
    G Verbruggen
    Polikliniek Reumatologie, 0K12, Universitair Hospitaal, De Pintelaan 185, B 9000 Ghent, Belgium
    Rheumatology (Oxford) 45:129-38. 2006
  6. ncbi Morbid anatomy of 'erosive osteoarthritis' of the interphalangeal finger joints: an optimised scoring system to monitor disease progression in affected joints
    Gust Verbruggen
    Department of Rheumatology, 0K12 IB Ghent University Hospital, De Pintelaan, 185, B 9000 Gent, Belgium
    Ann Rheum Dis 69:862-7. 2010
  7. ncbi Silkworm and spider silk scaffolds for chondrocyte support
    Kris Gellynck
    Department of Textiles, Ghent University, Technology Park 9, 9052, Zwijnaarde, Belgium
    J Mater Sci Mater Med 19:3399-409. 2008
  8. ncbi Invariant natural killer T cells are natural regulators of murine spondylarthritis
    Peggy Jacques
    Ghent University, 9000 Ghent, Belgium
    Arthritis Rheum 62:988-99. 2010
  9. ncbi Treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes
    Karl Fredrik Almqvist
    Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium
    Am J Sports Med 37:1920-9. 2009
  10. ncbi A pilot study of the use of an osteochondral scaffold plug for cartilage repair in the knee and how to deal with early clinical failures
    Aad A M Dhollander
    Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium
    Arthroscopy 28:225-33. 2012

Collaborators

Detail Information

Publications33

  1. ncbi Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage
    Jun Wang
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 48:1281-91. 2003
    ..CONCLUSION: These findings reveal a new paradigm by which IGF-1 influences chondrocyte metabolism, by reversing the IL-1-mediated catabolic pathway through up-regulation of its decoy receptor...
  2. ncbi Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification
    Gust Verbruggen
    Correspondence to Gust Verbruggen, Ghent University Hospital, Rheumatology Department, De Pintelaan 185, BE 9000 Ghent, Belgium
    Ann Rheum Dis 71:891-8. 2012
    ..The effects of adalimumab in controlling progression of structural damage in erosive hand osteoarthritis (HOA) were assessed...
  3. ncbi Osteochondral repair in synovial joints
    Gust Verbruggen
    Ghent University Hospital, Department of Rheumatology, Ghent, Belgium
    Curr Opin Rheumatol 19:265-71. 2007
    ....
  4. ncbi Characterisation of human knee meniscus cell phenotype
    P C M Verdonk
    Department of Rheumatology, Ghent University, Belgium
    Osteoarthritis Cartilage 13:548-60. 2005
    ..The composition of this ECM offers a variable to define the distinct meniscus cell phenotype...
  5. ncbi Chondroprotective drugs in degenerative joint diseases
    G Verbruggen
    Polikliniek Reumatologie, 0K12, Universitair Hospitaal, De Pintelaan 185, B 9000 Ghent, Belgium
    Rheumatology (Oxford) 45:129-38. 2006
    ..Examples are corticosteroids, some sulphated polysaccharides, chemically modified tetracyclines, diacetylrhein/rhein, glucosamine and avocado/soybean unsaponifiables...
  6. ncbi Morbid anatomy of 'erosive osteoarthritis' of the interphalangeal finger joints: an optimised scoring system to monitor disease progression in affected joints
    Gust Verbruggen
    Department of Rheumatology, 0K12 IB Ghent University Hospital, De Pintelaan, 185, B 9000 Gent, Belgium
    Ann Rheum Dis 69:862-7. 2010
    ....
  7. ncbi Silkworm and spider silk scaffolds for chondrocyte support
    Kris Gellynck
    Department of Textiles, Ghent University, Technology Park 9, 9052, Zwijnaarde, Belgium
    J Mater Sci Mater Med 19:3399-409. 2008
    ..To create scaffolds with silkworm cocoon, spider egg sac and spider dragline silk fibres and examine their use for chondrocyte attachment and support...
  8. ncbi Invariant natural killer T cells are natural regulators of murine spondylarthritis
    Peggy Jacques
    Ghent University, 9000 Ghent, Belgium
    Arthritis Rheum 62:988-99. 2010
    ..To investigate the role of invariant natural killer T (iNKT) cells in TNF(DeltaARE/+) mice, an animal model of spondylarthritis (SpA) with both gut and joint inflammation...
  9. ncbi Treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes
    Karl Fredrik Almqvist
    Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium
    Am J Sports Med 37:1920-9. 2009
    ..The repair of osteochondral lesions is imperfect and transient; chondral lesions do not heal in mature cartilage. Attempts have been made to restore cartilage lesions by filling the defects with a temporary artificial biocompatible matrix...
  10. ncbi A pilot study of the use of an osteochondral scaffold plug for cartilage repair in the knee and how to deal with early clinical failures
    Aad A M Dhollander
    Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium
    Arthroscopy 28:225-33. 2012
    ..To present our short-term experience with an osteochondral scaffold plug (TruFit plug; Smith & Nephew, Andover, MA) for cartilage repair in the knee and, more importantly, to discuss our approach to treat early clinical failures...
  11. ncbi Transplantation of viable meniscal allograft. Surgical technique
    Peter C M Verdonk
    Department of Orthopaedic Surgery, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    J Bone Joint Surg Am 88:109-18. 2006
    ..In this study, we present the results of a survival analysis of the clinical outcomes of our first 100 procedures involving transplantation of viable medial and lateral meniscal allografts performed in ninety-six patients...
  12. ncbi Midterm results of the treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes
    Aad A M Dhollander
    Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent, Belgium
    Am J Sports Med 40:75-82. 2012
    ..The treatment of chondral lesions is still an important challenge for the orthopaedic surgeon. Attempts have been made to restore cartilage lesions by filling the defects with a temporary biocompatible matrix...
  13. ncbi Meniscal allograft transplantation: long-term clinical results with radiological and magnetic resonance imaging correlations
    Peter C M Verdonk
    Department of Orthopaedic Surgery, Ghent University Hospital, De Pintelaan 185, 9000, Gent, Belgium
    Knee Surg Sports Traumatol Arthrosc 14:694-706. 2006
    ..Level of evidence is therapeutic study, Level IV and retrospective analysis of prospectively collected data...
  14. ncbi Clinical observations programme in SpA: disease parameters, treatment options and practical management issues
    Dirk Elewaut
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Rheumatol Int 29:239-50. 2009
    ..By targeting the underlying inflammatory mechanisms, TNFalpha blockade can treat any extra-articular manifestations of SpA...
  15. ncbi Analysis of chondrocyte functional markers and pericellular matrix components by flow cytometry
    Gust Verbruggen
    Department of Rhumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
    Methods Mol Med 100:183-208. 2004
    ..g., some matrix metalloproteinases and their natural inhibitors, were also studied. Finally, flow cytometry was used to assess the results of some pharmacological interventions on the aforementioned variables in cultured chondrocytes...
  16. ncbi A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis
    Pieter Dewint
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    J Immunol 180:2608-15. 2008
    ..Therefore, we conclude that GR monomers are sufficient for inhibition of inflammation in vivo...
  17. ncbi Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism
    Sara Groeneboer
    Department of Rheumatology, Laboratory of Connective Tissue Biology, Ghent University Hospital, Ghent, Belgium
    Rheumatology (Oxford) 50:1226-35. 2011
    ..To compare the ability of different cyclodextrin polysulphate (CDPS) derivatives to affect human articular cartilage cell metabolism in vitro...
  18. ncbi Reliability and construct validity of ultrasonography of soft tissue and destructive changes in erosive osteoarthritis of the interphalangeal finger joints: a comparison with MRI
    Ruth Wittoek
    Department of Rheumatology, University Hospital Ghent, Gent, Belgium
    Ann Rheum Dis 70:278-83. 2011
    ..To study the reliability and construct validity of ultrasound in interphalangeal finger joints affected by erosive osteoarthritis (EOA) and non-EOA with MRI as the reference method...
  19. ncbi Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
    Lode Melis
    Department of Rheumatology, Ghent University Hospital, Belgium
    Ann Rheum Dis 69:618-23. 2010
    ..This study aimed to evaluate the role of Th17-associated cytokines in spondyloarthritis pathogenesis by measuring their levels in the joints and circulation as well as correlating them with disease activity parameters...
  20. ncbi Differential expression of alphaB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis
    Stijn Lambrecht
    Ghent University, Ghent, Belgium
    Arthritis Rheum 60:179-88. 2009
    ....
  21. ncbi Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease
    Sara Bogaert
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    BMC Immunol 11:61. 2010
    ..Inflammation was quantified by measuring expression of the inflammatory mediators IL8 and TNF...
  22. ncbi A multiparameter approach to monitor disease activity in collagen-induced arthritis
    Sylvie Seeuws
    Department of Rheumatology, Ghent University, De Pintelaan 185, Ghent, 9000, Belgium
    Arthritis Res Ther 12:R160. 2010
    ..However, it is still unclear which of these methods represents the most discriminating measure of disease activity...
  23. ncbi Chondroitin sulfate in the management of erosive osteoarthritis of the interphalangeal finger joints
    Gust Verbruggen
    Department of Rheumatology, Ghent University Hospital, Gent, Belgium
    Adv Pharmacol 53:491-505. 2006
  24. ncbi Impairment and impact of pain in female patients with Ehlers-Danlos syndrome: a comparative study with fibromyalgia and rheumatoid arthritis
    Lies Rombaut
    Ghent University and Artevelde University College, Ghent, Belgium
    Arthritis Rheum 63:1979-87. 2011
    ....
  25. ncbi Structural and inflammatory sonographic findings in erosive and non-erosive osteoarthritis of the interphalangeal finger joints
    Ruth Wittoek
    Department of Rheumatology, University Hospital Gent, De Pintelaan, Gent, Belgium
    Ann Rheum Dis 69:2173-6. 2010
    ....
  26. ncbi Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymus
    Michael B Drennan
    Department of Rheumatology, Laboratory for Molecular Immunology and Inflammation, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Immunol 183:2213-6. 2009
    ..We propose that the expression of CXCR3 ligands in the thymic medullary epithelium promotes the chemotactic retention of mature iNKT thymocytes and prevents leakage of iNKT cells into the peripheral circulation...
  27. ncbi Predictors of functional impairment and pain in erosive osteoarthritis of the interphalangeal joints: Comparison with controlled inflammatory arthritis
    Ruth Wittoek
    University Hospital Ghent, Ghent, Belgium
    Arthritis Rheum 64:1430-6. 2012
    ....
  28. ncbi The effect of Lidocaine on the viability of cultivated mature human cartilage cells: an in vitro study
    Tom F Jacobs
    Department of Anesthesia, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Knee Surg Sports Traumatol Arthrosc 19:1206-13. 2011
    ..Local anesthetics, and in particular Lidocaine, are also used for diagnostic joint infiltrations. A controlled laboratory study was performed to investigate the possible toxic effect of Lidocaine on human articular chondrocytes...
  29. ncbi Transplantation of viable meniscal allograft. Survivorship analysis and clinical outcome of one hundred cases
    Peter C M Verdonk
    Department of Physical Medicine, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    J Bone Joint Surg Am 87:715-24. 2005
    ..In this study, we present the results of a survival analysis of the clinical outcomes of our first 100 procedures involving transplantation of viable medial and lateral meniscal allografts performed in ninety-six patients...
  30. ncbi Structure-modifying capacity of anti-tumour necrosis factor-alpha therapy in ankylosing spondylitis
    Filip De Keyser
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Drugs 64:2793-811. 2004
    ..However, despite these concerns, anti-TNFalpha therapy represents a major therapeutic advancement in the treatment of AS...
  31. ncbi A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner
    Ken Coppieters
    Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Immunol 179:2300-9. 2007
    ..In conclusion, these findings suggest long-term, ligand-specific, time-dependent, and partially IFN-gamma-dependent immunomodulatory effects of iNKT cells in collagen-induced arthritis...
  32. ncbi Biocompatibility and biodegradability of spider egg sac silk
    Kris Gellynck
    Faculty of Applied Sciences, Department of Textiles, Ghent University, Technologiepark 9, 9052 Zwijnaarde, Belgium
    J Mater Sci Mater Med 19:2963-70. 2008
    ..The enzymatical cleaning could diminish the tensile properties, but enhanced the biocompatibility of the SpESS fibers rendering them appropriate for use in biomaterial application where the slow biodegradability is an advantage...
  33. ncbi Chondroitin sulfate as a structure-modifying agent
    Daniel Uebelhart
    Department of Rheumatology and Institute of Physical Medicine, University Hospital, Zurich, Switzerland
    Adv Pharmacol 53:475-88. 2006