Xavier Rogiers

..Organ allocation systems and collaboration between centers play a crucial role in the chances to let suitable patients profit from this valuable source of extra grafts...

..Moreover, neoadjuvant chemotherapy improves the nutritional status of patients with pancreatic cancer. This multicenter phase III trial (NEOPAC) has been designed to explore the efficacy of neoadjuvant chemotherapy...

..It was the aim of this prospective observational cohort study to analyze the outcome of incisional hernia repair using small-pore versus large-pore meshes and using a standardized, open, retromuscular surgical technique...

..Other risk factors are age, biopsy-proven acute rejection, and CMV infection...

..This report describes the evolution of the authors' experience using laparoscopic LLS for different indications including living liver donation...

..A similar operation is still considered as experimental if performed in the deceased donor liver. The aim of this study is to evaluate the technical evolution and the results of this variant splitting technique...

..The number of registries is increasing, but few of them perform reliability audits by comparing the data contained in the database with data contained in hospital charts...

..As with split LT or domino LT, LRLT aims to provide more patients to be transplanted. Special attention is paid to reducing the risk for the donor, which is now estimated to be 0.5% mortality and 21% postoperative morbidity...

..Consequently, we developed a procedure that splits the MHV, thus creating an MHV on both grafts. In this short article, we report on this splitting technique and our first initial experience...

..The similar incidence of arterial complications among patients receiving LLS or ERG suggests that maintenance of the celiac trunk with LLS is not detrimental for right-sided grafts...

..This article details the data reviewed by the liver committee and their recommendations on policy development for the expanded application of split-liver transplantation...

..This has implications for the analysis of sources of acute hepatitis B in patients after LT and possibly for consideration of antiviral prophylaxis in anti-HBc/anti-HBs/HBV DNA-positive patients...

..Prospective studies using more specific instruments with an emphasis on the long-term psychosocial outcome of LDLT are needed for future research...

..In conclusion, this study demonstrates that everolimus in combination with oral cyclosporine had an acceptable safety and tolerability profile, paving the way for additional studies in this transplant indication...

..The aim of this study was to investigate the results of transplantation for BCS, focusing on overall outcome, on prognostic factors and on the impact of the underlying disease...

..Furthermore, the models provide a means of assessing the risk of post-transplantation mortality, giving clinicians important data on which to base strategic decisions about transplant policy in particular individuals or groups...

..We speculate that the split liver technique used in our center could lead to this rare complication due to the different anatomic position of the liver transplant in the abdomen...

..Liver transplantation can be curative; the benefit of antioxidant treatment is discussed controversially. We summarize our experience with neonatal hemochromatosis over the past 13 years...

..Therefore, previous extrahepatic malignancy should not be considered a contraindication for OLT per se, but the oncologic/hematologic prognosis should be considered, particularly with respect to the current 5-year survival rate of OLT...

..We suggest a very restrictive recommendation of external biliary diversion. However, gene therapy may be a future option for children with PFIC...

..TNF-alpha-induced up-regulation of IL-8 via nuclear factor-kappaB in CAFs is an inflammatory pathway, potentially permissive for cancer invasion that may represent a novel therapeutic target...

..In conclusion, the psychological burden was temporary in nature. Our findings can be considered as arguments for the current practice to address family members as donors in cases of HCC and ALF...

..These results require further examination and the appropriate form of psychosocial offers for these patients should be developed in further research...

..Transplantation of the extended right liver lobe provides a safe and efficient procedure in adult patients to expand the number of available grafts...

..Dual graft LDLT solves the problem of graft-size insufficiency and avoids critical right lobectomy in the donor. This procedure can be safely performed and opens up the possibility of LDLT to even more families in the Western world...

..We conclude that basiliximab provides safe and effective induction immunosuppression in pediatric liver graft recipients. Short- and even long-term results are excellent...

..As a consequence, intensified postoperative thromboprophylaxis or lifelong anticoagulant therapy may be necessary if this thrombophilic gene defect is detected...

..Uncontrolled hemorrhage from esophageal varices is one of the most devastating complications of portal hypertension in patients with advanced cirrhosis...

..The purpose of this study was to compare the security and effectiveness of the different surgical procedures used for treatment of the liver infestations with larvae of the dog tapeworm (Echinoocccus granulosus)...

..Children who are younger and more physically developed at the time of transplantation will have a better mental-development prognosis...

..PVE results in a significantly more efficient increase in liver volume and a shorter hospital stay...

..Based on this, the liver can be considered a paired organ, and mandatory splitting of good-quality livers can be recommended...

..With respect to haemodynamic changes, the model of rat portal branch ligation (PBL) provides the unique opportunity to discriminate transcriptional events, which selectively result from increased portal flow...

..We addressed this question by examining the expression of liver function proteins related to glucose homeostasis and acute-phase response in a corresponding animal model...

..The interaction of CD95 with its ligand, CD95L(FasL), induces apoptosis and thus the source of the death-inducing ligand is critical for understanding the pathomechanism of liver damage involving the CD95-system...

..This study, focusing on short- and long-term outcomes, summarizes our 10-year experience with liver transplantation (LTx) in infants aged less than 6 months...

..In summary, these data suggest that vWF may serve as a significant mediator of platelet recruitment and hepatocellular injury in the graft following reperfusion...

..The aim of this study was to determine whether portal occlusion induces host reactions which promote cancer invasion and angiogenesis...

..In this regard, we investigated whether liver resection leads to a release of stem cell marker-positive (+) cells into the peripheral circulation...

..This could indicate differential effects of liver disease and consecutive metabolic derangements on brain development during the preoperative phase...

..The challenge is to increase graft survival to the same level. The long-term management of the transplant patients, with the aim of avoiding late graft loss and achieving excellent quality of life, will become the center of the debate...

..These data highlight central roles for RAGE and MPDDCs in modulation of cell death-promoting mechanisms in massive hepatectomy and suggest that RAGE blockade is a novel strategy to promote regeneration in the massively injured liver...

..The crucial prerequisite to performing this procedure is a minimal morbidity and mortality risk to the healthy living donor. Little is known about the learning curve involved with this type of surgery...

..Analyzing our series, we have concluded that the year of transplantation is the most important prognostic factor in patient and graft survival in a multivariate analysis...