Claus Bachert

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi Allergic Rhinitis and its impact on asthma update (ARIA 2008). The Belgian perspective
    C Bachert
    ENT Department, URL, University Hosptial Gent, Belgium
    B-ENT 4:253-7. 2008
  2. ncbi Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
    Wouter Huvenne
    Upper Airways Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent University, Ghent, Belgium
    Respir Res 12:69. 2011
  3. ncbi The role of sinus disease in asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 6:29-36. 2006
  4. ncbi Belgian guidelines for the treatment of acute rhinosinusitis in general practice
    C Bachert
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    B-ENT 3:175-7. 2007
  5. ncbi Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 114:838-44. 2004
  6. ncbi Superantigens and nasal polyps
    Claus Bachert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Curr Allergy Asthma Rep 3:523-31. 2003
  7. ncbi Levocetirizine: a modern H(1)-antihistamine for the treatment of allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, Univerisity Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Expert Rev Clin Immunol 1:495-510. 2005
  8. ncbi A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Clin Ther 31:921-44. 2009
  9. ncbi Rhinosinusitis and asthma: a link for asthma severity
    C Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, Ghent, 9000, Belgium
    Curr Allergy Asthma Rep 10:194-201. 2010
  10. ncbi Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, De Pintelaan 185, BE 9000 Ghent, Belgium
    Clin Drug Investig 30:109-22. 2010

Detail Information

Publications137 found, 100 shown here

  1. ncbi Allergic Rhinitis and its impact on asthma update (ARIA 2008). The Belgian perspective
    C Bachert
    ENT Department, URL, University Hosptial Gent, Belgium
    B-ENT 4:253-7. 2008
    ..This document has now been updated: ARIA 2008. In this article, it is aimed to summarize the newly updated and published version of "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008" in a Belgian perspective...
  2. ncbi Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice
    Wouter Huvenne
    Upper Airways Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent University, Ghent, Belgium
    Respir Res 12:69. 2011
    ..Colonization with Staphylococcus aureus results in release of virulent enterotoxins, with superantigen activity which causes T cell activation...
  3. ncbi The role of sinus disease in asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 6:29-36. 2006
    ..This concept primarily refers to the well established link between allergic rhinitis and asthma, but it also covers a possible link between sinus disease and asthma (allergic or nonallergic) and other lower airway disease...
  4. ncbi Belgian guidelines for the treatment of acute rhinosinusitis in general practice
    C Bachert
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    B-ENT 3:175-7. 2007
    ..It is recommended to treat ARS with topical glucocorticosteroids 200 mcg BID. Antibiotics are recommended for the treatment of severe ARS, if need be, together with topical glucocorticosteroids BID...
  5. ncbi Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 114:838-44. 2004
    ..The Xyzal in Persistent Rhinitis Trial is the first large, long-term clinical trial studying patients with persistent rhinitis as defined by Allergic Rhinitis and its Impact on Asthma...
  6. ncbi Superantigens and nasal polyps
    Claus Bachert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Curr Allergy Asthma Rep 3:523-31. 2003
    ..This review summarizes our current understanding of the possible role of S. aureus enterotoxins in chronic severe airway disease, such as nasal polyposis...
  7. ncbi Levocetirizine: a modern H(1)-antihistamine for the treatment of allergic rhinitis
    Claus Bachert
    Department of Oto Rhino Laryngology, Univerisity Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Expert Rev Clin Immunol 1:495-510. 2005
    ..It is also reported to reduce comorbidities as well as overall treatment costs when administered continuously over the longterm...
  8. ncbi A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Clin Ther 31:921-44. 2009
    ..First-generation and older second-generation antihistamines, while effective against nasal itching, sneezing, and rhinorrhea, have limited efficacy in relieving nasal congestion...
  9. ncbi Rhinosinusitis and asthma: a link for asthma severity
    C Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, Ghent, 9000, Belgium
    Curr Allergy Asthma Rep 10:194-201. 2010
    ..Recent findings in severe asthma patients confirm the role of superantigens in lower airway disease...
  10. ncbi Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, De Pintelaan 185, BE 9000 Ghent, Belgium
    Clin Drug Investig 30:109-22. 2010
    ....
  11. ncbi Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 126:962-8, 968.e1-6. 2010
    ..Nasal polyps often are associated with asthma. The phenotype of these patients is unknown...
  12. ncbi Role of staphylococcal superantigens in upper airway disease
    Claus Bachert
    Upper Airway Research Laboratory, Ear Nose and Throat Department, University Hospital Ghent, Ghent, Belgium
    Curr Opin Allergy Clin Immunol 8:34-8. 2008
    ..Enterotoxins derived from Staphylococcus aureus have been implicated in the pathophysiology of nasal polyps as disease-modifying factors; recent findings using therapeutic proof-of-concept approaches support this hypothesis...
  13. ncbi Effect of mometasone furoate nasal spray on quality of life of patients with acute rhinosinusitis
    Claus Bachert
    Ear, Nose and Throat Department, University Hospital, Ghent, Belgium
    Rhinology 45:190-6. 2007
    ..Treatment with MFNS 200 g b.i.d. is associated with a significant improvement in HRQoL compared with placebo in patients with acute, uncomplicated rhinosinusitis...
  14. ncbi Efficacy of second-generation antihistamines in patients with allergic rhinitis and comorbid asthma
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    J Asthma 48:965-73. 2011
    ..The recent identification of a fourth histamine receptor has reinforced clinical interest in the pleiotropic effects of histamine and the relative roles of histamine receptors in mediating immune and inflammatory responses...
  15. ncbi Management of nasal polyposis
    C Bachert
    Dept of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    B-ENT . 2005
    ..Nevertheless medical therapy must be continued after surgery to prevent recurrences. Algorithms of decision are finally proposed [corrected]..
  16. ncbi Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging st
    Claus Bachert
    University of Ghent, Ghent, Belgium
    Clin Ther 27:993-1003. 2005
    ..Both are available over the counter for use at the standard recommended doses of 500 and 1000 mg per single use...
  17. ncbi Treatment of respiratory allergy with allergy immunotherapy tablets
    C Bachert
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, University Hospital Ghent, Belgium
    Allergy 66:57-9. 2011
    ..Safety profiles favour AIT over SCIT. Studies suggest that tablets in all aspects are superior to sublingual drops. AITs for other allergies including house dust mite and birch and ragweed pollen are in development...
  18. ncbi Pharmacological management of nasal polyposis
    Claus Bachert
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Drugs 65:1537-52. 2005
    ..This review summarises current knowledge on pathogenesis as well as established and future approaches in the pharmacological management of bilateral eosinophilic nasal polyposis...
  19. ncbi Desloratadine treatment for intermittent and persistent allergic rhinitis: a review
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Clin Ther 29:1795-802. 2007
    ..Desloratadine is effective in the treatment of AR across all classifications of disease, either seasonal/perennial or intermittent/persistent...
  20. ncbi Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial
    Claus Bachert
    University of Ghent, ENT Department, Ghent, Belgium
    Rhinology 47:51-8. 2009
    ..To evaluate the efficacy and safety of the herbal drug preparation from the roots of Pelargonium sidoides (EPs 7630) compared to placebo...
  21. ncbi Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease
    Nan Zhang
    Upper Airway Research Laboratory URL, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 122:961-8. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the accumulation of inflammatory cells; however, an eosinophil predominance is seen in white (Belgian), but not Asian (south Chinese), patients with polyps...
  22. ncbi Chronic rhinosinusitis with and without nasal polyps: what is the difference?
    Wouter Huvenne
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 9:213-20. 2009
    ..This disease differentiation will not only increase our knowledge of the pathophysiology of sinusitis but may lead to new diagnostic and therapeutic strategies specifically targeted and adapted to the diagnosed disease entity...
  23. ncbi Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis
    Claus Bachert
    Upper Airway Research Laboratory, ENT-Department, University Hospital Ghent, Ghent, Belgium
    Clin Allergy Immunol 20:163-75. 2007
  24. ncbi Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 85, Ghent, Belgium
    Respir Res 7:75. 2006
    ..We aimed with this study to investigate the tissue expression of leukotrienes and prostaglandin E2 receptors in chronic rhinosinusitis patients and the link of this regulation with eosinophilic inflammation...
  25. ncbi Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China
    Nan Zhang
    Ear, Nose, and Throat Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium
    Am J Rhinol 20:445-50. 2006
    ..One-third of patients with polyps showed an IgE response to SAEs...
  26. ncbi Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins
    Claudina Angela Perez-Novo
    Department of Otorhinolaryngology, Upper Airways Research Laboratory, Gent University Hospital, Belgium
    Am J Rhinol 20:456-60. 2006
    ..We studied the possible impact of SE-induced immune responses on the eicosanoid production in nasal polyp (NP) patients...
  27. ncbi Pathophysiology of chronic rhinosinusitis
    Peter Tomassen
    Upper Airways Research Laboratory, Department of Otorhinolaryngology and Logopaedic Audiological Science, Ghent University, Ghent, Belgium
    Proc Am Thorac Soc 8:115-20. 2011
    ..Identification of specific disease subgroups and their etiologies is an important and challenging task for future research...
  28. ncbi Identification of the nasal mucosa as a new target for leptin action
    Jasmien Taildeman
    Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium
    Histopathology 56:789-98. 2010
    ..Conclusions: Leptin receptors and their biological ligand leptin are expressed in the nasal mucosa, suggesting a possible role in upper airway immunology...
  29. ncbi Pathogenesis of chronic rhinosinusitis: inflammation
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 128:728-32. 2011
    ..This review focuses on recent evidence that sheds new light on our current knowledge regarding the inflammatory process of CRS to further unravel its pathogenesis...
  30. ncbi T-cell regulation in chronic paranasal sinus disease
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 121:1435-41, 1441.e1-3. 2008
    ..Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a T(H)2-skewed eosinophilic inflammation, whereas chronic rhinosinusitis without nasal polyps (CRSsNP) represents a predominant T(H)1 milieu...
  31. ncbi Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 121:110-5. 2008
    ..Increasing evidence points toward a modifying role of Staphylococcus aureus and its products in the pathogenesis of nasal polyposis...
  32. ncbi Detection of Staphylococcus aureus in nasal tissue with peptide nucleic acid-fluorescence in situ hybridization
    Marie Noëlle Corriveau
    Upper Airways Research Laboratory URL, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Am J Rhinol Allergy 23:461-5. 2009
    ....
  33. ncbi Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: studies on the relationship
    Claudina A Pérez-Novo
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 133:255-60. 2004
    ..In this study, we therefore aimed to determine, whether aspirin sensitivity was related to an immune response to SAEs, and how both criteria would be related to eosinophilic inflammation...
  34. ncbi Different regulation of cigarette smoke induced inflammation in upper versus lower airways
    Wouter Huvenne
    Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent University, Belgium
    Respir Res 11:100. 2010
    ..We investigated and compared the effects of CS on upper and lower airways, in a mouse model of subacute and chronic CS exposure...
  35. ncbi TGF-beta signaling and collagen deposition in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 124:253-9, 259.e1-2. 2009
    ..Chronic rhinosinusitis is an inflammatory disease with distinct cytokine and remodeling patterns...
  36. ncbi Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients
    Thibaut Van Zele
    Ear, Nose, and Throat Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol 22:223-7. 2008
    ..The purpose of this study was to investigate the presence of S. aureus enterotoxin genes and the agr subtype in bacterial DNA of S. aureus strains isolated from the middle meatus of nasal polyp and control patients...
  37. ncbi Oral steroids and doxycycline: two different approaches to treat nasal polyps
    Thibaut Van Zele
    Department of Otorhinolaryngology, University Hospital Ghent, 9000 Ghent, Belgium
    J Allergy Clin Immunol 125:1069-1076.e4. 2010
    ..There is little scientific evidence to support the current practice of using oral glucocorticosteroids and antibiotics to treat patients with chronic rhinosinusitis and nasal polyps...
  38. ncbi Collection of nasal secretions for immunological analysis
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Eur Arch Otorhinolaryngol 261:242-6. 2004
    ..The method is non-invasive, well standardized and reproducible and therefore may serve as a valid tool for future investigations...
  39. ncbi Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolarynogy, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    J Allergy Clin Immunol 115:1189-96. 2005
    ....
  40. ncbi Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to Staphylococcus aureus enterotoxin B
    P W Hellings
    Laboratory of Experimental Immunology, Department of Otorhinolaryngology, University Hospitals, Faculty of Medicine, University of Leuven, Belgium
    Clin Exp Allergy 36:1063-71. 2006
    ..We used a mouse model of airway allergy to study the effects of nasal or bronchial contact with SEB on bronchial allergic inflammation...
  41. ncbi Pathogenesis of chronic rhinosinusitis
    Paul Van Cauwenberge
    Department of Otorhinolaryngology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 6:487-94. 2006
    ..These findings question the current assumption that NP is a subgroup of CRS, but suggest that CRS and NP should probably be considered as distinct disease entities...
  42. ncbi Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 118:1133-41. 2006
    ..Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic inflammation and high IL-5 levels...
  43. ncbi Tissue remodeling in chronic rhinosinusitis
    Nicholas Van Bruaene
    Upper Airways Research Laboratory, Department of Oto Rhino Laryngology, Ghent University, Belgium
    Curr Opin Allergy Clin Immunol 11:8-11. 2011
    ..To summarize the current knowledge on remodeling in chronic sinus disease...
  44. ncbi Transforming growth factor beta1 in nasal remodeling: differences between chronic rhinosinusitis and nasal polyposis
    Jean-Baptiste Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, Belgium
    Am J Rhinol 18:267-72. 2004
    ..We show that TGF-beta1 expression is related to fibrosis, differentiating CRS without polyps from NP...
  45. ncbi Chronic sinusitis and rhinitis: clinical terminology "Chronic Rhinosinusitis" further supported
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Gent, Belgium
    Rhinology 48:54-8. 2010
    ..We therefore investigated the immunological background of the chronically inflamed nasal and sinusal mucosa...
  46. ncbi The expression of fibrinolytic components in chronic paranasal sinus disease
    Takayuki Sejima
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol Allergy 25:1-6. 2011
    ..To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucosa of CRS...
  47. ncbi Anti-IgE for the treatment of allergic rhinitis--and eventually nasal polyps?
    Katia Verbruggen
    Department of Otorhinolaryngology, Upper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Int Arch Allergy Immunol 148:87-98. 2009
    ....
  48. ncbi Syk-kinase inhibition prevents mast cell activation in nasal polyps
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Rhinology 49:100-6. 2011
    ..Spleen tyrosine kinase (Syk) is positioned upstream of the IgE receptor signal transducing pathway and may represent an important target for the treatment of nasal inflammatory diseases...
  49. ncbi Secretion of TGF-betal, TGF-beta2, EGF and PDGF into nasal fluid after sinus surgery
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Eur Arch Otorhinolaryngol 259:234-8. 2002
    ..This is the first study proposing a follow-up method for nasal and sinus mucosal healing after surgery in order to determine cytokine secretion profiles...
  50. ncbi Pilot study using doxycycline-releasing stents to ameliorate postoperative healing quality after sinus surgery
    Wouter Huvenne
    Upper Airway Research Laboratory URL, ENT Department, Ghent University Hospital, Ghent, Belgium
    Wound Repair Regen 16:757-67. 2008
    ....
  51. ncbi Staphylococcus aureus superantigens and airway disease
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, De Pintelaan 185, B 9000, Belgium
    Curr Allergy Asthma Rep 2:252-8. 2002
    ..This circumstantial evidence is currently limited to rhinitis, sinusitis, and possibly asthma, but may, if supported, open a new understanding of pathomechanisms and therapeutic targets...
  52. ncbi Allergic rhinitis, rhinosinusitis, and asthma: one airway disease
    Claus Bachert
    ENT Department, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Immunol Allergy Clin North Am 24:19-43. 2004
  53. ncbi Staphylococcus aureus enterotoxin B regulates prostaglandin E2 synthesis, growth, and migration in nasal tissue fibroblasts
    Claudina A Pérez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    J Infect Dis 197:1036-43. 2008
    ..We therefore studied the possible influence of Staphylococcus aureus enterotoxin B (SEB) on the cyclooxygenase (COX) pathway and basic functions of airway structural cells...
  54. ncbi Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis
    Philippe Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Allergy Clin Immunol 128:989-95.e1-8. 2011
    ..Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival...
  55. ncbi Macrophage mannose receptor in chronic sinus disease
    S Claeys
    Department of Otorhinolaryngology, University Hospital, Ghent University, De Pintelaan 185, B-9000 Ghent, Belgium
    Allergy 59:606-12. 2004
    ..Macrophages expressing MMR, accumulated in cell aggregates in NPs, play a possible key role in pathogen-macrophage interaction in NP disease...
  56. ncbi Local complement activation in nasal polyposis
    Thibaut Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Laryngoscope 119:1753-8. 2009
    ....
  57. ncbi Predictive and monitoring value of matrix metalloproteinase-9 for healing quality after sinus surgery
    Jean Baptiste Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, De Pintelaan 185, B 9000 Ghent, Belgium
    Wound Repair Regen 12:412-8. 2004
    ..MMP-9 is the first objective factor suitable to predict and monitor the healing quality after sinus surgery, indicating MMP-9 as a possible therapeutic target...
  58. ncbi Wound healing of the nasal and paranasal mucosa: a review
    Jean-Baptiste Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Am J Rhinol 16:77-84. 2002
    ..However, only poor and aspecific correlations can be described between endoscopically and histomorphologically defined postoperative phases...
  59. ncbi Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis
    P Gevaert
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Allergy 58:371-9. 2003
    ..Given the key role of IL-5 in eosinophil function, we investigated SOL IL-5Ralpha expression pattern in an eosinophil-associated disease such as nasal polyposis (NP)...
  60. ncbi Effect of corticosteroids on wound healing after endoscopic sinus surgery
    M Jorissen
    ENT Department, HNS, University of Leuven, Leuven, Belgium
    Rhinology 47:280-6. 2009
    ..Approximately 20% patients with chronic rhinosinusitis undergoing Functional Endoscopic Sinus Surgery (FESS) experience impaired wound healing, leading to recurrences of sinusitis and polyps...
  61. ncbi Local inflammation in chronic upper airway disease
    Lien Calus
    Upper Airways Research Laboratory, Department of otorhinolaryngology 1P1, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Curr Pharm Des 18:2336-46. 2012
    ..Defining and predicting response to therapy in individual CRS patients is a challenge for future research...
  62. ncbi Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue
    Joke Patou
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    J Inflamm (Lond) 6:11. 2009
    ..We have aimed to activate mast cells within ex-vivo human nasal tissue by IgE/anti-IgE specific (epsilon chain specific) stimulations and in this respect to test the usability of nasal polyps versus inferior turbinates..
  63. ncbi Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA
    Claudina Pérez
    Faculty of Medicine and Health Sciences, Department of Otorhynolaringology, Ghent University Hospital De Pintelaan 185, 9000 Ghent, Belgium
    BMC Biotechnol 3:17. 2003
    ..The aim of this study was to develop a reliable and sensitive real-time quantitative PCR assay to analyse the expression level of each isoform...
  64. ncbi Mediators in nasal polyposis
    Claus Bachert
    Department of Oto Rhino Laryngology, Ghent University Hospital, B 9000 Ghent, Belgium
    Curr Allergy Asthma Rep 2:481-7. 2002
    ....
  65. ncbi Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis
    J B Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Allergy 59:54-60. 2004
    ..CONCLUSIONS: Chronic sinusitis and NP show different pattern of MMP-7/-9 and TIMP-1 expression. We suggest that this difference in regulation of enzymes is related to the respective tissue remodelling observed in both diseases...
  66. ncbi Microbiology of chronic sinusitis
    P B van Cauwenberge
    State University of Ghent, Department of Otorhinolaryngology, Belgium
    Acta Otorhinolaryngol Belg 51:239-46. 1997
    ..It is postulated that, although bacteria are very important in acute sinusitis, their role in chronic sinusitis is minimal, the bacteria being opportunistic colonisers...
  67. ncbi Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients
    P Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 64:725-32. 2009
    ....
  68. ncbi Human beta-defensins and toll-like receptors in the upper airway
    S Claeys
    Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 58:748-53. 2003
    ..Toll-like receptor expression in all these tissues illustrates a possibly important immunological sentinel function of upper airway mucosa...
  69. ncbi Total and specific IgE in nasal polyps is related to local eosinophilic inflammation
    C Bachert
    Department of Otorhinolaryngology, Ghent University Hospital, B-9000 Ghent, Belgium
    J Allergy Clin Immunol 107:607-14. 2001
    ..Similarly, the presence of specific IgE to staphylococcal enterotoxins A and B also points to a possible role of bacterial superantigens...
  70. ncbi Interleukin-5, eosinophilic diseases and therapeutic intervention
    Lennart Zabeau
    VIB09 Dept Medical Protein Research, Ghent University, Belgium
    Curr Drug Targets Inflamm Allergy 2:319-28. 2003
    ..Here, we review the current status of IL-5 and IL-5 receptor research, with emphasis on strategies to interfere with IL-5 function...
  71. ncbi Evidence-based management of nasal polyposis by intranasal corticosteroids: from the cause to the clinic
    Claus Bachert
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium claus bachert ugent be
    Int Arch Allergy Immunol 155:309-21. 2011
    ..Treatment with these mainstay options has been found to improve quality of life, which, along with symptom improvement, is a key factor in disease treatment...
  72. ncbi Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
    Dmitri V Krysko
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Belgium
    Trends Immunol 32:157-64. 2011
    ..Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondrial DAMPs and discuss their contribution to inflammation and development of human pathologies...
  73. ncbi Impairment of phagocytosis of apoptotic cells and its role in chronic airway diseases
    Olga Krysko
    Department of Oto Rhino Laryngology, Ghent University Hospital, UZ Gent, MRB, Belgium
    Apoptosis 15:1137-46. 2010
    ..Finally, we will address possible therapeutic strategies, such as the use of macrolide antibiotics and statins, for modulating apoptotic cell clearance...
  74. ncbi Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa
    Sarah Glorieux
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 6:e22160. 2011
    ..Remarkably, interactions of herpesviruses with human mucosa, the locus of infection, remain poorly understood and the underlying mechanisms in stromal infection remain controversial...
  75. ncbi Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue
    P Gevaert
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Allergy 60:71-9. 2005
    ..aureus, and tissue eosinophilia in a relevant subgroup of polyp patients...
  76. ncbi Staphylococcus aureus enterotoxin B facilitates allergic sensitization in experimental asthma
    W Huvenne
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 40:1079-90. 2010
    ..Staphylococcus aureus Enterotoxin B (SEB) has immunomodulatory effects in allergic airway disease. The potential contribution of SEB to the sensitization process to allergens remains obscure...
  77. ncbi Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery
    J B Watelet
    Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Laryngoscope 115:56-61. 2005
    ..In this work, we aimed to explore the source of MMP-9 and the influence of inflammation on MMP-9 expression and release in nasal tissue and secretions during airway remodelling after surgery...
  78. ncbi Objective outcome after functional endoscopic sinus surgery: prediction factors
    J B Watelet
    Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium
    Laryngoscope 114:1092-7. 2004
    ..Whereas the first postoperative phase showed similar characteristics for all patients, the healing course differed between patients from month 1 to the end point...
  79. ncbi T cell inflammatory response, Foxp3 and TNFRS18-L regulation of peripheral blood mononuclear cells from patients with nasal polyps-asthma after staphylococcal superantigen stimulation
    C A Pérez Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Clin Exp Allergy 40:1323-32. 2010
    ..Staphylococcal superantigens may modulate airway inflammatory disease...
  80. ncbi Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators
    S Claeys
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Belgium
    Clin Exp Allergy 35:467-72. 2005
    ..Innate defence markers and inflammatory mediators in NP from patients with CF were compared with non-cystic fibrosis nasal polyps (non-CF-NP) to determine a possible different immunological background in macroscopically similar tissue...
  81. ncbi Local immunoglobulin production in nasal polyposis is modulated by superantigens
    T Van Zele
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Clin Exp Allergy 37:1840-7. 2007
    ..We aimed to study the systemic and local production of Igs in relation to plasma cells, B cells and specific IgE to SAEs...
  82. ncbi Differentiation of chronic sinus diseases by measurement of inflammatory mediators
    T Van Zele
    Upper Airway Research Laboratory (URL, Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent
    Allergy 61:1280-9. 2006
    ..CONCLUSION: Based on cellular and mediator profiles, we suggest that CRS, NP, and CF-NP are distinct disease entities within the group of chronic sinus diseases...
  83. ncbi Role of staphylococcal superantigens in airway disease
    C Bachert
    Upper Airway Research Laboratory, ENT Department, University Hospital Ghent, Ghent, Belgium
    Chem Immunol Allergy 93:214-36. 2007
    ..However, therapeutic approaches are so far limited and empirical, and need further improvement to tackle this currently underestimated clinical challenge...
  84. ncbi Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone
    Koen Van Crombruggen
    Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 383:613-26. 2011
    ..These vasodilatations can be suppressed by the EP(1/3) receptor agonist sulprostone at subnanomolar concentrations...
  85. ncbi An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis
    N Zhang
    ENT-Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium
    Rhinology 43:162-8. 2005
    ..Therapeutic approaches are so far empirical, and need further study, also serving to proof the clinical relevance of the concept...
  86. ncbi Wound healing after paranasal sinus surgery: neutrophilic inflammation influences the outcome
    J B Watelet
    Department of Otorhinolaryngology and Department of Pathology, Ghent University Hospital, Ghent, Belgium
    Histopathology 48:174-81. 2006
    ..The aim of this study was to explore systematically the different histomorphological processes and cell populations involved in the wound repair of the paranasal mucosa...
  87. ncbi Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis
    O Krysko
    The Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    Allergy 66:396-403. 2011
    ..Conclusions:? Decreased phagocytosis of S. aureus and an M2 activation phenotype in CRSwNP could potentially contribute to persistence of chronic inflammation in CRSwNP...
  88. ncbi Mucosal tissue polyclonal IgE is functional in response to allergen and SEB
    N Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    Allergy 66:141-8. 2011
    ..Staphylococcus aureus may modify airway disease by inducing local formation of polyclonal IgE antibodies (abs), the role of which is unknown...
  89. ncbi Patient preferences and sensory comparisons of three intranasal corticosteroids for the treatment of allergic rhinitis
    Claus Bachert
    Department of Ear, Nose, and Throat, University Hospital, Ghent, Belgium
    Ann Allergy Asthma Immunol 89:292-7. 2002
    ....
  90. ncbi Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GALEN study
    C Bachert
    University Hospital Ghent, Belgium
    Allergy 64:520-33. 2009
    ..This review summarizes the state of the art on chronic rhinosinusitis and nasal polyposis in different aspects of the disease. It defines potential gaps in the current research, and points to future research perspectives and targets...
  91. ncbi Glucocorticosteroids in allergic inflammation: clinical benefits in allergic rhinitis, rhinosinusitis, and otitis media
    P Van Cauwenberge
    Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Immunol Allergy Clin North Am 25:489-509, vi. 2005
    ..Because of their well-known anti-inflammatory effects, the role of glucocorticosteroids in the management of these three disorders has been questioned, evaluated, and, in some cases, established...
  92. ncbi Human mast cells express leptin and leptin receptors
    Jasmien Taildeman
    Department of Pathology, Ghent University Hospital, Ghent University, Block A, 5th Floor, De Pintelaan 185, 9000 Ghent, Belgium
    Histochem Cell Biol 131:703-11. 2009
    ..Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells...
  93. ncbi The innate immune system and its role in allergic disorders
    Liesbet Vandenbulcke
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium
    Int Arch Allergy Immunol 139:159-65. 2006
    ..In the development and progression of allergic disorders, the innate immune system plays an important role...
  94. ncbi Up-regulation of IL-18 in allergic rhinitis
    B Verhaeghe
    Department of Otorhinolaryngology, Ghent University Hospital, Belgium
    Allergy 57:825-30. 2002
    ..The persistence of elevated IL-18 concentrations until after the season and the high concentrations in PAR compared to SAR suggests its role in persistent allergic inflammation...
  95. ncbi Staphylococcus aureus enterotoxins: a key in airway disease?
    C Bachert
    Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent, Belgium
    Allergy 57:480-7. 2002
  96. ncbi Endoscopic endonasal surgery (EES) in skull base repairs and CSF leakage
    C Bachert
    ENT-Department Head and Neck Surgery, University Hospital Ghent, Belgium
    Acta Otorhinolaryngol Belg 54:179-89. 2000
    ..This also applies for lesions of other aetiologies. The Belgian data support the statement that the endonasal endoscopic approach is a suitable and successful technique to close CSF leaks in the vast majority of our patients...
  97. ncbi The common cold
    P B van Cauwenberge
    Dept of Otorhinolaryngology, Ghent University Hospital, Belgium
    Acta Otorhinolaryngol Belg 54:397-401. 2000
    ..As regulators of chemotaxis, transmigration and activators of inflammatory and immunocompetent cells, cytokines and mediators were shown to play a crucial role in the pathogenesis of a rhinovirus infection...
  98. ncbi CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue
    C A Pérez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium
    Allergy 65:304-10. 2010
    ..The objective was to determine the involvement of prostaglandin D(2) (PGD(2)) and its receptors in the chemotaxis of Th2 cells, using nasal polyp tissue...
  99. ncbi Endoscopic endonasal surgery for paranasal sinus mucoceles
    P Rombaux
    ENT Department, Head and Neck Surgery, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Acta Otorhinolaryngol Belg 54:115-22. 2000
    ..9% of the patients. Only 3 patients showed recurrence. Endoscopic endonasal marsupialisation of paranasal sinus mucoceles is a reliable therapeutic option with favorable results and is supported by the questioned ENT surgeons in Belgium...
  100. ncbi Decreased FOXP3 protein expression in patients with asthma
    S Provoost
    Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Allergy 64:1539-46. 2009
    ..In this study, we aimed to evaluate circulating T(reg), defined by the protein FOXP3, in both control subjects and patients with stable asthma...