Vincent Detours

Summary

Country: Belgium

Publications

  1. ncbi Integration and cross-validation of high-throughput gene expression data: comparing heterogeneous data sets
    Vincent Detours
    IRIBHM, Free University of Brussels, Bldg C, Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    FEBS Lett 546:98-102. 2003
  2. ncbi Gene expression profiles of post-Chernobyl thyroid cancers
    Vincent Detours
    IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Endocrinol Diabetes Obes 15:440-5. 2008
  3. ncbi Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers
    V Detours
    Institute of Interdisciplinary Research, School of Medicine, Univertisté Libre de Bruxelles ULB, Campus Erasme, CP602, Route de Lennik 808, Brussels, Belgium
    Br J Cancer 97:818-25. 2007
  4. ncbi Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype
    Wilma C G van Staveren
    Institute of Interdisciplinary Research IRIBHM, Brussels, Belgium
    Cancer Res 67:8113-20. 2007
  5. ncbi Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis
    Wilma C G van Staveren
    Institute of Interdisciplinary Research (IRIBHM, School of Medicine, Belgium
    Proc Natl Acad Sci U S A 103:413-8. 2006
  6. ncbi Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers
    Agnes Burniat
    Institute of Interdisciplinary Research, School of Medicine, Department of Endocrinology, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Endocrinology 149:5107-17. 2008
  7. ncbi Absence of a specific radiation signature in post-Chernobyl thyroid cancers
    V Detours
    Institute of Interdisciplinary Research, School of Medicine, Free University of Brussels, Campus Erasme, Route de Lennik 808, B 1070 Brussels, Belgium
    Br J Cancer 92:1545-52. 2005
  8. ncbi Gene expression and the biological phenotype of papillary thyroid carcinomas
    L Delys
    Institute of Interdisciplinary Research, School of Medicine, Universite Libre de Bruxelles, Campus Erasme, Brussels, Belgium
    Oncogene 26:7894-903. 2007
  9. ncbi Most random gene expression signatures are significantly associated with breast cancer outcome
    David Venet
    IRIDIA CoDE, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Comput Biol 7:e1002240. 2011
  10. ncbi Gene expression in thyroid autonomous adenomas provides insight into their physiopathology
    Sandrine Wattel
    Institute of Interdisciplinary Research, School of Medicine, Free University of Brussels, Brussels, Belgium
    Oncogene 24:6902-16. 2005

Collaborators

Detail Information

Publications14

  1. ncbi Integration and cross-validation of high-throughput gene expression data: comparing heterogeneous data sets
    Vincent Detours
    IRIBHM, Free University of Brussels, Bldg C, Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    FEBS Lett 546:98-102. 2003
    ..A detailed review of four selected studies reveals how some of these limitations may be circumvented and illustrates what can be achieved through data integration...
  2. ncbi Gene expression profiles of post-Chernobyl thyroid cancers
    Vincent Detours
    IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Endocrinol Diabetes Obes 15:440-5. 2008
    ..We discuss new evidence supporting the existence of a susceptibility to develop cancer following radiation exposure that is variable in the general population and could be measurable from gene expression...
  3. ncbi Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers
    V Detours
    Institute of Interdisciplinary Research, School of Medicine, Univertisté Libre de Bruxelles ULB, Campus Erasme, CP602, Route de Lennik 808, Brussels, Belgium
    Br J Cancer 97:818-25. 2007
    ..These signatures in PTCs could reflect the susceptibility profiles of the patients, suggesting the feasibility of a radiation susceptibility test...
  4. ncbi Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype
    Wilma C G van Staveren
    Institute of Interdisciplinary Research IRIBHM, Brussels, Belgium
    Cancer Res 67:8113-20. 2007
    ..The use of any cell line as a model for a cancer therefore requires prior careful and thorough validation for the investigated property...
  5. ncbi Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis
    Wilma C G van Staveren
    Institute of Interdisciplinary Research (IRIBHM, School of Medicine, Belgium
    Proc Natl Acad Sci U S A 103:413-8. 2006
    ..These results suggest that in tumorigenesis, activation of proliferation pathways may be complemented by suppression of multiple corresponding negative feedbacks, i.e., specific tumor suppressors...
  6. ncbi Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers
    Agnes Burniat
    Institute of Interdisciplinary Research, School of Medicine, Department of Endocrinology, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Endocrinology 149:5107-17. 2008
    ..They constitute a good model, especially in young animals, to study the respective role of the biological processes shared with human PTC and will allow testing drugs targeting these validated variables...
  7. ncbi Absence of a specific radiation signature in post-Chernobyl thyroid cancers
    V Detours
    Institute of Interdisciplinary Research, School of Medicine, Free University of Brussels, Campus Erasme, Route de Lennik 808, B 1070 Brussels, Belgium
    Br J Cancer 92:1545-52. 2005
    ....
  8. ncbi Gene expression and the biological phenotype of papillary thyroid carcinomas
    L Delys
    Institute of Interdisciplinary Research, School of Medicine, Universite Libre de Bruxelles, Campus Erasme, Brussels, Belgium
    Oncogene 26:7894-903. 2007
    ..6) Numerous overexpressed genes favor the hypothesis of a collective migration mode of tumor cells...
  9. ncbi Most random gene expression signatures are significantly associated with breast cancer outcome
    David Venet
    IRIDIA CoDE, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Comput Biol 7:e1002240. 2011
    ..The methods we present help to overcome this problem...
  10. ncbi Gene expression in thyroid autonomous adenomas provides insight into their physiopathology
    Sandrine Wattel
    Institute of Interdisciplinary Research, School of Medicine, Free University of Brussels, Brussels, Belgium
    Oncogene 24:6902-16. 2005
    ....
  11. ncbi Genes expressed in specific areas of the human fetal cerebral cortex display distinct patterns of evolution
    Nelle Lambert
    Institut de Recherches en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 6:e17753. 2011
    ..Our findings point to a subset of genes with a unique combination of cortical areal expression and evolutionary patterns, suggesting that they play important roles in the transcriptional network underlying human-specific neural traits...
  12. ncbi Roles of hydrogen peroxide in thyroid physiology and disease
    Y Song
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, School of Medicine, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    J Clin Endocrinol Metab 92:3764-73. 2007
    ..This review analyzes the protection mechanisms of the cell and the pathological consequences of disorders of this system...
  13. ncbi Negative feedbacks in normal cell growth and their suppression in tumorigenesis
    W C G van Staveren
    Institute of Interdisciplinary Research (IRIBHM, University of Brussels, Brussels, Belgium
    Cell Cycle 5:571-2. 2006
  14. ncbi Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?
    W C G van Staveren
    IRIBHM, Universite Libre de Bruxelles ULB, Campus Erasme, School of Medicine, Route de Lennik 808, B 1070 Brussels, Belgium
    Biochim Biophys Acta 1795:92-103. 2009
    ..The properties of the cell lines are compared to those of the postulated cancer stem cells and their use as models in this regard are discussed. Furthermore, other proper and possible uses of the cell lines are discussed...