Two faces of protein kinase C?: the contrasting roles of PKC? in cell survival and cell deathAlakananda Basu
Department of Molecular Biology and Immunology, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX, USA
ScientificWorldJournal 10:2272-84. 2010
..This review discusses the current literature on the contrasting roles of PKC? in cell survival and cell death...
- NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner
Eswar Shankar
Department of Molecular Biology and Immunology, University of North Texas, Health Science Center, Fort Worth, Texas, USA
J Mol Signal 5:4. 2010
..During a yeast-based drug screening, NSC109268 was identified to enhance cellular sensitivity to cisplatin. The objective of the present study is to determine if p53 is responsible for cisplatin sensitization by NSC109268...
- Enhancement of cisplatin sensitivity by NSC109268 in budding yeast and human cancer cells is associated with inhibition of S-phase progression
Dilip Jain
Department of Cell Biology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA
Cancer Chemother Pharmacol 66:945-52. 2010
..We explored if similar effects could be found in human cancer cells and if cell cycle analysis could hint at the underlying molecular mechanism...
- Proteolytic cleavage of p70 ribosomal S6 kinase by caspase-3 during DNA damage-induced apoptosis
Rohini Dhar
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Biochemistry 48:1474-80. 2009
..These results suggest that p70S6K is a novel substrate for caspase-3 and that the proteolytic cleavage of p70S6K is important for cisplatin-induced apoptosis...
- Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2
Alakananda Basu
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Cell Signal 21:1680-5. 2009
..Depletion of PKC epsilon also enhanced PKC delta downregulation by PDBu. These results suggest that downregulation of PKC delta is regulated by PKC epsilon and mammalian target of rapamycin complex 2 (mTORC2)...
- Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation
Dongmei Lu
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Apoptosis 12:1893-900. 2007
..PKCepsilon was coimmunoprecipitated with Bax in MCF-7 cells. These results suggest that PKCepsilon mediates its antiapoptotic effect partly by preventing activation and translocation of Bax to the mitochondria...
- S6 kinase 2 promotes breast cancer cell survival via Akt
Savitha Sridharan
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
Cancer Res 71:2590-9. 2011
..Taken together, our study shows that the two homologues of S6K have distinct effects on Akt activation and cell survival. Thus, targeting S6K2 may be an effective therapeutic strategy to treat cancers...
- PKCepsilon induces Bcl-2 by activating CREB
Eswar Shankar
Department of Molecular Biology and Immunology, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX 76107, USA
Int J Oncol 36:883-8. 2010
..In addition, knockdown of CREB sensitized MDA-MB-231 cells to TRAIL-mediated cell death. These results suggest that PKCepsilon regulates Bcl-2 induction through activation of the transcription factor CREB...
- Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway
Alakananda Basu
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Cancer Res 68:2795-802. 2008
..Furthermore, down-regulation of caspase-2 by rottlerin can explain its antiapoptotic function during DNA damage-induced apoptosis...
- Manipulation of PKC isozymes by RNA interference and inducible expression of PKC constructs
Alakananda Basu
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas, USA
Methods Enzymol 446:141-57. 2008
..In this chapter, we describe the use of RNA interference (siRNA) technology and tetracycline-inducible expression of PKC isozymes to study their function in apoptosis...
- Constitutive activation of p70 S6 kinase is associated with intrinsic resistance to cisplatin
Rohini Dhar
Department of Molecular Biology and Immunology, University of North Texas Health Science Center and Institute for Cancer Research, Fort Worth, TX 76107, USA
Int J Oncol 32:1133-7. 2008
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- Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death
Dongmei Lu
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
J Biol Chem 281:22799-807. 2006
..These results suggest that PKCepsilon activates Akt via DNA-PK to mediate its antiapoptotic function. Furthermore, we report for the first time that DNA-PK can regulate receptor-initiated apoptosis via Akt...
