Effect of rosiglitazone in sodium arsenite-induced experimental vascular endothelial dysfunctionTajpreet Kaur
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002, India
Arch Pharm Res 33:611-8. 2010
..p., 2 weeks). Thus, it may be concluded that rosiglitazone reduces oxidative stress, activates eNOS and enhances the generation of nitric oxide to prevent sodium arsenite-induced VED in rats...
- Are PPAR alpha agonists a rational therapeutic strategy for preventing abnormalities of the diabetic kidney?
Pitchai Balakumar
Cardiovascular Pharmacology Division, Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa 125055, India
Pharmacol Res 65:430-6. 2012
..However, fenofibrate has been shown to cause renal dysfunction in established renal disorders. The present review addressed the rationale of employing PPAR? agonists in the management of diabetic nephropathy...
- Preconditioning the hyperlipidemic myocardium: fact or fantasy?
Pitchai Balakumar
Cardiovascular Pharmacology Division, Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences RITS, Sirsa, India
Cell Signal 24:589-95. 2012
..Additionally, novel pharmacologic interventions to attenuate hyperlipidemia-associated exaggerated I/R-induced myocardial injury have been discussed...
- Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of statins?
Pitchai Balakumar
Cardiovascular Pharmacology Division, Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa 125 055, India
J Mol Cell Cardiol 52:83-92. 2012
..The eNOS modulatory role of statins may have an imperative influence on the functional regulation of cardiovascular system and may offer new perspectives for the better use of statins in ameliorating cardiovascular disorders...
- Do resident renal mast cells play a role in the pathogenesis of diabetic nephropathy?
Pitchai Balakumar
Department of Physiology, Faculty of Medicine, University of Montreal, Succ Centre Ville, Montreal, QC, H3C 3J7, Canada
Mol Cell Biochem 330:187-92. 2009
..Recent studies suggest the involvement of renal mast cell infiltration and degranulation in diabetic nephropathy. The present review focuses on the role of resident renal mast cells in diabetic nephropathy...
- Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?
Pitchai Balakumar
Department of Pharmacology, SB College of Pharmacy, Sivakasi 626 130, India
Pharmacol Res 62:179-86. 2010
..In addition, based on the experimental and clinical studies, the possible therapeutic approach to prevent gentamicin-induced nephrotoxicity has been discussed...
- The impairment of preconditioning-mediated cardioprotection in pathological conditions
Pitchai Balakumar
Department of Physiology, Faculty of Medicine, University of Montreal, Succ Centre Ville, Montreal, Quebec H3C 3J7, Canada
Pharmacol Res 60:18-23. 2009
..In this review, we have critically discussed the possible mechanisms involved in the modulation of cardioprotective potential of ischemic preconditioning in various pathological conditions...
- Recent advances in pharmacotherapy for diabetic nephropathy: current perspectives and future directions
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India
Pharmacol Res 60:24-32. 2009
..In addition, the recently identified potential target sites involved in the pathogenesis of diabetic nephropathy have been delineated...
- Pathophysiology of diabetic nephropathy: involvement of multifaceted signalling mechanism
Pitchai Balakumar
Department of Physiology, University of Montreal, CP 6128, Succ Centreville, Montreal, QC H3C 3J7, Canada
J Cardiovasc Pharmacol 54:129-38. 2009
..The purpose of this review is to bring together the current information concerning the signalling systems involved in the pathogenesis of diabetic nephropathy...
- Is nicotine a key player or spectator in the induction and progression of cardiovascular disorders?
Pitchai Balakumar
Department of Physiology, University of Montreal, Quebec, Canada
Pharmacol Res 60:361-8. 2009
..In addition, the pharmacological interventions to ameliorate chronic nicotine exposure-induced cardiovascular abnormalities have been delineated...
- Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga, Punjab, India
J Cardiovasc Pharmacol 54:204-12. 2009
..The present study investigated the effect of 2-chloro-N-cyclopentyladenosine (CCPA), a selective adenosine-A1 receptor agonist, in hyperhomocysteinemia-induced attenuation of the cardioprotective effect of IPC...
- Emerging role of PPAR ligands in the management of diabetic nephropathy
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India
Pharmacol Res 60:170-3. 2009
..In the present review, we discussed the novel role of PPARalpha and PPARgamma agonists in the management of diabetic nephropathy...
- Arsenic exposure and cardiovascular disorders: an overview
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga, Punjab, 142 001, India
Cardiovasc Toxicol 9:169-76. 2009
..The present review critically discussed the detrimental role of arsenic in the cardiovascular system...
- Experimental models for nephropathy
Pitchal Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Institute of Pharmaceutical Sciences and Drug Research, Moga, India
J Renin Angiotensin Aldosterone Syst 9:189-95. 2008
..In the present review, we have discussed various animal models for nephropathy, which may open vistas for developing new drugs to treat nephropathy...
- Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142001, Punjab, India
Pharmacol Res 58:356-63. 2008
....
- Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142 001, India
Mol Cell Biochem 320:149-62. 2009
....
- PPAR dual agonists: are they opening Pandora's Box?
Pitchai Balakumar
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India
Pharmacol Res 56:91-8. 2007
....
- Healing the diabetic heart: does myocardial preconditioning work?
Pitchai Balakumar
Cardiovascular Pharmacology Division, Department of Pharmacology, Rajendra Institute of Technology and Sciences RITS, Sirsa, India
Cell Signal 24:53-9. 2012
..These are important to be understood for better exploitation of preconditioning strategies in limiting I/R-induced myocardial injury in the diabetic heart...
- Interplay between statins and PPARs in improving cardiovascular outcomes: a double-edged sword?
Pitchai Balakumar
Cardiovascular Pharmacology Division, Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa, India
Br J Pharmacol 165:373-9. 2012
..The present review addressed the underlying principles pertaining to the modulatory role of statins on PPARs...
- Pleiotropic actions of fenofibrate on the heart
Pitchai Balakumar
Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa 125055, India
Pharmacol Res 63:8-12. 2011
..In this review, we critically discussed recently identified pleiotropic actions of fenofibrate on the heart. Moreover, the novel cardioprotective effects of fenofibrate against various cardiac disorders have been delineated...
- The multifaceted therapeutic potential of benfotiamine
Pitchai Balakumar
Department of Pharmacology, SB College of Pharmacy, Sivakasi 626130, India
Pharmacol Res 61:482-8. 2010
..Interestingly, few recent studies demonstrated additional non-AGE-dependent pharmacological actions of benfotiamine. The present review critically analyzed the multifaceted therapeutic potential of benfotiamine...
- Potential target sites to modulate vascular endothelial dysfunction: current perspectives and future directions
Pitchai Balakumar
I S F Institute of Pharmaceutical Sciences and Drug Research, Moga 142001, Punjab, India
Toxicology 245:49-64. 2008
..The present review delineates various potential target sites for vascular endothelial dysfunction, which may open a new vista for exploring novel pharmacological agents to treat various cardiovascular disorders...
- Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared?
Pitchai Balakumar
Department of Pharmacology, SB College of Pharmacy, Sivakasi 626 130, India
Pharmacol Res 62:365-83. 2010
..Elucidation of signaling cascades that initiate cardiac hypertrophy will open up a new area of research in developing innovative therapeutics for the treatment of pathological cardiac hypertrophy...
- Pre-conditioning and postconditioning to limit ischemia-reperfusion-induced myocardial injury: what could be the next footstep?
Pitchai Balakumar
ISF Institute of Pharmaceutical Sciences and Drug Research, Moga 142001, Punjab, India
Pharmacol Res 57:403-12. 2008
..Moreover, the clinical relevance and factors affecting the cardioprotective potentials of pre- and postconditioning have been delineated...
- Vascular endothelial dysfunction: a tug of war in diabetic nephropathy?
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142 001, Punjab, India
Biomed Pharmacother 63:171-9. 2009
..Thus it is suggested that diabetes-induced VED could be one of the culprits involved in the pathogenesis of diabetic nephropathy...
- The novel role of fenofibrate in preventing nicotine- and sodium arsenite-induced vascular endothelial dysfunction in the rat
Jagdeep Kaur
Pharmacology Division, ISF College of Pharmacy, Moga, 142 001, Punjab, India
Cardiovasc Toxicol 10:227-38. 2010
....
- Modulation of cardioprotective effect of ischemic pre- and postconditioning in the hyperhomocysteinemic rat heart
Pitchai Balakumar
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Punjab, India
Methods Find Exp Clin Pharmacol 31:71-9. 2009
....
- The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta
Ankur Rohilla
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142 001, Punjab, India
Biomed Pharmacother 63:787-91. 2009
..The present study investigated the possible role of PKC-delta in Hhcy-induced suppression of myocardial infarct size-limiting effect of IPOC...
- The low dose combination of fenofibrate and rosiglitazone halts the progression of diabetes-induced experimental nephropathy
Mandeep Kumar Arora
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Moga 142 001, Punjab, India
Eur J Pharmacol 636:137-44. 2010
....
- Possible role of JAK-2 in attenuated cardioprotective effect of ischemic preconditioning in hyperhomocysteinemic rat hearts
Gurfateh Singh
Cardiovascular Pharmacology Division, ISF College of Pharmacy, Punjab, India
Yakugaku Zasshi 129:523-35. 2009
....
- PPAR ligands: are they potential agents for cardiovascular disorders?
Pitchai Balakumar
Cardiovascular Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, India
Pharmacology 80:1-10. 2007
..The function of PPARdelta and its potential as a cardiovascular therapeutic target are currently under investigation. The present review focuses on the merits and limitations of PPAR agonists with regard to their use in CVD...
- Effect of bis (maltolato) oxovanadium (BMOV) in uric acid and sodium arsenite-induced vascular endothelial dysfunction in rats
Seema Jindal
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
Int J Cardiol 128:383-91. 2008
....
- Effect of mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats
Amrit Pal Singh
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
J Cardiovasc Pharmacol 51:596-604. 2008
..The present study has been designed to investigate the effect of sodium cromoglycate and ketotifen, mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats...
- Ameliorative effect of combination of fenofibrate and rosiglitazone in pressure overload-induced cardiac hypertrophy in rats
Madhankumar Rose
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
Pharmacology 80:177-84. 2007
..Thus, it may be concluded that dual activation of PPARalpha and PPARgamma may provide synergistic benefits in preventing the development of pathological cardiac hypertrophy...
- Resident cardiac mast cells: are they the major culprit in the pathogenesis of cardiac hypertrophy?
Pitchai Balakumar
ISF Institute of Pharmaceutical Sciences and Drug Research, Moga, Punjab, India
Basic Clin Pharmacol Toxicol 102:5-9. 2008
..Moreover, recent studies suggest the involvement of mast cells in cardiac hypertrophy and heart failure. The present review focuses on the role of mast cells in the development of cardiac hypertrophy and heart failure...
- The possible role of caspase-3 in pathological and physiological cardiac hypertrophy in rats
Pitchai Balakumar
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
Basic Clin Pharmacol Toxicol 99:418-24. 2006
..However, caspase-3 may not be involved in chronic swimming test-induced physiological cardiac hypertrophy...
- Rodent models of heart failure
Pitchai Balakumar
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
J Pharmacol Toxicol Methods 56:1-10. 2007
..However, all animal models used have advantages and limitations, and the issues determining transfer from preclinical to clinical require critical evaluation. The present review focuses upon rodent models of heart failure...
- Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats
Pitchai Balakumar
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India
Pharmacology 78:91-7. 2006
..These results have implicated Rho-kinase in PAAC-induced LV dysfunction and pathological cardiac hypertrophy. However, Rho-kinase may not be involved in CST-induced physiological cardiac hypertrophy...
