Septic acute kidney injury in critically ill patients: clinical characteristics and outcomesSean M Bagshaw
Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
Clin J Am Soc Nephrol 2:431-9. 2007
..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
- Diuretics in the management of acute kidney injury: a multinational survey
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
Contrib Nephrol 156:236-49. 2007
..Diuretics are a common intervention in critically ill patients with acute kidney injury (AKI). However, there is no information that describes the practice patterns of diuretic use by clinicians...
- Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury
Sean M Bagshaw
Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
J Crit Care 24:129-40. 2009
..The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes...
- Recent trials in critical care nephrology
Rinaldo Bellomo
Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia, USA
Contrib Nephrol 165:299-309. 2010
....
- A multi-center evaluation of early acute kidney injury in critically ill trauma patients
Sean M Bagshaw
Division of Critical Care Medicine, Walter C Mackenzie Centre, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Ren Fail 30:581-9. 2008
..Few studies have evaluated the epidemiology of acute kidney injury (AKI) in trauma...
- The impact of early hypoglycemia and blood glucose variability on outcome in critical illness
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 8440 112 ST NW Edmonton, Alberta, Canada
Crit Care 13:R91. 2009
..We describe the incidence, clinical factors and outcomes associated with an early hypoglycemia and BG variability in critically ill patients...
- A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury
Sean M Bagshaw
Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
Nephrol Dial Transplant 24:2739-44. 2009
..When unknown, current recommendations are to estimate a baseline SCr by the MDRD equation. However, the MDRD approach assumes a glomerular filtration rate of approximately 75 mL/min/1.73 m(2). This method has not been validated...
- Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, AB T6G2B7, Canada
Intensive Care Med 36:452-61. 2010
..We sought to determine whether there are unique patterns to plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) in septic compared with non-septic AKI...
- Early blood glucose control and mortality in critically ill patients in Australia
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Crit Care Med 37:463-70. 2009
..To measure temporal trends in blood glucose (BG) control and describe their association with hospital mortality in a cohort of critically ill patients from Australia...
- The SPARK Study: a phase II randomized blinded controlled trial of the effect of furosemide in critically ill patients with early acute kidney injury
Sean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 12 Walter C, Mackenzie Centre, 8440 112 Street, Edmonton, Alberta, Canada
Trials 11:50. 2010
..The primary analysis will be intention-to-treat. Planned recruitment will be complete by June 2011 and results available by December 2011. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT00978354...
- Early acute kidney injury and sepsis: a multicentre evaluation
Sean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, 3C1, 12 Walter C Mackenzie Centrel, University of Alberta Hospital, University of Alberta, 8440 112 St NW, Edmonton, Alberta, T6G2B7 Canada
Crit Care 12:R47. 2008
..We conducted a study to evaluate the incidence, risk factors and outcomes associated with early acute kidney injury (AKI) in sepsis...
- [Review article: Acute kidney injury in critical illness]
Sean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada
Can J Anaesth 57:985-98. 2010
..This review provides a focused and comprehensive update on emerging evidence related to acute kidney injury (AKI)...
- An evaluation of intraoperative renal support during liver transplantation: a matched cohort study
Ambica Parmar
Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada
Blood Purif 32:238-48. 2011
..Intraoperative continuous renal replacement therapy (CRRT) has been utilized during liver transplantation (LT). Our objective was to assess intraoperative CRRT for metabolic control, postoperative complications and outcomes...
- A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
Nephrol Dial Transplant 23:1203-10. 2008
..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
- Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
Crit Care Resusc 9:60-8. 2007
..We systematically reviewed the literature comparing loop diuretics with control in the management of ARF...
- Pilot double-blind, randomized controlled trial of short-term atorvastatin for prevention of acute kidney injury after cardiac surgery
John R Prowle
Department of Intensive Care, Austin Health, Melbourne, Victoria, Australia
Nephrology (Carlton) 17:215-24. 2012
..To test whether short-term perioperative administration of oral atorvastatin could reduce incidence of postoperative acute kidney injury (AKI) in cardiac surgical patients...
- Epidemiology of septic acute kidney injury
Ambica Parmar
University of Alberta Hospital, Walter C Mackenzie Centre, Edmonton, Canada
Curr Drug Targets 10:1169-78. 2009
....
- Urinary biomarkers in septic acute kidney injury
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 112 Street, T6G 2B7, Edmonton, Alberta, Canada
Intensive Care Med 33:1285-96. 2007
..To appraise the literature on the value of urinary biomarkers in septic acute kidney injury (AKI)...
- Review article: Renal support in critical illness
Sean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada
Can J Anaesth 57:999-1013. 2010
..This review provides a focused and comprehensive update on established and emerging evidence in acute renal replacement therapy (RRT) for critically ill patients with acute kidney injury (AKI)...
- Urine abnormalities in acute kidney injury and sepsis
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Alta, Canada
Contrib Nephrol 165:274-83. 2010
..This review will summarize the urinary biochemistry and microscopy in septic AKI...
- Tracheostomy: from insertion to decannulation
Paul T Engels
Department of Surgery, Division of Critical Care Medicine, University of Alberta, Edmonton, Alta
Can J Surg 52:427-33. 2009
..We outline the potential acute and chronic complications of tracheostomy and their management, and we review the different tracheostomy tubes, their indications and when to remove them...
- Oliguria, volume overload, and loop diuretics
Sean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Crit Care Med 36:S172-8. 2008
..This contradiction between clinical practice and available evidence would suggest there is equipoise and need for higher-quality evidence to better characterize the role of loop diuretics in ICU patients with AKI...
- The histopathology of septic acute kidney injury: a systematic review
Christoph Langenberg
Department of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Melbourne, Victoria 3084, Australia
Crit Care 12:R38. 2008
..Accordingly, we systematically reviewed the literature to assess current knowledge on the histopathology of septic AKI...
- Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: a meta-analysis
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Crit Care Med 36:610-7. 2008
..To appraise the literature on the effect of initial renal replacement therapy (RRT) modality on clinical outcomes...
- Early diagnosis of acute kidney injury
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Canada
Curr Opin Crit Care 13:638-44. 2007
..The early detection of acute kidney injury may allow for timely preventive or therapeutic measures. This review discusses the role of traditional and novel biomarkers in early acute kidney injury diagnosis...
- Intraoperative renal support during liver transplantation
Derek R Townsend
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Liver Transpl 15:73-8. 2009
..In conclusion, our data suggest that intraoperative CRRT during OLT is achievable and safe. Intraoperative CRRT may be a valuable adjuvant therapy for those with preoperative AKI. Additional investigations are warranted...
- Epidemiology of cardiorenal syndromes
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Alta, Canada
Contrib Nephrol 165:68-82. 2010
..This review will provide a summary of the epidemiology of the CRS and its subtypes...
- A proposed algorithm for initiation of renal replacement therapy in adult critically ill patients
Sean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
Crit Care 13:317. 2009
..In addition, the proposed algorithm is intended to provide a foundation for prospective evaluation and the development of a broad consensus on when to initiate RRT in critically ill patients...
- A systematic review of urinary findings in experimental septic acute renal failure
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, AB, Canada
Crit Care Med 35:1592-8. 2007
..However, the scientific basis for such use has not been systematically evaluated. Thus, we appraised the value of common urinary findings for the diagnosis and classification of experimental septic acute renal failure...
- A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Alberta, Canada
Nephrol Dial Transplant 27:582-8. 2012
..Sepsis is the most common trigger for acute kidney injury (AKI) in critically ill patients. We sought to determine whether there are unique patterns to urine sediment in septic compared with non-septic AKI...
- The role of the medical emergency team in end-of-life care: a multicenter, prospective, observational study
Daryl A Jones
Division of Critical Care Medicine, University of Alberta, University of Alberta Hospital, Edmonton, Alberta, Canada
Crit Care Med 40:98-103. 2012
..To investigate the role of medical emergency teams in end-of-life care planning...
- Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Canada
Crit Care 11:R68. 2007
..There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved...
- Pathophysiology of septic acute kidney injury: what do we really know?
Li Wan
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Crit Care Med 36:S198-203. 2008
..If this were to happen, our therapeutic approaches would also be profoundly altered...
- Peri-operative medical emergency team activation in liver transplantation
Ambica Parmar
Division of Critical Care Medicine, University of Alberta Hospital, 3C1 12 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7 Canada
BMJ Qual Saf 20:243-50. 2011
..The medical emergency team (MET) system functions to promptly identify acutely ill patients at-risk for deterioration. Liver transplant (LT) patients are at-risk for serious post-operative complications...
- New insights on intravenous fluids, diuretics and acute kidney injury
Derek R Townsend
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
Nephron Clin Pract 109:c206-16. 2008
..In this review, we explore recent insights on intravenous fluid therapy, volume overload, and diuretic therapy in the context of the critically ill patients with AKI...
- A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis
Constantine J Karvellas
Division of Critical Care Medicine, University of Alberta, 3C1, 12 Walter C, Mackenzie Centre, 8440 122 Street, Edmonton, AB T6G2B7, Canada
Crit Care 15:R72. 2011
..Our aim was to investigate the impact of early versus late initiation of renal replacement therapy (RRT) on clinical outcomes in critically ill patients with acute kidney injury (AKI)...
- Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada
Intensive Care Med 35:871-81. 2009
..To describe the incidence and outcomes associated with early acute kidney injury (AKI) in septic shock and explore the association between duration from hypotension onset to effective antimicrobial therapy and AKI...
- Difference between pre-operative and cardiopulmonary bypass mean arterial pressure is independently associated with early cardiac surgery-associated acute kidney injury
Hussein D Kanji
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
J Cardiothorac Surg 5:71. 2010
..However, its pathophysiology remains incompletely understood. We hypothesized that intra-operative mean arterial pressure (MAP) relative to pre-operative MAP would be an important predisposing factor for CSA-AKI...
- Early diagnosis of acute kidney injury in critically ill patients
Robert Keyes
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Expert Rev Mol Diagn 8:455-64. 2008
..This article will review the pitfalls of current conventional testing in kidney injury and discuss the emergence of novel biomarkers with the potential to revolutionize the field of critical care nephrology...
- A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure
Constantine J Karvellas
Division of Critical Care Medicine, University of Alberta, Edmonton, Alta, Canada
Blood Purif 28:151-8. 2009
..We evaluated the clinical, physiological and laboratory parameters of SPAD in acetaminophen-induced acute liver failure (AALF)...
- Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study
Amanda L Roze des Ordons
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospital, Edmonton, Alberta, T6G2B7 Canada
BMC Cancer 10:516. 2010
..Our objectives were to describe the clinical characteristics and outcomes in critically ill AML patients...
- The long-term outcome after acute renal failure
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Curr Opin Crit Care 12:561-6. 2006
..Research priorities in critical care are increasingly focusing on long-term outcomes and prognosis for survivors of critical illness. This review will focus on long-term outcomes after acute renal failure...
- Conventional markers of kidney function
Sean M Bagshaw
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Crit Care Med 36:S152-8. 2008
....
- Disorders of sodium and water balance in hospitalized patients
Sean M Bagshaw
Department of Anesthesiology and Pain Medicine, Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 112 Street, Edmonton, AB, Canada, T6G 2B7
Can J Anaesth 56:151-67. 2009
..To review and discuss the epidemiology, contributing factors, and approach to clinical management of disorders of sodium and water balance in hospitalized patients...
- Cardiopulmonary bypass-associated acute kidney injury: a pigment nephropathy?
Michael Haase
Department of Intensive Care, Austin Health, Austin Hospital, Melbourne, Vic, Australia, and Department of Nephrology, Charite University Medicine, Berlin, Germany
Contrib Nephrol 156:340-53. 2007
..A trial of such treatment might be a reasonable future investigation in higher risk patients receiving CPB...
- Renal replacement therapy: when to start
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
Contrib Nephrol 174:232-41. 2011
..In this review, we discuss the theoretical benefits and risks of earlier, as compared to later initiation RRT, the accumulated data, and future directions for investigation...
- Best evidence in critical care medicine. Steroids to prevent post-extubation airway obstruction in adult critically ill patients
Sean M Bagshaw
University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Can J Anaesth 55:382-5. 2008
- Blood glucose control among critically ill patients with brain injury
Michael J Jacka
Department of Anaesthesiology and Pain Medicine, Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Can J Neurol Sci 36:436-42. 2009
..To evaluate the incidence of hypoglycemia, hyperglycemia and blood glucose (BG) variability in brain-injured patients and their association with clinical outcomes...
- Prolonging life and delaying death: the role of physicians in the context of limited intensive care resources
Robert C McDermid
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Philos Ethics Humanit Med 4:3. 2009
....
- Predictors of survival after cardiac or respiratory arrest in critical care units
Demetrios J Kutsogiannis
Division of Critical Care Medicine, University of Alberta, Edmonton, Alta
CMAJ 183:1589-95. 2011
..We investigated survival outcomes of adults whose arrest occurred in ICUs and determined predictors of decreased survival...
- Best evidence in critical care medicine. Steroids in sepsis: bulking up the evidence
Peter G Brindley
University of Alberta, Edmonton, Canada
Can J Anaesth 55:648-50. 2008
- ICU and critical care outreach for the elderly
Robert C McDermid
Division of Critical Care Medicine, University of Alberta, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
Best Pract Res Clin Anaesthesiol 25:439-49. 2011
..In addition, another aspect of the RRS, critical care outreach (CCO), may facilitate the identification of elderly patients for timely goal-oriented advanced care planning prior to clinical deterioration...
- A survey of nurses' beliefs about the medical emergency team system in a canadian tertiary hospital
Sean M Bagshaw
University of Alberta, Edmonton, Canada
Am J Crit Care 19:74-83. 2010
..Nurses are the primary activators of the medical emergency team (MET). Although the MET system can empower nurses to seek help in managing acutely ill patients, few data on nurses' beliefs about the system are available...
- Greater increase in urinary hepcidin predicts protection from acute kidney injury after cardiopulmonary bypass
John R Prowle
Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
Nephrol Dial Transplant 27:595-602. 2012
..Acute kidney injury (AKI) is a common and serious complication of cardiopulmonary bypass (CPB) surgery. Hepcidin, a peptide hormone that regulates iron homeostasis, is a potential biomarker of AKI following CPB...
- Fluid overload as a biomarker of heart failure and acute kidney injury
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
Contrib Nephrol 164:54-68. 2010
..Fluid accumulation and overload are common themes in the pathophysiology and clinical course of both HF and AKI...
- Urinary biochemistry in experimental septic acute renal failure
Christoph Langenberg
Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Nephrol Dial Transplant 21:3389-97. 2006
..Despite increased renal perfusion, UNa, FeNa and FeUn decreased significantly. Our findings suggest that, in sepsis, these urinary biochemical changes are not reliable markers of renal hypoperfusion...
- Epidemiology of renal recovery after acute renal failure
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Curr Opin Crit Care 12:544-50. 2006
..Herein, the epidemiology of renal recovery after acute renal failure will be described, along with potential predictive factors and interventions...
- Association between implementation of an intensivist-led medical emergency team and mortality
Constantine J Karvellas
Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
BMJ Qual Saf 21:152-9. 2012
..To evaluate the impact of implementation of a dedicated intensivist-led medical emergency team (IL-MET) on mortality in patients admitted to the intensive care unit (ICU)...
- The need to reform our assessment of evidence from clinical trials: a commentary
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
Philos Ethics Humanit Med 3:23. 2008
..That does not confer upon us a freedom to ignore the knowledge we already have, or to postpone the action that it appears to demand at a given time". (Sir Bradford Austin Hill 1)...
- The influence of volume management on outcome
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
Curr Opin Crit Care 13:541-8. 2007
..There is much controversy, however, about the type, timing and amount of fluid therapy. Here, we discuss the evidence available to guide such choices...
- Acute kidney injury in 2010: Advances in diagnosis and estimating disease prognosis
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1 12 Walter C Mackenzie Centre, 8440 112 Street NW, Edmonton, AB T6G 2B7, Canada
Nat Rev Nephrol 7:70-1. 2011
..It is hoped that these findings will lead to improvements in the diagnosis and prognosis of affected individuals...
- Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis
Sean M Bagshaw
Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
Ann Thorac Surg 82:1927-37. 2006
..The current evidence supports recommending the routine use of perioperative amiodarone for cardiac surgery...
- Frailty in the critically ill: a novel concept
Robert C McDermid
Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3C1 12 Walter C Mackenzie Centre, 8440 112 St NW, Edmonton, Canada T6G 2B7
Crit Care 15:301. 2011
....
- Octogenarians in the ICU: are you ever too old?
Robert C McDermid
Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1, 12 Walter C Mackenzie Centre, 8440 112 St NW, Edmonton, Alberta, Canada T6G 2B7
Crit Care 15:125. 2011
....
- Normotensive ischemic acute renal failure
Rinaldo Bellomo
N Engl J Med 357:2205; author reply 2205-6. 2007
- Intensive care unit-acquired urinary tract infections in a regional critical care system
Kevin B Laupland
Department of Critical Care Medicine, Center for Anti microbial Resistance, Calgary Health Region, Calgary Laboratory Services, and University of Calgary, Calgary, Alberta, Canada
Crit Care 9:R60-5. 2005
..The objectives of this study were to describe the occurrence, microbiology, and risk factors for acquiring UTIs in the ICU and to determine whether these infections independently increase mortality...
- Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
Sean M Bagshaw
Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
Crit Care 9:R700-9. 2005
..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
- One-year mortality of bloodstream infection-associated sepsis and septic shock among patients presenting to a regional critical care system
Kevin B Laupland
Department of Critical Care Medicine, University of Calgary, 3535 Research Road NW, Calgary, AB, T2L 2K8, Canada
Intensive Care Med 31:213-9. 2005
....
- A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Heidelberg, Victoria 3084, Australia
Nephrol Dial Transplant 23:1569-74. 2008
..The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to this system. It is currently unknown whether there are advantages between these criteria...
- Urinary biochemistry and microscopy in septic acute renal failure: a systematic review
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Heidelberg, Victoria 3084, Australia
Am J Kidney Dis 48:695-705. 2006
..More research is required to describe their accuracy, pattern, and time course in patients with septic ARF...
- Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
Michael Haase
Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
Crit Care Med 35:1324-31. 2007
..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
- Fluid resuscitation and the septic kidney
Sean M Bagshaw
Curr Opin Crit Care 12:527-30. 2006
..Thus, in this editorial, we consider the relevant literature and more recent insights into the effect of fluid resuscitation on the septic kidney...
- One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment
Sean M Bagshaw
Department of Critical Care Medicine, Calgary Health Region and University of Calgary, Alberta, Canada
Am J Kidney Dis 48:402-9. 2006
..Kidney dysfunction in the intensive care unit (ICU) results in increased morbidity, mortality, and health care costs; however, long-term mortality has not been described across strata of severity in kidney dysfunction...
- Acetylcysteine and renal function following coronary angiographic procedures
Sean M Bagshaw
JAMA 289:2795; author reply 2796. 2003
- Short- and long-term survival after acute kidney injury
Sean M Bagshaw
Nephrol Dial Transplant 23:2126-8. 2008
- Renal support in critically ill patients with acute kidney injury
Sean M Bagshaw
N Engl J Med 359:1960-1. 2008
- Acetylcysteine for prevention of contrast-induced nephropathy after intravascular angiography: a systematic review and meta-analysis
Sean M Bagshaw
Department of Critical Care Medicine, Calgary Health Region, Calgary, Canada
BMC Med 2:38. 2004
..Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography...
- Dialysis Disequilibrium Syndrome: brain death following hemodialysis for metabolic acidosis and acute renal failure--a case report
Sean M Bagshaw
Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
BMC Nephrol 5:9. 2004
..We describe a case of DDS-induced cerebral edema that resulted in irreversible brain injury and death following acute HD and review the relevant literature of the association of DDS and HD...
- Erythropoietin and transfusions among critically ill patients
Sean M Bagshaw
JAMA 289:1511; author reply 1512. 2003
- Theophylline for prevention of contrast-induced nephropathy: a systematic review and meta-analysis
Sean M Bagshaw
Department of Critical Care Medicine, Calgary Health Region, and Departments of Internal Medicine, University of Calgary, Calgary, Alberta, Canada
Arch Intern Med 165:1087-93. 2005
..However, findings are inconsistent across studies. A large, well-designed trial that incorporates the evaluation of clinically relevant outcomes is required to more adequately assess the role for theophylline in CIN prevention...
- Is regional citrate superior to systemic heparin anticoagulation for continuous renal replacement therapy? A prospective observational study in an adult regional critical care system
Sean M Bagshaw
Department of Critical Care Medicine, University of Calgary and Calgary Health Region, Foothills Medical Centre, Alberta, Canada
J Crit Care 20:155-61. 2005
..These data support small studies suggesting that citrate is a superior anticoagulant for CRRT and suggest the need for a future definitive randomized controlled trial...
- Prolonged refractory status epilepticus following acute traumatic brain injury: a case report of excellent neurological recovery
Adam D Peets
Department of Critical Care, University of Calgary, Calgary, Alberta, Canada
Crit Care 9:R725-8. 2005
..Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality...
- Acetylcysteine in the prevention of contrast-induced nephropathy: a case study of the pitfalls in the evolution of evidence
Sean M Bagshaw
Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
Arch Intern Med 166:161-6. 2006
....
- Is there a place for levosimendan in the intensive care unit?
Anthony Delaney
Northern Clinical School, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia
Crit Care Resusc 9:290-2. 2007
..Until their results can be fully scrutinised, and placed in the context of all available evidence, we should conclude that there is no place for levosimendan in the ICU...
- Percutaneous dilatational tracheostomy versus surgical tracheostomy in critically ill patients: a systematic review and meta-analysis
Anthony Delaney
Intensive Care Unit, Royal North Shore Hospital, Sydney, NSW, Australia
Crit Care 10:R55. 2006
....
- N-Acetylcysteine does not artifactually lower plasma creatinine concentration
Michael Haase
Director of Intensive Care Research, Austin Hospital, University of Melbourne, 3084 Heidelberg, Victoria, Australia
Nephrol Dial Transplant 23:1581-7. 2008
..However, it has been suggested that NAC may lower plasma creatinine levels independent of any effects on glomerular filtration rate (GFR)...
- Epidemiology of intensive care unit-acquired urinary tract infections
Sean M Bagshaw
Department of Critical Care Medicine, Calgary Laboratory Services, Calgary Health Region, and University of Calgary, Calgary, Alberta, Canada
Curr Opin Infect Dis 19:67-71. 2006
..There is a relative paucity of research on nosocomial urinary tract infection specifically acquired in the intensive care unit and further studies are needed to better define the epidemiology and management of these infections...
