Research Topics
Genomes and Genes | Anton WutzSummaryAffiliation: University of Vienna Country: Austria Publications
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Detail Information
Publications
Xist function: bridging chromatin and stem cellsAnton Wutz
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
Trends Genet 23:457-64. 2007..This review emphasizes the opportunity that Xist provides to functionally define epigenetic transitions in development, to understand cell identity, pluripotency and stem cell differentiation...- A chromosomal memory triggered by Xist regulates histone methylation in X inactivationAlexander Kohlmaier
Research Institute of Molecular Pathology, Vienna, Austria
PLoS Biol 2:E171. 2004.... - X inactivation XplainedAnton Wutz
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
Curr Opin Genet Dev 17:387-93. 2007..Chromosome-wide silencing is then initiated by the noncoding Xist RNA, which evolved with the mammalian Xic and covers the inactive X chromosome... - The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivationDieter Pullirsch
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
Development 137:935-43. 2010..This observation highlights a crucial role for spatial organization of chromatin changes in the maintenance of X inactivation... - Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencingStefan Schoeftner
Research Institute of Molecular Pathology, Vienna, Austria
EMBO J 25:3110-22. 2006..Our data show that Xist recruits PRC1 components by both PRC2 dependent and independent modes and in the absence of PRC2 function is sufficient for the establishment of Polycomb-based memory systems in X inactivation... - Cancer progenitors and epigenetic contexts: an Xisting connectionRuben Agrelo
Research Institute of Molecular Pathology, Vienna, Austria
Epigenetics 4:568-70. 2009..It has been demonstrated that Xist is functional in tumor cells, where SATB1 was identified as the first silencing factor for Xist mediated chromosome silencing... - Hematopoietic precursor cells transiently reestablish permissiveness for X inactivationFabio Savarese
Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, 1030 Vienna, Austria
Mol Cell Biol 26:7167-77. 2006..This suggests that Xist function is restricted in development by the limited activity of epigenetic pathways rather than by a change in the responsiveness of chromatin between embryonic and differentiated cell types... - ConteXt of change--X inactivation and diseaseRuben Agrelo
Research Institute of Molecular Pathology, Vienna, Austria
EMBO Mol Med 2:6-15. 2010..Understanding their reactivation will deepen our understanding of tumourigenesis and may be exploited for cancer therapy... - Xist and the order of silencingKaren Ng
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
EMBO Rep 8:34-9. 2007..Here, we critically review our understanding of dosage compensation in placental mammals and place these findings in the context of other cellular processes that intersect with mammalian dosage compensation... - Polycomb complexes act redundantly to repress genomic repeats and genesMartin Leeb
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
Genes Dev 24:265-76. 2010..This indicates a contribution of the Polycomb group system to the defense against parasitic DNA, and a potential role of genomic repeats in Polycomb-mediated gene regulation... - Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cellsMartin Leeb
Research Institute of Molecular Pathology, Vienna, Austria
J Cell Biol 178:219-29. 2007..Other chromatin marks associated with the initiation of X inactivation are not affected in Ring1B-deficient cells, suggesting compensation for the loss of Ring1B in X inactivation in contrast to the repression of lineage genes... - SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cellsRuben Agrelo
Research Institute of Molecular Pathology, Vienna, Austria
Dev Cell 16:507-16. 2009..Thus, our data establish SATB1 as a crucial silencing factor contributing to the initiation of X inactivation... - RNAs templating chromatin structure for dosage compensation in animalsAnton Wutz
Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
Bioessays 25:434-42. 2003..They do not appear to act in a sequence-specific manner but might provide scaffolds for co-operative binding of chromatin-associated complexes that enable spreading of chromatin modifications... - X chromosome inactivation sparked by non-coding RNAsMartin Leeb
Institute of Molecular Pathology, Vienna, Austria
RNA Biol 6:94-9. 2009..Here, we review non-coding RNAs that have been implicated in X chromosome inactivation. Focusing on the best studied transcripts Xist and Tsix we portray a current perspective on chromosome wide gene regulation by non-coding RNAs... - X inactivation and diseaseRuben Agrelo
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
Semin Cell Dev Biol 21:194-200. 2010..This dosage-compensation mechanism is based on the long functional Xist RNA. Here, we review our understanding of dosage compensation and Xist function in the context of disease... - A system for imaging the regulatory noncoding Xist RNA in living mouse embryonic stem cellsKaren Ng
Research Institute of Molecular Pathology, 1030 Vienna, Austria
Mol Biol Cell 22:2634-45. 2011..Our data reveal a strategy for visualizing Xist and indicate that spreading over the chromosome might involve dynamic binding and displacement... - Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivationShinwa Shibata
Department of Stem Cell Biology, Graduate School of Medicine, Kanazawa University, Takara machi, Kanazawa, Ishikawa, Japan
EMBO J 27:1816-26. 2008..The synergy of Polycomb group proteins and antisense Tsix transcription in Xist gene regulation explains why males can repress Xist without Tsix... - A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silencedJulie Chaumeil
Mammalian Developmental Epigenetic Group, UMR 218, Curie Institute, 75248 Paris Cedex 05, France
Genes Dev 20:2223-37. 2006.... - Chromosomal silencing and localization are mediated by different domains of Xist RNAAnton Wutz
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 30:167-74. 2002..Association of Xist RNA with chromatin is mediated by functionally redundant sequences that act cooperatively and are dispersed throughout the remainder of Xist but show little or no homology... - HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte developmentMattias Magnusson
Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund University Hospital, 221 84 Lund, Sweden
Blood 109:3687-96. 2007..These findings reveal novel molecular pathways that act downstream of HOXA10 and identify HOXA10 as a master regulator of postnatal hematopoietic development... - Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cellsCaroline Beard
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genesis 44:23-8. 2006..This strategy and the vectors described here are generally applicable to any locus in ES cells and should allow for the rapid production of mice with transgenes efficiently targeted to a defined site... - Hypoxic induction of Ctgf is directly mediated by Hif-1Debra F Higgins
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6144, USA
Am J Physiol Renal Physiol 287:F1223-32. 2004..Our findings have important implications for a number of fibrotic disorders in which hypoxia, CTGF, and TGF-beta(1) are involved, including renal, dermal, hepatic, and pulmonary fibrosis...