G K Wenning

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Multiple system atrophy: a primary oligodendrogliopathy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Ann Neurol 64:239-46. 2008
  2. ncbi Multiple system atrophy
    G K Wenning
    Department of Neurology, University Hospital Innsbruck, Austria
    Rev Neurol (Paris) 159:3S31-8. 2003
  3. ncbi Placebo-controlled trial of amantadine in multiple-system atrophy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Austria
    Clin Neuropharmacol 28:225-7. 2005
  4. ncbi Therapeutic strategies in multiple system atrophy
    Gregor K Wenning
    Innsbruck Medical University, Clinical Department of Neurology, Austria
    Mov Disord 20:S67-76. 2005
  5. ncbi The role of alpha-synuclein and tau in neurodegenerative movement disorders
    Gregor K Wenning
    Department of Neurology, Medical University, Innsbruck, Austria
    Curr Opin Neurol 18:357-62. 2005
  6. ncbi [Diagnosis and therapy of multiple system atrophy]
    G K Wenning
    Universitätsklinik für Neurologie, Innsbruck
    Praxis (Bern 1994) 90:1035-40. 2001
  7. ncbi Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
    Gregor K Wenning
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1391-402. 2004
  8. ncbi Multiple system atrophy: an update
    Gregor K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:S34-42. 2003
  9. ncbi Towards neurotransplantation in multiple system atrophy: clinical rationale, pathophysiological basis, and preliminary experimental evidence
    G K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    Cell Transplant 9:279-88. 2000
  10. ncbi Multiple system atrophy: pathophysiology and management
    G K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    CNS Drugs 15:839-52. 2001

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi Multiple system atrophy: a primary oligodendrogliopathy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Ann Neurol 64:239-46. 2008
    ..Although these syndromes vary in their respective cause of oligodendrogliopathy, they have in common myelin disruption that is often followed by axonal dysfunction...
  2. ncbi Multiple system atrophy
    G K Wenning
    Department of Neurology, University Hospital Innsbruck, Austria
    Rev Neurol (Paris) 159:3S31-8. 2003
    ..Several research groups have been formed in Europe (EMSA-SG, NNIPPS) and USA (NAMSA-SG) to address these unmet needs...
  3. ncbi Placebo-controlled trial of amantadine in multiple-system atrophy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Austria
    Clin Neuropharmacol 28:225-7. 2005
    ..Reports on the open-label use of amantadine in MSA suggest variable antiparkinsonian efficacy. The authors therefore conducted a double-blind, placebo-controlled crossover trial of amantadine in MSA patients...
  4. ncbi Therapeutic strategies in multiple system atrophy
    Gregor K Wenning
    Innsbruck Medical University, Clinical Department of Neurology, Austria
    Mov Disord 20:S67-76. 2005
    ..Because no drug treatment consistently benefits patients with this disease in the long-term, palliative therapies are all the more important. Novel symptomatic and neuroprotective therapies are urgently required...
  5. ncbi The role of alpha-synuclein and tau in neurodegenerative movement disorders
    Gregor K Wenning
    Department of Neurology, Medical University, Innsbruck, Austria
    Curr Opin Neurol 18:357-62. 2005
  6. ncbi [Diagnosis and therapy of multiple system atrophy]
    G K Wenning
    Universitätsklinik für Neurologie, Innsbruck
    Praxis (Bern 1994) 90:1035-40. 2001
    ..Neurologically, the options for treating orthostatic hypertension and urogenital disorders are often overlooked...
  7. ncbi Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
    Gregor K Wenning
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1391-402. 2004
    ..Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients...
  8. ncbi Multiple system atrophy: an update
    Gregor K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:S34-42. 2003
    ..Several research groups have been formed in Europe (EMSA-SG, NNIPPS) and United States (NAMSA-SG), providing a framework for coordinated trial activity in MSA...
  9. ncbi Towards neurotransplantation in multiple system atrophy: clinical rationale, pathophysiological basis, and preliminary experimental evidence
    G K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    Cell Transplant 9:279-88. 2000
    ....
  10. ncbi Multiple system atrophy: pathophysiology and management
    G K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    CNS Drugs 15:839-52. 2001
    ..Neuroprotection strategies may slow down disease progression in MSA and the results of the first double-blind trial of riluzole (an inhibitor of glutamate release) in patients with MSA will be available in 2004...
  11. ncbi Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy)
    Z Puschban
    Neurological Research Laboratory, Department of Neurology, University Hospital Innsbruck, Austria
    Exp Neurol 164:166-75. 2000
    ..Our present results are relevant to future applications of neural grafting in MSA-SND...
  12. ncbi No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)
    R Waldner
    Neurological Research Laboratory, Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria
    Neuroscience 102:581-92. 2001
    ..We suggest that dopamine rich embryonic grafts fail to induce functional recovery in a novel 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)...
  13. ncbi Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy)
    C Scherfler
    Neurological Research Laboratory, University Hospital, Anichstrasse 35, 6020, Innsbruck, Austria
    Neuroscience 99:43-54. 2000
    ....
  14. ncbi Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy)
    C Scherfler
    Department of Neurology, University Hospital, Innsbruck, Austria
    J Neural Transm 112:1025-33. 2005
    ..Nonetheless, our study is the first to provide an experimental rationale for exploring possible neuroprotective effects of riluzole in MSA...
  15. ncbi Decision making under risk and under ambiguity in Parkinson's disease
    M Delazer
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuropsychologia 47:1901-8. 2009
    ....
  16. ncbi Diffusion-weighted imaging discriminates progressive supranuclear palsy from PD, but not from the parkinson variant of multiple system atrophy
    K Seppi
    Department of Neurology, University of Innsbruck, Austria
    Neurology 60:922-7. 2003
    ..CONCLUSIONS: These results show that DWI detects basal ganglia abnormalities in PSP patients within few years of disease onset, discriminating patients with PSP from those with PD, but not from those with MSA-P...
  17. ncbi In vivo magnetic resonance imaging of embryonic neural grafts in a rat model of striatonigral degeneration (multiple system atrophy)
    M F Schocke
    Department of Magnetic Resonance Imaging and Spectroscopy, Department of Neurology, Department of Anaesthesia, The Leopold Franzens University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria
    Neuroimage 12:209-18. 2000
    ..5 Tesla MRI scanner. Additionally, we obtained an excellent correlation between MRI and histological measurements...
  18. ncbi Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy)
    N Stefanova
    Department of Neurology, University Hospital of Innsbruck, Innsbruck, Austria
    Neurobiol Dis 15:630-9. 2004
    ....
  19. ncbi Progression of dysautonomia in multiple system atrophy: a prospective study of self-perceived impairment
    M Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Eur J Neurol 14:66-72. 2007
    ..This is the first study to investigate self-perceived dysautonomia severity in MSA and its evolution over time. Our data suggest that dysautonomia should be recognized as a key target for therapeutic intervention in MSA...
  20. ncbi Orthostatic hypotension and attention in Parkinson's disease with and without dementia
    C Peralta
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neural Transm 114:585-8. 2007
    ..828, P < 0.05; DeltaDBP and TEA-2, r = 0.828, P < 0.05). We conclude that OH is frequent in PDD and should be addressed therapeutically since it may exacerbate attentional dysfunction...
  21. ncbi Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy)
    Laura Mantoan
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020, Innsbruck, Austria
    Acta Neuropathol (Berl) 109:191-7. 2005
    ....
  22. ncbi Placebo-controlled trial of riluzole in multiple system atrophy
    K Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Eur J Neurol 13:1146-8. 2006
    ..It is unlikely that riluzole treatment could have clinically meaningful anti-Parkinsonian effects in MSA. A trial assessing the disease-modifying potential of riluzole in MSA is underway...
  23. ncbi Glial cell death induced by overexpression of alpha-synuclein
    N Stefanova
    Department of Neurology, University of Innsbruck, Austria
    J Neurosci Res 65:432-8. 2001
    ....
  24. ncbi Striatal dopamine transporter function in dementia with Lewy bodies and Parkinson's disease
    G Ransmayr
    Department of Neurology, University Hospital Innsbruck, Austria
    Eur J Nucl Med 28:1523-8. 2001
    ..Whether these findings are helpful in the differential diagnosis of DLB and PD needs to be examined in further studies...
  25. ncbi Riluzole in Huntington's disease (HD): an open label study with one year follow up
    K Seppi
    Department of Neurology, Innsbruck University Hospital, Austria
    J Neurol 248:866-9. 2001
    ..A double-blind, placebo-controlled trial appears highly warranted to establish definitely the symptomatic versus neuroprotective actions of riluzole in HD...
  26. ncbi Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  27. ncbi Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  28. ncbi How to diagnose MSA early: the role of magnetic resonance imaging
    K Seppi
    Department of Neurology, Innsbruck Medical University, Austria
    J Neural Transm 112:1625-34. 2005
    ..The aim of this article is to review the role of different MRI techniques in the differential diagnosis of PD and MSA...
  29. ncbi Dopamine D4 receptor polymorphism and idiopathic Parkinson's disease
    M F Kronenberg
    Department of Neurology, Innsbruck University Hospital, Austria
    Eur J Hum Genet 7:397-400. 1999
    ..Therefore, the dopamine D4 receptor polymorphism does not confer genetic susceptibility to IPD and cannot explain the decreased novelty seeking in IPD patients...
  30. ncbi Multiple system atrophy
    G K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    Semin Neurol 21:33-40. 2001
    ..We also review the role of additional investigations that may support a clinical diagnosis of MSA. Finally, we briefly discuss the management of MSA, focusing on possible future therapeutic strategies...
  31. ncbi Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
    Klaus Seppi
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    Mov Disord 19:1438-45. 2004
    ..Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD...
  32. ncbi Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
    ..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
  33. ncbi Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?
    Nadia Stefanova
    Department of Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 219:368-71. 2009
    ..Our data suggest that the presence of MSA-like alpha-synuclein oligodendrogliopathy and related to it pro-inflammatory microenvironment may compromise the connectivity and neurorestorative outcome of striatal grafts...
  34. ncbi Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy
    Zoe Puschban
    Experimental Neurodegeneration Laboratory, Department of Neurology, University Hospital Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria
    Brain Res Bull 68:54-8. 2005
    ..e. early stage disease with limited striatal dysfunction...
  35. ncbi Progression of parkinsonism in multiple system atrophy
    Klaus Seppi
    Department of Neurology, University Hospital, Innsbruck, Austria
    J Neurol 252:91-6. 2005
    ..Furthermore, motor progression appeared to be accelerated during the early disease stages.Our data allow sample size calculations that may be helpful for the planning of future therapeutic trials...
  36. ncbi Voxel based morphometry reveals a distinct pattern of frontal atrophy in progressive supranuclear palsy
    C Brenneis
    Department of Neurology and Radiology, University Hospital, Innsbruck, Austria
    J Neurol Neurosurg Psychiatry 75:246-9. 2004
    ..Frontal lobe atrophy is a well known neuropathological feature of progressive supranuclear palsy (PSP), accompanied by characteristic neuropsychological deficits...
  37. ncbi A novel grading scale for striatonigral degeneration (multiple system atrophy)
    G K Wenning
    Department of Neurology, University of Innsbruck School of Medicine, Innsbruck, Austria
    J Neural Transm 109:307-20. 2002
    ..Prospective clinicopathologic studies are required to validate the proposed SND grading scale and may result in further subdivisions, particularly of SND grade III...
  38. ncbi Diagnostic criteria for multiple system atrophy and progressive supranuclear palsy
    G K Wenning
    Division of Clinical Neurobiology, Department of Neurology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Rev Neurol (Paris) 166:829-33. 2010
    ..In this review, we will discuss diagnostic issues in MSA and PSP...
  39. ncbi Striatal transplantation in a rodent model of multiple system atrophy: effects on L-Dopa response
    Martin Köllensperger
    Section for Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 87:1679-85. 2009
    ..Therefore, striatal transplantation should be further defined preclinically as a possible therapeutic option for patients with MSA-P and a failing L-Dopa response...
  40. ncbi Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG)
    Felix Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:179-86. 2006
    ..Our data contribute to the ongoing validation process of UMSARS, and they facilitate the planning and implementation of future neuroprotective intervention trials...
  41. ncbi Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:353-8. 2007
    ..593; P = 0.01) in the stepping test. These findings contribute further to the behavioral characterization of the double lesion rat model of MSA, improving its value in the evaluation of future neurorestorative strategies...
  42. ncbi [Dementia with Lewy bodies]
    G Ransmayr
    Universitätsklinik für Neurologie, Anichstrasse 35, A 6020 Innsbruck
    Nervenarzt 71:929-35. 2000
    ..The disease is treated with L-dopa, atypical neuroleptics, acetylcholine esterase inhibitors, antihypotensive agents, and peripheral anticholinergic and alpha receptor-blocking medications to improve neurogenic bladder dysfunction...
  43. ncbi Atrophy pattern in SCA2 determined by voxel-based morphometry
    Christian Brenneis
    Department of Neurology, University Hospital of Innsbruck, Innsbruck, Australia
    Neuroreport 14:1799-802. 2003
    ..Two mechanisms could contribute to the observed cortical atrophy. It could be either the result of primary supratentorial degeneration as part of the disease process and/or secondary atrophy due to cerebellar deafferentation...
  44. ncbi Topography of cerebral monoamine transporter availability in families with SCA2 mutations: a voxel-wise [123I]beta-CIT SPECT analysis
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Nucl Med Mol Imaging 33:1084-90. 2006
    ..To this end, nine patients were studied with [(123)I]beta-CIT SPECT...
  45. ncbi How to diagnose dementia with Lewy bodies: state of the art
    Felix Geser
    Clinical Department of Neurology, Medical University Innsbruck, Austria
    Mov Disord 20:S11-20. 2005
    ..We review the present state of the best practice in the clinical diagnosis of DLB. Future modifications of diagnostic criteria would ideally include the full range of clinical presentations that can be associated with LB disease...
  46. ncbi In vitro models of multiple system atrophy
    Nadia Stefanova
    Neurological Research Laboratory, Department of Neurology, University Hospital of Innsbruck, Austria
    Mov Disord 20:S53-6. 2005
    ..With this simplified system, we have demonstrated that alpha-synuclein significantly affects the survival of glia and its vulnerability to environmental stress, which might represent a major step in the pathogenesis of MSA...
  47. ncbi Assessing disease progression with MRI in atypical parkinsonian disorders
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:S699-702. 2009
    ..The article reviews the current state of the art focusing on three atypical parkinsonian disorders: multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB)...
  48. ncbi Topography of dopamine transporter availability in progressive supranuclear palsy: a voxelwise [123I]beta-CIT SPECT analysis
    Klaus Seppi
    Department of Neurology, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Arch Neurol 63:1154-60. 2006
    ..Most previous SPECT studies have adopted region-of-interest methods for analysis, which are subjective and operator dependent...
  49. ncbi Homocysteine and serum markers of immune activation in primary dystonia
    Ulf J Muller
    University Hospital of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 20:1663-7. 2005
    ..HCY is a neuronal excitotoxic amino acid and hyperhomocysteinemia is considered an independent vascular risk factor. Further studies are required to define the background of hyperhomocysteinemia in primary dystonia...
  50. ncbi Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration
    Nadia Stefanova
    Neurodegeneration Research Laboratory, Innsbruck MSA Study Group, Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci Res 78:87-91. 2004
    ..We conclude that despite its astrocytic and microglial suppression, minocycline failed to attenuate lesion-induced neuronal damage in the SND rat model...
  51. ncbi Exaggerated auditory startle responses in multiple system atrophy: a comparative study of parkinson and cerebellar subtypes
    Markus Kofler
    Department of Neurology, Hospital Hochzirl, Anna Dengel Haus, A 6170 Zirl, Austria
    Clin Neurophysiol 114:541-7. 2003
    ....
  52. ncbi Diffusion-weighted imaging in Huntington's disease
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1043-7. 2006
    ..Diffusion-weighted imaging appears to be a promising surrogate marker for disease severity in HD. Sensitivity to change remains to be established longitudinally...
  53. ncbi Progression of putaminal degeneration in multiple system atrophy: a serial diffusion MR study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuroimage 31:240-5. 2006
    ....
  54. ncbi Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort): a population-based study
    Gregor K Wenning
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Lancet Neurol 4:815-20. 2005
    ..A fifth of all movement disorders were diagnosed to be probably drug-induced. INTERPRETATION: There is a high prevalence of and substantial under-recognition and under-treatment of movement disorders in the general community...
  55. ncbi Diffusion weighted imaging best discriminates PD from MSA-P: A comparison with tilt table testing and heart MIBG scintigraphy
    Martin Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 22:1771-6. 2007
    ..6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA-P...
  56. ncbi Cortical atrophy in the cerebellar variant of multiple system atrophy: a voxel-based morphometry study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:159-65. 2006
    ..We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid-frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex...
  57. ncbi Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study
    Christian Brenneis
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 254:191-6. 2007
    ..The UPDRS-III score was not significantly correlated with any brain region. Our data suggest that cortical atrophy is prominent in MSA-P and early degeneration of the basal ganglia drives late onset cortical atrophy...
  58. ncbi Basal forebrain atrophy is a distinctive pattern in dementia with Lewy bodies
    Christian Brenneis
    Department of Neurology, University Hospital of Innsbruck, Anichstr 35, 6020 Innsbruck, Austria
    Neuroreport 15:1711-4. 2004
    ..Atrophy of insular cortex was found in both patient groups...
  59. ncbi Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imaging
    Sylvia M Boesch
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    J Magn Reson Imaging 25:564-9. 2007
    ..To assess and compare biochemical and volumetric features of the cerebellum in patients with spinocerebellar ataxia type 2 (SCA2) and patients with the cerebellar variant of multiple system atrophy (MSA-C)...
  60. ncbi Abnormalities of dopaminergic neurotransmission in SCA2: a combined 123I-betaCIT and 123I-IBZM SPECT study
    Sylvia M Boesch
    Department of Neurology, University of Innsbruck, Austria
    Mov Disord 19:1320-5. 2004
    ..Both slowness of limb movements as well as dystonia in the ataxic SCA2 phenotype may reflect dysfunction not only at cerebellar but also at basal ganglia level...
  61. ncbi Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson's disease
    Michael F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neuroimage 21:1443-51. 2004
    ..Because rADCs in one direction are dependent on the slice orientation relative to the directions of fiber tracts, Trace(D) imaging appears to be more accurate in the separation of MSA-P from PD...
  62. ncbi Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 129:538-42. 2006
    ..Whether DWI can be used as a marker to identify individuals at risk to develop this disease remains to be shown...
  63. ncbi Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats
    Christoph Scherfler
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Neuroimage 24:822-31. 2005
    ..SPECT-MRI-based estimation of regional [123I]IBZM uptake provides a cost effective and widely available in vivo imaging technique for assessing striatal integrity in animal studies...
  64. ncbi Rasagiline is neuroprotective in a transgenic model of multiple system atrophy
    Nadia Stefanova
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 210:421-7. 2008
    ..5 mg/kg rasagiline. The results of the study indicate that rasagiline confers neuroprotection in a transgenic mouse model of MSA and may therefore be considered a promising disease-modifying candidate for human MSA...
  65. ncbi The role of alpha-synuclein in the pathogenesis of multiple system atrophy
    Gregor K Wenning
    Department of Neurology, University of Innsbruck, School of Medicine, Anichstrasse 35, 6020, Innsbruck, Austria
    Acta Neuropathol (Berl) 109:129-40. 2005
    ..Transgenic MSA mouse models are now available to determine these aspects of cellular disturbance experimentally...
  66. ncbi Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
    Christoph Scherfler
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Brain 128:1605-12. 2005
    ..We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]beta-CIT SPECT in patients with uncertain parkinsonism...
  67. ncbi Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
    Christian Brenneis
    Department of Neurology, University Hospital, Innsbruck, Austria
    Mov Disord 18:1132-8. 2003
    ..Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA-P...
  68. ncbi Somatosensory evoked potentials in progressive supranuclear palsy
    M Kofler
    Department of Neurology, Hospital Hochzirl, Anna Dengel Haus, A 6170, Zirl, Austria
    J Neurol Sci 179:85-91. 2000
    ..We propose that cortical neurofibrillary pathology may lead to subclinical intracortical disinhibition accounting for the enlarged cortical SEPs in PSP...
  69. ncbi Impact of ambiguity and risk on decision making in mild Alzheimer's disease
    H Sinz
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Neuropsychologia 46:2043-55. 2008
    ....
  70. ncbi Cervical dystonia in spinocerebellar ataxia type 2: clinical and polymyographic findings
    S M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol Neurosurg Psychiatry 78:520-2. 2007
    ..CD has probably been underreported in patients with the ataxic SCA2 phenotype and should be considered as an additional clinical manifestation in patients with hereditary ataxia...
  71. ncbi Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD
    M F H Schocke
    Department of Radiology, University of Innsbruck, Austria
    Neurology 58:575-80. 2002
    ..Diffusion-weighted imaging may represent a useful diagnostic tool that can provide additional support for a diagnosis of Parkinson variant of multiple system atrophy...
  72. ncbi Supranuclear gaze palsy and eyelid apraxia in postencephalitic parkinsonism
    G K Wenning
    Department of Neurology, University Hospital, Innsbruck, Austria
    J Neural Transm 104:845-65. 1997
    ..Whether the dorsal tegmental nucleus, caudal to the supratrochlear nucleus, severely affected in all our PEP cases, has a role in vertical gaze needs to be further studied...
  73. ncbi Dystonia in multiple system atrophy
    S M Boesch
    Department of Neurology, University Hospital, Innsbruck, Austria
    J Neurol Neurosurg Psychiatry 72:300-3. 2002
    ..Levodopa induced dyskinesias were almost exclusively dystonic affecting predominantly craniocervical musculature. Future studies are required to elucidate the underlying pathophysiology of dystonia in MSA...
  74. ncbi Ultrastructure of alpha-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells
    N Stefanova
    Department of Neurology, University of lnnsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Neurosci Lett 323:37-40. 2002
    ....
  75. ncbi Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:847-52. 2006
    ..Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI...
  76. ncbi Restless legs syndrome in Parkinson's disease
    Cecilia M Peralta
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:2076-80. 2009
    ..7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD...
  77. ncbi The European Multiple System Atrophy-Study Group (EMSA-SG)
    F Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    J Neural Transm 112:1677-86. 2005
    ..Indeed, a trial on growth hormone in MSA has just been completed, and another on minocycline will be completed by the end of this year...
  78. ncbi Midbrain sonography in patients with essential tremor
    Heike Stockner
    Department of Neurology, Medical University Innsbruck, Austria
    Mov Disord 22:414-7. 2007
    ..These findings might correspond to an increased risk of ET patients to develop PD. Long-term follow-up will show if those with hyperechogenic SN develop PD, while these without will not...
  79. ncbi Abnormal responses to repetitive transcranial magnetic stimulation in multiple system atrophy
    Wolfgang N Löscher
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:174-8. 2007
    ..We suggest that these abnormalities reflect the motor cortex pathology found in MSA-P...
  80. ncbi Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome
    Christoph Schmidauer
    Department of Neurology, Innsbruck Medical University, Austria
    Ann Neurol 58:630-4. 2005
    ..These findings lend further support to nigral iron deficiency as a pathogenetic factor in RLS...
  81. ncbi Huntington's disease: present treatments and future therapeutic modalities
    Raphael M Bonelli
    University Clinic of Psychiatry, Karl Franzens University Graz, Graz University Clinic of Neurology, University of Innsbruck, Innsbruck, Austria
    Int Clin Psychopharmacol 19:51-62. 2004
    ..Finally, some cellular mechanisms are discussed in this paper because they are essential for future neuroprotective modalities, such as minocycline, unsaturated fatty acids or riluzole...
  82. ncbi Mortality in Parkinson's disease: a 20-year follow-up study
    Anja Diem-Zangerl
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 24:819-25. 2009
    ....
  83. ncbi Recent developments in multiple system atrophy
    Gregor K Wenning
    Section of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol 256:1791-808. 2009
    ..An outline of the rationale for managing symptomatic deterioration in MSA is provided together with a summary of novel experimental therapeutic approaches to decrease disease progression...
  84. ncbi Levodopa-induced sleepiness in the Parkinson variant of multiple system atrophy
    Klaus Seppi
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1281-3. 2006
    ..These findings suggest greater potential of levodopa to induce sleepiness in MSA compared with PD, which may be related to differences in basal ganglia and brainstem pathology between the two disorders...
  85. ncbi Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure
    Sylvia Stemberger
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Exp Neurol 224:459-64. 2010
    ....
  86. ncbi Tumor necrosis factor-alpha-induced cell death in U373 cells overexpressing alpha-synuclein
    Nadia Stefanova
    Department of Neurology, University of Innsbruck, Innsbruck, Austria
    J Neurosci Res 73:334-40. 2003
    ..We conclude that alpha-synuclein overexpression significantly increases the vulnerability of U373 cells to apoptosis through TNF-alpha-mediated pathways...
  87. ncbi Voxel based morphometry reveals specific gray matter changes in primary dystonia
    Karl Egger
    Department of Radiology, Innsbruck Medical University, Austria
    Mov Disord 22:1538-42. 2007
    ..This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes...
  88. ncbi Restless legs syndrome and motor activity during sleep in spinocerebellar ataxia type 6
    Sylvia M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria
    Sleep Med 7:529-32. 2006
    ..None of the patients had REM sleep behaviour disorder. Only one patient had mild REM sleep without atonia. CONCLUSIONS: Our pilot study suggests only minor sleep abnormalities in SCA6...
  89. ncbi Association of daytime sleepiness with COMT polymorphism in patients with parkinson disease: a pilot study
    Birgit Frauscher
    Innsbruck Medical University, Department of Neurology, Innsbruck, Austria
    Sleep 27:733-6. 2004
    ..To evaluate an association between catechol-O-methyltransferase (COMT) genotype and subjective daytime sleepiness in patients with Parkinson disease...
  90. ncbi Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
    Nadia Stefanova
    Department of Neurology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Acta Neuropathol 106:157-66. 2003
    ..This suggests that complex integrative mechanisms are likely to regulate the vulnerability of the striatum and SNc to cell death in SND/MSA-P...
  91. ncbi Disturbance of rapid eye movement sleep in spinocerebellar ataxia type 2
    Sylvia M Boesch
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1751-4. 2006
    ..Abnormal motor control during sleep with periodic leg movements and REM sleep without atonia occurs frequently in SCA2. This finding may reflect a dysfunction of dopaminergic and/or brainstem and cerebellar outflow pathways...
  92. ncbi Valvular heart disease in Parkinson's disease vs. controls: An echocardiographic study
    Cecilia Peralta
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 21:1109-13. 2006
    ..These results highlight the need for further prospective studies of the prevalence and underlying mechanisms of cardiac valvulopathy in PD patients treated with different dopamine agonists...
  93. ncbi Animal models of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    Trends Neurosci 28:501-6. 2005
    ..Here, the currently available MSA animal models will be reviewed and leads for future research will be identified...
  94. ncbi Disproportionate antecollis: a warning sign for multiple system atrophy
    Felix Geser
    Mov Disord 22:1986; author reply 1986-7. 2007