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Genomes and Genes | W J SchneiderSummaryAffiliation: University of Vienna Country: Austria Publications
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Publications
A model for modulation of leptin activity by association with clusterinTarek M Bajari
Institute of Medical Biochemistry, Department of Molecular Genetics, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
FASEB J 17:1505-7. 2003..Thus, bioavailability of leptin at a given tissue site may be determined by the levels of clusterin and/or by the relative distribution of certain relatives of the LDL receptor vis-à-vis active leptin receptors...- From cholesterol transport to signal transduction: low density lipoprotein receptor, very low density lipoprotein receptor, and apolipoprotein E receptor-2J Nimpf
Institute of Medical Biochemistry, Department of Molecular Genetics, University and Biocenter Vienna, Dr Bohr Gasse 9 2, A 1030, Vienna, Austria
Biochim Biophys Acta 1529:287-98. 2000..These findings suggest that to date, only the tip of an iceberg has been uncovered... - Receptor-associated protein in an oviparous species is correlated with the expression of a receptor variantK A Lindstedt
Department of Molecular Genetics, University and Biocenter Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
J Biol Chem 272:30221-7. 1997..Thus, in conjunction with the avian model of massive lipid transport to germ cells, these cells provide a novel comparative system amenable to investigation of the biological functions of RAP... - Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolismW J Schneider
Department of Molecular Genetics, University and Biocenter Vienna, Austria
Curr Opin Lipidol 8:315-9. 1997.... - The VLDL receptor: an LDL receptor relative with eight ligand binding repeats, LR8J Nimpf
Department of Molecular Genetics, University and Biocenter of Vienna, Austria
Atherosclerosis 141:191-202. 1998.... - The chicken oocyte receptor for yolk precursors as a model for studying the action of receptor-associated protein and lactoferrinT Hiesberger
Department of Molecular Genetics, University of Vienna, Austria
J Biol Chem 270:18219-26. 1995.... - Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulinC Brandes
Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, A 1030 Vienna, Austria
J Biol Chem 276:22160-9. 2001.... - The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2W Stockinger
The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Austria
J Biol Chem 275:25625-32. 2000..This complex might participate in ApoER2-specific reelin signaling and thus would explain the different phenotype of mice lacking the ApoER2 from that of VLDLR-deficient mice... - Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genesC Brandes
Department of Molecular Genetics, Biocenter and University of Vienna, Austria
Genomics 42:185-91. 1997.... - Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor familyH Bujo
Department of Molecular Genetics, Biocenter, Vienna, Austria
EMBO J 13:5165-75. 1994..Its key role in avian reproduction and extremely high evolutionary conservation shed new light on VLDLR function in mammals, which also express the gene in ovaries... - Multiple involvement of clusterin in chicken ovarian follicle development. Binding to two oocyte-specific members of the low density lipoprotein receptor gene familyM G Mahon
Department of Molecular Genetics, University and Biocenter Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
J Biol Chem 274:4036-44. 1999.... - Chicken coagulation factor XIIIA is produced by the theca externa and stabilizes the ovarian follicular wallB Recheis
Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Vienna A 1030, Austria
J Biol Chem 275:35320-7. 2000..Thus, coagulation factor XIIIA might play a key role in coping with the massive mechanical stress exerted by the large amount of yolk accumulating during the rapid growth phase of the oocyte... - The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brainW Stockinger
Department of Molecular Genetics, Biocenter and University of Vienna, Dr Bohrgasse 9 2, A 1030 Vienna, Austria
J Biol Chem 273:32213-21. 1998..proteinase complexes and/or of other substrates bound to alpha2-macroglobulin from the cerebrospinal fluid and from the surface of neurons... - A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickensS Mörwald
Department of Molecular Genetics, Biocenter and University of Vienna, Austria
Arterioscler Thromb Vasc Biol 17:996-1002. 1997..The features of LR11 suggest important roles in intercellular and intracellular ligand transport processes, some of which it may share with other brain-specific LDLR family members... - Transport of serum transthyretin into chicken oocytes. A receptor-mediated mechanismA V Vieira
Department of Molecular Genetics, University and Biocenter, Vienna, Austria
J Biol Chem 270:2952-6. 1995..These data strongly suggest that oocytic TTR is derived from the circulation, where it is a constitutive component, and deposited into yolk as a result of endocytosis mediated by a specific receptor... - The chicken homologue of zona pellucida protein-3 is synthesized by granulosa cellsM Waclawek
Department of Molecular Genetics, University and Biocenter Vienna, Vienna, Austria
Biol Reprod 59:1230-9. 1998.... - The major chicken egg envelope protein ZP1 is different from ZPB and is synthesized in the liverN Bausek
Institute of Medical Biochemistry, Department of Molecular Genetics, University and Biocenter Vienna, Dr Bohr Gasse 9 2, A 1030 Wien, Austria
J Biol Chem 275:28866-72. 2000..Thus, in the chicken, at least one of the major pvm components is synthesized in the liver and is transported via the bloodstream to the follicle... - Lipoprotein receptors in extraembryonic tissues of the chickenM Hermann
Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
J Biol Chem 275:16837-44. 2000..LR8 is a key mediator of a two-step pathway, which affects the uptake of VLDL from the yolk sac and the subsequent delivery of its components to the growing embryo... - Receptor-associated protein and members of the low density lipoprotein receptor family share a common epitope. An extended model for the development of passive Heymann nephritisT Hiesberger
Department of Molecular Genetics, Biocenter and University of Vienna, Dr Bohrgasse 9 2, A 1030 Vienna, Austria
J Biol Chem 271:28792-7. 1996..These findings suggest the existence of a common epitope(s) on RAP and members of the LDL receptor family. Based on these results, we present an extended molecular model for the development of passive Heymann nephritis... - Retinol in avian oogenesis: molecular properties of the carrier proteinA V Vieira
Department of Molecular Genetics, University and Biocenter Vienna, Austria
DNA Cell Biol 14:403-10. 1995..These results provide strong evidence that chicken RBP is an essential serum-to-yolk vitamin carrier with certain properties different from those of other such transporters... - Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression patternE Hengstschläger-Ottnad
Department of Molecular Genetics, University and Biocenter Vienna, Austria
J Biol Chem 270:26139-45. 1995.... - Expression and conservation of apolipoprotein AIV in an avian speciesA Steinmetz
Department of Molecular Genetics, University and Biocenter Vienna, A 1030 Vienna, Austria
J Biol Chem 273:10543-9. 1998..Although pronounced intestinal synthesis is common to apoAIVs, the features of the avian protein support the notion that it represents a prototype of an apoprotein that evolved to acquire possibly distinct functions in mammals and birds... - The low-density lipoprotein receptor family: genetics, function, and evolutionW J Schneider
Department of Molecular Genetics, University and Biocenter Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
Curr Atheroscler Rep 1:115-22. 1999.... - Low density lipoprotein receptor relatives in chicken ovarian follicle and oocyte developmentW J Schneider
Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University of Vienna, Vienna, Austria
Cytogenet Genome Res 117:248-55. 2007.... - LDL receptor relatives at the crossroad of endocytosis and signalingW J Schneider
The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Dr Bohrgasse 9/2, 1030 Vienna, Austria
Cell Mol Life Sci 60:892-903. 2003..Adaptor proteins interacting with the cytosolic domains of these receptors might orchestrate their ability to deliver their cargo or a signal... - A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signalingStefanie Koch
The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Vienna, Austria
EMBO J 21:5996-6004. 2002..This receptor fragment inhibits Reelin signaling in primary neurons, indicating that it can act in a dominant-negative fashion in the regulation of Reelin signaling during embryonic brain development... - A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouseS Novak
Department of Molecular Genetics, Biocenter and University of Vienna, Austria
J Biol Chem 271:11732-6. 1996..The presence of this novel receptor in brain of a bird and a rodent suggests an important and evolutionary conserved function... - The somatic cell-specific low density lipoprotein receptor-related protein of the chicken. Close kinship to mammalian low density lipoprotein receptor gene family membersJ Nimpf
Department of Molecular Genetics, Biocenter, Vienna, Austria
J Biol Chem 269:212-9. 1994..e. vitellogenesis, and that mammalian LRP/alpha 2MRs have acquired features required for functioning in plasma clearance of certain non-yolk proteins... - Regulation by estrogen of synthesis and secretion of apolipoprotein A-I in the chicken hepatoma cell line, LMH-2AMarcela Hermann
Department of Molecular Genetics, Institute of Medical Biochemistry, University and Biocenter Vienna, Dr Bohr Gasse 9 2, Vienna A 1030, Austria
Biochim Biophys Acta 1641:25-33. 2003..These interactions are more pronounced in estrogen-treated cells, most likely due to the dramatic estrogen-mediated induction of apoB synthesis and secretion... - The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptorWalter Stockinger
The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, A 1030 Vienna, Austria
EMBO J 21:4259-67. 2002..Our results identify SNX17 as a novel adaptor protein for LDLR family members and define a novel mechanism for modulation of their endocytic activity... - Role of leptin in reproductionTarek M Bajari
Max F Perutz Laboratories, Institute of Medical Biochemistry, Department of Molecular Genetics, Medical University of Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
Curr Opin Lipidol 15:315-9. 2004..This article focuses on recently gained knowledge concerning the different emerging aspects of the role of leptin in reproduction, through both its central hypothalamus-mediated and peripheral actions... - Molecular characterization of the first avian LDL receptor: role in sterol metabolism of ovarian follicular cellsSusanna Hummel
Institute of Medical Biochemistry, Department of Molecular Genetics, University and Biocenter Vienna, Austria
J Lipid Res 44:1633-42. 2003..In summary, the molecular characterization of the first avian LDLR reveals novel information about evolutionary, structural, and functional aspects of members of the supergene family of LDLR-related proteins... - Receptor-mediated mechanisms in ovarian follicle and oocyte developmentWolfgang J Schneider
Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University of Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
Gen Comp Endocrinol 163:18-23. 2009.... - Extracellular matrices of the avian ovarian follicle. Molecular characterization of chicken perlecanSusanna Hummel
Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Institute of Medical Biochemistry, Department of Molecular Genetics, Medical University of Vienna, A 1030 Vienna, Austria
J Biol Chem 279:23486-94. 2004..2002) Science 298, 2353-2358 and Takagi, J., Yang, Y., Liu, J. H., Wang, J. H., and Springer, T. A. (2003) Nature 424, 969-974), we propose a novel role of perlecan in mediating plasma-to-oocyte surface transport of VLDL particles... - Avian apolipoprotein A-V binds to LDL receptor gene family membersAndrea Dichlberger
Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
J Lipid Res 48:1451-6. 2007..We propose that a direct interaction with LRs may represent a novel, additional mechanism for the modulation of TG levels by apoA-V... - Reconstitution of the Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation is independent of receptor localization in lipid raftsHarald Mayer
Max F Perutz Laboratories, Department of Medical Biochemistry, University Department at the Vienna Biocenter, Medical University of Vienna, Vienna, Austria
Mol Cell Biol 26:19-27. 2006.... - Interaction of sperm with purified native chicken ZP1 and ZPC proteinsNina Bausek
Department of Molecular Genetics, Institute of Medical Biochemistry, Max F Perutz Laboratories, Medical University of Vienna, Biocenter, A 1030 Vienna, Austria
Biol Reprod 71:684-90. 2004..An antiserum directed against chicken ZP1 is capable of inhibiting sperm binding to the PVM. Taken together, these data suggest that ZP1, in addition to ZPC, plays a major role in the initial interactions between sperm and egg... - Identification of a novel chondroitin-sulfated collagen in the membrane separating theca and granulosa cells in chicken ovarian follicles: the granulosa-theca cell interface is not a bona fide basement membraneSusanna Hummel
Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University of Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
J Biol Chem 282:8011-8. 2007..Based on our data we propose that in addition to thecal perlecan, ggBM1 is involved in the transfer of yolk precursors from the thecal capillary bed to oocyte surface lipoprotein receptors mediating their uptake into oocytes... - ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of ReelinNuno Andrade
Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
Proc Natl Acad Sci U S A 104:8508-13. 2007..These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin... - Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migrationSophia M Blake
Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University Vienna, Vienna, Austria
EMBO J 27:3069-80. 2008..Lack of THBS-1 results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB... - The patatin-like lipase family in Gallus gallusJani Saarela
The Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
BMC Genomics 9:281. 2008..The mammalian gene family of patatin-like phospholipases (PNPLAs) has received significant attention, but studies in other vertebrates are lacking; thus, we have begun investigations of PNPLA genes in the chicken (Gallus gallus)... - Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptorsSarah Duit
Max F Perutz Laboratories, Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, Dr Bohrgasse 9 2, A 1030 Vienna, Austria
J Biol Chem 285:4896-908. 2010..These features contribute to a receptor-specific fine tuning of the Reelin signal, leading to a novel model that emphasizes negative feedback loops specifically mediated by ApoER2 and VLDL receptor, respectively... - Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytesShizuko Tachibana
Graduate School of Agricultural Science, Tohoku University, Aoba ku, Sendai 981 8555, Japan
Biochim Biophys Acta 1737:36-43. 2005.... - Modulation of sterol regulatory element binding protein-2 in response to rapid follicle development in chickensHyang Sook Seol
Graduate School of Agricultural Science, Tohoku University, Sendai, 981 8555, Japan
Comp Biochem Physiol B Biochem Mol Biol 147:698-703. 2007..These results suggest that SREBP-2, which might be regulated by LXRalpha, is involved in the rapid growth stages of follicle development in avian species... - LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptorsKousei Tanaga
Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan
Arterioscler Thromb Vasc Biol 24:1422-8. 2004.... - LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migrationYanjuan Zhu
Department of Clinical Cell Biology F5, Chiba University Graduate School of Medicine, Chiba, Japan
Circ Res 94:752-8. 2004..The novel mechanism of regulation of uPAR localization in SMCs accompanied with enhanced migration activity possibly constitutes an important factor in the process of atherosclerosis and arterial remodeling... - Disulfide-linked heterodimeric clusterin is a component of the chicken eggshell matrix and egg whiteKarlheinz Mann
, Martinsried D-82152, Germany
Matrix Biol 22:397-407. 2003.... - Enhanced expression of the LDL receptor family member LR11 increases migration of smooth muscle cells in vitroYanjuan Zhu
Department of Clinical Cell Biology F5, Chiba University Graduate School of Medicine, Chiba, Japan
Circulation 105:1830-6. 2002..To further clarify the involvement of LR11 in the process of atherosclerosis, we have characterized the migration and invasion activities of LR11-overexpressing SMCs... - Molecular characterization and expression of the cholesteryl ester transfer protein gene in chickensKan Sato
Animal Science, Applied Bioproduction Science, Biological Production, Tokyo University of Agriculture and Technology, 183 8509, Japan
Comp Biochem Physiol B Biochem Mol Biol 148:117-23. 2007.... - Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in miceMeizi Jiang
Department of Genome Research and Clinical Application, Chiba University Graduate School of Medicine, Chiba, Japan
J Clin Invest 118:2733-46. 2008..Thus, we demonstrate a requirement for sLR11 in Ang II-induced SMC migration and propose what we believe is a novel role for sLR11 as a biomarker of carotid IMT... - A secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells, accelerates formation of lipid-laden macrophagesKenji Ohwaki
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Arterioscler Thromb Vasc Biol 27:1050-6. 2007..Here we investigated whether the secreted soluble form of LR11 (solLR11) enhances adhesion, migration, and lipid accumulation in macrophages using animal models and cultured systems... - Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein compositionChristian Wadsack
Clinic of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, A 8036 Graz, Austria
Am J Physiol Endocrinol Metab 292:E476-84. 2007..28 +/- 0.20, P = 0.002). We conclude that LDL-R and SR-BI levels are altered in IUGR pregnancies. These differences were associated with changes in LDL, but not HDL, mobility and cholesterol concentration in maternal circulation... - Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cellsMeizi Jiang
Department of Genome Research and Clinical Application, Chiba University Graduate School of Medicine, Chiba, Japan
Biochem Biophys Res Commun 348:1367-77. 2006..Modulation of the LR11/uPAR system with statins suggests a novel treatment strategy for atherogenesis based on suppression of intimal SMC migration... - Impairment of VLDL secretion by medium-chain fatty acids in chicken primary hepatocytes is affected by the chain lengthKan Sato
Laboratory of Animal Nutrition, Graduate School of Agricultural Science, Tohoku University
J Nutr 135:1636-41. 2005.... - Perlecan and its immunoglobulin like domain IV are abundant in vitreous and serum of the chick embryoManimalha Balasubramani
Department of Neurobiology, University of Pittsburgh, 1402 BST, 3500 Terrace Street, Pittsburgh, PA 15261, USA
Matrix Biol 23:143-52. 2004..In addition, we found that perlecan as a substrate does not support, rather inhibits neurite outgrowth... - Species specificity in avian sperm:perivitelline interactionSarah G Stewart
Avian Reproduction Group, University of Abertay Dundee, Bell Street, Dundee DD1 1HG, UK
Comp Biochem Physiol A Mol Integr Physiol 137:657-63. 2004..This may be a factor in the frequency of hybrid production in birds... - Effects of atorvastatin on lipid metabolism in normolipidemic and hereditary hyperlipidemic, non-laying hensRobert G Elkin
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907 1151, USA
Comp Biochem Physiol B Biochem Mol Biol 143:319-29. 2006..Down-regulation of HMGR gene expression due to higher baseline levels of circulating CHOL may explain why RO birds responded less robustly than NL hens to AT administration...