Research Topics
Genomes and Genes | Johannes GrillariSummaryAffiliation: University of Natural Resources and Applied Life Sciences Country: Austria Publications
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Detail Information
Publications
GiSAO.db: a database for ageing researchEdith Hofer
Division for Bioinformatics, Biocenter, Innsbruck Medical University, Schöpfstrasse, Austria
BMC Genomics 12:262. 2011..For an effective analysis and interpretation of expression profiles it is necessary to store and manage huge amounts of data in an organized way, so that these data can be accessed and processed easily...- Post-translational modification of cellular proteins by ubiquitin and ubiquitin-like molecules: role in cellular senescence and agingJohannes Grillari
Institute of Applied Microbiology, Department of Biotechnology, University for Natural Resources and Applied Life Sciences, Vienna, Muthgasse 18, A 1190 Vienna, Austria
Adv Exp Med Biol 694:172-96. 2010.... - Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4Johannes Grillari
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Vienna A 1190, Austria
J Biol Chem 284:29193-204. 2009..Thus we suggest that Blom7alpha is a novel splicing factor of the K homology domain family that might be implicated in alternative splicing by helping to position the CDC5L-SNEV(Prp19-Pso4) complex at the splice sites... - miR-17-92 cluster: ups and downs in cancer and agingJohannes Grillari
Department of Biotechnology, University of Natural Resources and Applied Life Sciences Vienna, Austria
Biogerontology 11:501-6. 2010..Therefore, we here briefly summarize how this cluster is transcriptionally regulated, which target mRNAs have been confirmed so far and how this might be linked to modulation of organismal life-spans... - Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stageJohannes Grillari
Department of Biotechnology, University of Natural Resources and Applied Life Sciences Vienna, Austria
Exp Gerontol 45:302-11. 2010..Even more so, as miRNAs are implicated in many age-associated pathologies, and as RNAi and miRNA based therapeutics are on their way to clinics... - Contributions of DNA interstrand cross-links to aging of cells and organismsJohannes Grillari
Institute of Applied Microbiology, Department of Biotechnology, BOKU University of Natural Resources and Applied Life Sciences, Vienna, Muthgasse 18 1190 Vienna, Austria
Nucleic Acids Res 35:7566-76. 2007..However, since ICL-inducing drugs cause damage different from ICL and since all currently known ICL repair factors work in more than one pathway, further work will be needed to dissect the actual contribution of ICL damage to aging... - Aging and the ubiquitinome: traditional and non-traditional functions of ubiquitin in aging cells and tissuesJohannes Grillari
Department of Biotechnology, Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Vienna Muthgasse 18, A 1190 Vienna, Austria
Exp Gerontol 41:1067-79. 2006.... - SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assemblyJohannes Grillari
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences Vienna, Austria Muthgasse 18, A 1190 Vienna
Nucleic Acids Res 33:6868-83. 2005.... - Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicingHanna Dellago
Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria
Biochem J 438:81-91. 2011..These results suggest a novel and unexpected role of Exo70 in nuclear mRNA splicing, where it might signal membrane events to the splicing apparatus... - SNEV overexpression extends the life span of human endothelial cellsRegina Voglauer
Institute of Applied Microbiology, Department of Biotechnology, University of Natural Resources and Applied Life Sciences Muthgasse 18, A 1190 Vienna, Austria
Exp Cell Res 312:746-59. 2006..These data suggest that high levels of SNEV might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells... - hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristicsMatthias Wieser
Aging and Immortalization Research, Institute of Applied Microbiology, Department of Biotechnology, BOKU University of Natural Resources and Applied Sciences, Vienna, Austria
Am J Physiol Renal Physiol 295:F1365-75. 2008..Therefore, these cells are proposed as a valuable model system not only for cell biology but also for toxicology, drug screening, biogerontology, as well as tissue engineering approaches... - Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasomeMarlies Löscher
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
Biochem J 388:593-603. 2005..Additionally, our results provide the first evidence for a physical link between components of the ubiquitin-proteasome system and the spliceosome... - Early embryonic lethality of mice lacking the essential protein SNEVKlaus Fortschegger
Institute of Applied Microbiology, Muthgasse 18, A 1190 Vienna, Austria
Mol Cell Biol 27:3123-30. 2007..Our experiments demonstrate that the SNEV protein is essential, functionally nonredundant, and indispensable for mouse development... - Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineeringMatthias Hackl
Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 19, A 1190 Vienna, Austria
J Biotechnol 153:62-75. 2011.... - Nuclear flow FISH: isolation of cell nuclei improves the determination of telomere lengthsMatthias Wieser
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Exp Gerontol 41:230-5. 2006..Moreover, NFF will find broader applications, whenever in situ hybridization signals have to be quantitated... - Comparison of early passage, senescent and hTERT immortalized endothelial cellsMartina Wei-Fen Chang
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna, Austria
Exp Cell Res 309:121-36. 2005..Although these cells are highly differentiated, the protein expression profile of the cell line is different to that of normal early passage and senescent cells... - A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cellsVaibhav Jadhav
Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria telephone 43 1 47654 6230 fax 43 1 47654 6675
Biotechnol Bioeng 109:1376-85. 2012..Thus our system represents a general platform to functionally screen candidates for rational cell factory design. Biotechnol. Bioeng. 2012; 109:1376-1385. © 2012 Wiley Periodicals, Inc... - Dynamic mRNA and miRNA profiling of CHO-K1 suspension cell culturesJuan A Hernandez Bort
Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Biotechnol J 7:500-15. 2012..In addition, as miRNAs generally act as negative post-transcriptional regulators of mRNAs, we looked for changes in their expression that were inverse to those of their predicted target mRNAs... - Low telomerase activity: possible role in the progression of human medullary thyroid carcinomaGuido Stadler
Institute of Applied Microbiology, Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Eur J Cancer 44:866-75. 2008.... - Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell linesMatthias Hackl
Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria
J Biotechnol 158:151-5. 2012.... - MicroRNAs as targets for engineering of CHO cell factoriesDethardt Müller
Institute of Applied Microbiology, Department of Biotechnology, BOKU University of Natural Resources and Applied Life Sciences, Vienna, Muthgasse 18, 1190 Vienna, Austria
Trends Biotechnol 26:359-65. 2008..However, we also summarize the limitations and challenges that will have to be overcome to exploit fully miRNA technology... - miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human agingMatthias Hackl
Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Aging Cell 9:291-6. 2010..Decrease in these miRNAs correlated with increased transcript levels of some established target genes, especially the cdk inhibitor p21/CDKN1A. These results establish miRNAs as novel markers of cell aging in humans... - Acute adrenergic stress inhibits proliferation of murine hematopoietic progenitor cells via p38/MAPK signalingElisabeth Schraml
Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
Stem Cells Dev 18:215-27. 2009.... - Large-scale production and characterization of novel CD4+ cytotoxic T cells with broad tumor specificity for immunotherapyClaudia Jursik
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
Mol Cancer Res 7:339-53. 2009..These results suggest that TKTCs have a high potential as a novel tool in the adoptive immunotherapy of cancer... - Age-related alterations in the protein expression profile of C57BL/6J mouse pituitariesGorji Marzban
Institute of Applied Microbiology, University of Agricultural Sciences, Muthgasse 18, House B, A 1190 Vienna, Austria
Exp Gerontol 37:1451-60. 2002.... - Biogerontology in AustriaUrsula Azizi-Semrad
Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
Biogerontology 12:3-10. 2011..This article describes the work of selected research groups involved in biogerontology in a geographic arrangement... - Identification of cultivation-independent markers of human endothelial cell senescence in vitroHermann Unterluggauer
Department of Mol Cell Biology, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Rennweg 10, 6020, Innsbruck, Austria
Biogerontology 8:383-97. 2007.... - Haploinsufficiency of senescence evasion factor causes defects of hematopoietic stem cells functionsElisabeth Schraml
Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria
Stem Cells Dev 17:355-66. 2008..These data suggest that the expression of SNEV is closely associated with the growth of murine HSCs and determines the proliferative and repopulating capacity of phenotypically defined HSC subsets... - The use of genetically engineered model systems for research on human agingGuenter Lepperdinger
Department of Extracellular Matrix Research, Institute for Biomedical Aging Research, Austria Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
Front Biosci 13:7022-31. 2008..This has led to the identification of candidate genes, which are being tested for their impact on lifespan regulation in yeast, the fruit fly Drosophila melanogaster and the nematode C. elegans...