Research Topics
Genomes and Genes | Gottfried BaierSummaryAffiliation: University of Innsbruck Country: Austria Publications
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Detail Information
Publications
PKCdelta is involved in signal attenuation in CD3+ T cellsThomas Gruber
Department of Medical Biology and Human Genetics, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
Immunol Lett 96:291-3. 2005..These findings suggest that PKCdelta serves a so far unrecognized role in TCR-induced negative regulation of IL-2 cytokine production and T cell proliferation...- Molecular genetics and structural genomics of the human protein kinase C gene moduleKurt Kofler
Institute for Medical Biology and Human Genetics, University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
Genome Biol 3:RESEARCH0014. 2002..In this study we systematically address the genomic locations and gene structures of the human PKC gene module... - The PKC gene module: molecular biosystematics to resolve its T cell functionsGottfried Baier
Institute of Medical Biology and Human Genetics, University of Innsbruck, Austria
Immunol Rev 192:64-79. 2003.... - PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytesThomas Gruber
Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
Mol Immunol 45:117-26. 2008..Together, these data demonstrate that atypical PKCzeta/iota isotypes serve as direct downstream targets of PKCtheta in the signalling pathway leading to NF-kappaB activation in T lymphocytes... - PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytesNatascha Hermann-Kleiter
Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstr 41, A 6020 Innsbruck, Austria
Blood 107:4841-8. 2006..Taken together, this opposite effect between the positive PKCtheta and the negative cAMP/PKA signaling pathways appears rate limiting for NF-AT transactivation and IL-2 secretion responses of CD3(+) T lymphocytes... - Protein kinase C beta is dispensable for TCR-signalingNikolaus Thuille
Department for Medical Biology and Human Genetics, Innsbruck Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
Mol Immunol 41:385-90. 2004..Thus, PKCbeta-deficient T cells had similar physiological thresholds for activation in vitro. These findings suggest that PKCbeta plays a redundant role in TCR-induced regulation of IL-2 cytokine production and T cell proliferation... - Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cellsChrista Pfeifhofer
Institute of Medical Biology and Human Genetics, University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
J Exp Med 197:1525-35. 2003..Our finding suggests that PKCtheta plays a critical and nonredundant role in T cell receptor-induced NFAT activation... - PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytesThomas Gruber
Department of Medical Genetics, Clinical and Molecular Pharmacology, Medical University of Innsbruck, Schopfstrasse 41, A 6020 Innsbruck, Austria
Immunol Lett 132:6-11. 2010..Together, these results reveal a crucial role of PKCtheta in positive selection of thymocytes in a pathway leading to the activation of ERK, AP-1, NFAT, and NFkappaB... - Defective IgG2a/2b class switching in PKC alpha-/- miceChrista Pfeifhofer
Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
J Immunol 176:6004-11. 2006..Our genetic data, thus, define PKCalpha as the physiological and nonredundant PKC isotype in signaling pathways that are necessary for T cell-dependent IFN-gamma production and IgG2a/2b Ab responses... - Protein kinase Cepsilon is dispensable for TCR/CD3-signalingThomas Gruber
Department for Medical Biology and Human Genetics, Medical University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
Mol Immunol 42:305-10. 2005..Thus, PKCepsilon-deficient T-cells had similar physiological thresholds for activation in vitro. This finding suggests that PKCepsilon plays a redundant role in TCR-induced regulation of T-cell proliferation... - AKT1/PKBalpha is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signalingBirgit Bauer
Department of Medical Biology and Human Genetics, University of Innsbruck, Austria
FEBS Lett 541:155-62. 2003.... - Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP)Christina Lutz
Institute for Medical Biology and Human Genetics, the Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria A6020
J Biol Chem 277:43143-51. 2002..Taken together, we here demonstrate that sIgG-LRP protein sequesters activated JNK into the plasma membrane compartment in intact cells, inhibiting nuclear activation of the JNK-dependent transcription factors Elk-1 and cJun... - Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1Karl Maly
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
FEBS Lett 521:205-10. 2002.... - Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners in TCR/CD28 signal integrationBirgit Bauer
Institute for Medical Biology and Human Genetics, University of Innsbruck, Schoepfstr. 41, A-6020 Innsbruck, Austria
Mol Immunol 38:1087-99. 2002..Here, we attempt to summarize the regulation as well as downstream signaling pathways of PKC and AKT/PKB isotypes, that may act additive in TCR/CD28 induced proliferation and survival of peripheral CD4+ T-lymphocytes... - Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylationKonstantina Nika
Program of Inflammation, Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Mol Cell Biol 26:1806-16. 2006..This represents a novel mechanism for the active immune synapse recruitment and activation of a phosphatase in TCR signaling... - Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation"Thomas Gruber
Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Austria
Science 312:55; author reply 55. 2006..Reports, 1 April 2005, p. 114) that the Thr-538 phosphorylation of PKC is regulated by T cell receptor activation. Other mechanisms, such as autophosphorylation of Thr-219, might orchestrate the cellular function of PKC in T cells... - Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase CMartin Villalba
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
J Cell Biol 157:253-63. 2002..These results provide evidence that a nonconventional PI3-K- and Vav-dependent pathway mediates the selective membrane recruitment and, possibly, activation of PKCtheta in T cells... - The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunityNatascha Hermann-Kleiter
Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University Innsbruck, 6020 Innsbruck, Austria
Immunity 29:205-16. 2008..Our study establishes NR2F6 as a transcriptional repressor of IL-17 expression in Th17-differentiated CD4(+) T cells in vitro and in vivo... - The MAGUK family protein CARD11 is essential for lymphocyte activationHiromitsu Hara
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Immunity 18:763-75. 2003..Our results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling... - Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytesNikolaus Thuille
Department for Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
EMBO J 24:3869-80. 2005..We conclude that autophosphorylation of PKCtheta at Thr-219 plays an important role in the correct targeting and cellular function of PKCtheta upon antigen receptor ligation... - Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulationMarina von Essen
Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark
J Immunol 176:7502-10. 2006..Finally, we found that PKCtheta was mainly implicated in down-regulation of directly engaged TCR, whereas PKCalpha was involved in down-regulation of nonengaged TCR... - The immunological synapse: kinases in T cell signalling as potential drug targetsGottfried Baier
Medical University of Innsbruck, Austria
Immunol Lett 105:3-5. 2006..g. asthma, rheumatoid arthritis, multiple sclerosis and transplant rejection)... - 7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathwayChristiane Enzinger
Institute for Medical Chemistry and Biochemistry, Innsbruck, Austria
Eur J Cell Biol 81:197-202. 2002..Results suggest that 7,8-dihydroneopterin-induced apoptosis of T-lymphocytes is mediated by a Bcl-2-sensitive pathway... - Loss of PKC-delta alters cardiac metabolismManuel Mayr
Department of Cardiac and Vascular Sciences, St George s Hospital Medical School, London SW17 0RE, UK
Am J Physiol Heart Circ Physiol 287:H937-45. 2004..The consequences of these metabolic alterations on sensitivity to myocardial ischemia are further explored in the accompanyingpaper (20)...