Research Topics
Genomes and Genes | Johannes A SchmidSummaryAffiliation: Medical University of Vienna Country: Austria Publications
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Publications
IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaBJohannes A Schmid
Center for Biomolecular Medicine and Pharmacology, Medical University Vienna, Austria
Cytokine Growth Factor Rev 19:157-65. 2008....- Evolutions in science triggered by green fluorescent protein (GFP)Johannes A Schmid
Centre for Biomolecular Medicine and Pharmacology, Medical University Vienna, Waehringerstrasse 13a, 1090 Vienna, Austria
Chembiochem 6:1149-56. 2005 - Fluorescent proteins and fluorescence resonance energy transfer (FRET) as tools in signaling researchJohannes A Schmid
Center for Biomolecular Medicine and Pharmacology, Department for Vascular Biology and Thrombosis Research, Medical University of Vienna, Austria
Thromb Haemost 97:378-84. 2007.... - Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosomeLukas Orel
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical Univ of Vienna, Austria
J Cell Mol Med 14:1555-68. 2010..Upon activation of cells with tumour necrosis factor-alpha, the CSN complex dissociates from IKK's allowing full and rapid activation of the NF-kappaB pathway by the concerted action of interacting protein complexes... - Some secrets of fluorescent proteins: distinct bleaching in various mounting fluids and photoactivation of cyan fluorescent proteins at YFP-excitationNaila Malkani
Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria
PLoS ONE 6:e18586. 2011..In the latter case, the quantum physical phenomenon of fluorescence resonance energy transfer (FRET) is exploited by specific microscopy techniques to visualize proximity of proteins... - Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signalingKalsoom Sughra
Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria
PLoS ONE 5:e12683. 2010..Since many NF-kappa B activating pathways converge at the level of IKK2, molecular interactions of this kinase are pivotal for regulation of NF-kappa B signaling... - A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostateAndreas Birbach
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
Genesis 47:757-64. 2009.... - Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor modelAndreas Birbach
Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
Neoplasia 13:692-703. 2011..In conclusion, our data show that loss of smooth muscle and invasiveness of the tumor are not coupled in our model, with inflammation leading to increased tumor size and a dedifferentiated stroma... - Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodiesVladimir M Korkhov
Institute of Pharmacology, Center of Biomolecular Medicine and Pharmacology, Medical University Vienna, Waehringer Strasse 13a, A 1090 Vienna, Austria
J Mol Biol 378:337-52. 2008..Our findings are consistent with a model in which the transmembrane segment of calnexin participates in chaperoning the inter- and intramolecular arrangement of hydrophobic segment in oligomeric proteins... - Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIKAndreas Birbach
Department of Vascular Biology and Thrombosis Research, University of Vienna Medical School and Competence Center Bio Molecular Therapeutics, Schwarzspanierstr 17, 1090 Vienna, Austria
J Cell Sci 117:3615-24. 2004..Thus, subcellular distribution of NIK to different compartments might be a means of regulating the function of this kinase... - Application of spectral imaging microscopy in cytomics and fluorescence resonance energy transfer (FRET) analysisRupert C Ecker
Competence Center BioMolecular Therapeutics, Vienna, Austria
Cytometry A 59:172-81. 2004..Specific signal detection has been a fundamental issue in fluorescence microscopy. In the context of tissue samples, this problem has been even more pronounced, with respect to spectral overlap and autofluorescence... - Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporterHerwig Just
Institute of Pharmacology, University of Vienna Medical School, Währinger Strasse 13a, A 1090 Vienna, Austria
J Biol Chem 279:6650-7. 2004..The currently identified interaction sites drive homophilic interactions. This is consistent with assembly of SERT oligomers in an array-like structure containing multimers of dimers... - Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activationFrank Henkler
Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
J Biol Chem 278:29216-30. 2003.... - GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase betaKarin Ebner
Department of Vascular Biology and Thrombosis Research, University of Vienna, Brunnerstrasse 59, A 1235 Vienna, Austria
Blood 102:192-9. 2003..Further biologic studies using GMCSF-dependent TF-1 cells indicated that GMCSF-triggered activation of NF-kappaB is important for cell survival and proliferation... - Fluorescence resonance energy transfer in the study of cancer pathwaysJohannes A Schmid
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Curr Opin Oncol 15:55-64. 2003..Moreover, it can be exploited to develop sensitive and efficient drug screening systems and to design valuable diagnostic tools... - Direct binding of Nur77/NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNF alpha -induced PAI-1 expressionFlorian Gruber
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
Blood 101:3042-8. 2003..High expression levels of Nur77 and its colocalization with PAI-1 in atherosclerotic tissues indicate that the described mechanism for PAI-1 regulation may also be operative in vivo... - Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasomeMarlies Löscher
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
Biochem J 388:593-603. 2005..Additionally, our results provide the first evidence for a physical link between components of the ubiquitin-proteasome system and the spliceosome... - BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathwaysJinming Yang
Veterans Affairs Medical Center and Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Clin Cancer Res 12:950-60. 2006..Therefore, IKK may serve as a potential target for melanoma therapy... - Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleusAndreas Birbach
Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
J Biol Chem 277:10842-51. 2002..We conclude that NF-kappaB.IkappaB complexes and the upstream signaling kinases NIK and IKK1 shuttle between cytoplasm and nucleus of nonactivated cells and that this process leads to a basal transcriptional activity of NF-kappaB...