Research Topics
Genomes and GenesSpecies | O ReichSummaryAffiliation: Medical University of Graz Country: Austria Publications
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Detail Information
Publications
Polymorphism 1558 C > T in the aromatase gene (CYP19A1) in low-grade endometrial stromal sarcomaO Reich
Department of Obstetrics and Gynecology, Medical University of Graz, Austria
Eur J Gynaecol Oncol 32:626-7. 2011..Polymorphism 1558 C > T in the aromatase gene may represent a high-risk allele with increased local estrogen levels...
p185HER2 overexpression and HER2 oncogene amplification in recurrent vulvar Paget's diseaseOlaf Reich
Department of Obstetrics and Gynecology, Medical University of Graz, Austria
Mod Pathol 18:354-7. 2005..All patients with scores 2 and 3 showed HER2 oncogene amplification. Overexpression of p185Her2 and HER2 oncogene amplification appears to be common in recurrent vulvar Paget's disease...
Estrogen sulfotransferase expression in endometrial stromal sarcomas: an immunohistochemical studyOlaf Reich
Department of Obstetrics and Gynecology, University of Graz, Graz, Austria
Pathol Res Pract 203:85-7. 2007..ESS without EST expression may have increased levels of biologically active estrogen, which explains the tumor progression of this entity and these patients may be at increased risk for recurrences and metastases...
[Is early first intercourse a risk factor for cervical cancer?]O Reich
Klinische Abteilung für Allgemeine Gynäkologie, Geburtshilflich gynäkologische Klinik der Medizinischen Universität Graz, Auenbruggerplatz 14, AT 8036 Graz, Austria
Gynakol Geburtshilfliche Rundsch 45:251-6. 2005..Education appears important to encourage responsible sexual behaviour in young people...
Gonadotropin-releasing hormone receptor expression in endometrial stromal sarcomas: an immunohistochemical studyOlaf Reich
Department of Obstetrics and Gynecology, Medical University of Graz, Austria
Mod Pathol 18:573-6. 2005....
Hormonal therapy of endometrial stromal sarcomaOlaf Reich
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
Curr Opin Oncol 19:347-52. 2007..Low-grade endometrial stromal sarcomas are steroid receptor positive tumors with slow tumor progression and high recurrence rates, which lack established treatment protocols. We present an update on hormonal therapy options...
Why do human papillomavirus infections induce sharply demarcated lesions of the cervix?Olaf Reich
Department of Obstetrics and Gynecology, Medical University Graz, Austria
J Low Genit Tract Dis 12:8-10. 2008..In cervical carcinogenesis, the link between formal pathogenesis apparent as colposcopic and histomorphologic changes and the causal pathogenesis of HPV-induced genetic changes is still missing and an issue for future research...
High levels of xenoestrogens in patients with low-grade endometrial stromal sarcoma--report of two casesO Reich
Department of Obstetrics and Gynecology, Medical University of Graz, Austria
Eur J Gynaecol Oncol 31:105-6. 2010..Endometrial stromal sarcomas (ESS) are rare uterine tumors with unknown etiological risk factors, but estrogen-dependent growth promotion...
DNA cytometry as a first-line method for diagnosis of cervical precancer with respect to clinical behaviourO Reich
Department of Obstetrics and Gynecology, Medical University of Graz, Austria
Eur J Gynaecol Oncol 31:372-4. 2010..The objective of this study was to estimate DNA image cytometry (DNA-ICM) as a first-line diagnostic method for diagnosis of cervical precancer with respect to its clinical behaviour...
Clear cell carcinoma of the uterine cervix: pathology and prognosis in surgically treated stage IB-IIB disease in women not exposed in utero to diethylstilbestrolO Reich
Department of Obstetrics and Gynecology, University of Graz, Auenbruggerplatz 14, Graz, A 8036, Austria
Gynecol Oncol 76:331-5. 2000....
Cervical intraepithelial neoplasia III: long-term outcome after cold-knife conization with clear marginsO Reich
Department of Obstetrics and Gynecology, University of Graz, Graz, Austria
Obstet Gynecol 97:428-30. 2001..To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia or squamous cell carcinoma in situ (CIN III) after cold-knife conization with clear margins...
Prognostic factors in surgically treated stage ib-iib cervical carcinomas with special emphasis on the importance of tumor volumeM Trattner
Department of Obstetrics and Gynecology, St Johann s Hospital, Salzburg, Austria
Gynecol Oncol 82:11-6. 2001..The aim of the study was to analyze the importance of tumor volume as a prognostic factor for overall survival (OS) in surgically treated stage Ib-IIb cervical carcinoma...
Survey of adjuvant hormone therapy in patients after endometrial stromal sarcomaO Reich
Department of Gynecology, Medical University of Graz, Austria
Eur J Gynaecol Oncol 27:150-2. 2006..DISCUSSION: Adjuvant hormonal therapy presently appears to be used predominantly in women with advanced or recurrent endometrial stromal sarcomas but is also a potential option for patients after surgery without residual tumor...
Expression of oestrogen and progesterone receptors in low-grade endometrial stromal sarcomasO Reich
Department of Obstetrics and Gynecology, University of Graz, Austria
Br J Cancer 82:1030-4. 2000..This may have implications for hormone therapy in the management of these tumours. These results suggest that ER and PR should be routinely quantified in LGSSs by immunohistochemical methods...
Microinvasive carcinoma of the cervix: site of first focus of invasionO Reich
Department of Obstetrics and Gynecology, University of Graz, Austria
Obstet Gynecol 97:890-2. 2001..To evaluate the topography of the first invasive focus in microinvasive squamous cell carcinoma of the uterine cervix...
Aromatase expression in low-grade endometrial stromal sarcomas: an immunohistochemical studyOlaf Reich
Department of Obstetrics and Gynecology, University of Graz, Graz, Austria
Mod Pathol 17:104-8. 2004..The high percentage of aromatase positivity in low-grade endometrial stromal sarcomas may have implications in the management of these tumors and offer new treatment modalities such as hormonal therapy with aromatase inhibitors...
Expression of platelet-derived growth factor receptor in low-grade endometrial stromal sarcomas in the absence of activating mutationsB Liegl
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 50:448-52. 2007....
Small-cell carcinoma of the uterus and the vagina: experience with ten patientsEdgar Petru
Department of Obstetrics and Gynecology, University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria
Arch Gynecol Obstet 271:316-9. 2005..Patients tend to develop distant metastasis early and thus are potential candidates for systemic therapy. We reviewed the experience with small-CCs of the uterus and vagina at two Austrian University hospitals...
Recurrent endometrial stromal sarcoma after treatment with high-dose chemotherapy and autologous stem-cell support: A case reportP Klaritsch
Departments of Obstetrics and Gynecology, Medical University of Graz, Austria
Eur J Gynaecol Oncol 27:297-8. 2006..The patient is currently alive and free of disease nine years after the initial diagnosis. Conclusion: Aggressive chemotherapy with autologous stem-cell support seems to be ineffective in patients with ESS...
Are endometrial carcinoma cells disseminated at hysteroscopy functionally viable?G Arikan
Department of Obstetrics and Gynecology, tUniversity of Graz, Auenbruggerplatz 14, Graz, 8036, Austria
Gynecol Oncol 83:221-6. 2001..CONCLUSIONS: Our model suggests that hysteroscopy can cause dissemination of malignant cells into the abdominal cavity from uteri containing endometrial carcinoma and that these cells can be functionally viable and adhere to a matrix...
Lack of specific immunological disease pattern in vulvar lichen sclerosusZeno Földes-Papp
Clinical Immunology and Jean Dausset Laboratory, Medical University of Graz, Auenbruggerplatz 8, A 8036 Graz LKH, Austria
Exp Mol Pathol 79:176-85. 2005..This may be especially true of such diseases as vulvar LS, where local skin scarring might represent a local tissue response secondary to an initial insult by immune or other processes...
CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III)S Regauer
Institute of Pathology, Medical University Graz, Graz, Austria
Histopathology 50:629-35. 2007..Cytokeratin (CK) 17 is a marker for cervical reserve (stem) cells, which give rise to metaplasia. The aim was to determine whether AIM can be reclassified into metaplasia and CIN III based on p16 and CK17 immunohistochemistry...
Early vulvar lichen sclerosus: a histopathological challengeS Regauer
Institute of Pathology, Working Groups of Dermatopathology and Gynaecopathology and Department of Gynaecology and Obstetrics, Medical University Graz, Graz, Austria sigrid
Histopathology 47:340-7. 2005..Recognition and treatment of these early stages of LS may result in longstanding remission. Progression to atrophic stages with their associated morbidity and even to squamous cell carcinoma may be prevented...
Hyperglycemia regulates the glucose-transport system of clonal choriocarcinoma cells in vitro. A potential molecular mechanism contributing to the adjunct effect of glucose in tumor therapyT Hahn
Department of Obstetrics and Gynecology, University of Graz, Austria
Int J Cancer 78:353-60. 1998..We speculate that this mechanism may contribute to the beneficial effects of induced hyperglycemia as an adjuvant in tumor therapy...
Pretreatment hemoglobin, platelet count, and prognosis in endometrial carcinomaK F Tamussino
Department of Obstetrics and Gynecology, University of Graz, Graz, Austria
Int J Gynecol Cancer 11:236-40. 2001..Low hemoglobin was strongly associated with other unfavorable prognostic factors so that it was significant in the univariate but not the multivariate analysis...
Numerical chromosomal aberrations of chromosome 1 and 7 in dysplastic cervical smearsD Pieber
Department of Obstetrics and Gynecology, Karl Franzens University, Auenbruggerplatz 14, A 8036 Graz, Austria
Life Sci 67:671-8. 2000..In contrast, trisomy of chromosome 1 is observed only in high grade dysplasia and may be a marker for pre-malignant lesions...
Endometrial stromal sarcoma--observational evidence of a genetic background?O Reich
Department of Obstetrics and Gynecology, Medical University of Graz, Austria
Eur J Gynaecol Oncol 26:288-90. 2005....
Prognostic significance of preoperative DNA flow cytometry in surgically-treated cervical cancerO Reich
Department of Obstetrics and Gynecology, University of Graz, Austria
Eur J Gynaecol Oncol 24:13-7. 2003..CONCLUSION: DNA ploidy and DNA heterogeneity are of prognostic importance in cervical cancer. DNA flow cytometry may be used preoperatively to identify low-risk and high-risk patients within a given stage...
Cervical intraepithelial neoplasia III: long-term follow-up after cold-knife conization with involved marginsOlaf Reich
Department of Obstetrics and Gynecology, University of Graz, Graz, Austria
Obstet Gynecol 99:193-6. 2002..To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia (CIN) III or squamous carcinoma in situ after cold-knife conization with involved margins...
Vasculitis in lichen sclerosus: an under recognized feature?S Regauer
Institute of Pathology, Medical University of Graz, Graz, Austria
Histopathology 45:237-44. 2004..LS is a skin disease of presumed autoimmune origin. Autoimmune diseases are mediated by lymphocytes which occasionally produce a lymphocytic vasculitis...
Monoclonal gamma-T-cell receptor rearrangement in vulvar lichen sclerosus and squamous cell carcinomasSigrid Regauer
Institute of Pathology and Departmentof Obstetrics and Gynecology, University of Graz, Graz, Austria
Am J Pathol 160:1035-45. 2002..The resulting local immune dysregulation in LS may provide a permissive environment for the development of a SCC...
Multifocal stromal invasion in microinvasive squamous cell carcinoma of the cervix: how to measure and stage these lesionsOlaf Reich
Department of Obstetrics and Gynecology, University of Graz, Austria
Int J Gynecol Pathol 21:416-7. 2002
Parametrial spread of cervical cancer in patients with negative pelvic lymph nodesRaimund Winter
Department of Obstetrics and Gynecology, University of Graz, Graz, Austria
Gynecol Oncol 84:252-7. 2002..We studied the incidence and prognostic implications of parametrial involvement according to tumor volume in a series of cervical cancer patients with negative pelvic lymph nodes...
Recurrent verruciform xanthoma of the vulvaOlaf Reich
Department of Obstetrics and Gynecology, University of Graz, Austria
Int J Gynecol Pathol 23:75-7. 2004..The differential diagnosis includes seborrheic keratosis, verruca simplex, condyloma acuminatum, granular cell myoblastoma, vulvar intraepithelial neoplasia, bowenoid papulosis, erythroplasia of Queyrat, and verrucous carcinoma...
Delivery outcome after cold-knife conization of the uterine cervixPhilipp Klaritsch
Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, Graz, Austria
Gynecol Oncol 103:604-7. 2006..To estimate the risk for preterm delivery and obstetric complications in women with prior cold-knife conization...
Expression of indoleamine 2,3-dioxygenase in carcinoma of human endometrium and uterine cervixPeter Sedlmayr
Institute of Histology and Embryology, Karl Franzens University, Graz, Austria
Adv Exp Med Biol 527:91-5. 2003..On the other hand, IDO as also known to inhibit tumor cell proliferation by tryptophan depletion...
Hormonal treatment with aromatase inhibitors for patients with endometrial stromal sarcomaOlaf Reich
Gynecol Oncol 98:173-4; author reply 174-5. 2005
Grading of malignancy has no clinical relevance in patients with endometrial stromal sarcomaOlaf Reich
Gynecol Oncol 105:277-8; author reply 278-9. 2007
Cytologic diagnosis of low grade endometrial stromal sarcoma by staining for estrogen and progesterone receptorsOlaf Reich
Acta Cytol 46:790-2. 2002
Do drugs that stimulate ovulation increase the risk for endometrial stromal sarcoma?Olaf Reich
Hum Reprod 20:1112; author reply 1112-3. 2005
Is tamoxifen an option for patients with endometrial stromal sarcoma?Olaf Reich
Gynecol Oncol 96:561; author reply 561. 2005
Lymph node metastasis in FIGO stage IA1 cervical cancer?Arnim A Bader
Gynecol Oncol 99:790-1; author reply 791. 2005
Estrogen replacement therapy and tamoxifen are contraindicated in patients with endometrial stromal sarcomaOlaf Reich
Gynecol Oncol 102:413-4; author reply 414. 2006
Heterogeneous gonadotropin-releasing hormone receptor expression in ovarian granulosa cell tumorsOlaf Reich
Gynecol Oncol 102:599-600. 2006
Should lymphadenectomy be performed in patients with endometrial stromal sarcoma?Olaf Reich
Gynecol Oncol 97:982; author reply 982-3. 2005
