Research Topics
Species | Alexander KainzSummaryAffiliation: Medical University of Vienna Country: Austria Publications
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Detail Information
Publications
Impaired metabolism in donor kidney grafts after steroid pretreatmentJulia Wilflingseder
Department of Nephrology KH Elisabethinen, Linz, Austria
Transpl Int 23:796-804. 2010..Potential interventional targeted therapy based on these findings includes peroxisome proliferator-activated receptor agonists or caspase inhibitors...- Impact of UGT2B7 His268Tyr polymorphism on the outcome of adjuvant epirubicin treatment in breast cancerSumit Parmar
Institute of Medical and Laboratory Diagnostics, Elisabethinen Hospital Linz, Fadingerstrasse 1, Linz, 4020, Austria
Breast Cancer Res 13:R57. 2011..The present study aimed to describe the impact of the UGT2B7His268Tyr polymorphism on invasive disease-free survival in breast cancer patients after epirubicin treatment... - Steroid pretreatment of organ donors to prevent postischemic renal allograft failure: a randomized, controlled trialAlexander Kainz
Medical University of Vienna, Vienna, Austria
Ann Intern Med 153:222-30. 2010..Posttransplantation acute renal failure (ARF) occurs in roughly 25% of recipients of organs from deceased donors. Inflammation in the donor organ is associated with risk for ARF... - Association of ESA hypo-responsiveness and haemoglobin variability with mortality in haemodialysis patientsAlexander Kainz
Department of Nephrology, KH Elisabethinen, Linz, Austria
Nephrol Dial Transplant 25:3701-6. 2010..Therefore, we conducted a retrospective cohort study to evaluate ESA responsiveness and haemoglobin variability in association with mortality... - Histogenomics: association of gene expression patterns with histological parameters in kidney biopsiesPaul Perco
Department of Nephrology, Medical University of Vienna, Vienna, Austria
Transplantation 87:290-5. 2009..Several studies investigated the association of histologic scores of donor kidney biopsies obtained before engraftment with posttransplant outcomes. Discrimination and goodness of fit of these scores, however, is low... - Glucose control is associated with patient survival in diabetic patients after renal transplantationFranz Wiesbauer
Department of Cardiology, Medical University of Vienna, Vienna, Austria
Transplantation 89:612-9. 2010..However, in diabetic renal-allograft recipients, the effect of different treatment strategies on outcomes is undetermined... - Calcineurin inhibitor-based immunosuppressive therapy, donor age, and long-term outcome after kidney transplantationGeorg Heinze
Section of Clinical Biometrics, Core Unit for Medical Statistics and Informatics, Medical University Vienna, Vienna, Austria
Transplantation 87:1821-9. 2009..It is unclear whether the choice of maintenance immunosuppression modulates the negative effect of advanced donor age on outcome after renal transplantation... - Gene-expression profiles and age of donor kidney biopsies obtained before transplantation distinguish medium term graft functionAlexander Kainz
Department of Nephrology, KH Elisabethinen Linz, and Medical University of Vienna, Vienna, Austria
Transplantation 83:1048-54. 2007..Donor factors such as age profoundly influence long-term graft function after cadaveric renal transplantation, but the molecular signature of these aspects in the allograft remains unknown... - Molecular biomarker candidates of acute kidney injury in zero-hour renal transplant needle biopsiesReka Korbély
Department of Nephrology, KH Elisabethinen, Linz, Austria
Transpl Int 24:143-9. 2011..The area under the curve of the receiver operating characteristic ranges between 0.75 and 0.83. LCN2 and HAVCR1 gene expression levels in zero-hour biopsies show potential to act as early biomarkers for DGF... - Mycophenolate mofetil use is associated with prolonged graft survival after kidney transplantationAlexander Kainz
Department of Nephrology, KH Elisabethinen, Linz, Austria
Transplantation 88:1095-100. 2009..Mycophenolate mofetil has replaced azathioprine in many transplant centers, but data on hard outcomes such as graft and patient survival are lacking... - Transcriptional response in the unaffected kidney after contralateral hydronephrosis or nephrectomyPeter Hauser
Department of Nephrology, Medical University Vienna, Austria
Kidney Int 68:2497-507. 2005..CONCLUSION: Release of growth inhibition by nephrectomy leads to immediate cell cycle activation after unilateral nephrectomy, whereas UUO kidneys counterbalance filtration failure by activation of several transporters... - Molecular predictors for anaemia after kidney transplantationJulia Wilflingseder
Department of Nephrology, KH Elisabethinen, Linz, Austria
Nephrol Dial Transplant 24:1015-23. 2009..Anaemia of chronic kidney disease is a well-studied comorbidity, but the molecular predictors of post-transplant anaemia remain elusive... - ACE-inhibitor or AT2-antagonist therapy of renal transplant recipients is associated with an increase in serum potassium concentrationsChrista Mitterbauer
Department of Nephrology, KH Elisabethinen, Fadingerstrasse 1, 4010 Linz, Austria
Nephrol Dial Transplant 23:1742-6. 2008..The aim of this study was to investigate the association of ACEI/ARB use and serum potassium levels in renal graft recipients... - Effect of intraportal infusion of tacrolimus on ischaemic reperfusion injury in orthotopic liver transplantation: a randomized controlled trialIvan Kristo
Department of Transplantation, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
Transpl Int 24:912-9. 2011..Intrahepatic administration of tacrolimus did not result in a reduction of AST and ALT within the first week after transplantation... - Mortality in renal transplant recipients given erythropoietins to increase haemoglobin concentration: cohort studyGeorg Heinze
Core Unit of Medical Statistics and Informatics, Medical University of Vienna, 1090 Vienna, Austria
BMJ 339:b4018. 2009..To determine the optimal range of increase in haemoglobin concentration with treatment with erythropoietins that is safe and is not associated with mortality... - Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockadePaul Perco
Department of Nephrology, Medical University of Vienna, Austria
Transpl Int 19:146-57. 2006..These data suggest that T lymphoctes of tolerant mice exhibit a distinct molecular expression profile, which needs to be evaluated in other experimental tolerance models to determine whether it is a universal signature of tolerance... - The association between angiotensin converting enzyme inhibitor or angiotensin receptor blocker use during postischemic acute transplant failure and renal allograft survivalGeorg Heinze
Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Vienna, Austria
Transplantation 82:1441-8. 2006..48 (95% confidence interval: 0.24-0.91, P=0.025). CONCLUSIONS: Use of ACEI/ARB in patients experiencing delayed allograft function was associated with longer actual and functional transplant survival... - Antithymocyte globulin use for treatment of biopsy confirmed acute rejection is associated with prolonged renal allograft survivalAlexander Kainz
Department of Nephrology, Krankenhaus der Elisabethinen, Linz, Austria
Transpl Int 23:64-70. 2010..87-2.77, P = 0.137). These data suggest that rejecting renal allografts treated with ATG exhibit longer graft survival than OKT3 treated transplant kidneys. Causal inference, however, cannot be drawn from this associational study... - Alterations in gene expression in cadaveric vs. live donor kidneys suggest impaired tubular counterbalance of oxidative stress at implantationAlexander Kainz
Department of Nephrology, University of Vienna, Vienna, Austria
Am J Transplant 4:1595-604. 2004..These data suggest that CAD kidneys exhibit a distinctly different set of transcripts in the TI compartment but not in the G compartment when compared with LIV kidneys... - Hemoglobin variability after renal transplantation is associated with mortalityAlexander Kainz
KH Elisabethinen, Linz, Austria
Transpl Int 25:323-7. 2012..11; 1.51-2.94; P<0.001). No association with functional graft loss could be detected (HR: 1.34; 0.93-1.93; P=0.121). These findings suggest that hemoglobin variability is associated with mortality of renal allograft recipients... - Gene expression and biomarkers in renal transplant ischemia reperfusion injuryPaul Perco
Krankenhaus der Elisabethinen, Linz, Austria
Transpl Int 20:2-11. 2007.... - Body mass index modifies the risk of cardiovascular death in proteinuric chronic kidney diseaseRudolf P Obermayr
3rd Medical Department, Donauspital im SMZ OST, Medical Research Society DC Vienna, Medical University Vienna, Vienna, Austria
Nephrol Dial Transplant 24:2421-8. 2009..This study sought to investigate this paradox as well as a possible risk modification by proteinuria on the relationship of BMI with earlier stages of chronic kidney disease (CKD) concerning cardiovascular mortality... - Sodium setpoint and sodium gradient: influence on plasma sodium change and weight gainManfred Hecking
Department of Medicine III, Medical University of Vienna, Austria
Am J Nephrol 33:39-48. 2011..We determined the relationship between setpoint, gradient and pre- to postdialysis PNa change (delta PNa), and studied associations with dialysis-related variables... - Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencingIvelina Mineva
Department of Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria
Cell Stress Chaperones 10:171-84. 2005..The differential expression of alphaB-crystallin and Hsp27-1 indicates functional differences between both proteins... - Analysis of liver function in renal transplant recipients undergoing C2-monitoring for cyclosporineManfred Hecking
Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
Transpl Int 21:223-33. 2008..Collectively, our data emphasize the need for increased awareness toward individual predispositions for CsA-sensitivity...