Research Topics
| Erich HeidenreichSummaryAffiliation: Medical University of Vienna Country: Austria Publications
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Detail Information
Publications
A mutation-promotive role of nucleotide excision repair in cell cycle-arrested cell populations following UV irradiationErich Heidenreich
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, Vienna, Austria
DNA Repair (Amst) 9:96-100. 2010..Thus, the NER pathway, responsible for a normally accurate repair of UV-induced DNA damage, paradoxically is required for the generation and/or fixation of UV-induced frameshift mutations specifically in non-replicating cells...
Adaptive mutation in Saccharomyces cerevisiaeErich Heidenreich
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
Crit Rev Biochem Mol Biol 42:285-311. 2007..This review focuses comprehensively on adaptive mutation in this organism and summarizes our current understanding of this issue...
Non-homologous end joining dependency of gamma-irradiation-induced adaptive frameshift mutation formation in cell cycle-arrested yeast cellsErich Heidenreich
Institute of Cancer Research, Division of Molecular Genetics, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
Mutat Res 556:201-8. 2004..Inaccuracy of the NHEJ repair pathway may extensively contribute to the incidence of frameshift mutations in resting (non-dividing) eukaryotic cells, and thus act as a driving force in tumor development...
The relevance of oxidative stress and cytotoxic DNA lesions for spontaneous mutagenesis in non-replicating yeast cellsFerdinand Steinboeck
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
Mutat Res 688:47-52. 2010..Our results support the hypothesis that (via an active NHEJ DSB repair pathway) the incidence of spontaneous frameshift mutations in a cell cycle-arrested state is considerably governed by oxidative stress...
The nuclear actin-related protein of Saccharomyces cerevisiae, Arp4, directly interacts with the histone acetyltransferase Esa1pFerdinand Steinboeck
Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
J Biochem 141:661-8. 2007..We propose that the interaction of Arp4 with Esa1p is crucial for proper functioning and targeting of the NuA4 complex...
Novel regulatory properties of Saccharomyces cerevisiae Arp4Ferdinand Steinboeck
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, A 1090 Vienna, Austria
J Biochem 139:741-51. 2006..The same effect was observed upon treatment with rapamycin, indicating an unexpected relationship of Arp4 to TOR-mediated cell cycle arrest...
Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cellsErich Heidenreich
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
Mutat Res 593:187-95. 2006....
Polymerase zeta dependency of increased adaptive mutation frequencies in nucleotide excision repair-deficient yeast strainsErich Heidenreich
Division of Molecular Genetics, Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
DNA Repair (Amst) 3:395-402. 2004..Such a hitherto unappreciated activity of polymerase zeta in non-replicating cells may contribute to the incidence of mutations in evolution, aging and cancer...
Starvation for an essential amino acid induces apoptosis and oxidative stress in yeastHerfried Eisler
Division of Molecular Genetics, Institute of Cancer Research, Medical University of Vienna, A-1090 Vienna, Austria
Exp Cell Res 300:345-53. 2004..These results indicate that starvation for an essential amino acid results in severe cell stress, which may finally be the trigger of programmed cell death...
Non-homologous end joining as an important mutagenic process in cell cycle-arrested cellsErich Heidenreich
Division of Molecular Genetics, Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
EMBO J 22:2274-83. 2003..Thus our results provide evidence that G(0) cells with unrepressed NHEJ capacity pay for a large-scale chromosomal stability with an increased frequency of small-scale mutations, a finding of potential relevance for carcinogenesis...
