Heinrich Kovar

Summary

Country: Austria

Publications

  1. ncbi Downstream EWS/FLI1 - upstream Ewing's sarcoma
    Heinrich Kovar
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Zimmermannplatz 10, 1090 Vienna, Austria
    Genome Med 2:8. 2010
  2. ncbi CD133 expression in chemo-resistant Ewing sarcoma cells
    Xiaohua Jiang
    Saban Research Institute, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    BMC Cancer 10:116. 2010
  3. ncbi Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma
    Idriss M Bennani-Baiti
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    Clin Cancer Res 16:3769-78. 2010
  4. ncbi Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro
    Dave N T Aryee
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    Cancer Res 70:4015-23. 2010
  5. ncbi Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial
    Marie Cecile Le Deley
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Zimmermannplatz 10, 1090 Vienna, Austria
    J Clin Oncol 28:1982-8. 2010
  6. ncbi A molecular function map of Ewing's sarcoma
    Maximilian Kauer
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    PLoS ONE 4:e5415. 2009
  7. ncbi EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
    Jozef Ban
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    Cancer Res 68:7100-9. 2008
  8. ncbi EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage
    Jozef Ban
    Children s Cancer Research Institute, Kinderspitalgasse 9, A1190 Vienna, Austria
    Adv Exp Med Biol 587:41-52. 2006
  9. ncbi Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein
    Laura Spahn
    Children s Cancer Research Institute, St Anna Kinderspital, A 1090 Vienna, Austria
    Oncogene 22:6819-29. 2003
  10. ncbi Response of Ewing tumor cells to forced and activated p53 expression
    Heinrich Kovar
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, 1090 Vienna, Austria
    Oncogene 22:3193-204. 2003

Collaborators

  • Dave N T Aryee
  • idriss m. bennani-baiti
  • Pancras Cw Hogendoorn
  • Alan Craft
  • O Oberlin
  • Olivier Delattre
  • Jozef Ban
  • Christine Siligan
  • Laura Spahn
  • Xiaohua Jiang
  • Marie Cecile Le Deley
  • Karl Ludwig Schaefer
  • Maximilian Kauer
  • Christopher Poremba
  • Gunhild Jug
  • Sarka Pospisilova
  • Johannes A Schmid
  • Elizabeth R Lawlor
  • Ynnez Gwye
  • Timothy J Triche
  • Samantha C Brownhill
  • Uta Dirksen
  • Christine Cao
  • Long Hung
  • Andreas Ranft
  • Sue A Burchill
  • Dorothea Douglas
  • Thomas Lion
  • Stelly Ballet
  • Gaelle Pierron
  • Heribert Jurgens
  • Julien Marandet
  • Ian J Lewis
  • Darren Russell
  • Michaela Nesslböck
  • Gabriele Koehler
  • Paul Meltzer
  • Reinhard Kofler
  • Sean Davis
  • Bob Walker
  • Oskar Smrzka
  • Raphaela Schwentner
  • Max Kauer
  • Karin Muehlbacher
  • Karl-Ludwig Schaefer
  • Michael Kreppel
  • Jozet Ban
  • Radostina Bachmaier
  • Robert Petermann

Detail Information

Publications14

  1. ncbi Downstream EWS/FLI1 - upstream Ewing's sarcoma
    Heinrich Kovar
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Zimmermannplatz 10, 1090 Vienna, Austria
    Genome Med 2:8. 2010
    ..Modulation of EWS/FLI1 expression is not only a desirable therapeutic goal, but may also occur under physiological conditions and influence the course of the disease...
  2. ncbi CD133 expression in chemo-resistant Ewing sarcoma cells
    Xiaohua Jiang
    Saban Research Institute, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    BMC Cancer 10:116. 2010
    ..Recently, the cell surface protein CD133 was identified as a putative marker of tumor-initiating cells in ESFT. We evaluated ESFT tumors and cell lines to determine if high levels of CD133 are associated with drug resistance...
  3. ncbi Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma
    Idriss M Bennani-Baiti
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    Clin Cancer Res 16:3769-78. 2010
    ..We tested this premise in Ewing's sarcoma (ES), a highly metastatic cancer of bone and soft tissues that lacks validated molecular metastasis and prognostic indicators...
  4. ncbi Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro
    Dave N T Aryee
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    Cancer Res 70:4015-23. 2010
    ....
  5. ncbi Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial
    Marie Cecile Le Deley
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Zimmermannplatz 10, 1090 Vienna, Austria
    J Clin Oncol 28:1982-8. 2010
    ..10). CONCLUSION In contrast to retrospective studies, the prospective evaluation did not confirm a prognostic benefit for type 1 EWS-FLI1 fusions...
  6. ncbi A molecular function map of Ewing's sarcoma
    Maximilian Kauer
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    PLoS ONE 4:e5415. 2009
    ....
  7. ncbi EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
    Jozef Ban
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria
    Cancer Res 68:7100-9. 2008
    ..Our data link EWS-FLI1 to the NOTCH and p53 pathways and provide a plausible basis both for NOTCH tumor suppressor effects and oncogenesis of cancers that retain wild-type p53...
  8. ncbi EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage
    Jozef Ban
    Children s Cancer Research Institute, Kinderspitalgasse 9, A1190 Vienna, Austria
    Adv Exp Med Biol 587:41-52. 2006
    ..Together, our study represents a first approach to the separation of essential molecular consequences from noise generated by the EWS-FLI1 gene rearrangement in ESFT...
  9. ncbi Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein
    Laura Spahn
    Children s Cancer Research Institute, St Anna Kinderspital, A 1090 Vienna, Austria
    Oncogene 22:6819-29. 2003
    ..Therefore, the functional consequences of homo- and hetero-oligomerization of EWS and EWS-FLI1 proteins remain to be elucidated...
  10. ncbi Response of Ewing tumor cells to forced and activated p53 expression
    Heinrich Kovar
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, 1090 Vienna, Austria
    Oncogene 22:3193-204. 2003
    ..All together, our results demonstrate that despite significant variability in the outcome, cell death or cell cycle arrest, the p53 downstream pathway and the DNA damage signaling pathway are functionally intact in EFT...
  11. ncbi Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway
    Laura Spahn
    Children s Cancer Research Institute, St Anna Kinderspital, 1090 Vienna, Austria
    Cancer Res 62:4583-7. 2002
    ....
  12. ncbi Context matters: the hen or egg problem in Ewing's sarcoma
    Heinrich Kovar
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Semin Cancer Biol 15:189-96. 2005
    ..This article addresses the problem by considering the tissue distribution of FLI1 and ERG expression and by reviewing evidence for combinatorial control of EWS-ets activity...
  13. ncbi Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y
    Sarka Pospisilova
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Mol Cancer Res 2:296-304. 2004
    ..Our results, therefore, show that a p53 mutant may behave differently when tested in its authentic cellular context...
  14. ncbi Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model
    Heinrich Kovar
    Children s Cancer Research Institute, St Anna Kinderspital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Semin Cancer Biol 13:275-81. 2003
    ..In vitro suppression of EWS-FLI1 expression will allow to define the phenotypic characteristics of dormant tumor cells that may give rise to late relapses, enabling improved diagnosis and treatment even of minimal residual disease...