Research Topics
| Dorothea OrthSummaryAffiliation: Innsbruck Medical University Country: Austria Publications
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Detail Information
Publications
Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157 in AustriaDorothea Orth
Austrian Reference Center for Enterohemorrhagic Escherichia coli, Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria
Wien Klin Wochenschr 121:108-12. 2009..Typing methods relying solely on investigation of O157 will detect these strains but should nevertheless also be avoided, so that the prevalent non-O157 strains causing HUS are not missed...- The Shiga toxin genotype rather than the amount of Shiga toxin or the cytotoxicity of Shiga toxin in vitro correlates with the appearance of the hemolytic uremic syndromeDorothea Orth
Austrian Reference Centre for Enterohaemorrhagic Escherichia coli, Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, A 6020 Innsbruck, Austria
Diagn Microbiol Infect Dis 59:235-42. 2007..We hypothesize that the stx genotype and perhaps other yet unknown virulence factors rather than the amount of Stx or the in vitro cytotoxicity correlate with the development of HUS... - Variability in tellurite resistance and the ter gene cluster among Shiga toxin-producing Escherichia coli isolated from humans, animals and foodDorothea Orth
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Austrian Reference Laboratory for Enterohemorrhagic Escherichia coli, Schöpfstr 41, A 6020 Innsbruck, Austria
Res Microbiol 158:105-11. 2007..We conclude that the use of tellurite-containing media in screening for STEC will allow the detection of STEC O26, O111, O145 and non-sorbitol-fermenting O157, but most strains (in this study 74.3%) from other serotypes will be missed... - Emerging Shiga toxin-producing Escherichia coli serotypes in Europe: O100:H- and O127:H40Dorothea Orth
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Austrian Reference Laboratory for EHEC STEC VTEC, Schöpfstr 41, 6020, Innsbruck, Austria
Curr Microbiol 53:428-9. 2006..Non-O157 STEC infections in humans are currently under-diagnosed. This report highlights the need for, and importance of, screening for Shiga toxins or serotypes other than just O157... - Cytolethal distending toxins in Shiga toxin-producing Escherichia coli: alleles, serotype distribution and biological effectsDorothea Orth
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Austrian Reference Laboratory for Enterohaemorrhagic Escherichia coli, Schopfstrasse 41, A 6020 Innsbruck, Austria
J Med Microbiol 55:1487-92. 2006..The data demonstrate that CDT is present in some STEC serotypes only. However, more studies are required to evaluate whether CDT presence is associated with severe disease... - EspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3/C3b and C5Dorothea Orth
Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
Infect Immun 78:4294-301. 2010..Downregulation of complement by EspP in vivo may influence the colonization of EHEC bacteria in the gut or the disease severity of HUS... - Prevalence, structure and expression of urease genes in Shiga toxin-producing Escherichia coli from humans and the environmentDorothea Orth
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Austrian Reference Laboratory for Enterohaemorrhagic E coli, Schöpfstr 41, 6020 Innsbruck, Austria
Int J Hyg Environ Health 209:513-20. 2006.... - Prevention and treatment of enterohemorrhagic Escherichia coli infections in humansDorothea Orth
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Austrian Reference Centre for Enterohaemorrhagic Escherichia coli, Schöpfstr 41, A 6020 Innsbruck, Austria
Expert Rev Anti Infect Ther 6:101-8. 2008..These approaches have been demonstrated to be effective in animal models but clinical trials are lacking... - Serine protease espP subtype alpha, but not beta or gamma, of Shiga toxin-producing Escherichia coli is associated with highly pathogenic serogroupsAbdul Basit Khan
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University and Austrian Reference Centre for Enterohaemorrhagic Escherichia coli, Schöpfstr 41, A 6020 Innsbruck, Austria
Int J Med Microbiol 299:247-54. 2009..Regarding the espP subtypes, only subtype alpha, but not beta and gamma, were found in HUS patients. Moreover, we could demonstrate that espP, and in particular subtype alpha, is associated with highly pathogenic serogroups... - Shiga toxin activates complement and binds factor H: evidence for an active role of complement in hemolytic uremic syndromeDorothea Orth
Department of Hygiene, Innsbruck Medical University and Austrian Reference Centre for Enterohaemorrhagic Escherichia coli, Innsbruck, Austria
J Immunol 182:6394-400. 2009..e., to regions involved in the surface recognition function of FH. In conclusion, complement, and in particular FH, not only plays an important role in atypical HUS, but most probably also in EHEC-induced HUS... - Tetracycline-resistant Escherichia coli strains are inherited from parents and persist in the infant's intestines in the absence of selective pressureMartina Prelog
Department of Pediatrics, Medical University Innsbruck, A 6020 Innsbruck, Austria
Eur J Pediatr 168:1181-7. 2009..Therefore, the persistence of resistant E. coli and their possible capacity to cause symptomatic infection or transfer its resistance genes to other bacteria deserves more attention... - Comparison of an immunochromatographic rapid test with enzyme-linked immunosorbent assay and polymerase chain reaction for the detection of Shiga toxins from human stool samplesKatharina Grif
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Austrian Reference Centre for Enterohemorrhagic Escherichia coli, A 6020 Innsbruck, Austria
Diagn Microbiol Infect Dis 59:97-9. 2007..The Duopath-test showed a lower sensitivity and specificity... - Complement in typical hemolytic uremic syndromeDorothea Orth
Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria
Semin Thromb Hemost 36:620-4. 2010..First, it activates complement, and second, it delays the functions of its control protein factor H on the cell surface, both known to damage the kidney... - Serological evidence for tick-borne encephalitis, borreliosis, and human granulocytic anaplasmosis in MongoliaGernot Walder
Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
Int J Med Microbiol 296:69-75. 2006..Seroprevalence against A. phagocytophilum was 2.3% in Selenge province, 5.6% in Bulgan province, 2.8% in Dornogov province, and 3.0% in Tov province and Ulaanbaatar. We conclude that all three pathogens are endemic in Mongolia... - Diminished response to tick-borne encephalitis vaccination in thymectomized childrenMartina Prelog
Department of Pediatrics I, Medical University Innsbruck, Innsbruck, Austria
Vaccine 26:595-600. 2008..These changes in T cell subsets and the decreased ability to respond to new antigens in thymectomized children, as observed here, may precede more striking effects such as higher infection rates or autoimmune conditions as they age... - Emergence of VIM-1-carbapenemase-producing Enterobacter cloacae in Tyrol, AustriaIngrid Heller
Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Schöpfstr 41 2, 6020 Innsbruck, Austria
J Med Microbiol 61:567-71. 2012..These findings demonstrate the emergence of VIM-1-producing Enterobacter in Tyrol, western Austria. The clonal relationship confirms the risk of spread of these organisms and their possible persistence over time... - Bactobilia after liver transplantation: frequency and antibiotic susceptibilityGunda Millonig
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria
Liver Transpl 12:747-53. 2006..In our cohort we had the best antibiotic susceptibility results for positive cultures in LT patients with piperacillin/tazobactam, ciprofloxacin, or amoxycillin/clavulanic acid... - What makes an enterohemorrhagic Escherichia coli?Dorothea Orth
Clin Infect Dis 43:1168-9. 2006