Research Topics
| A C HurtSummaryAffiliation: WHO Collaborating Centre for Reference and Research on Influenza Country: Australia Publications
| Collaborators
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Detail Information
Publications
Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 virusesAeron C Hurt
WHO Collaborating Centre for Reference and Research on Infl uenza, Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn St, North Melbourne, 3051 Victoria, Australia
Emerg Infect Dis 18:109-12. 2012..Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity...- Performance of six influenza rapid tests in detecting human influenza in clinical specimensAeron C Hurt
World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
J Clin Virol 39:132-5. 2007..The rapid tests have also been used to detect outbreaks in institutions and may play a role in pandemic influenza control... - Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South AfricaAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, Victoria, Australia
Antiviral Res 83:90-3. 2009..The mutation had no impact on zanamivir susceptibility. Ongoing surveillance is essential to monitor how these strains may spread or persist in the future and to evaluate the effectiveness of treatments against them... - Zanamivir-resistant influenza viruses with a novel neuraminidase mutationAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
J Virol 83:10366-73. 2009..Compared to susceptible influenza A (H1N1) viruses, the Q136K mutant strains displayed greater viral fitness than the wild-type virus in MDCK cells but equivalent infectivity and transmissibility in a ferret model... - In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza virusesAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
Antimicrob Agents Chemother 53:4433-40. 2009..This study identified the mutations that can arise in A(H5N1) under either oseltamivir or zanamivir selective pressure and the potential for dual neuraminidase mutations to result in dramatically reduced drug susceptibility... - Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza virusesAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Victoria, Australia
Drugs 69:2523-31. 2009.... - Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret modelAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria 3051, Australia
Antiviral Res 87:361-6. 2010..Further animal studies and human clinical trials are necessary to optimize neuraminidase inhibitor dosing strategies for the treatment of influenza A(H5N1) infections... - Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures modelAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
J Virol 84:9427-38. 2010..Our statistical inferences are essential for the development of the next generation of mathematical models of the emergence and spread of oseltamivir-resistant influenza in human populations... - Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 InfluenzaAeron C Hurt
World Health Organization WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Vic, Australia
N Engl J Med 365:2541-2. 2011..Community circulation of an oseltamivir-resistant strain of the novel pandemic influenza A (H1N1) virus has been identified in Australia... - Resistance to anti-influenza drugs: adamantanes and neuraminidase inhibitorsAeron C Hurt
World Health Organization Collaborating Centre for Reference and Research on Influenza, Monash University, School of Applied Sciences, 45 Poplar Road, Parkville, Victoria 3052, Australia
Expert Rev Anti Infect Ther 4:795-805. 2006..In this review, resistance to the adamantanes and neuraminidase inhibitors will be discussed in relation to both epidemic and pandemic influenza viruses... - Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanesA C Hurt
World Health Organisation Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
Antiviral Res 73:228-31. 2007..These results support the use of neuraminidase inhibitors as the most appropriate class of antiviral drug to prevent or treat human A(H5N1) virus infections... - Neuraminidase inhibitor-resistant and -sensitive influenza B viruses isolated from an untreated human patientAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, Victoria 3052, Australia
Antimicrob Agents Chemother 50:1872-4. 2006..Here, we describe the analysis of a mixed viral population that contained a novel D197E amino acid substitution that was responsible for this reduction... - Isolation of avian influenza viruses from two different transhemispheric migratory shorebird species in AustraliaA C Hurt
World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Australia
Arch Virol 151:2301-9. 2006..No H5N1 viruses were detected. All isolated viruses were non-pathogenic in domestic chickens. These results further demonstrate the potential for migratory shorebirds to carry and potentially spread influenza viruses... - Adamantane resistance in influenza A(H1) viruses increased in 2007 in South East Asia but decreased in Australia and some other countriesI G Barr
WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Melbourne, Victoria, Australia
Antiviral Res 80:200-5. 2008.... - Increased adamantane resistance in influenza A(H3) viruses in Australia and neighbouring countries in 2005I G Barr
WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne 3052, Australia
Antiviral Res 73:112-7. 2007..In this study we analysed recent human influenza A strains isolated in Australia and regionally for evidence of resistance to adamantanes and found evidence of significant resistant emerging during 2005... - The emergence of adamantane resistance in influenza A(H1) viruses in Australia and regionally in 2006I G Barr
WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Melbourne 3052, Australia
Antiviral Res 75:173-6. 2007..8% of the 2006 viruses had a resistant genotype. By comparison, 58.6% of influenza A(H3) viruses isolated in 2006 that were tested at the Centre, had a resistant genotype... - Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivirAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, VIC 3052, Australia
Antiviral Res 62:37-45. 2004.... - Surveillance for neuraminidase inhibitor resistance in human influenza viruses from AustraliaAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia
Commun Dis Intell 27:542-7. 2003.... - Identification of a human influenza type B strain with reduced sensitivity to neuraminidase inhibitor drugsAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Melbourne, VIC 3052, Australia
Virus Res 103:205-11. 2004..Further investigations are in progress to identify the basis for this reduced sensitivity... - An influenza A(H3) reassortant was epidemic in Australia and New Zealand in 2003I G Barr
WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria, Australia
J Med Virol 76:391-7. 2005..This was suggestive of the re-introduction of influenza A(H3) from other countries, however, there was still low level circulation of the reassortant virus in 2004 with isolates detected in Australia and Singapore... - A novel means of identifying the neuraminidase type of currently circulating human A(H1) influenza virusesAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, Melbourne, VIC 3052, Australia
Virus Res 103:79-83. 2004..5% for the identification of neuraminidase type N1 or N2. This assay enables a large number of influenza A viruses to be screened at low cost to determine relative levels of A(H1N2) or A(H1N1) viruses circulating in the population... - In vitro generation and characterisation of an influenza B variant with reduced sensitivity to neuraminidase inhibitorsAi Lee Cheam
World Health Organisation Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, Victoria 3052, Australia
Antiviral Res 63:177-81. 2004..Tissue culture assays demonstrated that the HA mutation caused a seven-fold reduction in sensitivity to oseltamivir carboxylate, and a 90-fold reduction in sensitivity to zanamivir... - Neuraminidase inhibitor drug susceptibility differs between influenza N1 and N2 neuraminidase following mutagenesis of two conserved residuesHui Ting Ho
World Health Organisation Collaborating Centre for Reference and Research on Influenza, Parkville, Vic, Australia
Antiviral Res 76:263-6. 2007..This study confirmed the essential role of NA active site residues in viral fitness, and identified clear differences in the role of residues E227 and E276 in NA inhibitor resistance with N1 and N2 neuraminidases... - Genetic analysis of two influenza A (H1) swine viruses isolated from humans in Thailand and the PhilippinesN Komadina
WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Rd, Parkville, VIC 3052, Australia
Virus Genes 35:161-5. 2007.... - Circulation and antigenic drift in human influenza B viruses in SE Asia and Oceania since 2000Ian G Barr
WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria
Commun Dis Intell 30:350-7. 2006..This is an important consideration for influenza vaccine formulation decisions, as only one influenza B component is traditionally included in the annual trivalent influenza vaccine... - A comparison of a rapid test for influenza with laboratory-based diagnosis in a paediatric populationRobert Alexander
Royal Children's Hospital, Parkville, Victoria
Commun Dis Intell 29:272-6. 2005.... - Influenza viruses with reduced sensitivity to the neuraminidase inhibitor drugs in untreated young childrenAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, Parkville, Victoria
Commun Dis Intell 32:57-62. 2008..Given these results it may be important to enhance neuraminidase inhibitor susceptibility testing of viruses from patients in the less than two years cohort... - Performance of influenza rapid point-of-care tests in the detection of swine lineage A(H1N1) influenza virusesAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria, Australia
Influenza Other Respi Viruses 3:171-6. 2009..In April 2009, an A(H1N1) influenza virus of swine lineage was detected in humans in the USA, and in just over a month has infected over 10,000 people in more than 40 countries... - The global circulation of seasonal influenza A (H3N2) virusesColin A Russell
Department of Zoology, University of Cambridge, Cambridge, UK
Science 320:340-6. 2008.... - Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)Nadezhda E Yun
Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
Virology 374:198-209. 2008..A single intramuscular peramivir injection protected mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets...