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Genomes and GenesSpecies | P L ThompsonSummaryAffiliation: Western Australia Country: Australia Publications
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Publications
Under-ascertainment of Aboriginality in records of cardiovascular disease in hospital morbidity and mortality data in Western Australia: a record linkage studyTom G Briffa
University of Western Australia, Crawley, Australia
BMC Med Res Methodol 10:111. 2010..We estimated the under-ascertainment of Aboriginal status in linked morbidity and mortality databases in patients hospitalised with cardiovascular disease...- Cardiovascular risk among urban Aboriginal peoplePeter L Thompson
Western Australian Heart Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA
Med J Aust 179:143-6. 2003..To describe the results of a program for detecting high cardiovascular risk in an urban Aboriginal community... - Effect of pravastatin compared with placebo initiated within 24 hours of onset of acute myocardial infarction or unstable angina: the Pravastatin in Acute Coronary Treatment (PACT) trialPeter L Thompson
Department of Cardiovascular Medicine, Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia
Am Heart J 148:e2. 2004..The efficacy of statin drugs after an acute coronary event is now well established, but the evidence for statin use in the early treatment of acute coronary events remains unclear... - Clinical relevance of statins: instituting treatment early in acute coronary syndrome patientsP L Thompson
Departments of Medicine and Public Health, University of Western Australia, Department of Cardiovascular Medicine, Sir Charles Gairdner Hospital, 4th Floor, G Block, Nedlands, Perth, WA 6009, Australia
Atheroscler Suppl 2:15-9. 2001..The largest of these is the Australian Pravastatin Acute Coronary Treatment (PACT) study, which will compare early outcomes in patients treated with pravastatin versus placebo prescribed within the first 24 h of an acute coronary event... - Determinants of carotid intima-medial thickness in an urban Australian Aboriginal populationPamela J Bradshaw
School of Population Health University of Western Australia, Nedlands, WA 6009, Australia
Atherosclerosis 192:218-23. 2007..We studied the determinants of carotid atherosclerosis in urban-dwelling Australian Aboriginals at high risk of atherosclerotic mortality and morbidity... - Polymorphisms in the angiotensinogen gene are associated with carotid intimal-medial thickening in females from a community-based populationC M Chapman
Clinical Biochemistry, PathCentre, Locked Bag 2009, 6909, Nedlands, Australia
Atherosclerosis 159:209-17. 2001..We investigated the association of polymorphisms in the angiotensinogen (AGT) and angiotensin II receptor type 1 (AGTR1) genes with increased intima-media thickness (IMT) and the presence of plaques in carotid arteries... - Antioxidant vitamins and the risk of carotid atherosclerosis. The Perth Carotid Ultrasound Disease Assessment study (CUDAS)B M McQuillan
Gairdner Campus of the Heart Research Institute of Western Australia, Western, Nedlands, Perth, Australia
J Am Coll Cardiol 38:1788-94. 2001..No benefit was demonstrated for supplemental antioxidant vitamin use... - The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart diseaseP A McCaskie
Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, Perth, Western Australia
Clin Genet 70:114-21. 2006..19-0.78, p = 0.008). These findings replicate those of previous studies in three independent populations and suggest that the genetic determinants of CHD are complex and cannot be entirely explained through intermediate phenotypes... - Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesityJ Hung
Sir Charles Gairdner Hospital Campus of the Heart Research Institute of Western Australia, Perth, Western Australia, Australia
Int J Obes (Lond) 32:772-9. 2008..We examined whether the relationship between adiponectin and inflammatory markers, insulin resistance and MetS was independent of obesity... - The apolipoprotein AII rs5082 variant is associated with reduced risk of coronary artery disease in an Australian male populationJing Xiao
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Australia
Atherosclerosis 199:333-9. 2008..We conclude that the APOAII rs5082 polymorphism appears to be cardioprotective in this representative Caucasian Australian population... - Interleukin-18 levels are not associated with subclinical carotid atherosclerosis in a community population. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)Caroline M L Chapman
Clinical Biochemistry, PathWest, QEII Medical Centre, Perth, WA, Australia
Atherosclerosis 189:414-9. 2006..05). In a cross-sectional community population, IL-18 levels were related to traditional risk factors and inflammatory markers but were not independently associated with subclinical carotid atherosclerosis... - Promoter polymorphism of the gene for CD14 receptor is not associated with sub-clinical carotid atherosclerosis in a community populationJoseph Hung
Sir Charles Gairdner Hospital Unit of the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
Eur J Cardiovasc Prev Rehabil 11:344-9. 2004..We examined if this polymorphism was associated with sub-clinical carotid atherosclerosis in a community population... - Serum ferritin and C282Y mutation of the hemochromatosis gene as predictors of asymptomatic carotid atherosclerosis in a community populationE Rossi
Department of Clinical Biochemistry, PathCentre, Queen Elizabeth II Medical Centre, Nedlands, Western Australia
Stroke 31:3015-20. 2000..The purpose of the study was to test whether either is a risk predictor for asymptomatic carotid atherosclerosis... - Preventing recurrent events long term after coronary artery bypass graft: suboptimal use of medications in a population studyPamela J Bradshaw
School of Population Health, University of Western Australia, Perth, Australia
Am Heart J 147:1047-53. 2004..We assessed the prevalence and correlates of pharmacotherapy for prevention of new cardiac events in a large population-based series... - Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening: results from the Perth Carotid Ultrasound Disease Assessment Study (CUDAS)John P Beilby
PathCentre, Western Australian Centre for Pathology and Medical Research, Clinical Biochemistry, Nedlands, Western Australia, Australia
Stroke 34:869-74. 2003.... - Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community populationCaroline M L Chapman
Clinical Biochemistry, Western Australian Centre for Pathology and Medical Research, Western Australia, Perth, Australia
Eur Heart J 24:1494-9. 2003..We examined the association of a common functional variant in the IL-6 gene with carotid intimal-medial wall thickness (IMT) and the presence of plaques in a randomly selected, cross-sectional Australian population... - Early initiation of statin therapy after a coronary eventBarry McKeown
Department of Cardiovascular Medicine and Heart Research Institute, Sir Charles Gairdner Hospital, and West Australian Institute of Medical Research, Nedlands, Perth
Curr Opin Lipidol 13:631-5. 2002..Recent observational studies and randomized trials have addressed some of the questions regarding early initiation of statins in acute coronary syndromes... - Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community populationJohn P Beilby
Clinical Biochemistry, Western Australian Centre for Pathology and Medical Research PathCentre and School of Surgery and Pathology, University of Western Australia, Perth, Western Australia
J Hypertens 23:537-42. 2005..Stromelysin-1 gene expression is partly regulated by a common polymorphism in the promoter region of either five or six consecutive adenosine bases (5A/6A)... - Role of coronary interventional procedures in improved postinfarction survival in the 1990sC Blanton
Department of Medicine, University of Western Australia, Western Perth, Australia
Am J Cardiol 87:832-7. 2001.... - Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular diseaseSteven Wiltshire
Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, Australia
Hum Genet 123:307-13. 2008..In conclusion, we found no robust evidence for the associations between K198N and hypertension, systolic blood pressure or HDL levels seen in previous studies... - 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thicknessPamela A McCaskie
Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
Hum Genet 123:445-53. 2008..This study is novel as it is the first to examine the association between 15-lipoxygenase polymorphisms and atherosclerotic indicators. These findings suggest a possible role of ALOX15 polymorphisms in focal plaque formation... - Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart diseasePamela A McCaskie
Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Nedlands, WA, 6009, Australia
Hum Genet 121:401-11. 2007..These results suggest that raising HDL-C via CETP inhibition may not alter risk of CHD. Randomized control trials are needed to determine whether CETP inhibition will in reality reduce risk of CHD by raising HDL-C... - Effect of colchicine (0.5 mg twice daily) on high-sensitivity C-reactive protein independent of aspirin and atorvastatin in patients with stable coronary artery diseaseMark Nidorf
West Australian Heart Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
Am J Cardiol 99:805-7. 2007..Additional controlled studies are warranted to confirm this observation and determine whether long-term use of low-dose colchicine can improve clinical outcomes in patients with advanced vascular disease... - Mortality and recurrent cardiac events after coronary artery bypass graft: long term outcomes in a population studyP J Bradshaw
School of Population Health, University of Western Australia, Western Australia, Australia
Heart 88:488-94. 2002..To determine 30 day mortality, long term survival, and recurrent cardiac events after coronary artery bypass graft (CABG) in a population... - A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesityM M Swarbrick
Department of Clinical Biochemistry, PathCentre, Nedlands, Western Australia 6009, Australia
Eur J Endocrinol 144:277-82. 2001..The aim of this investigation was to determine whether a PPAR gamma 2 Pro12Ala polymorphism was associated with cardiovascular risk factors (obesity, blood pressure, diabetes and blood lipids) in Western Australian Caucasians (n=663)... - Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistanceJoseph Hung
Sir Charles Gairdner Hospital Campus of the Heart Research Institute of Western Australia, and School of Medicine and Pharmacology, University of Western Australia, Nedlands, Perth
Arterioscler Thromb Vasc Biol 25:1268-73. 2005..We sought to determine whether an elevated IL-18 concentration was a risk predictor for metabolic syndrome in a community population independent of obesity and hyperinsulinemia... - Erectile dysfunction predicts generalised cardiovascular disease: evidence from a case-control studyBronwyn G A Stuckey
Keogh Institute for Medical Research, Nedlands, WA, Australia
Atherosclerosis 194:458-64. 2007..To determine whether idiopathic erectile dysfunction, in the absence of overt cardiovascular disease or cardiovascular risk factors, is associated with vascular or autonomic dysfunction... - Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease populationKim W Carter
Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, WA, Australia
Hum Genet 124:199-206. 2008.... - Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunctionGerard T Chew
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Diabetes Care 31:1502-9. 2008..To investigate the effects of fenofibrate and coenzyme Q(10) (CoQ) on diastolic function, ambulatory blood pressure (ABP), and heart rate (HR) in type 2 diabetic subjects with left ventricular diastolic dysfunction (LVDD)... - Coronary heart disease events in Aboriginal Australians: incidence in an urban populationPamela J Bradshaw
School of Population Health, University of Western Australia, Perth, WA, Australia
Med J Aust 190:583-6. 2009..To determine the incidence of coronary heart disease (CHD) events in an urban Aboriginal population... - Patient delay in responding to symptoms of possible heart attack: can we reduce time to care?Judith C Finn
Centre for Nursing Research, Sir Charles Gairdner Hospital, and School of Population Health, University of Western Australia, Perth, WA, Australia
Med J Aust 187:293-8. 2007..The National Heart Foundation of Australia proposes a comprehensive strategy to incorporate this approach into its future campaigns to reduce patient delay for suspected heart attack... - Measuring the gap: accuracy of the Western Australian hospital morbidity data in the identification of adult urban Aboriginal and Torres Strait Islander peoplePamela J Bradshaw
School of Population Health, University of Western Australia, Australia
Aust N Z J Public Health 33:276-9. 2009..To assess the sensitivity of the recording of Aboriginality in the Western Australia Linked Data... - Return to work after coronary artery bypass surgery in a population of long-term survivorsPamela J Bradshaw
School of Population Health, The University of Western Australia, M431, 35 Stirling Highway, Crawley, WA 6009, Australia
Heart Lung Circ 14:191-6. 2005..Return to paid employment may be facilitated by coronary artery bypass graft (CABG) surgery. We assessed work status in a population-based study of long-term outcomes of CABG... - Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery diseaseBrenda L Powell
Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Perth, Australia
Hum Genet 124:263-70. 2008..There were significant effects of the variant on mean IMT and risk of CAD. A role for PARL in metabolic conditions cannot be excluded and more comprehensive genetic studies are warranted... - Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjectsRichard J Woodman
School of Medicine and Pharmacology, University of Western Australia, West Australian Institute of Medical Research, GPO Box X2213, Perth, WA 6847, Australia
Clin Sci (Lond) 106:353-8. 2004..7 +/- 0.5%; P = 0.17 compared with placebo). In healthy subjects with hyperhomocysteinaemia, but without additional cardiovascular risk, endothelial function is unimpaired and folic acid supplementation has no additional effect... - Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosisCaroline M L Chapman
Clinical Biochemistry, Western Australian Centre for Pathology and Medical Research, Perth, Western Australia
Stroke 35:1619-24. 2004..Monocyte count may represent an inexpensive, easy-to-measure risk marker for subclinical carotid atherosclerosis... - Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE)Prakash Deedwania
UCSF School of Medicine, San Francisco, Calif, USA
Circulation 115:700-7. 2007..However, no studies to date have assessed intensive versus moderate statin therapy in older patients with stable coronary syndromes... - Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trialsMatthias Briel
Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
JAMA 295:2046-56. 2006..CONCLUSION: Based on available evidence, initiation of statin therapy within 14 days following onset of ACS does not reduce death, MI, or stroke up to 4 months... - Sex in the CCU: women with non-ST-segment elevation acute coronary syndrome may do no worse despite less interventionPamela J Bradshaw
Heart 93:1327-8. 2007 - Asymptomatic long-term survivors of coronary artery bypass surgery enjoy a quality of life equal to the general populationPamela J Bradshaw
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Am Heart J 151:537-44. 2006..Health-related quality of life (HRQOL) among long-term survivors of coronary artery bypass surgery is an important outcome that has been little studied at the population level...