Research Topics
Species | Catherine M SuterSummaryAffiliation: Victor Chang Cardiac Research Institute Country: Australia Publications
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Publications
Paramutation: the tip of an epigenetic iceberg?Catherine M Suter
Victor Chang Cardiac Research Institute, 405 Liverpool St, Darlinghurst, Sydney, NSW 2010, Australia
Trends Genet 26:9-14. 2010..When viewed in this context, paramutation is only one aspect of a common and broadly distributed form of inheritance based on epigenetic states...- CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementationJennifer E Cropley
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
PLoS ONE 5:e9055. 2010..Phenotypic variation between A(vy) mice indicates that the epigenetic state of the IAP is unstable in the germline... - Inheritance of a cancer-associated MLH1 germ-line epimutationMegan P Hitchins
Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
N Engl J Med 356:697-705. 2007..These findings demonstrate a novel pattern of inheritance of cancer susceptibility and are consistent with transgenerational epigenetic inheritance... - A sustained dietary change increases epigenetic variation in isogenic miceCheryl C Y Li
Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, Australia
PLoS Genet 7:e1001380. 2011..This finding presents the possibility that epigenetic variation within populations can be induced by environmental change, providing a vehicle for disease predisposition and possibly a substrate for natural selection... - Germline epimutation in humansJennifer E Cropley
Molecular Genetics Division, Victor Chang Cardiac Research Institute, Sydney, Australia
Pharmacogenomics 9:1861-8. 2008..In this article, we will review the recent findings with germline epimutation at the tumor suppressor gene MLH1, discuss the possible etiology of this phenomenon, and the implications of germline epimutation in humans... - Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancerMegan P Hitchins
Department of Medical Oncology, St Vincent s Hospital, Victoria Street, Darlinghurst, New South Wales 2010, Australia
Cancer Res 67:9107-16. 2007..Simultaneous epigenetic silencing of this cluster of 3p22 genes may contribute to the development or progression of this type of cancer... - Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcriptionLaura J Ng
Victor Chang Cardiac Research Institute, Darlinghurst 2010, Australia
Nucleic Acids Res 37:1152-9. 2009.... - Germ-line epigenetic modification of the murine A vy allele by nutritional supplementationJennifer E Cropley
Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst 2010, Sydney, Australia
Proc Natl Acad Sci U S A 103:17308-12. 2006..Although other reports have suggested such heritable epigenetic changes, this study demonstrates that a specific mammalian gene can be subjected to germ-line epigenetic change... - Germline epimutation: A basis for epigenetic disease in humansDavid I K Martin
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
Ann N Y Acad Sci 1054:68-77. 2005..The application of this principle to the thalassemias is discussed... - Epigenetic programming by maternal nutrition: shaping future generationsCheryl Chui Ying Li
Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool Street, Darlinghurst, NSW 2010, Australia
Epigenomics 2:539-49. 2010..Here, we discuss epigenetics as a mediator of disease risk in response to nutritional cues. The potential for maternal nutrition to heritably alter epigenetic states may have implications for population health and adaptive evolution...