Research Topics
Species | John J ZaundersSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivoPaul R Gorry
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Retrovirology 4:66. 2007....- Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stagesJing Qin Wu
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
Retrovirology 4:83. 2007.... - Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infectionJohn J Zaunders
Centre for Immunology, St Vincent s Hospital, and University of New South Wales, Sydney, Australia
Blood 103:2238-47. 2004..Moreover, expression of CCR5 may render them particularly susceptible to cytopathic effects during progressive HIV-1 infection... - CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cellsJohn J Zaunders
Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
J Virol 80:10151-61. 2006..The current study provides important information on the differentiation of IL-2+ vaccinia virus-specific memory cells, allowing further study of antiviral effector CD4+ T cells in healthy adults and their dysfunction in HIV-1 infection... - Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infectionJohn J Zaunders
Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
J Virol 80:10162-72. 2006..Taken together, the loss of HIV-specific CD4+ T cells is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in GALT, and a high expression of the inhibitory receptor CTLA-4... - Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infectionJohn J Zaunders
Centre for Immunology, St Vincent s Hospital, Victoria St, Darlinghurst, NSW 2010 Australia
Blood 106:1660-7. 2005..These results suggest that the antiviral response to HIV-1 infection includes highly activated CCR5(+)CD4(+) cytotoxic effector cells, which are susceptible to both apoptosis and cytopathic infection with HIV-1, and rapidly decline... - Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytesJ J Zaunders
Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
AIDS Res Hum Retroviruses 15:1519-27. 1999.... - Increased turnover of CCR5+ and redistribution of CCR5- CD4 T lymphocytes during primary human immunodeficiency virus type 1 infectionJ J Zaunders
Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
J Infect Dis 183:736-43. 2001..In contrast, in acute EBV infection, proliferating CCR5+ CD4 T cells accumulated to very high levels, suggesting they have an important role in the early antiviral response, which may be impaired in HIV-1 infection... - High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)John J Zaunders
Centre for Immunology, St Vincent s Hospital, Sydney, New South Wales, Australia
J Immunol 183:2827-36. 2009..In addition to revealing the true extent of Ag-specific human CD4(+) memory T lymphocytes, its greatest use will be as a simple in vitro monitor of CD4(+) T cell responses to Ags such as tuberculosis infection or vaccines... - Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremiaJ J Zaunders
Centre for Immunology, St Vincent s Hospital, UNSW, Darlinghurst, Australia 2010 Australia
J Infect Dis 180:320-9. 1999..The persistence of HIV-1 DNA together with increased CD8 T lymphocyte turnover and activation indicate continued expression of viral antigens... - Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infectionWayne B Dyer
Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia
Retrovirology 5:112. 2008..We examined the mechanisms that differentiated delayed progressors from LTNP in this cohort... - A culture amplified multi-parametric intracellular cytokine assay (CAMP-ICC) for enhanced detection of antigen specific T-cell responsesC Mee Ling Munier
HIV Immunovirology Laboratory, St Vincent s Centre for Applied Medical Research, Sydney, NSW, Australia
J Immunol Methods 345:1-16. 2009..The CAMP-ICC provides much more information than conventional functional T-cell assays allowing simultaneous determination of proliferative capacity and cytokine production by both CD4 and CD8+ T cells... - The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: final results from a randomized clinical trial (Pulse)Mark T Bloch
Holdsworth House Medical Practice, Sydney, New South Wales, Australia
J Acquir Immune Defic Syndr 42:192-202. 2006..196 cells, respectively, P = 0.006). CONCLUSIONS: Hydroxyurea was not found to be beneficial when used in association with STIs in patients during PHI... - Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2John J Zaunders
Centre for Immunology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
J Infect Dis 187:1735-47. 2003..Understanding cytokine effects on CCR5(+) T cells will be important in understanding chronic HIV-1 replication and pathogenesis... - Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infectionSarah C Sasson
National Centre in HIV Epidemiology and Clinical Research, Sydney, Australia
J Infect Dis 193:505-14. 2006.... - IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markersSarah C Sasson
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
Cytokine 50:58-68. 2010..Patients with B-cell derived neoplasms had elevated circulating IL-10 and decreased BAFF. These findings support a role for the IL-7/IL-7R system in B-cell oncogenesis... - The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostasis and the challenges facing its utilization as a novel therapySarah C Sasson
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
Curr Drug Targets 7:1571-82. 2006..Ultimately this understanding may lead to therapeutics that manipulate and optimise signalling through the IL-7/IL-7R system... - Progressive activation of CD127+132- recent thymic emigrants into terminally differentiated CD127-132+ T-cells in HIV-1 infectionSarah C Sasson
The Kirby Institute, The University of New South Wales, Sydney, Australia
PLoS ONE 7:e31148. 2012..We investigated the correlates of loss of CD127 from the T-cell surface to understand mechanisms underlying this homeostatic dysregulation... - Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration diseaseNabila Seddiki
Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
Eur J Immunol 39:391-403. 2009..These data suggest that despite substantial Treg expansion in IRD, their ability to induce suppression, and thereby downregulate aberrant immune responses, is compromised... - Greater reversal of CD4+ cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine, and nelfinavir before complete HIV type 1 seroconversionDon E Smith
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW 2010, Australia
AIDS Res Hum Retroviruses 19:189-99. 2003..Despite poorer prognostic markers at baseline ES subjects achieved responses similar to those of LS subjects after 1 year of treatment... - Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twentyJohn M Murray
School of Mathematics, University of NSW, Sydney, Australia
Immunol Cell Biol 81:487-95. 2003..7 year half-life of the productive thymus so that by age 55 only 5% of naive production arises from thymic export... - An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC)M R Birch
HIV Epidemiology Research Unit HERU, Australian Red Cross Blood Service NSW ARCBS NSW, Level 3 131 Clarence Street, Sydney, NSW 2000, Australia
J Clin Virol 22:263-70. 2001..In contrast, in the SA cohort, comparison study group for the SBBC, five of 24 remain therapy naïve after 15 years infection with HIV-1 and all have detectable VL... - Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and CopaxoneJuliana Croitoru-Lamoury
Centre for Immunology, St Vincent s Hospital, Department of Neurology, Sydney NSW, Australia
J Interferon Cytokine Res 27:53-64. 2007..Administration of cytokines, including IFN-beta and Copaxone, may be important in stem cell transplantation therapies and perhaps important in the efficacy of existing MS therapies... - Cell turnover and cell tropism in HIV-1 infectionMiles P Davenport
Dept of Pathology, Faculty of Medicine, University of New South Wales, NSW 2052, Kensington, Australia
Trends Microbiol 10:275-8. 2002..As the division rate of naive T cells increases with CD4+ depletion, X4 viruses come to dominate in late disease... - CD8+ anti-human immunodeficiency virus suppressor activity (CASA) in response to antiretroviral therapy: loss of CASA is associated with loss of viremiaJ Wilkinson
Centre for Immunology, St Vincent s Hospital, Sydney, NSW 2010, Australia
J Infect Dis 180:68-75. 1999..However, changes in CASA did not correlate with changes in any T lymphocyte subset. CASA increases with improving immune function but appears more dependent on ongoing HIV replication... - Phenotypic analysis of CD8+ T lymphocytes in a cohort of HIV type 1-infected patients treated with saquinavir, ritonavir, and two nucleoside analogs for 1 year, and association with plasma HIV type 1 RNAG R Kaufmann
Centre for Immunology, St Vincent s Hospital, Darlinghurst, NSW, Australia
AIDS Res Hum Retroviruses 15:963-72. 1999..A complete normalization of immunologic changes of CD8+ T lymphocytes would therefore require a more potent drug regimen or a longer duration of therapy... - Long-term immunological response in HIV-1-infected subjects receiving potent antiretroviral therapyG R Kaufmann
National Centre in HIV Epidemiology and Clinical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
AIDS 14:959-69. 2000..To determine the long-term T-lymphocyte response to highly active antiretroviral therapy (HAART) and to define predictors of the immunological response... - Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infectionAnthony D Kelleher
Immunovirology and Pathogenesis Program, National Centre in HIV Epidemiology and Clinical Research, University of North South Wales, Level 2, 376 Victoria Street, Darlinghurst, NSW, 2010, Australia
Curr HIV/AIDS Rep 3:5-12. 2006.... - Characterization of the phenotypic and lymphokine profile associated with strong CD8+ anti-HIV-1 suppressor activity (CASA)J Wilkinson
Centre for Immunology, St Vincent s Hospital, Sydney, Australia
Clin Exp Immunol 127:145-50. 2002..Strong CASA was therefore associated with rapidly replicating CD8+ T cells of the phenotype CD8+CD28+Ki67+ that expressed greater levels of IL-2 and the ligands RANTES and I-309... - 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and PreventionLisa Maher
National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia
Med J Aust 187:610-2. 2007 - Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infectionSharon R Lewin
Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia
J Acquir Immune Defic Syndr 47:140-47. 2008..Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI)... - Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunctionDaniel E Kaufmann
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 8:1246-54. 2007..These data, indicating a reversible immunoregulatory pathway selectively associated with CD4(+) T cell dysfunction, provide a potential target for immunotherapy in HIV-infected patients... - Comprehensive analyses of a unique HIV-1-infected nonprogressor reveal a complex association of immunobiological mechanisms in the context of replication-incompetent infectionBin Wang
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead, New South Wales 2145, Australia
Virology 304:246-64. 2002..Understanding how to induce these protective immune responses in other individuals could provide a major step forward in the design of effective immunotherapies or vaccines against HIV infection... - First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infectionBin Wang
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
Virology 312:135-50. 2003..Further study on the antigenic properties of this strain may assist in the development of HIV vaccines and therapeutics... - Characterization of CD4(+) CTLs ex vivoVictor Appay
Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 168:5954-8. 2002..The existence of CD4(+) cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response...