Research Topics
| J P WhiteheadSummaryAffiliation: University of Queensland Country: Australia Publications
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Detail Information
Publications
Adiponectin--a key adipokine in the metabolic syndromeJ P Whitehead
Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Diabetes Obes Metab 8:264-80. 2006....- Insulin and oleate promote translocation of inosine-5' monophosphate dehydrogenase to lipid bodiesJonathan P Whitehead
Department of Diabetes and Obesity, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Traffic 5:739-49. 2004..These data support a role for IMPDH in the dynamic regulation of lipid bodies and fatty acid metabolism and regulation of its activity by subcellular redistribution in response to extracellular factors that modify lipid metabolism... - Distinct adiponectin profiles might contribute to differences in susceptibility to type 2 diabetes in dogs and humansK R Verkest
Centre for Companion Animal Health, The University of Queensland, Brisbane, QLD, Australia
Domest Anim Endocrinol 41:67-73. 2011..Dogs with chronic, naturally occurring obesity do not have selectively reduced HMW adiponectin, and adiponectin does not appear to be important in the development of canine obesity-associated insulin resistance... - The role of Ca2+ in insulin-stimulated glucose transport in 3T3-L1 cellsJ P Whitehead
Institute for Molecular Bioscience and the Department of Physiology and Pharmacology, University of Queensland, St Lucia, Queensland 4072, Australia
J Biol Chem 276:27816-24. 2001..Finally, BAPTA-AM may inhibit the activity of the facilitative transporters by binding directly to the transporter itself... - Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanismJ C Molero
Institute for Molecular Biosciences and the Department of Physiology and Pharmacology, University of Queensland, St Lucia, Queensland 4072, Australia
J Biol Chem 276:43829-35. 2001..These studies reveal a new and unexpected effect of nocodazole in mammalian cells which appears to occur independently of its microtubule-depolymerizing effects... - Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscleJ P Whitehead
Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QR, U K
Biochem J 349:775-81. 2000..Thus, in contracting skeletal muscle, insulin stimulates glucose uptake and activates PKB, but not p70(S6K), by a PI 3-kinase-dependent mechanism that is independent of changes in IRS-1- and IRS-2-associated PI 3-kinase activity... - Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetesIngrid J Hickman
Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Diabetes Obes Metab 9:438-40. 2007..The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes... - The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and type 2 diabetesL K Phillips
Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
J Clin Endocrinol Metab 95:4455-9. 2010..Postprandial dysmetabolism is emerging as an important cardiovascular risk factor. Augmentation index (AIx) is a measure of systemic arterial stiffness and independently predicts cardiovascular outcome... - Adiposity and adiponectin in dogs: investigation of causes of discrepant results between two studiesK R Verkest
Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland, Brisbane, Australia
Domest Anim Endocrinol 41:35-41. 2011..Obesity might decrease adiponectin concentrations in intact but not in neutered dogs... - Synergistic effects of ascorbic acid and thiazolidinedione on secretion of high molecular weight adiponectin from human adipocytesF J Rose
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
Diabetes Obes Metab 12:1084-9. 2010..To test the hypothesis that ascorbic acid (AA) and thiazolidinedione (TZD) would have additive effects on HMW adiponectin secretion by virtue of different modes of action... - Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytesSherry Ngo
Metabolic Medicine Program, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Queensland 4102, Australia
Mol Cell Endocrinol 302:33-40. 2009..These data suggest Dex inhibits glucose uptake in adipocytes, at least in part, by reducing AS160 phosphorylation and interaction with 14-3-3... - Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytesC H Widberg
Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Am J Physiol Endocrinol Metab 296:E121-31. 2009..Together these data highlight the unique nature of the role of FGF-1 during the earliest stages of adipogenesis and establish a role for FGFR1 in human adipogenesis, identifying FGFR1 as a potential therapeutic target to reduce obesity... - Signalling through the insulin receptorJ P Whitehead
The Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, 4072, Australia
Curr Opin Cell Biol 12:222-8. 2000..When inappropriately dissociated from this matrix the signalling network collapses concomitant with loss of insulin sensitivity... - Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoformsJennifer H Gunter
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD 4102, Brisbane, Australia
Int J Biochem Cell Biol 40:1716-28. 2008.... - IRS-1 regulation in health and diseaseCarsten Schmitz-Peiffer
Cell Signalling Group, Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
IUBMB Life 55:367-74. 2003.... - GLUT4--at the cross roads between membrane trafficking and signal transductionF Simpson
Institute for Molecular Biosciences and the Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
Traffic 2:2-11. 2001..Below we discuss some of these complexities and highlight new data that are bringing us closer to the resolution of these questions... - Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesityHua Su
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
Biochem Biophys Res Commun 386:351-5. 2009..002) and adipocyte size (p=0.03) and number. These data suggest that inhibition of IMPDH may represent a novel strategy to reduce adipose tissue mass... - The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrityElaine C Thomas
Centre for Diabetes and Endocrine Research, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD 4102, Australia
Int J Biochem Cell Biol 38:1686-99. 2006.... - Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activityJørgen Jensen
Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, Oslo, 0033, Norway
Pflugers Arch 456:969-78. 2008..These results indicate that the combination of adrenaline and insulin may activate novel signalling molecules rather than just summing up their effects on linear pathways... - High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infectionAmy Y-H Wang
Centre for Diabetes and Endocrine Research, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Am J Gastroenterol 100:2717-23. 2005..The greater degree of insulin resistance in genotype 1 appears to be a genotype-specific effect... - Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signalingJørgen Jensen
Department of Physiology, National Institute of Occupational Health, Oslo, Norway
Am J Physiol Endocrinol Metab 290:E154-E162. 2006..quot;Insulin resistance" is observed at the level of glycogen synthase, and the reduced glycogen synthesis leads to increased levels of glucose 6-phosphate, glycolytic flux, and accumulation of nonphosphorylated 2-deoxyglucose... - Adiponectin--it's all about the modificationsFiona Simpson
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
Int J Biochem Cell Biol 42:785-8. 2010..Strategies that modulate processes governing PTM of adiponectin represent attractive therapeutic approaches... - Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulationAyanthi A Richards
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Queensland, Australia
Mol Endocrinol 24:229-39. 2010..These data suggest an important role for sialic acid content in the regulation of circulating adiponectin levels and highlight the importance of understanding mechanisms regulating adiponectin sialylation/desialylation... - TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue--influence of BMI and adipose distributionManuela Good
Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland, Australia 4102
Diab Vasc Dis Res 3:26-33. 2006..Furthermore, adipose tissue from obese subjects already appears insulin 'resistant' and this may be a result of the increased TNF levels... - Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modificationsAyanthi A Richards
Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
Mol Endocrinol 20:1673-87. 2006..Collectively, these data suggest that adiponectin multimer composition is affected by changes in PTM in response to physiological factors... - Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum: a potential mechanism for olanzapine-induced insulin resistance in patients with schizophreniaAyanthi A Richards
Centre for Diabetes and Endocrine Research, The University of Queensland, Brisbane, Queensland, Australia
J Clin Psychopharmacol 26:232-7. 2006..This may not be a direct effect of olanzapine on adipocyte expression or secretion of adiponectin. These observations provide insights into possible mechanisms for the association between olanzapine treatment and insulin resistance...