Research Topics
| R F UrenSummaryAffiliation: University of Sydney Country: Australia Publications
| Collaborators
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Detail Information
Publications
Patterns of lymphatic drainage from the skin in patients with melanomaRoger F Uren
Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, 100 Carillon Avenue, Newtown, Sydney, New South Wales 2042, Australia
J Nucl Med 44:570-82. 2003..Micrometastatic disease can be present in any sentinel node regardless of its location, and for the SLNB technique to be accurate, all true sentinel nodes must be biopsied in every patient...- Lymphatic drainage of the skinRoger F Uren
Divisions of Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, The Department of Medicine, The University of Sydney, Sydney, and The Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Ann Surg Oncol 11:179S-85S. 2004..Because micrometastatic disease can be present in any SN regardless of its location, all true SNs must be biopsied. LS is an important first step to ensure this goal is achieved... - Sentinel lymph node biopsy in patients with melanoma and breast cancerR F Uren
Nuclear Medicine and Diagnostic Ultrasound, Royal Prince Alfred Hospital Medical Centre, Newtown, New South Wales, Australia
Intern Med J 31:547-53. 2001..A further advantage of lyamphatic mapping is that drainage to sentinel nodes in unusual locations is identified, leading to more accurate nodal staging than could be achieved with routine dissection of the closest node field... - The reproducibility in routine clinical practice of sentinel lymph node identification by pre-operative lymphoscintigraphy in patients with cutaneous melanomaRoger F Uren
Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre and Discipline of Medicine, The University of Sydney, Sydney, NSW, Australia
Ann Surg Oncol 14:899-905. 2007..These results indicate that in routine clinical practice LS is a highly reproducible procedure to locate and radiolabel the SLNs prior to biopsy in patients with melanoma... - Interval nodes: the forgotten sentinel nodes in patients with melanomaR F Uren
Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, 100 Carillon Ave, Suite 206, Newtown, New South Wales 2042, Australia
Arch Surg 135:1168-72. 2000..If drainage to such interval nodes is ignored by the surgeon during sentinel node biopsy, metastatic melanoma will be missed in some patients... - High-resolution ultrasound to diagnose melanoma metastases in patients with clinically palpable lymph nodesR F Uren
Nuclear Medicine and Diagnostic Ultrasound, Missenden Medical Centre, Camperdown, NSW, Australia
Australas Radiol 43:148-52. 1999..A normal ultrasound finding does not exclude micrometastases, but a lymph node showing the two key ultrasound features aforementioned is highly likely to contain metastatic disease and should be treated accordingly... - The utility of ultrasound in patients with melanomaRoger F Uren
Nuclear Medicine and Diagnostic Ultrasound, Suite 206, RPAH Medical Center, 100 Carillon Avenue, Newtown, NSW 2042, Sydney, Australia
Expert Rev Anticancer Ther 7:1633-42. 2007..In the future the use of ultrasound contrast agents may improve the sensitivity of ultrasound in the detection of very small metastatic deposits... - Direct lymphatic drainage from a melanoma on the back to paravertebral lymph nodes in the thoraxR F Uren
Nuclear Medicine and Diagnostic Ultrasound, Missenden Medical Centre, Camperdown, New South Wales, Australia
Clin Nucl Med 24:388-9. 1999..There was also drainage directly to the right groin and via a series of interval nodes to the right axilla. Knowledge of the presence of such drainage may influence the surgical management of patients... - Variability of cutaneous lymphatic flow rates in melanoma patientsR F Uren
Missenden Medical Centre, Camperdown, NSW, Australia
Melanoma Res 8:279-82. 1998..These results can be used to optimize the timing of blue dye injection prior to surgery and may influence the sentinel node biopsy method to be used in individuals who show no early drainage... - Metastatic occlusion of a lymphatic collecting vessel in a patient with cutaneous melanoma and clinically normal lymph nodesRoger F Uren
Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, Newton, NSW, Australia
Clin Nucl Med 32:312-3. 2007 - The role of lymphoscintigraphy in the detection of lymph node drainage in melanomaRoger F Uren
Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, 100 Carillon Avenue, Newtown, NSW 2042, Australia
Surg Oncol Clin N Am 15:285-300. 2006..In this way, lymphoscintigraphy has a direct beneficial impact on the surgical management of patients who have melanoma... - Internal mammary lymph node metastasis in breast cancer: predictive models to assist with prognostic influenceF Noushi
Department of Surgical Oncology, Mater and Royal North Shore Hospital, University of Sydney, Lindfield, NSW 2071, Sydney, Australia
Breast 20:278-83. 2011..1-6).. - Single-dose isotope injection for both preoperative lymphoscintigraphy and intraoperative sentinel lymph node identification in melanoma patientsJ F Thompson
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Melanoma Res 7:500-6. 1997.... - Internal mammary node metastasis in breast cancer: predictive models to determine status & management algorithmsF Noushi
Department of Surgical Oncology, Mater and Royal North Shore Hospital, University of Sydney, Sydney, Australia
Eur J Surg Oncol 36:16-22. 2010..Through mathematical modeling based on large datasets this study aims to estimate the current rate of IMN and sentinel node metastasis... - Popliteal lymph node metastasis from primary cutaneous melanomaJ F Thompson
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia
Eur J Surg Oncol 26:172-6. 2000..To document the incidence of popliteal lymph node involvement by metastatic melanoma and to consider the implications of this information for clinical management... - Lymphatic mapping of the breast: locating the sentinel lymph nodesR F Uren
Nuclear Medicine and Diagnostic Ultrasound, Suite 206, RPAH Medical Center, 100 Carillon Avenue, Newtown, N S W 2042, Australia
World J Surg 25:789-93. 2001..It is possible that in the future accurate nodal staging in each individual will involve biopsy of all sentinel lymph nodes, regardless of their location... - Lymphatic mapping and sentinel node biopsy for melanomaJ F Thompson
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Department of Surgery, University of Sydney, Sydney, New South Wales
Expert Rev Anticancer Ther 1:446-52. 2001..It is already clear, however, that SN examination provides very accurate staging, and SN biopsy is therefore essential for all melanoma patients entering adjuvant therapy trials... - High-resolution lymphoscintigraphy is essential for recognition of the significance of internal mammary nodes in breast cancerA J Spillane
Department of Surgical Oncology, The University of Sydney, Sydney, Australia
Ann Oncol 20:977-84. 2009..Controversy relates to the technique of lymphatic mapping, safety of IMN SNB, the significance of positive IMN, and potential to impact survival... - Gallium and thallium scintigraphy in pediatric peripheral primitive neuroectodermal tumor (Askin tumor) of the chest wallR Howman Giles
Department of Nuclear Medicine, Royal Alexandra Hospital for Children, Sydney, Australia
J Nucl Med 36:814-6. 1995..Histology showed a peripheral neuroectodermal tumor of the chest wall typical of the malignancy described as the Askin tumor. The 201Tl studies were a more accurate method of following tumor response to therapy than 67Ga scintigraphy... - Surgical management of primary cutaneous melanoma: excision margins and the role of sentinel lymph node examinationJohn F Thompson
Sydney Melanoma Unit, Level 3, Gloucester House, Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2006, Australia
Surg Oncol Clin N Am 15:301-18. 2006..Minimally invasive and noninvasive methods of SN assessment, such as magnetic resonance spectroscopy, are being evaluated... - Sentinel lymph node biopsy in melanomaRoger F Uren
Discipline of Medicine University of Sydney Sydney, New South Wales Australia
J Nucl Med 47:191-5. 2006 - Neuroblastoma and other neuroendocrine tumorsRobert Howman-Giles
Department of Nuclear Medicine, Children s Hospital at Westmead, Sydney, NSW, Australia
Semin Nucl Med 37:286-302. 2007..Newer radiopharmaceuticals, including PET agents, are being evaluated for the assessment of NET. Nuclear medicine techniques play a major role in the management of neuroblastoma and NET... - Three-dimensional visualisation of lymphatic drainage patterns in patients with cutaneous melanomaHayley M Reynolds
Bioengineering Institute, University of Auckland, Auckland, New Zealand
Lancet Oncol 8:806-12. 2007..We aimed to map these data onto a three-dimensional computer model to provide improved visualisation and analysis of lymphatic drainage from sites of cutaneous melanoma... - Confirmation of sentinel lymph node identity by analysis of fine-needle biopsy samples using inductively coupled plasma-mass spectrometryAlison Beavis
Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, New South Wales, Australia
Ann Surg Oncol 15:934-40. 2008..This involved the use of inductively coupled plasma-mass spectrometry (ICP-MS) to analyze antimony concentrations in fine-needle biopsy (FNB) samples from surgically procured lymph nodes... - False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathologyRooshdiya Z Karim
Department of Anatomical Pathology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Ann Surg 247:1003-10. 2008..To investigate a cohort of melanoma patients with false negative (FN) sentinel node (SN) biopsies (SNBs) to identify the reasons for the FN result... - Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapyRoss E Warner
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
Ann Surg Oncol 15:2509-18. 2008..However, its optimal treatment is uncertain. In this study, we aimed to assess the roles of lymphoscintigraphy and sentinel node (SN) biopsy, as well as radiotherapy, in the treatment of MCC... - Mapping melanoma lymphoscintigraphy data onto a 3D anatomically based modelHayley M Reynolds
The Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
Ann Biomed Eng 35:1444-57. 2007..7% probability of dual drainage to both node fields, with 95% confidence limits between 14.5 and 21.0%... - Lymphatic mapping in management of patients with primary cutaneous melanomaJohn F Thompson
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Lancet Oncol 6:877-85. 2005..Because it is impossible to predict the site or sites of sentinel nodes clinically in individual patients, routine preoperative lymphoscintigraphy is a prerequisite if reliable results are to be obtained from sentinel-node biopsy... - Antimony by ICP-MS as a marker for sentinel lymph nodes in melanoma patientsMichael Dawson
Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, 1 Broadway, Broadway, NSW 2007, Australia
Analyst 128:217-9. 2003..A sensitive, accurate and specific method for the analysis of antimony by ICP-MS is presented as a marker of the sentinel lymph node in melanoma patients... - Cancer surgery joins the dotsRoger F Uren
Nat Biotechnol 22:38-9. 2004 - Sentinel node biopsy for melanoma: Where have we been and where are we going?John F Thompson
Sydney Melanoma Unit and the Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, New South Wales, Australia
Ann Surg Oncol 11:147S-51S. 2004..Techniques such as in vivo proton magnetic resonance spectroscopy hold great promise and suggest that this goal might be achievable... - Failure to remove true sentinel nodes can cause failure of the sentinel node biopsy technique: evidence from antimony concentrations in false-negative sentinel nodes from melanoma patientsRichard A Scolyer
Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, Australia
Ann Surg Oncol 11:174S-8S. 2004..Our results suggest that an FN SNB can occur because of failure to remove the true SN as well as histopathologic misdiagnosis... - Correlation between preoperative lymphoscintigraphy and metastatic nodal disease sites in 362 patients with cutaneous melanomas of the head and neckJohannes H W de Wilt
Sydney Melanoma Unit and the Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, New South Wales, Australia
Ann Surg 239:544-52. 2004..7%). CONCLUSIONS: Metastases from head and neck melanomas can occur in any SN demonstrated by lymphoscintigraphy. SNs in discordant as well as predicted node fields should be removed and examined to optimize the accuracy of staging... - Nuclear medicine aspects of melanoma and breast lymphatic mappingRoger F Uren
Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, Camperdown, NSW, Australia
Semin Oncol 31:338-48. 2004..LS is an important first step to ensure this goal is achieved... - Teaching points on lymphatic mapping for melanoma from the Sydney Melanoma UnitJohn F Thompson
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Semin Oncol 31:349-56. 2004.... - Antimony concentrations in nodal tissue can confirm sentinel node identityRichard A Scolyer
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Mod Pathol 17:1191-7. 2004.... - Outcome in 846 cutaneous melanoma patients from a single center after a negative sentinel node biopsyVivian S K Yee
Sydney Melanoma Unit, Sydney Cancer Centre, Gloucester House, Royal Prince Alfred Hospital, Missenden Road, Camperdown, 2050 New South Wales, Australia
Ann Surg Oncol 12:429-39. 2005..In those with a negative SNB, primary tumor thickness and ulceration are independent predictors of survival. Incorrect pathologic diagnosis contributed to only a minority of the false-negative results in this study... - Minimally invasive radio-guided surgery for recurrent thyroid cancer using iodine-123Robert Mansberg
Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Clin Nucl Med 30:43-4. 2005 - Role of lymphoscintigraphy for selective sentinel lymphadenectomyRoger F Uren
Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre and Discipline of Medicine, The University of Sydney, Sydney, NSW, Australia
Cancer Treat Res 127:15-38. 2005..LS is an important first step in ensuring that this goal is achieved... - Ultrasound examination of sentinel nodes in the initial assessment of patients with primary cutaneous melanomaEmma C Starritt
Sydney Melanoma Unit, Sydney Cancer Centre and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, 2050, Australia
Ann Surg Oncol 12:18-23. 2005..5 mm in diameter. However, most metastatic melanoma deposits in SLNs are considerably smaller than this at the time of initial staging, and US therefore cannot be considered cost-effective in this setting... - Internal mammary node metastasis from primary cutaneous melanoma on the anterior chestJohn F Thompson
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
ANZ J Surg 75:723-5. 2005.... - A sentinel node biopsy does not increase the incidence of in-transit metastasis in patients with primary cutaneous melanomaDaan van Poll
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia
Ann Surg Oncol 12:597-608. 2005..2%, compared with 10.8% in patients with a tumor-positive sentinel node treated with immediate dissection (n = 102; P = .03). CONCLUSIONS: Performing an SNB in patients with melanoma treated by WLE does not increase the incidence of ITM... - Left-to-right cardiac shunt diagnosed on Tc-99m MAG-3 renal studyHamda Saleh
Department of Nuclear Medicine, The Children's Hospital at Westmead, UK
Clin Nucl Med 29:762-4. 2004 - Diagnosis of metastatic melanoma by fine-needle biopsy: analysis of 2,204 casesRajmohan Murali
Department of Anatomical Pathology, Sydney Cancer Centre, Australia
Am J Clin Pathol 127:385-97. 2007..FNB is a highly accurate, rapid, and cost-effective procedure for the diagnosis of metastatic melanoma and should be considered as the initial diagnostic procedure of choice in patients with melanoma with clinically suspected metastases... - Diagnostic accuracy of fine needle biopsy for metastatic melanoma and its implications for patient managementAnna Doubrovsky
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
Ann Surg Oncol 15:323-32. 2008..In this study, the accuracy of FNB for the diagnosis of metastatic melanoma was investigated... - Selective sentinel lymphadenectomy: progress to date and prospects for the futureJohn F Thompson
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
Cancer Treat Res 127:269-87. 2005....