Roger John Truscott

Summary

Affiliation: University of Wollongong
Country: Australia

Publications

  1. ncbi Post-translational modifications in the nuclear region of young, aged, and cataract human lenses
    Peter G Hains
    Save Sight Institute, University of Sydney, Sydney, NSW, 2001, Australia
    J Proteome Res 6:3935-43. 2007
  2. ncbi Age-related nuclear cataract-oxidation is the key
    Roger J W Truscott
    Australian Cataract Research Foundation, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia
    Exp Eye Res 80:709-25. 2005
  3. ncbi Are ancient proteins responsible for the age-related decline in health and fitness?
    Roger John Willis Truscott
    Save Sight Institute, University of Sydney, Sydney, NSW, Australia
    Rejuvenation Res 13:83-9. 2010
  4. ncbi Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition
    Roger John Truscott
    Save Sight Institute, University of Sydney, NSW 2001, Australia
    Exp Eye Res 88:241-7. 2009
  5. ncbi Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses
    Anastasia Korlimbinis
    Save Sight Institute, University of Sydney, GPO Box 4337, Sydney, NSW 2001, Australia
    Exp Eye Res 85:219-25. 2007
  6. ncbi Protein-bound UV filters in normal human lenses: the concentration of bound UV filters equals that of free UV filters in the center of older lenses
    Anastasia Korlimbinis
    Save Sight Institute, University of Sydney, NSW 2001, Sydney, Australia
    Invest Ophthalmol Vis Sci 48:1718-23. 2007
  7. ncbi Large-scale binding of ?-crystallin to cell membranes of aged normal human lenses: a phenomenon that can be induced by mild thermal stress
    Michael G Friedrich
    Save Sight Institute, Sydney University, Sydney, Australia
    Invest Ophthalmol Vis Sci 51:5145-52. 2010
  8. ncbi Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage
    Jasminka Mizdrak
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
    Free Radic Biol Med 44:1108-19. 2008
  9. ncbi Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract
    Anastasia Korlimbinis
    Australian Cataract Research Foundation, University of Wollongong, New South Wales 2522, Australia
    Biochemistry 45:1950-60. 2006
  10. ncbi Protein-bound kynurenine decreases with the progression of age-related nuclear cataract
    Santiago Vazquez
    Australian Cataract Research Foundation, University of Wollongong, Wollongong, New South Wales, Australia
    Invest Ophthalmol Vis Sci 45:879-83. 2004

Collaborators

  • J Andrew Aquilina
  • Michael J Davies
  • Mark J Walker
  • A J Hulbert
  • P S Sachdev
  • R Stocker
  • Anne Poljak
  • Ling Gao
  • Peter G Hains
  • Anastasia Korlimbinis
  • Joanne F Jamie
  • Michael G Friedrich
  • Karl R Heys
  • Nicole R Parker
  • Santiago Vazquez
  • Jasminka Mizdrak
  • Lisa M Taylor
  • Isla M Streete
  • Osamu Takikawa
  • Jessica R Nealon
  • Tamantha K Littlejohn
  • J Andrew Aquilina
  • Linda J Hazell
  • Danielle Thibault
  • Kevin L Schey
  • Yoke Berry
  • Todd W Mitchell
  • Stephen J Blanksby
  • Sarah K Abbott
  • Margaret Sheil
  • Mitsuhiro Fukao
  • Soichi Miwa
  • Roger T Dean
  • Margaret M Sheil
  • HongJie Fu

Detail Information

Publications31

  1. ncbi Post-translational modifications in the nuclear region of young, aged, and cataract human lenses
    Peter G Hains
    Save Sight Institute, University of Sydney, Sydney, NSW, 2001, Australia
    J Proteome Res 6:3935-43. 2007
    ..These findings suggest Trp oxidation may be involved in nuclear cataract development...
  2. ncbi Age-related nuclear cataract-oxidation is the key
    Roger J W Truscott
    Australian Cataract Research Foundation, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia
    Exp Eye Res 80:709-25. 2005
    ..Unfortunately, due to marked variability in the lenses of different species, there appears at present to be no ideal animal model system for studying human ARN cataract...
  3. ncbi Are ancient proteins responsible for the age-related decline in health and fitness?
    Roger John Willis Truscott
    Save Sight Institute, University of Sydney, Sydney, NSW, Australia
    Rejuvenation Res 13:83-9. 2010
    ..The human lens may be particularly useful for discovering which reactive metabolites in the body are of most importance for posttranslational modification of long-lived proteins...
  4. ncbi Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition
    Roger John Truscott
    Save Sight Institute, University of Sydney, NSW 2001, Australia
    Exp Eye Res 88:241-7. 2009
    ..Understanding such processes may allow us to glimpse the origin both of presbyopia and age-related nuclear cataract...
  5. ncbi Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses
    Anastasia Korlimbinis
    Save Sight Institute, University of Sydney, GPO Box 4337, Sydney, NSW 2001, Australia
    Exp Eye Res 85:219-25. 2007
    ....
  6. ncbi Protein-bound UV filters in normal human lenses: the concentration of bound UV filters equals that of free UV filters in the center of older lenses
    Anastasia Korlimbinis
    Save Sight Institute, University of Sydney, NSW 2001, Sydney, Australia
    Invest Ophthalmol Vis Sci 48:1718-23. 2007
    ..To survey the levels of protein-bound UV filters in the cortices and nuclei of normal human lenses as a function of age and to relate this to the concentration of free UV filters...
  7. ncbi Large-scale binding of ?-crystallin to cell membranes of aged normal human lenses: a phenomenon that can be induced by mild thermal stress
    Michael G Friedrich
    Save Sight Institute, Sydney University, Sydney, Australia
    Invest Ophthalmol Vis Sci 51:5145-52. 2010
    ..This study focused on membrane binding within the barrier region and the outermost lens cortex...
  8. ncbi Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage
    Jasminka Mizdrak
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
    Free Radic Biol Med 44:1108-19. 2008
    ..These data indicate that the covalent modification of lens proteins by Kyn derivatives yields photosensitizers that may enhance oxidation in older lenses and contribute to age-related nuclear cataract...
  9. ncbi Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract
    Anastasia Korlimbinis
    Australian Cataract Research Foundation, University of Wollongong, New South Wales 2522, Australia
    Biochemistry 45:1950-60. 2006
    ..In agreement with this hypothesis, no bound 3OHKyn could be detected in proteins isolated from ARN cataract lenses...
  10. ncbi Protein-bound kynurenine decreases with the progression of age-related nuclear cataract
    Santiago Vazquez
    Australian Cataract Research Foundation, University of Wollongong, Wollongong, New South Wales, Australia
    Invest Ophthalmol Vis Sci 45:879-83. 2004
    ..This finding suggests that in cataract there is a breakdown of the protein-bound adducts. Such further reactions of bound UV filters may contribute to the etiology of age-related nuclear cataract...
  11. ncbi Proteomic analysis of the oxidation of cysteine residues in human age-related nuclear cataract lenses
    Peter G Hains
    Save Sight Institute, University of Sydney, Sydney, NSW 2001, Australia
    Biochim Biophys Acta 1784:1959-64. 2008
    ..The vast majority of the loss of protein thiol observed in such lenses is due to disulphide bond formation...
  12. ncbi 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis
    Anastasia Korlimbinis
    Save Sight Institute, Sydney, NSW 2001, Australia
    Biochemistry 45:1852-60. 2006
    ..Thus, 3-hydroxykynurenine promotes the oxidation and modification of crystallins and may contribute to oxidative stress in the human lens...
  13. ncbi Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses
    Nicole R Parker
    Save Sight Institute, University of Sydney, Sydney, NSW, Australia
    Invest Ophthalmol Vis Sci 48:3705-13. 2007
    ..The aim of this study was to examine in vitro rates of formation and decomposition of the three major Kyn-amino acid adducts and possible consequences for the lens...
  14. ncbi Is hypochlorous acid (HOCl) involved in age-related nuclear cataract?
    Linda J Hazell
    The Heart Research Institute, University of Wollongong, NSW, Australia
    Clin Exp Optom 85:97-100. 2002
    ..CONCLUSIONS: On the basis of this study, no evidence was obtained to support a role for HOCl in age-related nuclear cataract...
  15. ncbi Age-related nuclear cataract and indoleamine 2,3-dioxygenase-initiated tryptophan metabolism in the human lens
    Osamu Takikawa
    Australian Cataract Research Foundation, University of Wollongong, NSW 2522, Australia
    Adv Exp Med Biol 527:277-85. 2003
    ..Yellowing of the aged lens may therefore be preventable by drug-induced suppression of IDO activity...
  16. ncbi Membrane association of proteins in the aging human lens: profound changes take place in the fifth decade of life
    Michael G Friedrich
    Save Sight Institute, Sydney University, Sydney, NSW, Australia
    Invest Ophthalmol Vis Sci 50:4786-93. 2009
    ..To characterize age-related changes to proteins in the center of the human lens...
  17. ncbi Phospholipid composition of the rat lens is independent of diet
    Jessica R Nealon
    School of Chemistry, University of Wollongong, Wollongong, 2522 NSW, Australia
    Exp Eye Res 87:502-14. 2008
    ..As phospholipids determine membrane fluidity and influence the activity and function of integral membrane proteins, regulation of their composition may be important for the function of the lens...
  18. ncbi Age-dependent deamidation of lifelong proteins in the human lens
    Peter G Hains
    Save Sight Institute, University of Sydney, Sydney, NSW, Australia
    Invest Ophthalmol Vis Sci 51:3107-14. 2010
    ..The aim of this study was to identify the sites of deamidation in older lenses...
  19. ncbi Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients
    Isla M Streete
    Australian Cataract Research Foundation, University of Wollongong, Wollongong, New South Wales, Australia
    Invest Ophthalmol Vis Sci 45:4091-8. 2004
    ..Because kynurenine levels in cataract were not significantly different from those of normal lenses, there may be a defect in the lenticular UV filter pathway at one, or both, of the steps that convert kynurenine to 3OHKG...
  20. ncbi Novel protein modification by kynurenine in human lenses
    Santiago Vazquez
    Australian Cataract Research Foundation and Department of Chemistry, University of Wollongong, New South Wales 2522, Australia
    J Biol Chem 277:4867-73. 2002
    ....
  21. ncbi Free and bound water in normal and cataractous human lenses
    Karl R Heys
    Save Sight Institute, Sydney University, Sydney, New South Wales 2001, Australia
    Invest Ophthalmol Vis Sci 49:1991-7. 2008
    ..To analyze free and total water in human normal and cataractous lenses...
  22. ncbi Asp274 and his346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase
    Tamantha K Littlejohn
    Australian Cataract Research Foundation, Department of Chemistry, University of Wollongong, New South Wales, Australia
    J Biol Chem 278:29525-31. 2003
    ..This observation indicates that Asp274 may coordinate to heme directly as the distal ligand or is essential in maintaining the conformation of the heme pocket...
  23. ncbi Inhibition of indoleamine 2,3 dioxygenase activity by H2O2
    Anne Poljak
    Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia
    Arch Biochem Biophys 450:9-19. 2006
    ..We present evidence that cysteine oxidation represents one mechanism of indoleamine 2,3-dioxygenase inhibition...
  24. ncbi Glutathione and NADH, but not ascorbate, protect lens proteins from modification by UV filters
    Lisa M Taylor
    Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW, Australia 2522
    Exp Eye Res 74:503-11. 2002
    ..Since GSH is present at far greater concentrations than NADH, these results show that in primate lenses, GSH is the key agent responsible for protecting the crystallins from covalent modification...
  25. ncbi UV filter instability: consequences for the human lens
    Lisa M Taylor
    Australian Cataract Research Foundation, University of Wollongong, Wollongong, N.S.W. 2522, Australia
    Exp Eye Res 75:165-75. 2002
    ..On the basis of these data it is likely that glutathione and NAD(P)H, but not ascorbate, protect proteins in the lens from modification by UV filters...
  26. ncbi Protein-bound kynurenine is a photosensitizer of oxidative damage
    Nicole R Parker
    Australian Cataract Research Foundation, Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
    Free Radic Biol Med 37:1479-89. 2004
    ....
  27. ncbi Protein aging: truncation of aquaporin 0 in human lens regions is a continuous age-dependent process
    Anastasia Korlimbinis
    Save Sight Institute, University of Sydney, NSW, Australia
    Exp Eye Res 88:966-73. 2009
    ..Once a significant proportion of AQP0 has been cleaved, this occlusion may contribute to the formation of the lens permeability barrier that develops at middle age...
  28. ncbi Identification of the new UV filter compound cysteine-L-3-hydroxykynurenine O-beta-d-glucoside in human lenses
    Peter G Hains
    Save Sight Institute, University of Sydney, Sydney, NSW 2001, Australia
    FEBS Lett 580:5071-6. 2006
    ..Quantitation studies revealed considerable variation in normal lens levels that may be traced to the marked instability of the cysteine adduct. The novel UV filter was not detected in advanced nuclear cataract lenses...
  29. ncbi Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, alpha-crystallin, in maintaining lens flexibility
    Karl R Heys
    Save Sight Institute, University of Sydney, Sydney, NSW 2001, Australia
    Aging Cell 6:807-15. 2007
    ..Presbyopia may be the result of a loss of alpha-crystallin coupled with progressive heat-induced denaturation of structural proteins in the lens during the first five decades of life...
  30. ncbi The photosensitiser xanthurenic acid is not present in normal human lenses
    Peter G Hains
    Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW 2522, Australia
    Exp Eye Res 77:547-53. 2003
    ..Therefore, it appears unlikely that xanthurenic acid plays a role in lens aging or human cataract...
  31. ncbi The stiffness of human cataract lenses is a function of both age and the type of cataract
    Karl R Heys
    Exp Eye Res 86:701-3. 2008
    ..5...