Research Topics
Species | G ShawSummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
Fetal control of parturition in marsupialsG Shaw
Department of Zoology, The University of Melbourne, Victoria, Australia
Reprod Fertil Dev 13:653-9. 2001..There is thus a strong case that fetal adrenal cortisol plays a key role in the preparation for birth and the timing of it. Further studies are in progress to more clearly define the mechanisms behind these actions of cortisol...- Comparative analysis of the mammalian WNT4 promoterHongshi Yu
ARC Centre of Excellence in Kangaroo Genomics, Department of Zoology, The University of Melbourne, Victoria 3010, Australia
BMC Genomics 10:416. 2009..This study uses comparative cross species sequence and functional analyses between humans and a marsupial (the tammar wallaby,Macropus eugenii) to refine the mammalian Wnt4 promoter... - Evolution of the CDKN1C-KCNQ1 imprinted domainEleanor I Ager
Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
BMC Evol Biol 8:163. 2008..The CDKN1C and IGF2 genes are both imprinted and syntenic in the mouse and human, but in marsupials only IGF2 is imprinted. This study examines the evolution of features that, in eutherians, regulate CDKN1C imprinting... - Expression and protein localisation of IGF2 in the marsupial placentaEleanor I Ager
Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
BMC Dev Biol 8:17. 2008..This study examines the role of IGF2 in the yolk sac placenta of the tammar wallaby, Macropus eugenii... - Differential expression of WNT4 in testicular and ovarian development in a marsupialHongshi Yu
Department of Zoology, The University of Melbourne, Victoria 3010, Australia
BMC Dev Biol 6:44. 2006.... - Role of the alternate pathway of dihydrotestosterone formation in virilization of the Wolffian ducts of the tammar wallaby, Macropus eugeniiGeoffrey Shaw
Department of Zoology, The University of Melbourne, Victoria, Australia
Endocrinology 147:2368-73. 2006..We conclude that dihydrotestosterone, largely formed in the tissue by the oxidation of androstanediol derived from the testes and also the 5alpha-reduction of testosterone, is responsible for Wolffian duct virilization in this species... - Production of prostaglandin f2alpha and its metabolite by endometrium and yolk sac placenta in late gestation in the tammar wallaby, Macropus EugeniiG Shaw
Department of Zoology, The University of Melbourne, Parkville, Victoria 3052, Australia
Biol Reprod 60:611-4. 1999..Thus, the surge in peripheral plasma PGFM levels seen at parturition may arise from increased uterine PG production, but further study is needed to define what triggers this release... - Sex down under: the differentiation of sexual dimorphisms during marsupial developmentM B Renfree
Department of Zoology, The University of Melbourne, Victoria, Australia
Reprod Fertil Dev 13:679-90. 2001..At birth, the marsupial neonate has a well-developed digestive, respiratory and circulatory system, but retains its fetal excretory system with a fully functional mesonephric kidney and undifferentiated gonads and genitalia... - Estrogen-induced gonadal sex reversal in the tammar wallabyD Coveney
Department of Zoology, The University of Melbourne, Victoria 3010, Australia
Biol Reprod 65:613-21. 2001..These results confirm that estrogen can inhibit early testicular development, and that testis determination occurs during a narrow window of time... - Differential regulation of contractility and nitric oxide sensitivity in gravid and nongravid myometrium during late pregnancy in a marsupialJ N Ingram
Department of Zoology, University of Melbourne, Victoria, 3010, Australia
Endocrinology 142:2244-51. 2001.... - Contraceptive effects of levonorgestrel implants in a marsupialC D Nave
Department of Zoology, The University of Melbourne, Victoria, Australia
Reprod Fertil Dev 12:81-6. 2000..This contraceptive system appears to offer a method of population control for the management of overabundant captive and selected wild populations of macropodid marsupials... - Reactivating tammar wallaby blastocysts oxidize glucoseR E Spindler
Department of Zoology, University of Melbourne, Parkville, Victoria, Australia
Biol Reprod 58:1425-31. 1998..The increased oxidation results in greater ATP production, which plausibly fuels the increased energy requirements of wallaby blastocysts during the early stages of reactivation... - Marsupial WT1 has a novel isoform and is expressed in both somatic and germ cells in the developing ovary and testisA J Pask
Department of Zoology, The University of Melbourne, Melbourne, Vic, Australia
Sex Dev 1:169-80. 2007..Our data suggest that WT1 has a conserved function in both the somatic and germ cell lineages of the gonads of marsupials... - The influence of estrogen on the developing male marsupialM B Renfree
Department of Zoology, The University of Melbourne, Victoria, Australia
Reprod Fertil Dev 13:231-40. 2001..The ability of estradiol to cause testis-to-ovary sex reversal in marsupials provides a new way of studying the interactions between genes and hormones in testicular differentiation... - Virilization of the urogenital sinus of the tammar wallaby is not unique to 5alpha-androstane-3alpha,17beta-diolM W Leihy
Department of Zoology, University of Melbourne, Victoria 3010, Parkville, Australia
Mol Cell Endocrinol 181:111-5. 2001.... - Germ cells, gonads and sex reversal in marsupialsM B Renfree
Department of Zoology, The University of Melbourne, Victoria, Australia
Int J Dev Biol 45:557-67. 2001.... - Effect of an anti-androgen on testicular descent and inguinal closure in a marsupial, the tammar wallaby (Macropus eugenii)D Coveney
Department of Zoology, University of Melbourne, Victoria 3010, Australia
Reproduction 124:865-74. 2002.... - Changes in semen quality and morphology of the reproductive tract of the male tammar wallaby parallel seasonal breeding activity in the femaleD B B P Paris
Department of Zoology, University of Melbourne, Victoria 3010, Australia
Reproduction 130:367-78. 2005..Semen quality may also improve in response to an increase in the number of available oestrous females... - Effects of oestrogen treatment on testicular descent, inguinal closure and prostatic development in a male marsupial, Macropus eugeniiD Coveney
Department of Zoology, The University of Melbourne, Victoria 3010, Australia
Reproduction 124:73-83. 2002..Therefore, the tammar wallaby may provide a useful experimental model animal in which to investigate the hormonal control of testicular migration and closure of the inguinal canal... - Reactivating tammar wallaby blastocysts oxidize fatty acids and amino acidsR E Spindler
Dept of Zoology, University of Melbourne, Parkville, Australia
J Reprod Fertil 115:79-86. 1999..4 +/- 0.3 pmol per embryo h-1). It is likely that metabolism of amino acids and fatty acids contributes to the energy supply during reactivation of tammar wallaby blastocysts after embryonic diapause... - Influence of donor age on development of gonadal tissue from pouch young of the tammar wallaby, Macropus eugenii, after cryopreservation and xenografting into miceD Mattiske
Department of Zoology, University of Melbourne, 3010, Australia
Reproduction 123:143-53. 2002..Assisted reproduction of endangered marsupials may also be feasible using follicles from pouch young grown as xenografts in a eutherian host... - Development of the penile urethra in the tammar wallabyM W Leihy
Department of Zoology, University of Melbourne, Melbourne, Vic, Australia
Sex Dev 5:241-9. 2011..This study suggests that there is an early window of time before day 60 when androgen imprinting must occur for normal penile development and closure of the urethral groove... - Long-term fertility control in the kangaroo and the wallaby using levonorgestrel implantsC D Nave
Department of Zoology, The University of Melbourne, Victoria, Australia
Reprod Suppl 60:71-80. 2002..Thus, levonorgestrel implants provide a safe, highly effective and long-term method of fertility control for macropodid marsupials and should be applicable for the management of overabundant captive and selected wild populations... - Structure and expression of the follicle-stimulating hormone receptor gene in a marsupial, Macropus eugeniiD Mattiske
Department of Zoology, University of Melbourne, Australia
Mol Reprod Dev 63:24-31. 2002..These results strongly suggest that alternate splicing is of functional significance in the ovary since it has remained a highly conserved character of this gene for over 100 million years of divergent evolution... - DiapauseM B Renfree
Department of Zoology, University of Melbourne, Parkville, Victoria, Australia
Annu Rev Physiol 62:353-75. 2000.... - SOX9 has both conserved and novel roles in marsupial sexual differentiationAndrew J Pask
Department of Zoology, The University of Melbourne, Melbourne, Australia
Genesis 33:131-9. 2002..These previously undescribed locations of SOX9 expression suggest that SOX9 may play additional roles in the differentiation of the marsupial reproductive system... - Administration of 5alpha-androstane-3alpha,17beta-diol to female tammar wallaby pouch young causes development of a mature prostate and male urethraMichael W Leihy
Department of Zoology, University of Melbourne, Victoria 3010, Australia
Endocrinology 143:2643-51. 2002..This further strengthens the hypothesis that 5alpha-adiol is the circulating androgen responsible in this species for virilization during development... - Retrotransposon silencing by DNA methylation can drive mammalian genomic imprintingShunsuke Suzuki
Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
PLoS Genet 3:e55. 2007.... - Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallabyShunsuke Suzuki
Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Mech Dev 122:213-22. 2005..These data confirm the existence of common imprinted regions in eutherians and marsupials during development, but suggest that the regulatory mechanisms that control imprinted gene expression differ between these two groups of mammals... - Intra-cytoplasmic sperm injection in a marsupialNadine M Richings
Department of Zoology, The University of Melbourne, Victoria, 3010, Australia
Reproduction 128:595-605. 2004..However, blastomeres were more closely apposed in embryos from tubal oocytes and cell-cell adhesion was more pronounced, indicating that the mucoid coat may be involved in maintaining the integrity of the conceptus during cleavage... - The development of the gubernaculum and inguinal closure in the marsupial Macropus eugeniiDouglas Coveney
Department of Zoology, The University of Melbourne, Victoria, Australia
J Anat 201:239-56. 2002..Tammars have a hopping mode of locomotion and, like humans, are essentially bipedal. We suggest that inguinal closure evolved in these two species because their upright posture may otherwise lead to a high incidence of inguinal hernias... - 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediateJean D Wilson
Department of Zoology, University of Melbourne, Victoria 3010, Australia
Endocrinology 144:575-80. 2003..We conclude that expression of steroid 5alpha-reductase in the developing wallaby testes allows formation of 5alpha-reduced androgens by a pathway that does not involve testosterone as an intermediate... - Androgen physiology: unsolved problems at the millenniumJean D Wilson
Medical Branch, Department of Internal Medicine, University of Texas Southwestern Medical Center, Room J6 110, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
Mol Cell Endocrinol 198:1-5. 2002..5alpha-adiol is the predominant androgen in neonatal testes in several placental mammals, but it is unclear whether it plays a similar role in other mammalian species... - Ontogeny and pathway of formation of 5alpha-androstane-3alpha,17beta-diol in the testes of the immature brushtail possum Trichosurus vulpeculaJean D Wilson
Department of Zoology, University of Melbourne, Victoria, Australia
Reprod Fertil Dev 17:603-9. 2005.... - Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expressionAndrew J Pask
Department of Zoology, University of Melbourne, Victoria 3010, Australia
Biol Reprod 70:160-7. 2004..It is not detectable in atretic follicles. Collectively, these studies suggest that AMH expression has been conserved during mammalian evolution and is intimately linked to upstream sex determination mechanisms... - Penile development is initiated in the tammar wallaby pouch young during the period when 5alpha-androstane-3alpha,17beta-diol is secreted by the testesMichael W Leihy
Department of Zoology, University of Melbourne, Gate 12, Royal Parade, Victoria 3010, Australia
Endocrinology 145:3346-52. 2004.... - Growth and histology of ovarian follicles after cold storage in the tammar wallabyNadine M Richings
Department of Zoology, The University of Melbourne, VIC 3010, Australia
Reprod Fertil Dev 18:677-88. 2006..As demonstrated in the tammar wallaby, cold storage has potential as a method for storage and transport of marsupial ovaries up to 24 h... - The hormonal control of sexual developmentMarilyn B Renfree
Department of Zoology, The University of Melbourne, Victoria, Australia
Novartis Found Symp 244:136-52; discussion 152-6, 203-6, 253-7. 2002..Collectively these studies have led to the development of new paradigms to explain the hormonal mechanisms mediating sexual differentiation... - Unsolved problems in male physiology: studies in a marsupialJean D Wilson
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
Mol Cell Endocrinol 211:33-6. 2003..In target tissues 5alpha-adiol acts via the androgen receptor after conversion to dihydrotestosterone but may have other actions as well. Whether 5alpha-adiol plays a role in male development in placental mammals is uncertain... - The marsupial model for male phenotypic developmentJean D Wilson
Department Internal Medicine, University of Texas Southwestern Medical Center, Dallas TX 75390 8857, USA
Trends Endocrinol Metab 13:78-83. 2002..5 alpha-Adiol is formed by immature testes in many species and appears to act in target tissues once it has been converted to dihydrotestosterone... - The evolution of the DLK1-DIO3 imprinted domain in mammalsCarol A Edwards
Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom
PLoS Biol 6:e135. 2008..A recent mammal-specific retrotransposition event led to the formation of a completely new gene only in the eutherian domain, which may have driven imprinting at the cluster... - Cross-fostering in Macropus eugenii leads to increased weight but not accelerated gastrointestinal maturationRosemary Waite
Department of Zoology, University of Melbourne, Victoria, 3010, Australia
J Exp Zoolog A Comp Exp Biol 303:331-44. 2005..No difference was found in stomach or small intestine development between these groups using the criteria employed in this study... - Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii )Josephine F Trott
Division of Molecular Biology and Genetics, Victorian Institute of Animal Science, Attwood, Victoria 3049, Australia
Biol Reprod 68:929-36. 2003..The present study demonstrates that the lactating tammar wallaby regulates both milk composition and the rate of milk production and that these determine the rates of PY growth and development, irrespective of the age of the PY...