Research Topics
| Nitin K SaksenaSummaryAffiliation: University of Sydney Country: Australia Publications
| Collaborators
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Detail Information
Publications
Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohortHaran Sivakumaran
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Virol J 4:107. 2007..It supports the belief that quasispecies variation in HIV-1 is a mechanism for selection towards defining a fitter gene variant that is capable of resisting the human immune system...- Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV diseaseJing Qin Wu
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Darcy Road, Westmead, NSW 2145, Australia
Retrovirology 8:18. 2011..Therefore, this work aimed to define the genomic basis of HIV interactions with the cellular transcriptome of both CD4+ and CD8+ T cells... - Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressorLeon Caly
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
Retrovirology 5:67. 2008..Importantly, an F72L point mutation in the LTNP was identified for the first time as being uniquely responsible for decreased Vpr nuclear import... - Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDSJasminka Sterjovski
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Retrovirology 4:89. 2007.... - HIV-1 nef suppression by virally encoded microRNAShinya Omoto
Molecular Biology and Retroviral Genetics Group, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
Retrovirology 1:44. 2004..Our recent study has shown that HIV-1 nef dsRNA from AIDS patients who are long-term non-progressors (LTNPs) inhibited the transcription of HIV-1... - Human immunodeficiency virus interactions with CD8+ T lymphocytesNitin K Saksena
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead, Australia
Curr HIV Res 6:1-9. 2008.... - First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementiaLi Zhou
Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
Mol Neurodegener 5:27. 2010..The pathogenesis of HIV-associated dementia (HAD) is poorly understood. To date, detailed proteomic fingerprinting directly from autopsied brain tissues of HAD and HIV non-dementia patients has not been performed... - Snapshot of HIV pathogenesis in ChinaNitin K Saksena
Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead NSW 2145 Sydney, Australia
Cell Res 15:953-61. 2005.... - HAART & the molecular biology of AIDS dementia complexNitin K Saksena
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Darcy Road, Westmead NSW 2145, Sydney, Australia
Indian J Med Res 121:256-69. 2005..In addition, an overview of various biological, molecular and therapeutic aspects that may influence HIV dementia (HIV-D) is provided... - Reservoirs of HIV-1 in vivo: implications for antiretroviral therapyNitin K Saksena
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia
AIDS Rev 5:3-18. 2003..In addition, it addresses the effect of sub-optimal drug concentrations on reservoir establishment and outlines future therapeutic strategies to counteract these reservoirs and sanctuaries... - Viral reservoirs an impediment to HAART: new strategies to eliminate HIV-1Nitin K Saksena
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead NSW 2145, Sydney, Australia
Curr Drug Targets Infect Disord 3:179-206. 2003..New strategies are needed for flushing hidden pockets of HIV in vivo. This review will focus mainly on novel strategies in the pipeline, along with the recent developments in the field... - Elite HIV controllers: myth or reality?Nitin K Saksena
Retroviral Genetics Division, Westmead Millennium Institute, Westmead Hospital, Westmead NSW, Sydney, Australia
AIDS Rev 9:195-207. 2007..Aspects dealing with cellular, humoral, innate, and adaptive immunity, which are relevant to nonprogressive HIV disease, are beyond the scope of this review... - Drug resistance and viral evolution in plasma and peripheral blood cells during structured treatment interruption (STI) and non-interrupted HAARTYuan Min Wang
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institutes, Westmead Hospital, The University of Sydney, Sydney, Australia
Curr HIV Res 5:235-50. 2007..In addition, little remains known how viral evolutionary process may differ between cell-free and cell-associated compartments, over time, in vivo in patients receiving HAART or STI... - Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infectionWayne B Dyer
Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia
Retrovirology 5:112. 2008..We examined the mechanisms that differentiated delayed progressors from LTNP in this cohort... - Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapyJing Qin Wu
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Darcy Road, Westmead, NSW 2145, Sydney, Australia
Retrovirology 5:24. 2008..Blood samples were collected over an average of 3 years and 5-8 time points were selected for microarray assay and statistical analysis... - Continuous crossover(s) events of HIV-1 CRF01_AE and B subtype strains in Malaysia: evidence of rapid and extensive HIV-1 evolution in the regionKatherine A Lau
Retroviral Genetics Division, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney, Australia
Curr HIV Res 6:108-16. 2008..This highlights the public health relevance of newly emerging second generation HIV-1 recombinant forms and their dispersal, along with their rapid and continuous evolution in the region... - Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAARTSimon J Potter
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Darcy Road, Westmead, Sydney NSW 2145, Australia
Virology 348:35-46. 2006.... - Evidence for possible biological advantages of the newly emerging HIV-1 circulating recombinant form from Malaysia - CRF33_01B in comparison to its progenitors - CRF01_AE and subtype BKatherine A Lau
Retroviral Genetics Division, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
Curr HIV Res 8:259-71. 2010..We therefore estimate a possible gradual replacement of the current predominance of CRF01_AE, as well as wider dissemination of CRF33_01B, together with the identification of other new CRF01_AE/B inter-subtype recombinants in Malaysia... - Assessment of drug resistance mutations in plasma and peripheral blood mononuclear cells at different plasma viral loads in patients receiving HAARTChoo Beng Chew
Center for Infectious Diseases and Microbiology Laboratory Systems, ICPMR, Westmead Hospital, Westmead, NSW 2145, Australia
J Clin Virol 33:206-16. 2005..The utility of PBMCs as an alternative source of resistance profiling was also demonstrated, and this approach may benefit the assessment of future drug regimens for HIV-infected patients... - Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementiaLi Zhou
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW, Sydney, Australia
BMC Infect Dis 9:192. 2009..HIV-1 penetrates the central nervous system, which is vital for HIV-associated dementia (HAD). But the role of cellular infiltration and activation together with HIV in the development of HAD is poorly understood... - HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartmentsYung Shwen Ho
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead NSW, 2145 Sydney, Australia
Virol J 5:14. 2008..Although it is known that glycosylation changes can dramatically influence virus recognition by the host antibody, the actual contribution of compartmental differences in N-linked glycosylation patterns remains unclear... - Evidence for predominance of CCR5-using HIV-1 strains during highly active antiretroviral therapyYuan Min Wang
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia
Curr HIV Res 5:221-34. 2007.... - Obstacles to successful antiretroviral treatment of HIV-1 infection: problems & perspectivesSimon J Potter
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Sydney, NSW, Australia
Indian J Med Res 119:217-37. 2004..In the present article, we discuss various obstacles to HIV therapy, and provide perspectives relating to these issues that are critical in determining the success or failure of HAART... - Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infectionJohn J Zaunders
Centre for Immunology, St Vincent s Hospital, and University of New South Wales, Sydney, Australia
Blood 103:2238-47. 2004..Moreover, expression of CCR5 may render them particularly susceptible to cytopathic effects during progressive HIV-1 infection... - Sensitive detection of the K103N non-nucleoside reverse transcriptase inhibitor resistance mutation in treatment-naïve HIV-1 infected individuals by rolling circle amplificationBin Wang
Center for Virus Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia
J Virol Methods 161:128-35. 2009..Importantly, the new RCA technology allows large-scale, sensitive detection of drug resistance mutations, including detection of minority populations with minimal equipment requirement... - Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stagesJing Qin Wu
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
Retrovirology 4:83. 2007.... - Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responsesJing Qin Wu
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW, Australia
Virology 380:124-35. 2008..These results will provide biological insights into natural control of HIV versus HIV control under HAART... - First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infectionBin Wang
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
Virology 312:135-50. 2003..Further study on the antigenic properties of this strain may assist in the development of HIV vaccines and therapeutics... - Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatmentTheresa K Smit
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Darcy Rd, Westmead NSW 2145, Sydney, Australia
J Virol 78:10133-48. 2004..The emergence of resistant virus in the CNS may have considerable influence on the outcome of neurologic disease and also the reseeding of HIV in the systemic circulation upon failure of therapy... - Full-length HIV type 1 genome analysis showing evidence for HIV type 1 transmission from a nonprogressor to two recipients who progressed to AIDSMeriet Mikhail
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Sydney, Australia
AIDS Res Hum Retroviruses 21:575-9. 2005..Overall, these studies highlight the utility of full genome sequencing in establishing epidemiologic linkage in a chronically infected HIV cohort after 10 years of initial infection... - Role of viral evolutionary rate in HIV-1 disease progression in a linked cohortMeriet Mikhail
Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Sydney, Australia
Retrovirology 2:41. 2005..By conducting 15 near full-length genome (8.7 kb) analysis from longitudinally derived patient PBMC samples enabled us to investigate the extent of molecular factors, which govern HIV disease progression... - Differential cellular distribution of HIV-1 drug resistance in vivo: evidence for infection of CD8+ T cells during HAARTSimon J Potter
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, New South Wales 2145, Australia
Virology 305:339-52. 2003..This study is the first to demonstrate the differential distribution of HIV drug resistance in different blood cell types during HAART and provides new insights into the infection of CD8+ T cells in vivo... - HIV-1 compartmentalization in diverse leukocyte populations during antiretroviral therapySimon J Potter
Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Darcy Road, Westmead, Sydney NSW 2145, Australia
J Leukoc Biol 76:562-70. 2004.... - Near full-length sequence analysis of a Unique CRF01_AE/B recombinant from Kuala Lumpur, MalaysiaKatherine A Lau
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead NSW 2145, Sydney, Australia
AIDS Res Hum Retroviruses 23:1139-45. 2007..Thus we suggest that 06MYKLD46 is a possible second-generation HIV-1 recombinant derived from CRF33_01B... - HIV-1 co-infection, superinfection and recombinationMegan C Steain
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
Sex Health 1:239-50. 2004..This review is aimed at providing a more thorough understanding of dual infections (both co-infection and super-infection) and the possible consequences of the emergence of recombinant HIV-1 strains... - Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infectionsBin Wang
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
Antiviral Res 87:16-21. 2010..In the light of emerging resistance, close monitoring and understanding of the nature and dynamics of resistance mutations in newly emerging strains should be a priority... - Analysis of HIV-1 sequences vertically transmitted to infants in Kisumu, KenyaMegan C Steain
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145 Sydney, Australia
J Clin Virol 36:298-302. 2006..Together, dual infections and the co-existence of multiple HIV-1 subtypes is encouraging the emergence of recombinant HIV strains and their rapid dispersal... - HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposureSebastiaan J van Hal
Centre for Infectious Diseases and Microbiology, ICPMR Westmead Hospital, University of Sydney, Westmead 2145, NSW, Australia
Retrovirology 6:12. 2009..Based on these findings, we would recommend ongoing surveillance of integrase mutations, and integrase region sequencing for patients prior to commencement of integrase inhibitors... - Complex patterns of the HIV-1 epidemic in Kuala Lumpur, Malaysia: evidence for expansion of circulating recombinant form CRF33_01B and detection of multiple other recombinantsBin Wang
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW, Sydney, Australia
Virology 367:288-97. 2007..The remaining 18% of samples were identified as unique recombinant forms (URFs)... - Short communication: absence of HIV infection in the choroid plexus of two patients who died rapidly with HIV-associated dementiaLi Zhou
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Australia
AIDS Res Hum Retroviruses 24:839-43. 2008..These data suggest that HIV entry to the CNS may be independent of the CPx. It also emphasizes that the CPx is unlikely to harbor a significant reservoir of HIV in patients who rapidly progress to dementia... - The possible contribution of HIV-1-induced syncytia to the generation of intersubtype recombinants in vitroMegan C Steain
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney, New South Wales, Australia
AIDS 22:1009-17. 2008..To develop a method for single syncytia isolation and delineate the possible contribution of syncytia to intersubtype recombination... - Hierarchical kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profilesPaul D Yoo
Centre for Distributed and High Performance Computing, University of Sydney, NSW, Australia
BMC Genomics 11:S22. 2010..82% CCI, 30.21 MSE, 0.8 STD, and 2.62 TBM on the three stages of AIDS disease progression of 50 HIV+ individuals. This framework is an invaluable bioinformatics tool that will be useful to the clinical assessment of viral pathogenesis... - Env gp120 sequence analysis of HIV type 1 strains from diverse areas of the brain shows preponderance of CCR5 usageMeet Shah
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Darcy Road, Westmead NSW 2145, Australia
AIDS Res Hum Retroviruses 22:177-81. 2006.... - Comprehensive analyses of a unique HIV-1-infected nonprogressor reveal a complex association of immunobiological mechanisms in the context of replication-incompetent infectionBin Wang
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead, New South Wales 2145, Australia
Virology 304:246-64. 2002..Understanding how to induce these protective immune responses in other individuals could provide a major step forward in the design of effective immunotherapies or vaccines against HIV infection... - Emerging trends of HIV epidemiology in AsiaKatherine A Lau
Retroviral Genetics Division, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Sydney, Australia
AIDS Rev 9:218-29. 2007..This appears to be an ongoing phenomenon and has resulted in an HIV-1 epidemic shift, with the expansion and dissemination of a wide variety of HIV-1 forms within this geographic region... - Rapid and sensitive detection of severe acute respiratory syndrome coronavirus by rolling circle amplificationBin Wang
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Darcy Rd, Westmead, Sydney, NSW 2145, Australia
J Clin Microbiol 43:2339-44. 2005..Furthermore, the RCA technology provides a faster, more sensitive, and economical option to currently available PCR-based methods... - Mechanisms involved in non-progressive HIV diseaseMeriet Mikhail
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney NSW 2145, Australia
AIDS Rev 5:230-44. 2003.... - Detection of influenza A H1N1 and H3N2 mutations conferring resistance to oseltamivir using rolling circle amplificationMegan C Steain
Department of Infectious Diseases and Immunology, University of Sydney, NSW 2006, Australia
Antiviral Res 84:242-8. 2009..These results were further confirmed by neuraminidase region sequencing. In conclusion, RCA technology can provide rapid (<24 h), high-throughput diagnosis of OTV resistance mutations with a high specificity and sensitivity... - Synthetic long oligonucleotides to generate artificial templates for use as positive controls in molecular assays: drug resistance mutations in influenza virus as an exampleBin Wang
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, New South Wales, Australia
Virol J 8:405. 2011..This work describes the development of a synthetic oligo-cassette for positive controls for accurate and highly sensitive diagnosis of several mutations relevant to influenza virus drug resistance... - Segregation of human immunodeficiency virus type 1 subtypes by risk factor in AustraliaBelinda L Herring
Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
J Clin Microbiol 41:4600-4. 2003..Subtype B strains of group M viruses predominate in Australia in HIV-1 transmitted by homosexual or bisexual contact and IDU. However, non-B subtypes have been introduced, mostly acquired via heterosexual contact... - HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sitesNitin K Saksena
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead, NSW, Sydney, Australia
HIV AIDS (Auckl) 2:103-22. 2010..This review provides an overview of HIV reservoir sites and discusses both the virtues and problems associated with therapies/strategies targeting these reservoir sites in vivo... - Interaction between HIV-1 and APOBEC3 sub-family of proteinsMaria E Arriaga
Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Sydney, Australia
Curr HIV Res 4:401-9. 2006..The main purpose of this review is to provide a detailed overview on HIV-specific interaction of APOBEC3 subfamily of proteins and discuss its potential role in HIV pathogenesis... - HIV type 1 sequence diversity and dual infections in KenyaMegan C Steain
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead NSW 2145, Sydney, Australia
AIDS Res Hum Retroviruses 21:882-5. 2005..These results imply that the HIV epidemic in western Kenya is a dynamic one and is continually evolving. Therefore, continued monitoring of the epidemic in this region is necessary if a vaccine for the area is to be developed... - Broad neutralization and complement-mediated lysis of HIV-1 by PEHRG214, a novel caprine anti-HIV-1 polyclonal antibodyErin E Verity
Department of Microbiology, Monash University, Clayton, Victoria, Australia
AIDS 20:505-15. 2006..By targeting host cell proteins present in the viral envelope, which are conserved among all strains tested, PEHRG214 potentially opens up a highly novel means of eliminating circulating virus in infected individuals... - Double-stranded nef RNA interferes with human immunodeficiency virus type 1 replicationTakuya Yamamoto
Division of Nutritional Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467-8603, Japan
Microbiol Immunol 46:809-17. 2002..At 48 hr, a defective nef dsRNA (556 nt) suppressed Luc activity more potently than did SF2 full-length nef dsRNA (744 nt), suggesting that approximately 500 nt-long nef dsRNA could interfere with the HIV-1 transcription... - Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohortLeon Cali
Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Monash, VIC 3800, Australia
AIDS Res Hum Retroviruses 21:728-33. 2005.... - Functional conservation of HIV-1 Vpr and variability in a mother-child pair of long-term non-progressorsYuqi Zhao
Children s Memorial Institute for Education and Research, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Virus Res 89:103-21. 2002..Thus, Vpr activities are generally conserved in naturally occurring viruses. The functionally defective Vpr identified in the mother-child pair of LTNPs are likely to be unique and may possibly contribute to the slow disease progression... - Transitory viremic surges in a human immunodeficiency virus-positive elite controller can shift the cellular transcriptome profile: a word of caution for microarray studiesJing Qin Wu
J Virol 82:10326-7. 2008 - HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptorsKaori Otake
Nagoya University Hospital, Japan
AIDS 18:189-98. 2004..Nef is known to play an important role in transcriptional events and viral replication, but the actual target of Nef in the nucleus remains to be identified... - Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 alleleLachlan Gray
Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne 3001, Victoria, Australia
J Virol 80:3684-91. 2006..The persistence of CCR5-using HIV-1 in two CCR5delta32 homozygotes suggests the conserved CCR5 binding domain of Env is highly stable and provides new mechanistic insights important for HIV-1 transmission and persistence... - Site stripping based on likelihood ratio reduction is a useful tool to evaluate the impact of non-clock-like behavior on viral phylogenetic reconstructionsPhilippe Lemey
Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B 3000, Leuven, Belgium
FEMS Immunol Med Microbiol 39:125-32. 2003..Our method was able to rapidly recover clock-like behavior and to indicate the presence and direction of a bias when estimates of divergence times using the unstripped data were flawed... - Tracing the origin and history of the HIV-2 epidemicPhilippe Lemey
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
Proc Natl Acad Sci U S A 100:6588-92. 2003....