Rebecca L Robker

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi Control of oocyte release by progesterone receptor-regulated gene expression
    Rebecca L Robker
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, SA, Australia
    Nucl Recept Signal 7:e012. 2009
  2. ncbi Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women
    Rebecca L Robker
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, 5005 Australia
    J Clin Endocrinol Metab 94:1533-40. 2009
  3. ncbi Inflammatory pathways linking obesity and ovarian dysfunction
    Rebecca L Robker
    School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Reprod Immunol 88:142-8. 2011
  4. ncbi ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice
    Hannah M Brown
    School of Paediatrics and Reproductive Health, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 83:549-57. 2010
  5. ncbi Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality
    Cadence E Minge
    School of Paediatrics and Reproductive Health, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 149:2646-56. 2008
  6. ncbi Altered composition of the cumulus-oocyte complex matrix during in vitro maturation of oocytes
    Kylie R Dunning
    Discipline of Obstetrics and Gynaecology, Research Centre for Reproductive Health, The University of Adelaide, Adelaide, SA, Australia
    Hum Reprod 22:2842-50. 2007
  7. ncbi High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates
    Linda Lin Yan Wu
    School of Pediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 151:5438-45. 2010
  8. ncbi Beta-oxidation is essential for mouse oocyte developmental competence and early embryo development
    Kylie R Dunning
    The Robinson Institute, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 83:909-18. 2010
  9. ncbi Development and hormonal regulation of the ovarian lymphatic vasculature
    Hannah M Brown
    School of Pediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    Endocrinology 151:5446-55. 2010
  10. ncbi Exogenous transforming growth factor beta1 replacement and fertility in male Tgfb1 null mutant mice
    Leanne J McGrath
    Discipline of Obstetrics and Gynaecology and Research Centre for Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Reprod Fertil Dev 21:561-70. 2009

Collaborators

Detail Information

Publications22

  1. ncbi Control of oocyte release by progesterone receptor-regulated gene expression
    Rebecca L Robker
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, SA, Australia
    Nucl Recept Signal 7:e012. 2009
    ..Rather, in ovarian granulosa cells, PGR may act as an inducible coregulator for constitutively bound Sp1/Sp3 transcription factors, which are key regulators for a discrete cohort of ovulatory genes...
  2. ncbi Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women
    Rebecca L Robker
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, 5005 Australia
    J Clin Endocrinol Metab 94:1533-40. 2009
    ..Obese women experience longer times to conception, even if they are young and cycling regularly, which is suggestive of alterations in ovarian function during the periconceptual period...
  3. ncbi Inflammatory pathways linking obesity and ovarian dysfunction
    Rebecca L Robker
    School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Reprod Immunol 88:142-8. 2011
    ..These studies are in their infancy but cumulatively provide basic information about the cellular mechanisms that may lead to the impaired ovulation and reduced oocyte developmental potential that is observed in obese females...
  4. ncbi ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice
    Hannah M Brown
    School of Paediatrics and Reproductive Health, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 83:549-57. 2010
    ....
  5. ncbi Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality
    Cadence E Minge
    School of Paediatrics and Reproductive Health, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 149:2646-56. 2008
    ..Improved blastocyst quality in obese females treated with rosiglitazone before mating indicates that peroxisome proliferator activated receptor-gamma is a key target for metabolic regulation of ovarian function and oocyte quality...
  6. ncbi Altered composition of the cumulus-oocyte complex matrix during in vitro maturation of oocytes
    Kylie R Dunning
    Discipline of Obstetrics and Gynaecology, Research Centre for Reproductive Health, The University of Adelaide, Adelaide, SA, Australia
    Hum Reprod 22:2842-50. 2007
    ....
  7. ncbi High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates
    Linda Lin Yan Wu
    School of Pediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 151:5438-45. 2010
    ..These results indicate that lipotoxicity may be occurring in ovarian cells of obese women and may contribute to the reduced pregnancy rates observed in response to obesity...
  8. ncbi Beta-oxidation is essential for mouse oocyte developmental competence and early embryo development
    Kylie R Dunning
    The Robinson Institute, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 83:909-18. 2010
    ..Thus, carnitine is an important cofactor for developing oocytes, and fatty acids are an important energy source for oocyte and embryo development...
  9. ncbi Development and hormonal regulation of the ovarian lymphatic vasculature
    Hannah M Brown
    School of Pediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    Endocrinology 151:5446-55. 2010
    ....
  10. ncbi Exogenous transforming growth factor beta1 replacement and fertility in male Tgfb1 null mutant mice
    Leanne J McGrath
    Discipline of Obstetrics and Gynaecology and Research Centre for Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Reprod Fertil Dev 21:561-70. 2009
    ....
  11. ncbi Recombinant human follicle-stimulating hormone alters maternal ovarian hormone concentrations and the uterus and perturbs fetal development in mice
    Rebecca L Kelley
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia
    Am J Physiol Endocrinol Metab 291:E761-70. 2006
    ..These results demonstrate that gonadotropin stimulation with rhFSH or eCG alters the preimplantation maternal environment, which results in reduced pregnancy rates and fetal development in the mouse...
  12. ncbi Increased beta-oxidation and improved oocyte developmental competence in response to l-carnitine during ovarian in vitro follicle development in mice
    Kylie R Dunning
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 85:548-55. 2011
    ..l-carnitine supplementation during in vitro follicle culture increased lipid metabolism and improved oocyte developmental competence...
  13. ncbi Molecular mechanisms of ovulation: co-ordination through the cumulus complex
    Darryl L Russell
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, South Australia, Australia
    Hum Reprod Update 13:289-312. 2007
    ..The convergence of ovulatory signals through the cumulus complex co-ordinates the key mechanistic processes that mediate and control oocyte maturation and ovulation...
  14. ncbi Effects of obesity on assisted reproductive technology outcomes
    Robert J Norman
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia
    Fertil Steril 89:1611-2. 2008
    ..Several studies have sought to determine the effects of obesity on the endometrium by analyzing outcomes in patients receiving ovum donation...
  15. ncbi Transient invasive migration in mouse cumulus oocyte complexes induced at ovulation by luteinizing hormone
    Lisa K Akison
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 86:125. 2012
    ....
  16. ncbi Troglitazone regulates peroxisome proliferator-activated receptors and inducible nitric oxide synthase in murine ovarian macrophages
    Cadence E Minge
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
    Biol Reprod 74:153-60. 2006
    ..Additionally, ovarian macrophages respond directly to troglitazone to downregulate expression of proinflammatory Nos2, providing mechanistic information about ovarian effects of TZD treatment...
  17. ncbi Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis
    Hannah M Brown
    School of Paediatrics and Reproductive Health, Research Centre for Reproductive Health, The University of Adelaide, Adelaide, South Australia, 5005, Australia
    Dev Biol 300:699-709. 2006
    ..These novel roles for ADAMTS-1 in structural maintenance of follicular basement membranes and lymphangiogenesis provide new mechanistic understanding of folliculogenesis, fertility and disease...
  18. ncbi Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development
    Linda L Wu
    The Robinson Institute, School of Paediatrics and Reproductive Health, Research Centre for Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Mol Endocrinol 26:562-73. 2012
    ....
  19. ncbi Utilization of endogenous fatty acid stores for energy production in bovine preimplantation embryos
    Melanie L Sutton-McDowall
    The Robinson Institute, Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Theriogenology 77:1632-41. 2012
    ..In conclusion, L-carnitine supplementation supported precompaction embryo development and there was an additive effect of +L-carnitine +carbohydrates on early embryo development, most likely through increased ?-oxidation within embryos...
  20. ncbi The impact of obesity on oocytes: evidence for lipotoxicity mechanisms
    Linda L Y Wu
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Reprod Fertil Dev 24:29-34. 2011
    ..Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality...
  21. ncbi PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility
    Cadence E Minge
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, South Australia 5005, Australia
    PPAR Res 2008:243791. 2008
    ..This review discusses the developing links between PPARG activity and female reproductive function, and highlights several mechanisms that may facilitate such a relationship...
  22. ncbi Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest
    Wendy V Ingman
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, South Australia
    Endocrinology 147:835-45. 2006
    ..This study demonstrates that TGFbeta1 is a critical determinant of normal ovarian function, operating through regulation of LH activity and generation of oocytes competent for embryonic development and successful initiation of pregnancy...