Research Topics
Genomes and Genes | Marie RansonSummaryAffiliation: University of Wollongong Country: Australia Publications
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Publications
In vitro cytotoxicity evaluation of some substituted isatin derivativesKara L Vine
School of Biological Sciences, University of Wollongong, NSW 2522, Australia
Bioorg Med Chem 15:931-8. 2007..These results indicate that di- and tri-substituted isatins may be useful leads for anticancer drug development in the future...- Plasminogen binding and cancer: promises and pitfallsMarie Ranson
Department of Biological Sciences and Institute for Biomolecular Sciences, University of Wollongong, Australia, 2522
Front Biosci 8:s294-304. 2003..In addition, some of the pitfalls and strategies encountered when conducting plasminogen receptor experiments are also addressed... - The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residuesMartina L Sanderson Smith
School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
J Bacteriol 189:1435-40. 2007..Thus, binding to plasminogen via arginine and histidine residues appears to be a conserved mechanism among plasminogen-binding M proteins... - Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytesJodi A Lee
School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, New South Wales, Australia
Thromb Haemost 104:1133-42. 2010.... - Dependence on endocytic receptor binding via a minimal binding motif underlies the differential prognostic profiles of SerpinE1 and SerpinB2 in cancerBlake J Cochran
School of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
J Biol Chem 286:24467-75. 2011..This has clear relevance to understanding the paradoxical disease outcomes associated with overexpression of these serpins in cancer... - Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profilesTamantha K Stutchbury
School of Biological Sciences, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia
Anticancer Drugs 22:24-34. 2011..In conclusion, these novel, all-in-one formulations represent a superior injectable form of 5-FU that allows codelivery of folinic acid. This should translate into improved patient tolerability with potential for enhanced efficacy... - Divergence in the plasminogen-binding group a streptococcal M protein family: functional conservation of binding site and potential role for immune selection of variantsMartina Sanderson-Smith
School of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
J Biol Chem 281:3217-26. 2006..These data suggest a link between selective immune pressure against the plasminogen-binding repeats and the functional conservation of the binding domain in PAM variants... - The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domainsMartina L Sanderson-Smith
School of Biological Sciences, University of Wollongong, Northfields Avenue, New South Wales 2522, Australia
J Biol Chem 281:25965-71. 2006.... - Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activationJason D McArthur
School of Biological Sciences, University of Wollongong, Wollongong, NSW, 2522, Australia
FASEB J 22:3146-53. 2008..This study indicates that variant streptokinase proteins secreted by S. pyogenes isolates display differing plasminogen activation characteristics and may therefore play distinct roles in disease pathogenesis... - N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agentsLidia Matesic
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia
Bioorg Med Chem 16:3118-24. 2008..The results allowed further development of structure-activity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM... - A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cellsDavid R Croucher
School of Biological Sciences, University of Wollongong, NSW 2522, Australia
Biochem J 408:203-10. 2007..We thus propose a structurally based mechanism for these differences between PAI-1 and PAI-2 and suggest that PAI-2 is able to inhibit and clear uPA activity without initiating mitogenic signalling events through VLDLr... - Trigger for group A streptococcal M1T1 invasive diseaseJason N Cole
School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, 2522, Australia
FASEB J 20:1745-7. 2006..pyogenes M1T1 with the human plasminogen activation system. Loss of SpeB activity in a subpopulation of S. pyogenes M1T1 at the site of infection results in accumulation of surface plasmin activity thus triggering systemic spread... - An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatinsKara L Vine
School of Biological Sciences, and Department of Chemistry, University of Wollongong, NSW 2522, Australia
J Med Chem 50:5109-17. 2007..49 muM. Various N-alkylisatins were also found to dramatically alter lymphocyte morphology, destabilize microtubules, inhibit tubulin polymerization, induce G2/M cell cycle arrest, and activate the effector caspase-3 and -7... - Synthesis and hydrolytic evaluation of acid-labile imine-linked cytotoxic isatin model systemsLidia Matesic
School of Chemistry, University of Wollongong, Wollongong, NSW, Australia
Bioorg Med Chem 19:1771-8. 2011..The ability to fine-tune hydrolysis rates in this way has potential implications for optimising imine linked, tumour targeting cytotoxin-protein conjugates... - Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactionsSergei Lobov
School of Biological Sciences, University of Wollongong, NSW, Australia
Thromb Haemost 100:319-29. 2008..These data open new possibilities for further investigations regarding the regulation of cellular plasmin generation in vivo, especially in tissues where PAI-2 and tPA may be co-expressed... - The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activityBlake J Cochran
School of Biological Sciences, University of Wollongong, NSW, 2522, Australia
BMC Biotechnol 9:43. 2009..Herein we validate the use in vitro of recombinant 6 x His-tagged-PAI-2 lacking the intrahelical loop between C and D alpha-helices (PAI-2 Delta CD-loop) for these purposes... - Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activityGillian E Stillfried
School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia
Breast Cancer Res 9:R14. 2007..However, few studies have used techniques that exclusively characterise cell-surface events and these mechanisms have not been investigated at the breast cancer cell surface... - Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: Implications for cellular proteolysis and adhesion in cancerSergei Lobov
School of Biological Sciences and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, 2522 NSW, Australia
Cancer Lett 303:118-27. 2011..Thus studies aimed at further characterising the interplay between PAI-1 and PAI-2 on uPA-dependent pro-invasive processes are warranted... - Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinomaTamantha K Stutchbury
School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
Mol Cancer Ther 6:203-12. 2007..This will allow detailed safety evaluation in a second species and for the initiation of human studies... - Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinateJulie M Locke
School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia
Anticancer Drugs 20:822-31. 2009.... - Forty years later and the role of plasminogen activator inhibitor type 2/SERPINB2 is still an enigmaJodi A Lee
School of Biological Sciences, University of Wollongong, Wollongong NSW, Australia
Semin Thromb Hemost 37:395-407. 2011..This review readdresses the evidence supporting a role for PAI-2 in fibrinolysis and proteolysis within extracellular environments and includes a review of the many potential intracellular functions attributed to PAI-2... - Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)Hayden Matthews
School of Chemistry, University of Wollongong, NSW 2522, Australia
Bioorg Med Chem Lett 21:6760-6. 2011..A key finding was that the well-studied 5-substituted analogs ethylisopropyl amiloride (EIPA) and hexamethylene amiloride (HMA) are approximately twofold more potent than amiloride as uPA inhibitors... - Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptorVineesh Indira Chandran
School of Biological Sciences and Center for Medical Bioscience, University of Wollongong, Australia
Cancer Lett 316:151-6. 2012..These results suggest that this novel isatin-based cytotoxin conjugated to a tumor targeting protein via an acid-labile linker warrants further preclinical testing... - Is plasminogen deployed as a Streptococcus pyogenes virulence factor?Mark J Walker
School of Biological Sciences, University of Wollongong, NSW, 2522 Australia
Trends Microbiol 13:308-13. 2005..Recent experimental evidence using a humanized transgenic mouse model suggests a crucial role for human plasminogen in the dissemination of S. pyogenes in vivo... - Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligandMelissa de Souza
School of Biological Sciences, University of Wollongong, NSW, Australia
Bioorg Med Chem 19:2549-56. 2011..The report highlights the dangers of identifying false-positive lead uPAR antagonists from competition assays employing labelled competing ligands other than the native HMW-uPA... - Cell surface antigens of Mycoplasma species bovine group 7 bind to and activate plasminogenKylie Bower
Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
Infect Immun 71:4823-7. 2003..Binding assays using plasminogen modified with a trifunctional cross-linking agent revealed several binding proteins... - P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cellsAndrew W Farrell
School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia
Biochim Biophys Acta 1800:1173-82. 2010..The extracellular ATP-gated cation channel, P2X7 receptor, has an emerging role in neoplasia, however progress in the field is limited by a lack of malignant cell lines expressing this receptor... - Kinetic analysis of plasminogen activator inhibitor type-2: urokinase complex formation and subsequent internalisation by carcinoma cell linesFares Al-Ejeh
School of Biological Sciences, University of Wollongong, NSW 2522, Australia
Exp Cell Res 297:259-71. 2004..PAI-2 was subsequently degraded, presumably within lysosomes. This study is the first to provide definitive evidence for uPA/uPAR-mediated PAI-2 endocytosis... - Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infectionFiona C McKay
Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
Infect Immun 72:364-70. 2004..Despite considerable amino acid sequence variation within the A1 repeat region of PAM where the plasminogen-binding domain maps, the critical lysine residue was conserved... - Revisiting the biological roles of PAI2 (SERPINB2) in cancerDavid R Croucher
Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales, Australia 2010
Nat Rev Cancer 8:535-45. 2008.... - The urokinase/PAI-2 complex: a new high affinity ligand for the endocytosis receptor low density lipoprotein receptor-related proteinDavid Croucher
School of Biological Sciences, University of Wollongong, New South Wales 2522
J Biol Chem 281:10206-13. 2006..Furthermore, lack of a direct interaction between PAI-2 and LRP implies that downstream signaling events initiated by PAI-1 may not be activated by PAI-2... - Peptides and small molecules targeting the plasminogen activation system: towards prophylactic anti-metastasis drugs for breast cancerJoel D A Tyndall
National School of Pharmacy, University of Otago, Dunedin, New Zealand
Recent Pat Anticancer Drug Discov 3:1-13. 2008.... - Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as alpha-enolaseDamien T O'Dwyer
Pediatric Endocrine Unit, John Hunter Children s Hospital, University of Newcastle, Newcastle, New South Wales 2310, Australia
J Clin Endocrinol Metab 87:752-7. 2002..However, this study is the first to indicate a role for alpha-enolase as an autoantigen in lymphocytic hypophysitis...