Research Topics
| T OmariSummaryAffiliation: University of Adelaide Country: Australia Publications
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Publications
Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux diseaseT I Omari
Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital and Department of Paediatrics, University of Adelaide, North Adelaide, Australia
Gut 51:475-9. 2002..Transient lower oesophageal sphincter relaxation (TLOSR) is the predominant mechanism of gastro-oesophageal reflux (GOR) in healthy infants but the mechanisms of GOR in infants with GOR disease (GORD) are poorly understood...- Assessment of intraluminal impedance for the detection of pharyngeal bolus flow during swallowing in healthy adultsTaher I Omari
Department of Paediatrics, University of Adelaide, and Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Adelaide, South Australia
Am J Physiol Gastrointest Liver Physiol 290:G183-8. 2006..Therefore, we conclude that intraluminal impedance measurement does not accurately reflect the bolus transit in the pharynx but does accurately reflect bolus transit across the UES and below... - Upper esophageal sphincter impedance as a marker of sphincter opening diameterTaher I Omari
Gastroenterology Unit, Women s and Children s Health Network, 72 King William Rd, North Adelaide SA 5006 South Australia
Am J Physiol Gastrointest Liver Physiol 302:G909-13. 2012..This variable, when combined with other pharyngeal AIM analysis variables, may allow characterization of the pathophysiology of swallowing dysfunction... - Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trialTaher I Omari
Department of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia
J Pediatr 149:468-74. 2006.... - Effect of omeprazole on acid gastroesophageal reflux and gastric acidity in preterm infants with pathological acid refluxTaher I Omari
Department of Paediatrics, University of Adelaide, Australia
J Pediatr Gastroenterol Nutr 44:41-4. 2007..The aim of this study was to determine the effect of 0.7 mg/kg/d omeprazole on gastric acidity and acid gastroesophageal reflux in preterm infants with reflux symptoms and pathological acid reflux on 24-h pH probe... - Pharmacokinetics and acid-suppressive effects of esomeprazole in infants 1-24 months old with symptoms of gastroesophageal reflux diseaseTaher Omari
Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, Department of Paediatrics, University of Adelaide, Australia
J Pediatr Gastroenterol Nutr 45:530-7. 2007..To evaluate the pharmacokinetics and acid-suppressive effects of esomeprazole in infants with gastroesophageal reflux disease (GERD)... - Gastroesophageal reflux in infants: can a simple left side positioning strategy help this diagnostic and therapeutic conundrum?T Omari
Gastroenterology Unit, Child Youth and Women s Health Service, North Adelaide, Australia
Minerva Pediatr 60:193-200. 2008..This review will evaluate the basis left-side positioning as a simple, non-pharmacological approach to the treatment of GER related symptoms in preterm and term infants 0-6 months of age... - Apnea-associated reduction in lower esophageal sphincter tone in premature infantsTaher I Omari
Gastroenterology Unit, Children, Youth and Women s Health Services, North Adelaide, Australia
J Pediatr 154:374-8. 2009..To characterize esophageal motility during episodes of prolonged apnea in premature infants... - Pharmacodynamics and systemic exposure of esomeprazole in preterm infants and term neonates with gastroesophageal reflux diseaseTaher Omari
Gastroenterology Unit, Children, Youth and Women s Health Services, North Adelaide, SA, Australia
J Pediatr 155:222-8. 2009..To characterize the pharmacodynamics and systemic exposure of esomeprazole in 26 preterm infants and term neonates with symptoms of gastroesophageal reflux and pathologic acid exposure... - Optimisation of the reflux-symptom association statistics for use in infants being investigated by 24-hour pH impedanceTaher I Omari
Gastroenterology Unit, Children, Youth, and Women s Health Service, North Adelaide, Australia
J Pediatr Gastroenterol Nutr 52:408-13. 2011..Infants, however, demonstrate a different symptom profile. The aim of the present study was to optimise criteria for calculation of SAP in infants with GER disease... - A method to objectively assess swallow function in adults with suspected aspirationTaher I Omari
Gastroenterology Unit, Child, Youth and Women s Health Service, North Adelaide, South Australia, Australia
Gastroenterology 140:1454-63. 2011..Pharyngeal manometry and impedance provide information on swallow function. We developed a new analysis approach for assessment of aspiration risk... - A novel method for the nonradiological assessment of ineffective swallowingTaher I Omari
Gastroenterology Unit, Child, Youth and Women s Health Service, North Adelaide, South Australia, Australia
Am J Gastroenterol 106:1796-802. 2011..This validation study evaluates a new manometry impedance-based approach for the objective assessment of pharyngeal function relevant to postswallow bolus residue... - Reproducibility and agreement of pharyngeal automated impedance manometry with videofluoroscopyTaher I Omari
Gastroenterology Unit, Child, Youth and Women s Health Service, North Adelaide, SA, Australia
Clin Gastroenterol Hepatol 9:862-7. 2011..We assessed intra-rater and inter-rater reproducibility of AIM analysis-derived variables; the diagnostic accuracy of AIM-based criteria for detecting aspiration was determined by using expertly scored videofluoroscopy as the standard... - Is the correction factor used in the breath test assessment of gastric emptying appropriate for use in infants?Taher I Omari
Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital and Department of Paediatrics, University of Adelaide, Adelaide, South Australia
J Pediatr Gastroenterol Nutr 41:332-4. 2005.... - Gastro-oesophageal reflux disease in infants and children: new insights, developments and old chestnutsTaher Omari
Centre for Pediatric and Adolescent Gastroenterology, Women's and Children's Hospital, North Adelaide, Australia
J Pediatr Gastroenterol Nutr 41:S21-3. 2005 - Multipoint measurement of intragastric pH in healthy preterm infantsT I Omari
Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital and Department of Paediatrics, University of Adelaide, Adelaide, South Australia
Arch Dis Child Fetal Neonatal Ed 88:F517-20. 2003..The diagnostic use of 24 hour oesophageal pH monitoring in infants is controversial because of the impact of feed buffering of gastric acidity... - Effect of cisapride on gastric emptying in premature infants with feed intoleranceC P Barnett
Neonatal Medicine Unit, Women s and Children s Hospital, North Adelaide, Australia
J Paediatr Child Health 37:559-63. 2001..To assess the effect of cisapride on gastric emptying and gastro-oesophageal reflux (GOR) symptoms in preterm infants with feed intolerance... - Development of pharyngo-esophageal physiology during swallowing in the preterm infantN Rommel
Centre for Pediatric and Adolescent Gastroenterology, Children, Youth and Women s Health Service, Women s and Children s Hospital, North Adelaide SA, Australia
Neurogastroenterol Motil 23:e401-8. 2011..The aim of this study was to assess the development of pharyngeal motility, UES function, and their coordination during nutritive swallowing in preterm infants... - Measurement of upper esophageal sphincter tone and relaxation during swallowing in premature infantsT Omari
Gastroenterology Unit, Women s and Children s Hospital, North Adelaide, South Australia 5006
Am J Physiol 277:G862-6. 1999..31 +/- 0.11 s. We conclude that in premature infants >/=33 wk postmenstrual age the motor mechanisms regulating UES resting pressure and the onset of UES relaxation are well developed... - Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonateMichiel P van Wijk
Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, Children, Youth and Women s Health Services, North Adelaide, Australia
J Pediatr 151:585-90, 590.e1-2. 2007..To identify a body-positioning regimen that promotes gastric emptying (GE) and reduces gastroesophageal reflux (GER) by changing body position 1 hour after feeding... - Vagal and sympathetic influences on the ferret lower oesophageal sphincterL A Blackshaw
Department of Gastrointestinal Medicine, Royal Adelaide Hospital, North Terrace, Australia
J Auton Nerv Syst 66:179-88. 1997..These may release substance P from peripheral myenteric plexus and prevertebral ganglionic endings causing activation of myenteric NANC inhibitory neurones and sympathetic neurones, respectively... - Validation of a novel luminal flow velocimeter with video fluoroscopy and manometry in the human esophagusJ M Andrews
Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia 5000
Am J Physiol 276:G886-94. 1999..This novel instrument measures intraluminal flow velocity and pressures concurrently, thus enabling direct study of pressure-flow relationships. Flow patterns differed between the proximal and distal esophagus... - Noninvasive breath tests can detect alterations in gastric emptying in the mouseE Symonds
Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, Department of Physiology, The University of Adelaide, SA, Australia
Eur J Clin Invest 32:341-4. 2002..Noninvasive breath tests may have significant utility for the measurement of gastric emptying in mice, but the tests' sensitivity for detection of changes in gastric emptying has not been evaluated... - The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor functionAmanda J Page
Nerve Gut Research Laboratroy, Hanson Institute, Department of Gastroenterology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
Gastroenterology 127:1739-47. 2004..We examined the influence of the DEG/ENaC channel ASIC1 on gastrointestinal mechanosensory function, on gastric emptying, and on fecal output. We also compared its role in gastrointestinal and somatic sensory function... - The effect of the GABAB receptor agonist baclofen on liquid and solid gastric emptying in miceErin Symonds
Centre for Paediatric Gastroenterology and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, and Department of Physiology, University of Adelaide, South Australia, Australia
Eur J Pharmacol 470:95-7. 2003..Baclofen accelerated gastric emptying of solids but delayed emptying of liquid, suggesting that it may have differential effects on proximal and distal stomach emptying... - Videomanometric evaluation of pharyngo-oesophageal dysmotility in children with velocardiofacial syndromeNathalie Rommel
Centre for Paediatric and Adolescent Gastroenterology, Australia
J Pediatr Gastroenterol Nutr 46:87-91. 2008 - Paradoxical impact of body positioning on gastroesophageal reflux and gastric emptying in the premature neonateTaher I Omari
Department of Paediatrics, University of Adelaide, Center for Paediatric and Adolescent Gastroenterology, Neonatal Medicine Unit, Women s and Children s Hospital, North Adelaide Australia
J Pediatr 145:194-200. 2004..To combine manometry and impedance to characterize the mechanisms of gastroesophageal reflux (GER) and to explore their relation to the rate of gastric emptying (GE) and body position... - Relation between pancreatic lipase activity and gastric emptying rate in children with cystic fibrosisErin L Symonds
Department of Gastroenterology, Women s and Children s Hospital, North Adelaide, South Australia
J Pediatr 143:772-5. 2003..Lipase function was assessed in the subjects with CF with and without PERT... - A mouse model for assessing the impact of ingested nutrients on gastric emptying rateErin L Symonds
Centre for Paediatric and Adolescent Gastroenterology, Women s and Children s Hospital, North Adelaide, South Australia, Australia
Clin Exp Pharmacol Physiol 34:132-3. 2007..4. The present study has shown that the breath test is sensitive enough to detect changes induced by altering the nutrient and caloric content of test meals... - Gastric emptying is altered with the presence of gastritisErin L Symonds
Gastroenterology Unit, Children, Youth and Women s Health Service, North Adelaide 5006, South Australia
Dig Dis Sci 53:636-41. 2008..Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis... - A combined 13CO2/H2 breath test can be used to assess starch digestion and fermentation in humansErin L Symonds
Gastroenterology Unit, Women s and Children s Hospital, North Adelaide, and Department of Physiology, University of Adelaide, Adelaide, South Australia
J Nutr 134:1193-6. 2004..Cooking resistant starch increased its degree of digestion from 36 to 72%. The (13)CO(2)/H(2) breath test can be used to estimate digestion and fermentation of starches in different physiologic and pathologic conditions...