Graham M Nicholson

Summary

Affiliation: University of Technology
Country: Australia

Publications

  1. ncbi Fighting the global pest problem: preface to the special Toxicon issue on insecticidal toxins and their potential for insect pest control
    Graham M Nicholson
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, P O Box 123, Broadway, NSW 2007, Australia
    Toxicon 49:413-22. 2007
  2. ncbi Insect-selective spider toxins targeting voltage-gated sodium channels
    Graham M Nicholson
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney P O Box 123, Broadway, NSW 2007, Australia
    Toxicon 49:490-512. 2007
  3. ncbi Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel
    Graham M Nicholson
    Neurotoxin Research Group, Department of Heath Sciences, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australia
    Toxicon 43:587-99. 2004
  4. ncbi Arachnid toxinology in Australia: from clinical toxicology to potential applications
    Graham M Nicholson
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, P O Box 123, City Campus, Broadway, NSW 2007, Australia
    Toxicon 48:872-98. 2006
  5. ncbi Differential blockade of neuronal voltage-gated Na(+) and K(+) channels by antidepressant drugs
    Graham M Nicholson
    Department of Health Sciences, University of Technology, PO Box 123, Sydney, Broadway NSW 2007, Australia
    Eur J Pharmacol 452:35-48. 2002
  6. ncbi A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus
    Monique J Windley
    School of Medical and Molecular Biosciences, University of Technology, Sydney, PO Box 123, Broadway NSW 2007, Australia
    Mol Pharmacol 80:1-13. 2011
  7. ncbi Spiders of medical importance in the Asia-Pacific: atracotoxin, latrotoxin and related spider neurotoxins
    Graham M Nicholson
    Neurotoxin Research Group, Department of Heath Sciences, University of Technology, PO Box 123, Sydney, Broadway, New South Wales 2007, Australia
    Clin Exp Pharmacol Physiol 29:785-94. 2002
  8. ncbi Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: a comparison with other osmotic agents and free radical scavengers
    Liesl C Birinyi-Strachan
    Neurotoxin Research Group, Department of Health Sciences, University of Technology, Sydney, Broadway, NSW, Australia
    Neuropharmacology 49:669-86. 2005
  9. ncbi The omega-atracotoxins: selective blockers of insect M-LVA and HVA calcium channels
    Youmie Chong
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, Broadway, NSW 2007, Australia
    Biochem Pharmacol 74:623-38. 2007
  10. ncbi The Janus-faced atracotoxins are specific blockers of invertebrate K(Ca) channels
    Simon J Gunning
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, NSW, Australia
    FEBS J 275:4045-59. 2008

Collaborators

Detail Information

Publications24

  1. ncbi Fighting the global pest problem: preface to the special Toxicon issue on insecticidal toxins and their potential for insect pest control
    Graham M Nicholson
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, P O Box 123, Broadway, NSW 2007, Australia
    Toxicon 49:413-22. 2007
    ..In addition, it reviews their potential for biopesticide discovery and validation of novel insecticide targets and provides an overview of the strengths and weaknesses of biopesticides in the global control of arthropod pests...
  2. ncbi Insect-selective spider toxins targeting voltage-gated sodium channels
    Graham M Nicholson
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney P O Box 123, Broadway, NSW 2007, Australia
    Toxicon 49:490-512. 2007
    ..These studies are being greatly assisted by the determination of the pharmacophore of these toxins, but without precise identification of their binding site and mode of action their potential in the above areas remains underdeveloped...
  3. ncbi Structure and function of delta-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel
    Graham M Nicholson
    Neurotoxin Research Group, Department of Heath Sciences, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australia
    Toxicon 43:587-99. 2004
    ..As such, delta-ACTX provide us with specific tools with which to study sodium channel structure and function and determinants for phyla- and tissue-specific actions of neurotoxins interacting with site-3...
  4. ncbi Arachnid toxinology in Australia: from clinical toxicology to potential applications
    Graham M Nicholson
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, P O Box 123, City Campus, Broadway, NSW 2007, Australia
    Toxicon 48:872-98. 2006
    ....
  5. ncbi Differential blockade of neuronal voltage-gated Na(+) and K(+) channels by antidepressant drugs
    Graham M Nicholson
    Department of Health Sciences, University of Technology, PO Box 123, Sydney, Broadway NSW 2007, Australia
    Eur J Pharmacol 452:35-48. 2002
    ..These actions on voltage-gated ion channels may underlie the therapeutic and toxic effects of these drugs...
  6. ncbi A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus
    Monique J Windley
    School of Medical and Molecular Biosciences, University of Technology, Sydney, PO Box 123, Broadway NSW 2007, Australia
    Mol Pharmacol 80:1-13. 2011
    ..This study therefore establishes these toxins as tools for studying the role of BK(Ca) channels in insects and lead compounds for the development of novel insecticides...
  7. ncbi Spiders of medical importance in the Asia-Pacific: atracotoxin, latrotoxin and related spider neurotoxins
    Graham M Nicholson
    Neurotoxin Research Group, Department of Heath Sciences, University of Technology, PO Box 123, Sydney, Broadway, New South Wales 2007, Australia
    Clin Exp Pharmacol Physiol 29:785-94. 2002
    ..In addition, they should provide valuable tools for the pharmacological and structural characterization of insecticide targets...
  8. ncbi Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: a comparison with other osmotic agents and free radical scavengers
    Liesl C Birinyi-Strachan
    Neurotoxin Research Group, Department of Health Sciences, University of Technology, Sydney, Broadway, NSW, Australia
    Neuropharmacology 49:669-86. 2005
    ....
  9. ncbi The omega-atracotoxins: selective blockers of insect M-LVA and HVA calcium channels
    Youmie Chong
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, Broadway, NSW 2007, Australia
    Biochem Pharmacol 74:623-38. 2007
    ..These findings validate both M-LVA and HVA Ca(v) channels as potential targets for insecticides...
  10. ncbi The Janus-faced atracotoxins are specific blockers of invertebrate K(Ca) channels
    Simon J Gunning
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, NSW, Australia
    FEBS J 275:4045-59. 2008
    ..This study establishes the Janus-faced atracotoxins as valuable tools for the study of invertebrate K(Ca) channels and suggests that K(Ca) channels might be potential insecticide targets...
  11. ncbi Cloning and activity of a novel ?-latrotoxin from red-back spider venom
    Andis Graudins
    Neurotoxin Research Group, School of Medical and Molecular Biosciences, University of Technology, Sydney, Broadway, NSW 2007, Australia
    Biochem Pharmacol 83:170-83. 2012
    ..However, we show that ?-LTX-Lh1a has key substitutions in the 4C4.1 epitope that explains the lack of binding of the monoclonal antibody...
  12. ncbi Characterisation of the heterotrimeric presynaptic phospholipase A(2) neurotoxin complex from the venom of the common death adder (Acanthophis antarcticus)
    Benjamin Blacklow
    Department of Medical and Molecular Biosciences, University of Technology, Sydney, NSW, Australia
    Biochem Pharmacol 80:277-87. 2010
    ..However, antivenom failed to reverse neurotoxicity. Early intervention with antivenom may therefore be important in severe cases of envenomation by A. antarcticus, given the presence of potent irreversible presynaptic neurotoxins...
  13. ncbi ?-Elapitoxin-Aa2a, a long-chain snake ?-neurotoxin with potent actions on muscle (?1)(2)??? nicotinic receptors, lacks the classical high affinity for neuronal ?7 nicotinic receptors
    Benjamin Blacklow
    Neurotoxin Research Group, Department of Medical and Molecular Biosciences, University of Technology, Sydney, P O Box 123, Broadway, NSW 2007, Australia
    Biochem Pharmacol 81:314-25. 2011
    ..EPTX-Aa2a therefore represents a novel atypical long-chain ?-neurotoxin that includes a fifth disulfide but exhibits differential affinity for nAChR subtypes...
  14. ncbi Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons
    Liesl C Birinyi-Strachan
    Neurotoxin Research Group, Department of Health Sciences, University of Technology, Sydney, Broadway NSW, Australia
    Toxicol Appl Pharmacol 204:175-86. 2005
    ..These data indicate that a block of potassium channels contributes to the increase in neuronal excitability, associated with a modulation of Nav channel gating, observed clinically in response to ciguatera poisoning...
  15. ncbi Isolation of delta-missulenatoxin-Mb1a, the major vertebrate-active spider delta-toxin from the venom of Missulena bradleyi (Actinopodidae)
    Simon J Gunning
    Department of Health Sciences, University of Technology, Sydney, NSW 2007, Australia
    FEBS Lett 554:211-8. 2003
    ..Delta-MSTX-Mb1a therefore provides evidence of a highly conserved spider delta-toxin from a phylogenetically distinct spider family that has not undergone significant modification...
  16. ncbi Identification of presynaptic neurotoxin complexes in the venoms of three Australian copperheads (Austrelaps spp.) and the efficacy of tiger snake antivenom to prevent or reverse neurotoxicity
    Francesca Marcon
    Neurotoxin Research Group, School of Medical and Molecular Biosciences, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australia
    Toxicon 58:439-52. 2011
    ....
  17. ncbi Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequence homology but not pharmacological properties with AVIT family proteins
    Suping Wen
    Neurotoxin Research Group, Department of Health Sciences, University of Technology, Sydney, P.O. Box 123, Broadway, NSW 2007, Australia
    Peptides 26:2412-26. 2005
    ....
  18. ncbi Presence of presynaptic neurotoxin complexes in the venoms of Australo-Papuan death adders (Acanthophis spp.)
    Benjamin Blacklow
    Department of Medical and Molecular Biosciences, University of Technology, Sydney, Broadway, NSW, Australia
    Toxicon 55:1171-80. 2010
    ..laevis species, and that early antivenom intervention is important in preventing further development of toxicity...
  19. ncbi Clinical and in vitro evidence for the efficacy of Australian red-back spider (Latrodectus hasselti) antivenom in the treatment of envenomation by a Cupboard spider (Steatoda grossa)
    Andis Graudins
    Department of Emergency Medicine, Westmead Hospital, Hawkesbury Road, Westmead, Sydney, NSW 2145 Australia
    Toxicon 40:767-75. 2002
    ..it may resemble latrodectism. These results indicate that RBSAV is likely to be effective in reversing symptoms of envenomation and should be considered in the treatment of patients with distressing or persisting symptoms...
  20. ncbi Synthesis and characterization of delta-atracotoxin-Ar1a, the lethal neurotoxin from venom of the Sydney funnel-web spider (Atrax robustus)
    Dianne Alewood
    Institute for Molecular Bioscience, University of Queensland, Queensland 4072 Australia
    Biochemistry 42:12933-40. 2003
    ..This successful oxidative refolding of synthetic delta-ACTX-Ar1a paves the way for future structure-activity studies to determine the toxin pharmacophore...
  21. ncbi A rational nomenclature for naming peptide toxins from spiders and other venomous animals
    Glenn F King
    Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia
    Toxicon 52:264-76. 2008
    ..In this article, we introduce a rational nomenclature that can be applied to the naming of peptide toxins from spiders and other venomous animals...
  22. ncbi Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom
    Volker Herzig
    Monash Venom Group, Department of Pharmacology, Monash University, Victoria, Australia
    Toxicon 51:1167-77. 2008
    ..bradleyi venom in vertebrates. These findings are consistent with clinical reports that mouse spiders, particularly species other than male M. bradleyi, do not appear to be a major medical problem in humans...
  23. ncbi Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider delta-atracotoxin
    Nicolas Gilles
    CEA, , Gif-sur-Yvette, France
    Eur J Biochem 269:1500-10. 2002
    ....
  24. ncbi CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons
    Helmut Kubista
    Center for Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Waehringerstrasse 13a, A 1090 Vienna, Austria
    Neuropharmacology 52:1650-62. 2007
    ..The high potency and selectivity of CSTX-1 for a subset of L-type channels in mammalian neurons may enable the toxin to be used as a molecular tool for the investigation of this family of Ca(v) channels...