Research Topics
Genomes and GenesSpecies | Tuan V NguyenSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapyTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Curr Opin Endocrinol Diabetes Obes 15:481-8. 2008..Description of recent progress in genetics and pharmacogenetics of osteoporosis...- Enhancement of absolute fracture risk prognosis with genetic marker: the collagen I alpha 1 geneBich N H Tran
Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, 2010 Sydney, NSW, Australia
Calcif Tissue Int 85:379-88. 2009..The nonograms presented here can be useful for individualizing the short- and intermediate-term prognosis of fracture risk and help identify high-risk individuals for intervention for appropriate management of osteoporosis... - Residual lifetime risk of fractures in women and menNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
J Bone Miner Res 22:781-8. 2007..Among those with BMD T-scores < or = -2.5, the risks increased to 65% in women and 42% in men... - Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for preventionAzam Baheiraei
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
BMC Musculoskelet Disord 6:34. 2005..This study was designed to estimate the modifiable distribution and determinants of bone mineral density (BMD) among Iranian women in Australia... - Bone turnover in elderly men: relationships to change in bone mineral densityTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
BMC Musculoskelet Disord 8:13. 2007..an individual; (ii) is there a relationship between baseline measurements of bone turnover markers and subsequent change in BMD; and (iii) is there a relationship between changes in bone turnover markers and changes in femoral neck BMD?.. - Identification of high-risk individuals for hip fracture: a 14-year prospective studyNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
J Bone Miner Res 20:1921-8. 2005..Preventive strategies should simultaneously target reducing falls and improvement of bone strength in both men and women... - Clinical risk indices, prediction of osteoporosis, and prevention of fractures: diagnostic consequences and costsChatlert Pongchaiyakul
Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
Osteoporos Int 16:1444-50. 2005..Its use in the general population can result in a high false-positive rate and incur significant cost to the community... - Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly womenTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 90:6575-9. 2005..Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I alpha1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women... - Femoral neck bone loss predicts fracture risk independent of baseline BMDTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
J Bone Miner Res 20:1195-201. 2005..In elderly women, greater loss of BMD at the femoral neck was associated with increased risk of fracture, independent of baseline BMD and age... - Abdominal fat and hip fracture risk in the elderly: the Dubbo Osteoporosis Epidemiology StudyNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, UNSW, Australia
BMC Musculoskelet Disord 6:11. 2005..It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years... - Incidence and risk factors for low trauma fractures in men with prostate cancerHenrik G Ahlborg
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Bone 43:556-60. 2008..The present study sought to determine the incidence of low trauma fracture in men with prostate cancer (PC), and to characterize the association between potential risk factors and fracture risk in these men... - Beta3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)Claire Y Wang
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, NSW, Australia
BMC Med Genet 7:57. 2006..The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians... - Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohortsPeter Y Liu
Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
J Clin Endocrinol Metab 92:3599-603. 2007..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time... - Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and womenDana Bliuc
Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
JAMA 301:513-21. 2009..There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture... - Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysisBich N H Tran
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
BMC Med Genet 9:55. 2008..Subsequent population-based studies of the association between the LRP5 gene and BMD have yielded conflicting results. The present study was aimed at examining the association between LRP5 gene and BMD by using meta-analysis... - Association between beta-blocker use and fracture risk: the Dubbo Osteoporosis Epidemiology StudyShuman Yang
Osteoporosis and Bone Biology Research, Garvan Institute of Medical Research, Australia
Bone 48:451-5. 2011..In humans, high bone mass is associated with reduce fracture risk. The present study sought to test the hypothesis that BB use is associated with reduced fracture risk... - Bone resorption and osteoporotic fractures in elderly men: the dubbo osteoporosis epidemiology studyChristian Meier
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
J Bone Miner Res 20:579-87. 2005..3 years, high bone resorption as assessed by S-ICTP was associated with increased risk of osteoporotic fracture, independent of BMD. Combining measurements of BMD and bone turnover may improve fracture prediction in elderly men... - Contribution of hip strength indices to hip fracture risk in elderly men and womenHenrik G Ahlborg
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia, and Department of Orthopaedics, Malmo University Hospital, Sweden
J Bone Miner Res 20:1820-7. 2005..However, the contribution of each of these indices to hip fracture prediction was modest in the presence of BMD... - Asymptomatic vertebral deformity as a major risk factor for subsequent fractures and mortality: a long-term prospective studyChatlert Pongchaiyakul
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
J Bone Miner Res 20:1349-55. 2005..CONCLUSION: Vertebral deformity was a strong predictor of subsequent risk of fractures, particularly symptomatic vertebral fracture, and may modify fracture-associated mortality in both elderly men and women... - Osteoporosis medication and reduced mortality risk in elderly women and menJacqueline R Center
Garvan Institute of Medical Research, and St Vincent s Hospital, Sydney, New South Wales, Australia
J Clin Endocrinol Metab 96:1006-14. 2011..Osteoporotic fractures are associated with premature mortality. Antiresorptive treatment reduces refracture but mortality reduction is unclear... - Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and womenJacqueline R Center
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 89:2776-82. 2004..It needs further exploration for a role in assessment of hip fracture risk across the sexes and particularly in men... - Risk factors for fracture in nonosteoporotic men and womenNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 92:955-62. 2007..It is not known which factors are associated with fracture in nonosteoporotic elderly. The aim of this study was to assess the association between fall-related risk factors and fracture risk in men and women without osteoporosis... - Genetic profiling and individualized prognosis of fractureBich N H Tran
Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
J Bone Miner Res 26:414-9. 2011..85 was around 25. These results suggest that genetic profiling could enhance the predictive accuracy of fracture prognosis and help to identify high-risk individuals for appropriate management of osteoporosis or intervention... - Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancerAndrew V Biankin
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
Gastroenterology 137:558-68, 568.e1-11. 2009..We evaluated the utility of multiple biomarkers from distinct biologic pathways as potential predictive markers of response to pancreatectomy and patient survival... - Limited utility of clinical indices for the prediction of symptomatic fracture risk in postmenopausal womenTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, 384 Victoria Street, 2010, Darlinghurst, NSW, Australia
Osteoporos Int 15:49-55. 2004..48. Clinical risk scores can be used to identify women likely to have low BMD (albeit with low specificity), but they are not a useful tool to identify women who will have a fracture... - On the association between statin and fracture: a Bayesian considerationNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Bone 40:813-20. 2007..This study utilized the Bayesian approach to combine existing evidence and update the association with consideration of potential bias... - Exploring factors influencing osteoporosis prevention and control: a qualitative study of Iranian men and women in AustraliaAzam Baheiraei
Bone and Mineral Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, University of New South Wales, Sydney, NSW, Australia
Maturitas 54:127-34. 2006..These findings provide insights into barriers that need to be overcome if preventive strategies and intervention programs can be developed to reduce the overall burden of osteoporosis in the community... - Bone loss, weight loss, and weight fluctuation predict mortality risk in elderly men and womenNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
J Bone Miner Res 22:1147-54. 2007..Low baseline BMD, rate of BMD loss, weight loss, and weight fluctuation are significant predictors of all-cause mortality in elderly men and women, independent of each other and of age, incident fracture, and concomitant diseases... - Timing of repeat BMD measurements: development of an absolute risk-based prognostic modelSteven A Frost
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
J Bone Miner Res 24:1800-7. 2009..The prognostic model and approach presented in this study may help improve the individualization and management of osteoporosis... - Within-subject variability and analytic imprecision of insulinlike growth factor axis and collagen markers: implications for clinical diagnosis and doping testsTuan V Nguyen
Garvan Institute of Medical Research and Department of Endocrinology, Sydney, Australia
Clin Chem 54:1268-76. 2008..We sought to determine short-term within-subject variability of these markers in a large cohort of healthy individuals... - Genetic effects on bone loss in peri- and postmenopausal women: a longitudinal twin studyJoanna Makovey
Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
J Bone Miner Res 22:1773-80. 2007..Results of genetic model-fitting analysis indicated genetic effects on bone loss account for approximately 40% of the between-individual variation in bone loss at the lumbar spine, forearm, and whole body... - Anti-hip fracture efficacy of biophosphonates: a Bayesian analysis of clinical trialsNguyen D Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, University of New South Wales, Sydney, Australia
J Bone Miner Res 21:340-9. 2006..90. CONCLUSIONS: In postmenopausal women with osteoporosis or low BMD, bisphosphonate treatment is associated with reduced risk of hip fracture... - Incidence of hip and other osteoporotic fractures in elderly men and women: Dubbo Osteoporosis Epidemiology StudyKevin P Chang
Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
J Bone Miner Res 19:532-6. 2004..Approximately one-half of hip fractures occurred before 80 years in men and two-thirds before 85 years in women. The age distribution of hip fractures underlines the need for earlier intervention in osteoporosis... - Osteoporosis: underrated, underdiagnosed and undertreatedTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Med J Aust 180:S18-22. 2004..Simple measures like vitamin D and calcium supplementation and use of hip protectors can reduce hip fractures, particularly in institutionalised and housebound elderly people.. - Bone mineral density-independent association of quantitative ultrasound measurements and fracture risk in womenTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
Osteoporos Int 15:942-7. 2004..The combination of QUS and BMD measurements may improve the accuracy of identification of women who will sustain a fracture... - Psychometric properties of the Persian version of the osteoporosis knowledge and health belief questionnairesAzam Baheiraei
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, University of New South Wales, Sydney, NSW, Australia
Maturitas 50:134-9. 2005 - Reproducibility and concordance in quantitative ultrasound measurements between densitometers: a comparative studyTuan V Nguyen
Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, Australia
J Clin Densitom 6:337-44. 2003..These data suggest that although there are systematic differences between the UBIS and Achilles+ scanners in QUS measurements, the precision of the two instruments is equivalent... - Risk factors for in-hospital post-hip fracture mortalitySteven A Frost
Osteoporosis and Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia
Bone 49:553-8. 2011..This study sought to examine risk factors of, and to develop prognostic model for, predicting in-hospital mortality among hip fracture patients... - Risk of subsequent fracture after low-trauma fracture in men and womenJacqueline R Center
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, University of New South Wales, Sydney, Australia
JAMA 297:387-94. 2007..There are few published long-term data on absolute risk of subsequent fracture (refracture) following initial low-trauma fracture in women and fewer in men... - p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongueRhonda A Kwong
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Clin Cancer Res 11:4107-16. 2005..This study addressed the role of p14(ARF) as a potential prognostic marker in this disease... - Genetic determination of bone mineral density: evidence for a major geneTuan V Nguyen
Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
J Clin Endocrinol Metab 88:3614-20. 2003..These findings clearly support the hypothesis that a large component of the variance in BMD is under genetic control, with strong evidence for a major gene locus influencing BMD transmission... - Predicting fractures in an international cohort using risk factor algorithms without BMDPhilip N Sambrook
University of Sydney Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia
J Bone Miner Res 26:2770-7. 2011..However, more sophisticated models incorporating multiple clinical risk factors including falls were not superior to more parsimonious models in predicting future fracture in this population...