Merrilee Needham

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi Genetics of inclusion-body myositis
    M Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Level 4, A Block, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia
    Muscle Nerve 35:549-61. 2007
  2. ncbi Apolipoprotein epsilon alleles in sporadic inclusion body myositis: a reappraisal
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia
    Neuromuscul Disord 18:150-2. 2008
  3. ncbi Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases
    M Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute ANRI, Queen Elizabeth II Medical Centre, Nedlands, Perth 6009, WA, Australia
    J Neurol Neurosurg Psychiatry 79:1056-60. 2008
  4. ncbi Prevalence of sporadic inclusion body myositis and factors contributing to delayed diagnosis
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute ANRI, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Perth 6009, Australia
    J Clin Neurosci 15:1350-3. 2008
  5. ncbi Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute ANRI, Queen Elizabeth II Medical Centre, Nedlands, Perth, WA 6009, Australia
    Neuromuscul Disord 19:763-5. 2009
  6. ncbi Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex
    Adrian P Scott
    School of Pathology and Laboratory Medicine, M504, University of Western Australia, Perth, Australia
    J Neuroimmunol 235:77-83. 2011
  7. ncbi Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia
    Lancet Neurol 6:620-31. 2007
  8. ncbi Progressive myopathy with up-regulation of MHC-I associated with statin therapy
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Australia
    Neuromuscul Disord 17:194-200. 2007
  9. ncbi Sporadic inclusion body myositis: a continuing puzzle
    M Needham
    Centre for Neuromuscular and Neurological Disorders, Level 4, A Block, Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, University of Western Australia, Perth, WA 6009, Australia
    Neuromuscul Disord 18:6-16. 2008

Detail Information

Publications9

  1. ncbi Genetics of inclusion-body myositis
    M Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Level 4, A Block, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia
    Muscle Nerve 35:549-61. 2007
    ..This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM...
  2. ncbi Apolipoprotein epsilon alleles in sporadic inclusion body myositis: a reappraisal
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia
    Neuromuscul Disord 18:150-2. 2008
    ..Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon2 allele...
  3. ncbi Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases
    M Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute ANRI, Queen Elizabeth II Medical Centre, Nedlands, Perth 6009, WA, Australia
    J Neurol Neurosurg Psychiatry 79:1056-60. 2008
    ..We studied a large cohort of patients with sIBM in order to determine the degree of phenotypic variability and different modes of presentation, as well as the influence of HLA haplotypes...
  4. ncbi Prevalence of sporadic inclusion body myositis and factors contributing to delayed diagnosis
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, Australian Neuromuscular Research Institute ANRI, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, Perth 6009, Australia
    J Clin Neurosci 15:1350-3. 2008
    ..2 years, which suggests that even the latest prevalence figure may be an underestimate, and emphasising the need to increase the level of awareness of the condition among the medical community...
  5. ncbi Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype
    Frank L Mastaglia
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australian Neuromuscular Research Institute ANRI, Queen Elizabeth II Medical Centre, Nedlands, Perth, WA 6009, Australia
    Neuromuscul Disord 19:763-5. 2009
    ..The findings indicate that interactions between the HLA-DRB1*03 allele and other alleles at the DRB1 locus can influence disease susceptibility and the clinical phenotype in sIBM...
  6. ncbi Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex
    Adrian P Scott
    School of Pathology and Laboratory Medicine, M504, University of Western Australia, Perth, Australia
    J Neuroimmunol 235:77-83. 2011
    ..1AH-specific susceptibility region was defined, spanning 172 kb and encompassing three genes--HLA-DRB3, HLA-DRA and BTNL2. It is thus likely that 8.1AH-derived susceptibility to sIBM originates from at least one of these genes...
  7. ncbi Inclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Australia
    Lancet Neurol 6:620-31. 2007
    ..This review covers the clinical presentation, diagnosis, treatment, and the latest information on genetic susceptibility and pathogenesis of sporadic inclusion body myositis...
  8. ncbi Progressive myopathy with up-regulation of MHC-I associated with statin therapy
    Merrilee Needham
    Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Australia
    Neuromuscul Disord 17:194-200. 2007
    ..The mechanism of this myopathy is uncertain but may involve the induction by statins of an endoplasmic reticulum stress response with associated up-regulation of MHC-I expression and antigen presentation by muscle fibres...
  9. ncbi Sporadic inclusion body myositis: a continuing puzzle
    M Needham
    Centre for Neuromuscular and Neurological Disorders, Level 4, A Block, Australian Neuromuscular Research Institute, Queen Elizabeth II Medical Centre, University of Western Australia, Perth, WA 6009, Australia
    Neuromuscul Disord 18:6-16. 2008
    ....