G S Lynch

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Beta2-agonist administration increases sarcoplasmic reticulum Ca2+-ATPase activity in aged rat skeletal muscle
    Jonathan D Schertzer
    Dept. of Physiology, The Univ. of Melbourne, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 288:E526-33. 2005
  2. ncbi Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice
    Jonathan D Schertzer
    Dept. of Physiology, The University of Melbourne, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 291:E499-505. 2006
  3. ncbi Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury
    Chris van der Poel
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, 3010, Australia
    J Inflamm (Lond) 8:41. 2011
  4. ncbi Expression profiling of skeletal muscle following acute and chronic beta2-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm
    Michael A Pearen
    Institute for Molecular Bioscience, The University of Queensland, Queensland 4072, Australia
    BMC Genomics 10:448. 2009
  5. ncbi Force deficits and breakage rates after single lengthening contractions of single fast fibers from unconditioned and conditioned muscles of young and old rats
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Physiol Cell Physiol 295:C249-56. 2008
  6. ncbi Anabolic agents for improving muscle regeneration and function after injury
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:852-8. 2008
  7. ncbi Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Physiol Rev 88:729-67. 2008
  8. ncbi Therapeutic approaches for muscle wasting disorders
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Pharmacol Ther 113:461-87. 2007
  9. ncbi Emerging drugs for sarcopenia: age-related muscle wasting
    Gordon S Lynch
    The University of Melbourne, Department of Physiology and Centre for Neuroscience, Victoria, 3010, Australia
    Expert Opin Emerg Drugs 9:345-61. 2004
  10. ncbi Tackling Australia's future health problems: developing strategies to combat sarcopenia--age-related muscle wasting and weakness
    G S Lynch
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia
    Intern Med J 34:294-6. 2004

Collaborators

Detail Information

Publications85

  1. ncbi Beta2-agonist administration increases sarcoplasmic reticulum Ca2+-ATPase activity in aged rat skeletal muscle
    Jonathan D Schertzer
    Dept. of Physiology, The Univ. of Melbourne, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 288:E526-33. 2005
    ..Our findings demonstrate that the mechanisms underlying age-related changes in contractile properties are fiber type dependent, whereas the effects of fenoterol administration are independent of age and fiber type...
  2. ncbi Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice
    Jonathan D Schertzer
    Dept. of Physiology, The University of Melbourne, Victoria 3010, Australia
    Am J Physiol Endocrinol Metab 291:E499-505. 2006
    ....
  3. ncbi Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury
    Chris van der Poel
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, 3010, Australia
    J Inflamm (Lond) 8:41. 2011
    ..abstract:..
  4. ncbi Expression profiling of skeletal muscle following acute and chronic beta2-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm
    Michael A Pearen
    Institute for Molecular Bioscience, The University of Queensland, Queensland 4072, Australia
    BMC Genomics 10:448. 2009
    ..Therefore, the aim of this study was to identify differential changes in gene expression in murine skeletal muscle associated with systemic (acute and chronic) administration of the beta(2)-AR agonist formoterol...
  5. ncbi Force deficits and breakage rates after single lengthening contractions of single fast fibers from unconditioned and conditioned muscles of young and old rats
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Physiol Cell Physiol 295:C249-56. 2008
    ....
  6. ncbi Anabolic agents for improving muscle regeneration and function after injury
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:852-8. 2008
    ....
  7. ncbi Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Physiol Rev 88:729-67. 2008
    ..Understanding beta-adrenergic signaling in skeletal muscle is important for identifying new therapeutic targets and identifying novel approaches to attenuate the muscle wasting concomitant with many diseases...
  8. ncbi Therapeutic approaches for muscle wasting disorders
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Pharmacol Ther 113:461-87. 2007
    ..The emphasis is on therapies that can increase muscle mass and improve functional outcomes that will ultimately lead to improvement in the quality of life for affected patients...
  9. ncbi Emerging drugs for sarcopenia: age-related muscle wasting
    Gordon S Lynch
    The University of Melbourne, Department of Physiology and Centre for Neuroscience, Victoria, 3010, Australia
    Expert Opin Emerg Drugs 9:345-61. 2004
    ..This review describes a selection of the emerging drugs that have been developed during the period 1997 - 2004, relevant to sarcopenia...
  10. ncbi Tackling Australia's future health problems: developing strategies to combat sarcopenia--age-related muscle wasting and weakness
    G S Lynch
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia
    Intern Med J 34:294-6. 2004
    ..Much research is needed to test the safety and efficacy of these exciting experimental strategies before they can be recommended for clinical application...
  11. ncbi Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice
    Jonathan D Schertzer
    Department of Physiology, The University of Melbourne, Melbourne, Vic, 3010, Australia
    Am J Pathol 171:1180-8. 2007
    ..Although the results in the myotoxic injury model suggest IGF-I signaling is important in this model, the results in the mdx model are mixed...
  12. ncbi Early functional muscle regeneration after myotoxic injury in mice is unaffected by nNOS absence
    Jarrod E Church
    Basic and Clinical Myology Laboratory, Dept of Physiology, The Univ of Melbourne, Victoria, 3010, Australia
    Am J Physiol Regul Integr Comp Physiol 301:R1358-66. 2011
    ..Our findings reveal that nNOS is not essential for functional muscle regeneration after acute myotoxic damage...
  13. ncbi Role of contraction-induced injury in the mechanisms of muscle damage in muscular dystrophy
    Gordon S Lynch
    Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol 31:557-61. 2004
    ..More research is needed to develop specific 'contraction assays' that will assist in the evaluation of the clinical significance of different therapeutic strategies for muscular dystrophy...
  14. ncbi Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice
    Kate T Murphy
    Basic and Clinical Myology Laboratory, Dept of Physiology, The Univ of Melbourne, Victoria 3010, Australia
    J Appl Physiol 110:1065-72. 2011
    ..These findings highlight the therapeutic potential of antibody-directed myostatin inhibition for disuse atrophy especially within the first 2 wk of disuse...
  15. ncbi Cellular mechanisms underlying temporal changes in skeletal muscle protein synthesis and breakdown during chronic {beta}-adrenoceptor stimulation in mice
    Rene Koopman
    Department of Physiology, University of Melbourne, Victoria 3010 Australia
    J Physiol 588:4811-23. 2010
    ..05) on day 1 only. These observations identify that formoterol treatment induces muscle anabolism, by reducing calpain activity and by enhancing protein synthesis via increased PI-3 kinase/Akt signalling...
  16. ncbi Making fast-twitch dystrophic muscles bigger protects them from contraction injury and attenuates the dystrophic pathology
    Stefan M Gehrig
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Am J Pathol 176:29-33. 2010
    ..These novel results further support the contention that anabolic agents have therapeutic potential for muscle wasting conditions including DMD...
  17. ncbi Update on emerging drugs for sarcopenia - age-related muscle wasting
    Gordon S Lynch
    The University of Melbourne, Department of Physiology, Basic and Clinical Myology Laboratory, Victoria 3010, Australia
    Expert Opin Emerg Drugs 13:655-73. 2008
    ....
  18. ncbi Emerging drugs for treating skeletal muscle injury and promoting muscle repair
    Stefan M Gehrig
    The University of Melbourne, Department of Physiology, Basic and Clinical Myology Laboratory, Victoria 3010, Australia
    Expert Opin Emerg Drugs 16:163-82. 2011
    ..More rigorous pre-clinical evaluations, especially of a drug's efficacy for improving function, would help minimize false leads and hasten development of effective approaches for treating muscle damage and promoting repair after injury...
  19. ncbi IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice
    G S Lynch
    Department of Physiology, The University of Melbourne, Victoria 3010, Melbourne, Australia
    Neuromuscul Disord 11:260-8. 2001
    ..The findings have important implications for the role of IGF-I in ameliorating muscle wasting associated with the muscular dystrophies...
  20. ncbi The effects of endurance exercise on dystrophic mdx mice. II. Contractile properties of skinned muscle fibres
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Proc Biol Sci 253:27-33. 1993
    ....
  21. ncbi Effects of beta 2-agonist administration and exercise on contractile activation of skeletal muscle fibers
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Appl Physiol 81:1610-8. 1996
    ..Indeed, in the mouse, low-intensity exercise appears to prevent these effects...
  22. ncbi Rigor force responses of permeabilized fibres from fast and slow skeletal muscles of aged rats
    D R Plant
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Clin Exp Pharmacol Physiol 28:779-81. 2001
    ..We conclude that the age-related decrease in force output is more likely attributed to a decrease in the force per cross-bridge and/or decreases in the efficiency of excitation-contraction coupling...
  23. ncbi In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement
    R Kapsa
    Melbourne Neuromuscular Research Institute and Department of Clinical Neurosciences, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Hum Gene Ther 12:629-42. 2001
    ..With further improvements to in vitro and in vivo gene repair efficiencies, SFHR may find some application in DMD and other genetic neuromuscular disorders in humans...
  24. ncbi Contractile properties of skinned muscle fibres from young and adult normal and dystrophic (mdx) mice
    D A Williams
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Physiol 460:51-67. 1993
    ..The presence of mixed nucleation and absence of fibres with embryonic contractile characteristics in mdx mice suggest that the dystrophin-negative fibres can repair locally occurring muscle damage...
  25. ncbi Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice
    Anna-Maree Axell
    Dept. of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Am J Physiol Endocrinol Metab 291:E506-16. 2006
    ..In addition, we showed that testosterone treatment increases resistance to fatigue of slow- but not fast-twitch muscle...
  26. ncbi Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue
    Leah J Harcourt
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Neuromuscul Disord 17:47-55. 2007
    ....
  27. ncbi Calcineurin-A alpha activation enhances the structure and function of regenerating muscles after myotoxic injury
    Nicole Stupka
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 293:R686-94. 2007
    ..Therefore, calcineurin activation can confer structural and functional benefits to regenerating skeletal muscles, which may be mediated in part by differential expression of MRFs...
  28. ncbi Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice
    Nicole Stupka
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Physiol 575:645-56. 2006
    ..We conclude that increased calcineurin activity may confer functional benefits to dystrophic skeletal muscles...
  29. ncbi Insulin-like growth factor-I analogue protects muscles of dystrophic mdx mice from contraction-mediated damage
    Stefan M Gehrig
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Exp Physiol 93:1190-8. 2008
    ..This study further indicates that modulation of IGF-I signalling has therapeutic potential for muscular diseases...
  30. ncbi Intramuscular beta2-agonist administration enhances early regeneration and functional repair in rat skeletal muscle after myotoxic injury
    James G Ryall
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, 3010 Australia
    J Appl Physiol 105:165-72. 2008
    ..Therefore, if the transient cardiovascular effects associated with intramuscular formoterol administration can be minimized, this form of treatment may have significant therapeutic potential for muscle-wasting conditions...
  31. ncbi Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia
    James G Ryall
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010 Australia
    J Gerontol A Biol Sci Med Sci 62:813-23. 2007
    ..The hypertrophy and increased force-producing capacity of EDL muscles persisted 4 weeks after withdrawal of treatment. The findings have major implications for potential clinical trials utilizing beta(2)-agonists for sarcopenia...
  32. ncbi Comparative evaluation of IGF-I gene transfer and IGF-I protein administration for enhancing skeletal muscle regeneration after injury
    J D Schertzer
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Grattan Street, Victoria 3010, Australia
    Gene Ther 13:1657-64. 2006
    ..Thus, the relative efficacy of different modes of delivery is an important consideration when assessing the therapeutic potential of various proteins for treating muscle injuries and skeletal muscle diseases...
  33. ncbi Therapies for improving muscle function in neuromuscular disorders
    G S Lynch
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Exerc Sport Sci Rev 29:141-8. 2001
    ..The information has application for treating the muscular dystrophies, cancer cachexia, weightlessness, immobilization, denervation, and disuse atrophy...
  34. ncbi Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Calcium 22:373-83. 1997
    ....
  35. ncbi Specific force of the rat extraocular muscles, levator and superior rectus, measured in situ
    B R Frueh
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Neurophysiol 85:1027-32. 2001
    ..We conclude that extraocular muscles are not intrinsically weaker than skeletal muscles...
  36. ncbi Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice
    S M Turpin
    St Vincent s Institute of Medical Research and the Department of Medicine, University of Melbourne, Fitzroy, Australia
    J Physiol 587:1593-605. 2009
    ..A broad transcriptional suppression of pro-apoptotic proteins may explain this resistance to lipid-induced cell death in skeletal muscle...
  37. ncbi Administration of insulin-like growth factor-I improves fatigue resistance of skeletal muscles from dystrophic mdx mice
    Paul Gregorevic
    Department of Physiology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Muscle Nerve 30:295-304. 2004
    ..The findings have important clinical implications, not just for the dystrophinopathies, but for all neuromuscular pathologies where fatigue of locomotor muscles limits functional capacity and decreases quality of life...
  38. ncbi Notexin causes greater myotoxic damage and slower functional repair in mouse skeletal muscles than bupivacaine
    David R Plant
    Basic and Clinical Myology Laboratory, Department of Physiology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Muscle Nerve 34:577-85. 2006
    ..05). The results demonstrate that notexin causes a more extensive and complete injury than bupivacaine, and is a useful model for studying muscle regeneration in mice...
  39. ncbi Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats
    James G Ryall
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Physiol 555:175-88. 2004
    ....
  40. ncbi Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice
    Jonathan D Schertzer
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Physiol Cell Physiol 294:C161-8. 2008
    ..The results demonstrate that IGF-I can ameliorate fundamental aspects of E-C coupling failure in dystrophic muscle fibers and that these effects are important for the improvements in cellular function induced by this growth factor...
  41. ncbi Stimulation of calcineurin Aalpha activity attenuates muscle pathophysiology in mdx dystrophic mice
    Nicole Stupka
    Basic and Clinical Myology Laboratory, Department of Physiology, University of Melbourne, Victoria, 3010, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R983-92. 2008
    ..Thus activation of the calcineurin signal transduction pathway has potential to ameliorate the mdx pathophysiology, especially in the diaphragm, through its effects on muscle degeneration and regeneration and endurance capacity...
  42. ncbi Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses
    James G Ryall
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Grattan Street, Victoria 3010, Australia
    Br J Pharmacol 147:587-95. 2006
    ....
  43. ncbi Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness
    James G Ryall
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Melbourne, Vic, 3010, Australia
    Biogerontology 9:213-28. 2008
    ..The aim is to review our current understanding of some of the cellular and molecular mechanisms responsible for age-related changes in skeletal muscle...
  44. ncbi Beta 2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol
    James G Ryall
    Department of Physiology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Am J Physiol Regul Integr Comp Physiol 283:R1386-94. 2002
    ..These data indicate that fenoterol has greater effects on the functional properties of rat skeletal muscles than clenbuterol...
  45. ncbi The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice
    Nicole Stupka
    Department of Physiology, The University of Melbourne, 3010, Parkville, Victoria, Australia
    Acta Neuropathol (Berl) 107:299-310. 2004
    ..Up-regulating this pathway may have clinical significance for DMD...
  46. ncbi Changes in contractile activation characteristics of rat fast and slow skeletal muscle fibres during regeneration
    Paul Gregorevic
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Physiol 558:549-60. 2004
    ....
  47. ncbi Contraction-induced injury to single permeabilized muscle fibers from mdx, transgenic mdx, and control mice
    G S Lynch
    Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109 2007, USA
    Am J Physiol Cell Physiol 279:C1290-4. 2000
    ....
  48. ncbi Force and power output of diaphragm muscle strips from mdx and control mice after clenbuterol treatment
    G S Lynch
    Institute of Gerontology and Department of Physiology, The University of Michigan, Ann Arbor, MI 48109 2007, USA
    Neuromuscul Disord 11:192-6. 2001
    ..The results indicate that clenbuterol treatment does not improve the structure or function of diaphragm muscles from mdx mice...
  49. ncbi Power output of fast and slow skeletal muscles of mdx (dystrophic) and control mice after clenbuterol treatment
    G S Lynch
    Institute of Gerontology and Departments of Physiology and Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109 2007, USA
    Exp Physiol 85:295-9. 2000
    ..The modest effects of clenbuterol treatment on the dynamic properties of skeletal muscle provide little support for any improvement in muscle function for the dystrophic condition...
  50. ncbi Year-long clenbuterol treatment of mice increases mass, but not specific force or normalized power, of skeletal muscles
    G S Lynch
    Institute of Gerontology, University of Michigan, Ann Arbor, USA
    Clin Exp Pharmacol Physiol 26:117-20. 1999
    ....
  51. ncbi Endurance training adaptations modulate the redox-force relationship of rat isolated slow-twitch skeletal muscles
    David R Plant
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 30:77-81. 2003
    ..We conclude that endurance training-adapted soleus muscles have a slightly altered redox-force relationship...
  52. ncbi Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration
    Paul Gregorevic
    Department of Physiology, The University of Melbourne, Victoria, Australia 3010
    Am J Pathol 161:2263-72. 2002
    ..As respiratory function is a mortality predictor in Duchenne muscular dystrophy patients, further evaluation of IGF-I intervention is recommended...
  53. ncbi Interleukin-15 administration improves diaphragm muscle pathology and function in dystrophic mdx mice
    Leah J Harcourt
    Department of Physiology, University of Melbourne, Victoria, Australia, 3010
    Am J Pathol 166:1131-41. 2005
    ....
  54. ncbi Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK
    Troy L Merry
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 298:E577-85. 2010
    ..In conclusion, ROS and NO are involved in regulating skeletal muscle glucose uptake during contraction via an AMPK-independent mechanism...
  55. ncbi Antibody-directed myostatin inhibition improves diaphragm pathology in young but not adult dystrophic mdx mice
    Kate T Murphy
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Pathol 176:2425-34. 2010
    ....
  56. ncbi Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice
    Nicole Stupka
    Department of Physiology, The University of Melbourne, Grattan Street, Melbourne, VIC 3010, Australia
    Neuromuscul Disord 16:337-46. 2006
    ..Thus, despite greater calcineurin activity in diaphragm compared to hindlimb muscles, regeneration events downstream of myoblast differentiation and mediated by the injured myofibre were severely compromised...
  57. ncbi Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    FASEB J 22:2676-89. 2008
    ..In conclusion, androgens are not required for peak muscle mass in females. In males, androgens act through the AR to regulate multiple gene pathways that control muscle mass, strength, and fatigue resistance...
  58. ncbi Hyperbaric oxygen modulates antioxidant enzyme activity in rat skeletal muscles
    P Gregorevic
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Eur J Appl Physiol 86:24-7. 2001
    ..We conclude that both acute and repeated HBO inhalation can alter enzymatic antioxidant activity in skeletal muscles...
  59. ncbi The effects of endurance exercise on dystrophic mdx mice. I. Contractile and histochemical properties of intact muscles
    A Hayes
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Proc Biol Sci 253:19-25. 1993
    ..The endurance exercise was beneficial to the mdx mice, enhancing the regeneration of function of their muscles by increasing the proportion of oxidative fibres and reducing muscle fatiguability...
  60. ncbi The potential and the pitfalls of beta-adrenoceptor agonists for the management of skeletal muscle wasting
    James G Ryall
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Pharmacol Ther 120:219-32. 2008
    ....
  61. ncbi Excitation-contraction coupling and sarcoplasmic reticulum function in mechanically skinned fibres from fast skeletal muscles of aged mice
    David R Plant
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Physiol 543:169-76. 2002
    ..Impaired excitation-contraction (E-C) coupling and a decrease in SR CRC function are mechanisms which are likely to contribute to the overall slowing of muscle contraction with age...
  62. ncbi Update on emerging drugs for cancer cachexia
    Kate T Murphy
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Melbourne 3010, Australia
    Expert Opin Emerg Drugs 14:619-32. 2009
    ..Conclusions: There are several existing and emerging drugs with the potential to ameliorate cancer cachexia, but the most efficacious treatment will probably come from combined drug therapies...
  63. ncbi Therapeutic clenbuterol treatment does not alter Ca2+ sensitivity of permeabilized fast muscle fibres from exercise trained or untrained horses
    David R Plant
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Muscle Res Cell Motil 24:471-6. 2003
    ..The results indicate that a therapeutic dose of clenbuterol to Standardbred horses does not affect the Ca(2+)-activated contractile characteristics of isolated muscle fibres...
  64. ncbi Optimizing plasmid-based gene transfer for investigating skeletal muscle structure and function
    Jonathan D Schertzer
    Department of Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Mol Ther 13:795-803. 2006
    ....
  65. ncbi Depolarization-induced contraction and SR function in mechanically skinned muscle fibers from dystrophic mdx mice
    David R Plant
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Am J Physiol Cell Physiol 285:C522-8. 2003
    ..05), indicating depressed SR Ca2+ release channel activity. Our findings indicate that fast fibers from mdx mice exhibit some impairment in the events mediating E-C coupling and SR Ca2+ release channel activity...
  66. ncbi beta-Adrenoceptor signaling in regenerating skeletal muscle after beta-agonist administration
    Felice Beitzel
    Basic and Clinical Myology Laboratory, Dept of Physiology, The Univ of Melbourne, Victoria, 3010 Australia
    Am J Physiol Endocrinol Metab 293:E932-40. 2007
    ..These mechanisms have important therapeutic implications for modulating beta-AR signaling to enhance muscle repair after injury...
  67. ncbi Beta2-adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle after injury
    Felice Beitzel
    Department of Physiology, The University of Melbourne, Victoria, 3010 Australia
    J Appl Physiol 96:1385-92. 2004
    ..These findings suggest a physiological role for beta(2)-adrenoceptor-mediated mechanisms in muscle regeneration and show clearly that fenoterol hastens recovery after injury, indicating its potential therapeutic application...
  68. ncbi Chronic beta-agonist administration affects cardiac function of adult but not old rats, independent of beta-adrenoceptor density
    Paul Gregorevic
    Dept. of Physiology, The Univ. of Melbourne, Victoria 3010, Australia
    Am J Physiol Heart Circ Physiol 289:H344-9. 2005
    ..These results provide important information regarding the potential effects of chronic beta-agonist use on cardiac function and the future development of safe and effective treatments for sarcopenia...
  69. ncbi Hyperbaric oxygen increases the contractile function of regenerating rat slow muscles
    Paul Gregorevic
    Department of Physiology, The University of Melbourne, Victoria, Australia 3010
    Med Sci Sports Exerc 34:630-6. 2002
    ..The data indicate that the outcome of HBO treatment of a muscle injury may be influenced by the fiber type composition of the injured muscle...
  70. ncbi Length-tension relationships are altered in regenerating muscles of the rat after bupivacaine injection
    David R Plant
    Dept. of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Appl Physiol 98:1998-2003. 2005
    ..01). The rightward shift in the length-tension curve of EDL muscles 60 days after bupivacaine injection is likely to contribute to the mechanism for their previously observed protection from contraction-induced injury...
  71. ncbi Effects of leukemia inhibitory factor on rat skeletal muscles are modulated by clenbuterol
    Paul Gregorevic
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    Muscle Nerve 25:194-201. 2002
    ..The hypertrophic effects of exogenous LIF on uninjured skeletal muscles indicate that LIF may have application in the treatment of conditions characterized by muscle wasting...
  72. ncbi Chronic beta2-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca2+-ATPase protein and activity
    James G Ryall
    Basic and Clinical Myology Laboratory, Department of Physiology, University of Melbourne, Victoria, Australia
    Am J Physiol Heart Circ Physiol 294:H2587-95. 2008
    ....
  73. ncbi Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice
    Elisabeth Huijsman
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Am J Physiol Endocrinol Metab 297:E505-13. 2009
    ..These results demonstrate an essential role for both ATGL and HSL in maintaining adequate FFA supply to sustain normal substrate metabolism at rest and during exercise...
  74. ncbi The role of beta-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders
    Rene Koopman
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Curr Opin Clin Nutr Metab Care 12:601-6. 2009
    ..This review describes the role of beta-adrenergic signaling in the mechanisms controlling muscle wasting due to its effects on protein synthesis, protein degradation, and muscle fiber phenotype...
  75. ncbi Hydrogen peroxide increases depolarization-induced contraction of mechanically skinned slow twitch fibres from rat skeletal muscles
    David R Plant
    Department of Physiology, University of Melbourne, Victoria 3010, Australia
    J Physiol 539:883-91. 2002
    ..The increase in depolarization-induced contraction in slow twitch fibres might be mediated by an increased SR Ca(2+) release during contraction and/or an increase in Ca(2+) sensitivity...
  76. ncbi Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function
    Kate T Murphy
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia
    FASEB J 24:4433-42. 2010
    ..These observations identify novel roles for myostatin in regulation of muscle mass and highlight the therapeutic potential of antibody-directed myostatin inhibition for sarcopenia...
  77. ncbi Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle
    Z Chen
    St Vincent s Institute of Medical Research, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, Vic, Australia
    FEBS Lett 460:343-8. 1999
    ..Sequence analysis revealed that glycogen synthase, a known AMPK substrate, co-immunoprecipitated with the AMPK alpha2beta2gamma1 complex...
  78. ncbi Novel role for ß-adrenergic signalling in skeletal muscle growth, development and regeneration
    James G Ryall
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Parkville, Vic, Australia
    Clin Exp Pharmacol Physiol 37:397-401. 2010
    ....
  79. ncbi Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice
    Kate T Murphy
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 301:R716-26. 2011
    ..The improvements in limb muscle mass and function highlight the therapeutic potential of antibody-directed myostatin inhibition for cancer cachexia...
  80. ncbi Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction
    Enzo R Porrello
    Dept of Physiology, The Univ of Melbourne, Parkville, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 296:R672-80. 2009
    ....
  81. ncbi Plasmid-based gene transfer in mouse skeletal muscle by electroporation
    Jonathan D Schertzer
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Methods Mol Biol 433:115-25. 2008
    ..As such, methodologies that allow the delivery of a transgene to levels that have a physiological effect and do not compromise muscle function will aid in the characterization of the role of specific proteins in vivo...
  82. ncbi Evaluating an internet weight loss program for diabetes prevention
    Michael R McCoy
    Health 1st Pty Ltd, 2 Stephenson Street, Richmond, Victoria 3121, Australia
    Health Promot Int 20:221-8. 2005
    ..Whether Internet delivery of these interventions can significantly reduce the risk for developing type 2 diabetes is worthy of further investigation. The findings have relevance for development of health promotion policies and practices...
  83. ncbi The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle
    Michael A Pearen
    Institute for Molecular Bioscience, Division of Molecular Genetics and Development, University of Queensland, St. Lucia, Queensland 4072, Australia
    Endocrinology 147:5217-27. 2006
    ..Concordantly the myostatin promoter was repressed by NOR-1 expression. In conclusion, NOR-1 is highly responsive to beta-adrenergic signaling and regulates the expression of genes controlling fatty acid use and muscle mass...
  84. ncbi The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle
    Michael A Pearen
    Institute for Molecular Bioscience, The University of Queensland, Queensland 4072, Australia
    Endocrinology 149:2853-65. 2008
    ..Finally, we demonstrate that NOR-1 is recruited to the lipin-1alpha and PDK-4 promoters, and this is consistent with NOR-1-mediated regulation of these genes. In conclusion, NOR-1 is necessary for oxidative metabolism in skeletal muscle...
  85. ncbi Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Perth, Western Australia, Australia
    Neurobiol Dis 31:1-19. 2008
    ....