R J Lewis

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi HPLC/tandem electrospray mass spectrometry for the determination of Sub-ppb levels of Pacific and Caribbean ciguatoxins in crude extracts of fish
    R J Lewis
    Queensland Agricultural Biotechnology Centre QDPI, University of Queensland, Australia
    Anal Chem 71:247-50. 1999
  2. ncbi The changing face of ciguatera
    R J Lewis
    Queensland Agricultural Biotechnology Centre DPI, Gehrmann Laboratories, The University of Queensland, QLD 4072, Australia
    Toxicon 39:97-106. 2001
  3. ncbi Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes
    R J Lewis
    Centre for Drug Design and Development 3D Centre, Institute for Molecular Bioscience, Department of Physiology and Pharmacology, CSIRO Tropical Agriculture, and Queensland Agricultural Biotechnology Centre QDPI, Australia
    J Biol Chem 275:35335-44. 2000
  4. ncbi Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA
    M J Scanlon
    Centre for Drug Design and Development, University of Queensland, St Lucia, Australia
    Structure 5:1585-97. 1997
  5. ncbi muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
    J Ekberg
    Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, QLD 4072, Australia
    Proc Natl Acad Sci U S A 103:17030-5. 2006
  6. ncbi Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter
    I A Sharpe
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    Nat Neurosci 4:902-7. 2001
  7. ncbi Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin-1
    J A Brock
    Department of Physiology and Pharmacology, University of Queensland, Australia
    Br J Pharmacol 116:2213-20. 1995
  8. ncbi NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G
    L Ragnarsson
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 96:283-91. 2006
  9. ncbi N-type calcium channel blockers: novel therapeutics for the treatment of pain
    C I Schroeder
    Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
    Med Chem 2:535-43. 2006
  10. ncbi The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor
    V W-W Tsai
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Australia
    Neuroscience 130:457-64. 2005

Collaborators

Detail Information

Publications10

  1. ncbi HPLC/tandem electrospray mass spectrometry for the determination of Sub-ppb levels of Pacific and Caribbean ciguatoxins in crude extracts of fish
    R J Lewis
    Queensland Agricultural Biotechnology Centre QDPI, University of Queensland, Australia
    Anal Chem 71:247-50. 1999
    ..25 ppb C-CTX-1 to be established. HPLC/MS/MS provides a sensitive analytical approach, not previously available, for the determination of Pacific and Caribbean ciguatoxins at sub-ppb levels in fish flesh...
  2. ncbi The changing face of ciguatera
    R J Lewis
    Queensland Agricultural Biotechnology Centre DPI, Gehrmann Laboratories, The University of Queensland, QLD 4072, Australia
    Toxicon 39:97-106. 2001
    ..Similarities and differences in ciguatera in the Pacific Ocean, Indian Ocean and Caribbean Sea are highlighted, and future research directions are suggested...
  3. ncbi Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes
    R J Lewis
    Centre for Drug Design and Development 3D Centre, Institute for Molecular Bioscience, Department of Physiology and Pharmacology, CSIRO Tropical Agriculture, and Queensland Agricultural Biotechnology Centre QDPI, Australia
    J Biol Chem 275:35335-44. 2000
    ..1)H NMR studies reveal that CVID possesses a combination of unique structural features, including two hydrogen bonds that stabilize loop 2 and place loop 2 proximal to loop 4, creating a globular surface that is rigid and well defined...
  4. ncbi Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA
    M J Scanlon
    Centre for Drug Design and Development, University of Queensland, St Lucia, Australia
    Structure 5:1585-97. 1997
    ..This study of the solution structure and mode of channel binding of PVIIA forms the basis for mapping the interacting residues at the conotoxin-ion channel interface...
  5. ncbi muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
    J Ekberg
    Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, QLD 4072, Australia
    Proc Natl Acad Sci U S A 103:17030-5. 2006
    ..The actions of MrVIB reveal that VGSC antagonists displaying selectivity toward Na(v)1.8 can alleviate chronic pain behavior with a greater therapeutic index than nonselective antagonists...
  6. ncbi Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter
    I A Sharpe
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    Nat Neurosci 4:902-7. 2001
    ..marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs...
  7. ncbi Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin-1
    J A Brock
    Department of Physiology and Pharmacology, University of Queensland, Australia
    Br J Pharmacol 116:2213-20. 1995
    ..In 100-400 pM CTX-1, the smooth muscle was depolarized to levels resembling those recorded in this artery during ongoing vasoconstrictor discharge in vivo...
  8. ncbi NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G
    L Ragnarsson
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 96:283-91. 2006
    ..We conclude that the combinations of subunits that comprise the NMDA receptor complex influence conantokin and glutamate affinities and the nature of the responses to conantokins...
  9. ncbi N-type calcium channel blockers: novel therapeutics for the treatment of pain
    C I Schroeder
    Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
    Med Chem 2:535-43. 2006
    ..2 calcium channel therapeutics, and finally the development of small molecules for the treatment of chronic pain...
  10. ncbi The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor
    V W-W Tsai
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Australia
    Neuroscience 130:457-64. 2005
    ..Both agents were non-competitive in the inhibitory phase. Overall, the data suggest that Con-G(A7) and ifenprodil interact differently with the polyamine modulation of the glutamate-N-methyl-D-aspartate receptor...