Research Topics
Genomes and Genes
| Richard P HarveySummaryAffiliation: University of New South Wales Country: Australia Publications
Research Grants
| Collaborators
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Detail Information
Publications
Patterning the vertebrate heartRichard P Harvey
Victor Chang Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, New South Wales, Australia
Nat Rev Genet 3:544-56. 2002....- Cardiovascular regenerative medicine: digging in for the long haulJason C Kovacic
Cardiology Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell Stem Cell 1:628-33. 2007..Collectively, a sense emerged that researchers in this field are "digging in for the long haul.".. - The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent mannerS Palmer
Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
J Cell Biol 153:985-98. 2001.... - The Hlx homeobox transcription factor is required early in enteric nervous system developmentMichael D Bates
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
BMC Dev Biol 6:33. 2006..We hypothesized that Hlx is required for ENS development... - BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4Milena B Furtado
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
Genes Dev 22:3037-49. 2008..We conclude that BMP/SMAD1 signaling sets a bilateral, repressive threshold for NODAL-dependent Nodal activation in LPM, limiting availability of SMAD4. This repressive threshold is essential for bistable output of the LR system... - Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardiumDonna Lai
Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
Circ Res 107:715-27. 2010..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide... - Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5Mauro W Costa
Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
PLoS ONE 6:e24812. 2011..We also observe SUMOylation of Nkx2-5 cofactors, which may be critical to Nkx2-5 regulation. Our data reveal highly complex regulatory mechanisms driven by SUMOylation to modulate Nkx2-5 activity... - Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptationFiona A Stennard
Victor Chang Cardiac Research Institute, St Vincent's Hospital, 384 Victoria Street, Darlinghurst 2010, New South Wales, Australia
Development 132:2451-62. 2005..These data suggest that mutations in human cardiac transcription factor genes, possibly including TBX20, underlie both congenital heart disease and adult cardiomyopathies... - Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathyEdwin P Kirk
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
Am J Hum Genet 81:280-91. 2007..They provide insights into how mutation of different genes in an interactive regulatory circuit lead to diverse clinical phenotypes, with implications for diagnosis, genetic screening, and patient follow-up... - T-box transcription factors and their roles in regulatory hierarchies in the developing heartFiona A Stennard
Victor Chang Cardiac Research Institute, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Development 132:4897-910. 2005.... - Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7Frederic Sierro
Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
Proc Natl Acad Sci U S A 104:14759-64. 2007..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4... - Adult cardiac-resident MSC-like stem cells with a proepicardial originJames J H Chong
Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
Cell Stem Cell 9:527-40. 2011..These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair... - Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heartFiona A Stennard
Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, 2010, Sydney, Australia
Dev Biol 262:206-24. 2003..We propose that Tbx20 plays an integrated role in the ancient myogenic program of the heart, and has been additionally coopted during evolution of vertebrates for endocardial cushion development... - Molecular pathways in myocardial development: a stem cell perspectiveMark J Solloway
Victor Chang Cardiac Research Institute, 384 Victoria Street, 2010, Darlinghurst, Australia
Cardiovasc Res 58:264-77. 2003..Stem cell-mediated myogenic repair in the heart represents a fifth modality, and an exciting frontier with basic and practical implications that remain to be explored... - A critical time for stem cell research in AustraliaAlan Trounson
Monash Immunology and Stem Cell Laboratories, Faculty of Medicine, Monash University, Clayton, Victoria, 3800, Australia
Cell Stem Cell 2:118-22. 2008..However, the inevitable "brain drain" and government and community expectations of quick commercial gains and rapid cures necessitate careful reconsideration of the identity and future of stem cell science in Australia... - Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardiumMathilda T M Mommersteeg
Heart Failure Research Center, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Circ Res 101:902-9. 2007..In conclusion, our data suggest a cellular mechanism for pulmonary myocardium formation and highlight the key roles played by Pitx2c and Nkx2-5 in its formation and identity... - An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferationOwen W J Prall
Victor Chang Cardiac Research Institute, Sydney 2010, Australia
Cell 128:947-59. 2007.... - Molecular pathway for the localized formation of the sinoatrial nodeMathilda T M Mommersteeg
Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Circ Res 100:354-62. 2007.... - Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18Vincent M Christoffels
Department of Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
Circ Res 98:1555-63. 2006.... - Progress and challenges in the genetics of congenital heart diseaseDavid S Winlaw
Med J Aust 182:100-1. 2005 - Foxh1 is essential for development of the anterior heart fieldIngo Von Both
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Dev Cell 7:331-45. 2004..Thus, Foxh1 and Nkx2-5 functionally interact and are essential for development of the AHF and its derivatives, the RV and OFT, in response to TGFbeta-like signals... - Hop is an unusual homeobox gene that modulates cardiac developmentFabian Chen
Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Cell 110:713-23. 2002..Hop encodes an unusual homeodomain protein that modulates SRF-dependent cardiac-specific gene expression and cardiac development... - Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5Edouard G Stanley
Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW, Australia
Int J Dev Biol 46:431-9. 2002..Our data suggest that the Nkx2-5IRESCre strain will be useful for genetic dissection of the multiple tiers of lineage allocation to the forming heart as well as of molecular interactions within the heart fields and heart tube... - NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesisChristine Biben
Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW, Australia
Int J Dev Biol 46:415-22. 2002..These data suggest roles for Nkx2-3 during pharyngeal organogenesis, although the considerable potential for genetic redundancy within and outside of this gene family may mask earlier functions in organ specification...
Research Grants
- Genetic modifiers of congenital heart diseaseRichard Harvey; Fiscal Year: 2005..Their relevance to incidence, penetrance and phentypic expression in familial and idiopathic ASDs in humans will be assessed using our patient DNA resource...