Research Topics
Species | D EylesSummaryAffiliation: University of Queensland Country: Australia Publications
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Publications
Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J miceLauren R Harms
School of Biomedical Sciences, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland 4072, Australia
Behav Brain Res 187:343-50. 2008....- Vitamin D3 and brain developmentD Eyles
Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Brisbane, Queensland 4076, Australia
Neuroscience 118:641-53. 2003..Our findings would suggest that low maternal vitamin D(3) has important ramifications for the developing brain... - Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brainDarryl W Eyles
Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
J Chem Neuroanat 29:21-30. 2005..The widespread distribution of 1alpha-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain... - Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brainD Eyles
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
J Steroid Biochem Mol Biol 103:538-45. 2007..Since disruptions of mitochondrial metabolism have been associated with both multiple sclerosis and schizophrenia, developmental vitamin D deficiency may be a heuristic animal model for the study of these two brain diseases... - The utility of neonatal dried blood spots for the assessment of neonatal vitamin D statusDarryl W Eyles
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, Australia
Paediatr Perinat Epidemiol 24:303-8. 2010..They could be used for case-control studies investigating the association between perinatal vitamin D status and later health outcomes... - A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrationsJohn J McGrath
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Locked Bag 500, Richlands Q4077, Australia
J Steroid Biochem Mol Biol 121:471-7. 2010..Further research is required in order to clarify the genetic architecture underlying 25OHD serum concentrations, and to unravel the mechanisms of action responsible for these associations... - Developmental vitamin D deficiency and risk of schizophrenia: a 10-year updateJohn J McGrath
Queensland Center for Mental Health Research, The Park Center for Mental Health, Wacol, Queensland 4076, Australia
Schizophr Bull 36:1073-8. 2010..This article provides a concise summary of the epidemiological and animal experimental research that has explored this hypothesis... - Developmental vitamin D (DVD) deficiency alters pup-retrieval but not isolation-induced pup ultrasonic vocalizations in the ratThomas H J Burne
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia
Physiol Behav 102:201-4. 2011..We speculate that the altered maternal-pup interactions identified in the DVD model may impact on early periods of brain development and behaviour... - The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegyptiLuciano A Moreira
School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
Parasit Vectors 4:28. 2011..Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced "bendy" and "shaky" phenotypes... - Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraintThomas H J Burne
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland 4076, Australia
Behav Brain Res 174:119-24. 2006..The time spent in the centre was not altered by prenatal diet or acute restraint. Thus, transient prenatal vitamin D deficiency induces a transient spontaneous hyperlocomotion in adulthood that is modulated by acute restraint stress... - Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA functionDarryl W Eyles
Queensland Centre for Mental Health Research, Wacol, The School of Biomedical Sciences, The University of Queensland, Brisbane, and Perinatal Research Centre, Royal Brisbane and Women s Hospital, Herston, Australia
Psychoneuroendocrinology 31:958-64. 2006..We conclude that the behavioural alterations induced by DVD deficiency are due to some adverse event in brain development rather than via an alteration in stress response... - Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophreniaJames P Kesby
School of Biomedical Science, University of Queensland, Brisbane, Australia
Biol Psychiatry 60:591-6. 2006..In light of the putative association between low prenatal vitamin D and schizophrenia, the discrete behavioral differences associated with the DVD model may help elucidate the neurobiological correlates of schizophrenia... - The association between birth weight, season of birth and latitudeJohn J McGrath
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
Ann Hum Biol 32:547-59. 2005..Birth weight is known to fluctuate with month of birth and with latitude; however the mechanisms underlying these gradients remain unclear... - The neurodevelopmental hypothesis of schizophrenia: a review of recent developmentsJohn J McGrath
Queensland Centre for Schizophrenia Research, The Park Center for Mental Health, Wacol, QLD 4076, Australia
Ann Med 35:86-93. 2003..The NDH has provided great impetus to the schizophrenia research community. Recent versions of the hypothesis have encouraged more focused and testable hypotheses... - Vitamin D3-implications for brain developmentJohn J McGrath
Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, Australia
J Steroid Biochem Mol Biol 89:557-60. 2004..It remains to be seen if these processes are of clinical relevance in humans, but in light of the high rates of hypovitaminosis D in pregnant women and neonates, this area warrants further scrutiny... - Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female ratsJames P Kesby
School of Biomedical Science, University of Queensland, Brisbane, QLD, 4072, Australia
Psychopharmacology (Berl) 208:159-68. 2010..DVD-deficient adult rats show novelty-induced hyperlocomotion and an enhanced locomotor response to MK-801, which can be ameliorated by pretreatment with the antipsychotic drug haloperidol... - Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspringDarryl W Eyles
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
Psychoneuroendocrinology 32:227-34. 2007..These findings suggest there may be a therapeutic window for maternal dietary intervention in the DVD model of psychosis... - Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult ratsThomas H J Burne
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
Behav Brain Res 154:549-55. 2004..Thus, transient prenatal Vitamin D deficiency induces hyperlocomotion in adulthood, without severe motor abnormalities... - Neonatal vitamin D status and risk of schizophrenia: a population-based case-control studyJohn J McGrath
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
Arch Gen Psychiatry 67:889-94. 2010..Clues from the epidemiology of schizophrenia suggest that low levels of developmental vitamin D may be associated with increased risk of schizophrenia... - Maternal vitamin D depletion alters neurogenesis in the developing rat brainXiaoying Cui
School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia
Int J Dev Neurosci 25:227-32. 2007..These results show that vitamin D can regulate cell proliferation in the developing brain. Further studies are warranted to examine the underlying mechanisms for these findings... - Developmental vitamin D3 deficiency induces alterations in immune organ morphology and function in adult offspringLouise Harvey
School of Biomedical Sciences, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland 4072, Australia
J Steroid Biochem Mol Biol 121:239-42. 2010..Given an increased incidence of vitamin D3 deficiency in women of child-bearing age these findings may be highly relevant for autoimmune disorders with a developmental basis... - Behavioural characterization of vitamin D receptor knockout miceThomas H J Burne
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
Behav Brain Res 157:299-308. 2005..Therefore, it appears that VDR -/- mice have muscular and motor impairments that significantly affects locomotor behaviour but seemingly no impairments in cognition as indicated by exploration, working memory or anxiety... - Big ideas for small brains: what can psychiatry learn from worms, flies, bees and fish?T Burne
Queensland Brain Institute, University of Queensland, St Lucia, Australia
Mol Psychiatry 16:7-16. 2011..Although these species may have small brains, they offer the neuropsychiatric research community opportunities to explore some of the most important research questions in our field... - Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startleThomas H J Burne
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Queensland 4111, Australia
Physiol Behav 81:651-5. 2004..We conclude that combined prenatal and chronic postnatal hypovitaminosis D, but not early life hypovitaminosis D, alters PPI... - 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neuronsJillanne Brown
School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia
Neurosci Lett 343:139-43. 2003..The role of vitamin D(3) during brain development warrants closer scrutiny... - Seasonal variation in birth weightJohn J McGrath
CMAJ 173:733; author reply 733-4. 2005 - Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult ratsAxel Becker
O v Guericke University, Faculty of Medicine, Institute of Pharmacology and Toxicology, Leipziger Str 44, 39120 Magdeburg, Germany
Behav Brain Res 161:306-12. 2005..The behavioural phenotype associated with this animal model may provide insights into the neurobiological correlates of the cognitive impairments of schizophrenia... - Hyperserotonaemia and reduced brain serotonin levels in NaS1 sulphate transporter null miceSooHyun Lee
School of Biomedical Sciences, University of Queensland, St Lucia, Australia
Neuroreport 18:1981-5. 2007..Our data indicate that decreased circulating SO4 concentrations modulate 5-HT neurotransmitter and receptor levels, in a manner consistent with the behavioural phenotypes of Nas1 mice...